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Bubb Kristen J KJ William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London, United - - 2014
-Pulmonary hypertension (PH) is a life-threatening disorder characterized by increased pulmonary artery pressure, remodeling of the pulmonary vasculature, and right ventricular failure. Loss of endothelium-derived nitric oxide (NO) and prostacyclin (PGI2) contributes to PH pathogenesis and current therapies are targeted to restore these pathways. Phosphodiesterases (PDEs) are a family of ...
Rogers Ka K Kingston Hospital NHS Trust, London, - - 2014
Intrapartum monitoring aims to identify fetal acidaemia. The fetal acidaemia threshold, reliably accountable for neonatal morbidity, or mortality, is less clear. The International Cerebral Palsy and American Congress of Obstetrics and Gynaecology task force, suggests: "pH <7 …. provides sufficient evidence to blame acute intrapartum events for the neonatal condition". ...
Toczek Marta M a Department of Biochemistry , Medical University of Gdańsk , Gdańsk , - - 2014
Enzymes of extracellular nucleotide catabolism, such as ecto-nucleoside triphosphate diphosphohydrolase (eNTPD), ecto-5'-nucleotidase (e5NT) and ecto-adenosine deaminase (eADA), control extracellular concentrations of adenine nucleotides and adenosine, furthermore in that way regulate inflammation, immune response, and platelets aggregation. In valves, disturbances of these processes may lead to their dysfunction and calcification. The ...
Bierbach Benjamin B Department of Cardiovascular Surgery, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, - - 2014
Visceral malperfusion after coronary artery bypass grafting (CABG) results in high morbidity and mortality. This study was designed to evaluate the effect of CABG performed by surgical techniques on visceral perfusion and function. Pigs (n = 28) were studied in four groups: I. Sham; II. Off-pump coronary artery bypass grafting ...
Weisel Friederike Christine FC Universities of Giessen and Marburg Lung Center, Member of the German Lung Center (DZL), Justus-Liebig-University Giessen, Giessen, - - 2014
Pulmonary hypertension (PH) is a life-threatening disease characterized by vascular remodeling and increased pulmonary vascular resistance. Chronic alveolar hypoxia in animals is often used to decipher pathways being regulated in PH. Here we aimed to investigate whether 1) chronic hypoxia-induced PH in mice can be reversed by reoxygenation and 2) ...
Misuraca Leonardo - - 2013
An 85-year-old woman was admitted to our institution for effort dyspnea. She had a history of mitral valve replacement with a 29 mm Carpentier-Edwards bioprosthesis (Edwards Lifesciences). Transthoracic echocardiography (TTE) showed aortic stenosis and senescence of the mitral bioprosthesis. The heart team opted for a transapical transcatheter aortic valve implantation ...
Mercier Olaf O Centre Chirurgical Marie Lannelongue, Paris-Sud University, Service de Chirurgie Thoracique, Vasculaire et de Transplantation cardio-pulmonaire, Le Plessis-Robinson, France ; Laboratoire de recherche chirurgicale and Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 999, Le Plessis-Robinson, - - 2013
None of the animal models have been able to reproduce all aspects of CTEPH because of the rapid resolution of the thrombi in the pulmonary vasculature. The aim of this study was to develop an easily reproducible large-animal model of chronic pulmonary hypertension (PH) related to the development of a ...
Weng Lihui - - 2013
We present herein characteristics of an in-situ forming hydrogel prepared from carboxymethyl chitosan and oxidized carboxymethyl cellulose for interventional therapies. The gelation, owing to the formation of Schiff base, occurred both with and without the presence of a radiographic contrast. The hydrogel exhibited a highly porous internal structure (pore diameter: ...
Prabu A - - 2013
Pulmonary hypertension (PH) can occur at any time during the course of systemic lupus erythematosus (SLE), and can be independent of lupus disease activity in other systems. The pathogenesis of PH in SLE can be multifactorial, but pulmonary arterial hypertension (PAH) is the commonest cause of PH in SLE. The ...
Shojaku H - - 2012
Objective: To demonstrate the usefulness of pre-operative selective embolisation of the thyroid arteries in an unusual case with a large, vascular thyroid tumour. Case report: A 29-year-old man presented with a large papillary carcinoma of the thyroid (weighing approximately 300 g on palpation) with extension to the mediastinum and compression of ...
Rao Nageswar - - 2012
Abstract  Inflammatory pseudotumor (also known as inflammatory myofibroblastic tumor) is an uncommon spindle cell lesion that was initially recognized in the lung and is now known to occur in virtually every major organ of the body. We report a case of a seven-year-old male who had an inflammatory pseudotumor of ...
Lin Harrison W - - 2012
This case report describes the presentation and management of a rare complication of pseudoaneurysm of the superior thyroid artery following tracheostomy. The majority of post-tracheostomy bleeding is managed either with packing or surgical re-exploration. However, angiography can pinpoint an arterial source of bleeding and allow the surgeon to address it ...
