Search Results
Results 351 - 400 of 1743
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Jones Jeffrey A - - 2009
The present study tested the hypothesis that changes in the resident endogenous cellular population accompany alterations in aortic collagen and elastin content during thoracic aortic aneurysm (TAA) development in a murine model. Descending thoracic aortas were analyzed at various time points (2, 4, 8, and 16 weeks) post-TAA induction (0.5 ...
Resch Markus - - 2009
Splanchnic vasodilation is the pathophysiological hallmark in the development of the hyperdynamic circulatory syndrome in liver cirrhosis and portal hypertension. This has been attributed so far mainly to a marked vascular hyporeactivity to endogenous vasoconstrictors. However, myogenic tone and vessel stiffness have not been addressed in mesenteric arteries in liver ...
Ohki Shin-ichi - - 2009
A 59-year-old man was transferred to our hospital because of mural thrombus in the ascending aorta. He had suffered some neurological dysfunctions such as transient dysorientation. Electrocardiogram showed normal sinus rhythm without premature beats. Trans-thoracic echocardiogram and three-dimensional CT showed a mobile mural mass sticking to the ascending aortic wall. ...
Krasinski Adam - - 2009
This study was designed to evaluate 3-D ultrasound (3DUS)-derived vessel wall volume (VWV), a 3-D measurement of the carotid artery intima and media, including atherosclerotic plaque, in patients enrolled in a randomized placebo-controlled three-month study of intensive atorvastatin treatment. Thirty-five subjects with carotid stenosis >60% who provided written informed consent ...
Roy S - - 2009
Vascular smooth muscle is a major structural element of the arterial wall. We examined the effects of cytoskeleton destruction, after administration of Cytochalasin D, on the biomechanical properties of porcine common carotids. Compared to untreated, maximally dilated controls, Cytochalasin D-treated arteries have shown a marked increase in compliance in the ...
Badran Hala Mahfouz - - 2009
BACKGROUND: Differential diagnosis between ischemic (IDCM) and the nonischemic type (NIDCM) of cardiomyopathy constitutes a challenge in the daily medical practice. Carotid and aortic elastic properties deteriorate in patients with coronary artery disease. However, their predictive role in differentiating IDCM from NIDCM has not been addressed so far. AIM OF ...
Kang Kyusik - - 2009
OBJECTIVES: Structural changes in the extracranial carotid artery are associated with an increase in left ventricular (LV) mass and relative wall thickness. The present study was performed to determine the relation of LV mass index and relative wall thickness to suspected atherosclerotic steno-occlusive disease of the intracranial arteries on magnetic ...
Liao Dan D Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, and Michael E. DeBakey VA Medical Center, Houston, TX 77030, - - 2009
Establishing thrombosis-resistant surface is crucial to develop tissue-engineered small diameter vascular grafts for arterial reconstructive procedures. The objective of this study was to evaluate the stability and anti-coagulation properties of heparin covalently linked to decellularized porcine carotid arteries. Cellular components of porcine carotid arteries were completely removed with chemical and ...
Mohler Emile R ER 3rd Department of Medicine, Cardiovascular Division, Section of Vascular Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. - - 2009
The measurement of carotid intima-medial thickness is a well-validated measure of cardiovascular risk. Although atherosclerosis occurs in the intima, this arterial layer is not measured alone because of the limitation in ultrasound resolution with standard-frequency probes. We evaluated the feasibility of using a 55-MHz ultrasound system with high resolution to ...
Stapleton C H - - 2009
The presence of axillary artery aneurysm and/or thrombus in overhead throwing athletes has been linked, theoretically, with the finding of compression by the humeral head induced by a diagnostic arm maneuver. However, whether this intermittent compression is incidental or of pathological significance has yet to be determined. Flow-mediated vasodilation (FMD), ...
Dorfmann A - - 2010
In this paper, we develop a physiologic wall stress analysis procedure by incorporating experimentally measured, non-uniform pressure loading in a patient-based finite element simulation. First, the distribution of wall pressure is measured in a patient-based lumen cast at a series of physiologically relevant steady flow rates. Then, using published equi-biaxial ...
Sorice Gian Pio - - 2009
The aetiology of aortic aneurysms (AAs) is the subject of intense clinical investigation. One of the critical points in their pathogenesis is the disruption of the balance between vascular extracellular matrix deposition and degradation. AAs are common features in some genetically determined diseases of the connective tissue, such as Marfan ...