Bogaard Harm J HJ Department of Pulmonary Medicine, VU University Medical Center, Amsterdam, The - - 2012
Pulmonary arterial hypertension (PAH) is a multi-factorial condition and the underlying pulmonary vascular disease is shaped by the combined action of genetic, epigenetic and immune-related factors. Whether and how gender, obesity and the metabolic syndrome modify PAH and associated right heart failure is under intense investigation. Estrogens may enhance the ...
Latib Azeem - - 2012
A 46-year-old woman known with relapsing Hodgkin's lymphoma diagnosed at age 5, treated with repeated cycles of radiotherapy and chemotherapy, presented with severe symptomatic radiation-induced aortic stenosis. She also had other late sequelae of radiotherapy including thyroid cancer, mediastinal fribrosis and left pulmonary fibrosis with severe restrictive lung disease and ...
Canpolat U - - 2012
A 56-year-old man presented with typical angina pectoris lasting >20 min associated with precordial ST-segment elevation. Urgent coronary angiography showed critical stenosis in the proximal segment of the left anterior descending artery, which resolved with intracoronary nitrate application. He was subsequently diagnosed with hyperthyroidism secondary to exposure of iodinated contrast agent ...
El-Essawy Manar T - - 2012
We report a case of a 40-year-old female with cirrhosis, hepatocellular carcinoma, and upper gastrointestinal bleeding who developed multiple pulmonary emboli after endoscopic injection sclerotherapy for gastric variceal bleeding. The patient did not have any respiratory symptoms after the sclerotherapy. A chest radiograph obtained one day after the procedure for ...
Gyasi M E - - 2012
Pterygium is a common ocular surface pathology in tropical environments. In the early stages, it may be managed medically with topical anti-inflammatory agents and ocular lubricants. However as the disease progresses, surgical excision becomes necessary and several anaesthetic methods may be used to assist this. We share our experience of ...
Van Renterghem Dirk - - 2012
Hemoptysis and pulmonary edema associated with nonsteroidal anti-inflammatory drug use is a known condition, but is probably underreported. The mechanisms of induction of pulmonary toxicity are still not well understood. We describe a case of hemoptysis and dyspnea in a scuba diver who was taking diclofenac.
Dinis-Oliveira Ricardo Jorge - - 2012
A "foam cone" exuding the mouth and nostrils is a recognized consequence of anoxia following pulmonary edema. In this report, we illustrate and explain this phenomenon in victims of heroin overdose.
Oyama Hirofumi - - 2012
The patient had thyroid cancer and underwent subtotal thyroidectomy. Local recurrence occurred on both sides 5 years and 6 months later. The sterno-hyoid muscle and sterno-thyroid muscle were severed and the tumor around the cricoid cartilage was removed. The tumor extended into the space between the right common carotid artery ...
Vermeulen Freddy - - 2012
A 34-year follow-up is described after a Konno aortoventriculoplasty to correct a restricted aortic annulus and a recurrent aortic prosthetic valve endocarditis with subannular and interventricular abscesses.
El-Kabbany Zeinab A - - 2012
Background. Alterations in thyroid hormones regulation and metabolism are frequently observed in patients with cirrhosis. Aims. To assess alterations in thyroid volume (TV), haemodynamics, and hormones in patients with cirrhosis and their relation to hepatic arterial haemodynamics, and disease severity. Methods. Forty cirrhotic patients were compared to 30 healthy subjects ...
Raine Dan D Department of Cardiology, North Tyneside General Hospital, North Shields, Tyne and Wear, UK. - - 2012
A 54-year-old woman with a background of psoriatic arthritis but no cardiac history was admitted with acute pulmonary oedema (November 2007) which required invasive ventilation and inotropic support. Investigations including ECG, transthoracic and transoesophageal echocardiography, coronary angiography, renal ultrasound and renal magnetic resonance angiography, cardiac MRI and urinary catecholamines were ...
Ribeiro D D DD Divisão de Hemostasia, Departamento de Hematologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, - - 2012
Venous thrombosis, including deep vein thrombosis and pulmonary embolism, is a common disease that frequently recurs. Recurrence can be prevented by anticoagulants, but this comes at the risk of bleeding. Therefore, assessment of the risk of recurrence is important to balance the risks and benefits of anticoagulant treatment. This review ...
Tang Wen-Jing - - 2012
The aim of this study was to provide some important information about the morphology and topography of the recurrent laryngeal nerve (RLN) and inferior thyroid artery (ITA), which significantly helps localize and protect the RLN in neck surgery, especially in thyroid surgery. Eighty adult cadavers (160 sides) fixed with formalin ...
Melki Elsa - - 2011
Spontaneous cervical-artery dissection (CAD) is a major cause of cerebral ischaemia in young adults. While their pathophysiology remains still poorly understood, CAD is considered today as a multifactorial disease determined by general and local predisposing factors; these predisposing factors being predominantly constitutional abnormalities of the arterial wall. Here, we report ...
Skrzat J - - 2011
The current study evaluates the passage of the atlantal segment of the vertebral artery through the atlas to the cranial cavity in the case of occipitalisation, and searches for potential bony obstacles that constrict the lumen of the vertebral artery. Morphometric analysis was performed of the ossified atlanto-occipital articulation of ...