Kornaat Peter R - - 2009
PURPOSE: The purpose of the study was to determine if a positive association exists between arterial vessel wall thickness and generalized osteoarthritis (OA). Our hypothesis is that generalized OA is another facet of the metabolic syndrome. MATERIALS AND METHODS: The medical ethical review board of our institution approved the study. ...
Hashimoto Junichiro - - 2009
Aging has a striking impact on the arterial structure and function. The principal structural change with age is medial degeneration that leads to a progressive stiffening of the large elastic arteries. Large artery stiffening increases aortic systolic and pulse pressures through an increase in the forward incident wave and an ...
Matlung Hanke L - - 2009
Shear stress is well known to be a key factor in the regulation of small-artery tone and structure. Although nitric oxide is a major endothelium-derived factor involved in short- and long-term regulation of vascular caliber, it is clear that other mechanisms also can be involved. This review discusses the evidence ...
Pearce Gillian - - 2009
We present data concerning the extraction of clots using the newly invented "GP" mechanical thrombectomy device (MTD). Artificial and porcine clots of various lengths were used in plastic tube models of an artery. We investigate the pressures and times taken for clot extraction together with the volumes of fluid extracted. ...
Bia Daniel - - 2009
While the situation of tissue donation and transplantation differs between Latin American and European countries, a common problem is tissue deficiency. Hence, at present, there is a pressing need to generate alternatives so as to increase the possibilities of obtaining the requested materials. Consequently, it would be of significant interest ...
McAdams R M - - 2009
Umbilical artery catheter (UAC) use is common in the management of critically ill neonates; however, little information exists regarding the anatomic and vascular effects of UAC placement in premature newborns. Baboons were delivered at 125 days of gestation (term=185 days), treated with surfactant, had UACs placed and were ventilated for ...
Russell Nicola S - - 2009
BACKGROUND AND PURPOSE: Vascular disease is increased after radiotherapy and is an important determinant of late treatment-induced morbidity and excess mortality. This study evaluates the nature of underlying pathologic changes occurring in medium-sized muscular arteries following irradiation. MATERIALS AND METHODS: Biopsies of irradiated medium-sized arteries and unirradiated control arteries were ...
Huo Yunlong - - 2009
A hemodynamic analysis is implemented in the entire coronary arterial tree of diastolically arrested, vasodilated pig heart that takes into account vessel compliance and blood viscosity in each vessel of a large-scale simulation involving millions of vessels. The feed hematocrit (Hct) is varied at the inlet of the coronary arterial ...
Mercier Nathalie - - 2009
To investigate a putative role for semicarbazide-sensitive amine oxidase (SSAO) in arterial extracellular matrix (ECM) organization, we compared arteries of growing Brown Norway (BN) rats after chronic administration of semicarbazide (SCZ) and beta-aminopropionitrile (BAPN), two inhibitors with different properties and relative specificities for SSAO and lysyl oxidase (LOX). The BN ...
Grassi Guido - - 2010
Obese persons are at increased cardiovascular risk and exhibit increased arterial stiffness and impaired endothelial function of large- and medium-size arteries. We hypothesized that normotensive subjects suffering from severe obesity would also present remodeling and endothelial dysfunction of small resistance arteries. A total of 16 lean (age: 49.6 +/- 2.9 ...
Conley Dylan - - 2010
The arrangement of jejunal and ileal arteries varies along the length of the small bowel, but the reasons for this and the functional implications are uncertain. The aims of this anatomical and histological study were to investigate quantitative differences between jejunal and ileal arteries and to investigate their relative muscularity. ...
Zhang Yanrong - - 2009
This study evaluated the value of high-frequency ultrasonograpy for early detection of dorsal artery of foot in patients with type 2 diabetes mellitus (MD). Eighty subjects including 40 patients with type 2 MD (T2DM group) and 40 healthy volunteers (NC group) were recruited. The intima-media thickness (IMT), the inner diameter ...
Gansburgsky A N - - 2009
The cerebral arterial smooth myocytes of dogs with experimental hypertension (n=12), its correction (n=10), and of intact dogs (n=8) were studied. The structure of myocyte population changed under conditions of vascular wall hyperfunction: the size of the cytoplasm and nuclei, DNA content in the nuclei, mitotic activity, and percentage of ...
Han Hai-Chao - - 2009
Though tortuosity and kinking are often observed in various arteries and arterioles, little is known about the underlying mechanisms. This paper presents a biomechanical analysis of bent buckling in long arterial segments with a small initial curvature using a thick-walled elastic cylindrical arterial model. The critical buckling pressure was established ...
Gao F - - 2009
This study was designed to test the hypothesis that a medium-term simulated microgravity by tail-suspension (SUS) induces hypertrophic and atrophic changes in the common carotid artery and abdominal aorta with their innermost smooth muscle (SM) layers being most profoundly affected. The second purpose was to elucidate whether vascular local renin-angiotensin ...
Choy Jenny Susana - - 2009
Since the right and left ventricles (RV and LV) function under different loading conditions, it is not surprising that they differ in their mechanics (intramyocardial pressure), structure, and metabolism; such differences may also contribute to differences in the coronary vessel wall. Our hypothesis is that intima-media thickness (IMT), IMT-to-radius (IMT-to-R) ...
Gavish Lilach - - 2009
AIMS: Increased early detection of abdominal aortic aneurysm (AAA) and the severe complications of its current treatment have emphasized the need for alternative therapeutic strategies that target pathogenetic mechanisms of progression and rupture. Recent in vitro studies from our laboratory have shown that low-level laser irradiation (LLLI) (780 nm) modifies ...
Ahlgren Asa Rydén - - 2009
Using ultrasound we recently demonstrated that in central elastic arteries as well as in large muscular arteries in humans there is a distinct longitudinal displacement of the arterial wall during the cardiac cycle. Further, for the first time, we also demonstrated that the inner parts of the vessel wall, the ...
Miao Cuilian - - 2009
The purpose of this study was to assess coronary arterial remodeling as a marker of subclinical atherosclerosis using coronary wall magnetic resonance imaging (MRI) in an asymptomatic population-based cohort. In early atherosclerosis, compensatory enlargement of both the outer wall of the vessel as well as the lumen, termed compensatory enlargement ...
Dwyer Harry A - - 2009
OBJECTIVES: Studied under clinical trials, transcatheter aortic valves (TAV) have demonstrated good short-term feasibility and results in high-risk surgical patients with severe aortic stenosis. However, their long-term safety and durability are unknown. The objective of this study is to evaluate hemodynamic changes within TAV created by bioprosthetic leaflet degeneration. METHODS: ...
Masson Ingrid - - 2009
A new protocol for cryopreservation of arteries frozen at -80 degrees C was compared to the reference protocol for cryopreservation at -150 degrees C and to freshly harvested arteries. The aim of the study is to evaluate both protocols as global procedures to freeze and thaw arteries commonly used in ...
Fahey Michael - - 2009
BACKGROUND: Many methods are used to measure arterial elasticity in children using echocardiography. There is no data to support the equivalence of the different techniques. The goal of this study was to evaluate the reproducibility of several techniques used to measure arterial elasticity using echocardiography. METHODS: Aortic distension in two ...
Watton Paul N - - 2009
We compare two constitutive models proposed to model the elastinous constituents of an artery. Holzapfel and Weizsäcker [1998. Biomechanical behavior of the arterial wall and its numerical characterization. Comput. Biol. Med. 28, 377-392] attribute a neo-Hookean response, i.e. Psi=c(I(1)-3)), to the elastin whilst Zulliger et al. [2004a. A strain energy ...
Hodis S - - 2009
Change in arterial stiffness is generally considered a risk factor for cardiovascular disease and, in various ways, has been associated with hypertension, diabetes, hyperlipidemia, atherosclerosis, and heart failure, likely because of altered dynamics of the wall and of the fluid-wall interplay in pulsatile flow. We present a comprehensive analytical study ...
Bia Daniel - - 2009
Native vessels-grafts biomechanical mismatch (BM) is related to graft failure. The BM could be reduced using human cryopreserved/defrosted arteries (cryografts), but post-thaw cryografts' recovery could be associated with an impaired biomechanical behavior. In vitro, we demonstrated that our cryopreservation methods do not affect arteries' biomechanics, but only post-implant studies would ...
Aoki Tomohiro - - 2009
Cerebral aneurysm (CA) is a relatively common disease and can cause a catastrophic subarachnoid hemorrhage with a high mortality and morbidity rate. Despite its clinical and social importance, the detailed mechanism of CA formation remains to be elucidated, resulting in the absence of effective medical treatment against CAs. Recent studies ...
Lindeman Jan H N - - 2009
BACKGROUND: Doxycycline has been shown to effectively inhibit aneurysm formation in animal models of abdominal aortic aneurysm. Although this effect is ascribed to matrix metalloproteinase-9 inhibition, such an effect is unclear in human studies. We reevaluated the effect of doxycycline on aortic wall protease content in a clinical trial and ...
Campos Luciene Cristina Gastalho - - 2009
AIMS: Cysteine- and glycine-rich protein 3/muscle LIM-domain protein (CRP3/MLP) mediates protein-protein interaction with actin filaments in the heart and is involved in muscle differentiation and vascular remodelling. Here, we assessed the induction of CRP3/MLP expression during arterialization in human and rat veins. METHODS AND RESULTS: Vascular CRP3/MLP expression was mainly ...
Seidlerova, Jitka
In line with Guyton’s work, the goal of our research was to explore in three European populations whether the properties of large arteries are associated with renal sodium handling, which itself changes with environmental factors and with variation in a large number of genes. Before engaging in the genetic analyses ...
Wang Zhong-He - - 2009
OBJECTIVE: In this experimental study with rabbits, the influence of intraarterial high-dose cisplatin with concomitant irradiation on arterial microanastomoses was evaluated to determine their impact on free-tissue transfers. METHODS: The right and left iliac arteries of 10 rabbits were injected with 150 mg/m of cisplatin (group 1). To serve as ...
Chiu Ing-Sh - - 2009
BACKGROUND: Reoperation is usually inevitable for congenital cardiac patients after insertion of an extracardiac valved conduit. We sought to verify that a transannular patch on the autologous posterior wall with the common wall between the aorta and pulmonary artery can replace the conventional operation using an extracardiac conduit. METHODS: From ...
Toprak Ahmet - - 2009
Differences in geometric adaptation of the left ventricle and associated cardiovascular risk may reflect the differential effects of classic risk factors and arterial stiffness on the left ventricle. In the present study, the influence of cardiovascular risk factors and arterial stiffness indexes on left ventricular (LV) geometry types were studied ...
Mueed Irem - - 2009
To evaluate the potential impact of using atherosclerotic radial artery (RA) conduits as grafts in coronary artery bypass surgery, we examined the vasoconstrictor and electrophysiological properties of mildly and severely atherosclerotic RAs. Vasoconstrictor responses were measured in cannulated and pressurized (85mmHg) RA segments and K(+) currents were measured in single ...
Hitchcock Kathryn E - - 2009
Optimal ultrasound parameters to enhance delivery of therapeutic-loaded echogenic immunoliposomes (ELIP) into the arterial wall are being developed for the treatment of atherosclerosis. The aim of this work was to determine whether anti-ICAM-targeted, rhodamine-labeled ELIP (Rh-ELIP) would adhere to and penetrate the vascular endothelium in atheromatous murine arterial segments with ...
Gkaliagkousi E - - 2009
The elasticity of a given arterial segment of the aorta and of big elastic arteries is not constant but depends on its distending pressure. As distending pressure increases, there is greater recruitment of inelastic collagen fibers and thereby a reduction in elasticity. It also depends on structural changes in the ...
Jaffe Ronen R Schulich Heart Programme, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario, - - 2009
We sought to perform the first systematic study of the natural history of chronic total arterial occlusions (CTOs) in an experimental model. Angioplasty of CTOs has low success rates. The structural and perfusion changes during CTO maturation, which may adversely affect angioplasty outcome, have not been systematically studied. Occlusions were ...
Jelski Wojciech - - 2009
OBJECTIVE: Human blood vessels contain a huge amount of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), which play a significant role in the metabolism of many biological substances and participate in various metabolic pathways. The aim of this study was the investigation of the differences between the activities of ADH ...
Hamed Sherifa A - - 2010
PURPOSE: The objective of this study is to provide evidence that primary hyperuricemia is associated with cochlear dysfunction as other metabolic diseases that interfere with cell metabolism. MATERIALS AND METHODS: Cochlear function was evaluated in 25 subjects with asymptomatic hyperuricemia using routine diagnostic audiometry along with transient evoked and distortion ...
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