Radke Peter W - - 2011
Aims: The vascular effects of drug- eluting balloon (DEB) deployment in the absence of coronary stents have not been characterised. This study evaluated potential vascular effects of paclitaxel-coated angioplasty balloons using different excipients in the absence of additional stents. Methods and results: A total 45 porcine arteries were treated with ...
Saguner Ardan M - - 2011
PURPOSE: Uncoated self-expanding nitinol stents (NS) are commonly oversized in peripheral arteries. In current practice, 1-mm oversizing is recommended. Yet, oversizing of NS may be associated with increased restenosis. To provide further evidence, NS were implanted in porcine iliofemoral arteries with a stent-to-artery-ratio between 1.0 and 2.3. Besides conventional uncoated ...
Saxena Pankaj - - 2011
Abstract  Coronary artery bypass graft (CABG) surgery is associated with a low risk of paraplegia. Spinal cord ischemia causing paraplegia following off-pump coronary artery bypass (OPCAB) surgery has not been described previously. We now describe a patient who developed paraplegia following OPCAB and review the literature on spinal cord ischemia ...
Geyer Stefan H - - 2011
Defining the role of genes in the genesis of congenital cardiovascular defects involves comparisons of the diameters of arteries measured in wild-type and genetically engineered mouse embryos. This study aims at evaluating the significance and reproducibility of measurements of the diameters of the great intrathoracic arteries of mouse embryos, as ...
Wu Teddy Y - - 2011
Reversible cerebral vasoconstriction syndrome (RCVS) is characterized by the triad of severe "thunderclap" headaches, neurological symptoms and transient segmental cerebral arterial vasoconstriction. We report a patient with RCVS following carotid endarterectomy and review the literature on RCVS following carotid revascularisation.
Tam Matthew D B S - - 2011
PURPOSE: Safe femoral arterial access is an important procedural step in many interventional procedures and variations of the anatomy of the region are well known. The aim of this study was to redefine the anatomy relevant to the femoral arterial puncture and simulate the results of different puncture techniques. METHODS: ...
Haussen Diogo C - - 2011
Contrast neurotoxicity (CN) following exposure to iodinated contrast is uncommon, and usually presents as cortical blindness due to bilateral occipital lobe involvement. Unilateral cortical dysfunction due to CN could mimic an acute stroke and has been rarely described. We report the case of an 89-year-old female who developed a transient ...
Agrawal Garima - - 2011
Pulmonary perfusion scintigraphy in a 28-year-old woman being evaluated for suspected pulmonary embolism showed no pulmonary abnormalities, but demonstrated diffusely increased activity in an enlarged thyroid gland on the Tc-99m macroaggregated albumin images. There was no history of prior radiopharmaceutical administration. Absent activity in the brain excluded a right-to-left shunt. ...
Borgarelli Michele - - 2011
Objective-To compare echocardiographic variables of dogs with postmortem anatomic measurements and histologic characteristics of the mitral valve (MV). Animals-21 cardiologically normal dogs. Procedures-The MV was measured echocardiographically by use of the right parasternal 5-chamber long-axis view. Dogs were euthanized, and anatomic measurements of the MV annulus (MVa) were performed at ...
Takayama Katsutoshi - - 2011
: The aim of this study was to determine the feasibility and usefulness of contrast-enhanced magnetic resonance angiography (CE-MRA) and 3-dimensional (3D) time-of-flight (TOF) MRA for follow-up of intracranial aneurysms treated using the Enterprise stent. : Five aneurysm cases using the Enterprise stent were prospectively analyzed and were followed up ...
Lee Jin-Bae - - 2011
A calcified nodule is a type of potentially vulnerable plaque accounting for approximately 2% to 7% of coronary events. Because its intravascular ultrasound (IVUS) features have never been validated, the aim of this study was to assess the IVUS characteristics of calcified nodules in comparison to histopathology. IVUS was performed ...
Varcoe Richard - - 2011
A 56-year-old male with a past history of coronary artery bypass graft surgery underwent stent implantation for a severe proximal left subclavian artery stenosis. Recurrent in-stent restenosis (ISR) resulted in the coronary subclavian steal syndrome (CSSS), with angina due to compromised blood flow in the left internal mammary artery/radial composite ...
Lohn Jonathan W G - - 2011
The main arterial supply of the facial skin envelope is the facial artery which serves as the main pedicle for a number of facial flaps, including a facial transplant graft. This study explored the course of the facial artery and vein, branching patterns, terminations, and anomalous variants. Cadaveric dissections of ...
Kapoor Aditya - - 2011
All three coronary arteries originating from a single coronary ostium is a rarity. Single coronary artery (CA) arising from the left aortic sinus is far more uncommon than one arising from the right sinus. Usually in such cases, the right coronary artery (RCA) arises as a distal continuation of the ...
Ashjazadeh Nahid - - 2011
Neurological manifestation may complicate Takayasu arteritis (TA). A 23-year-old girl with sudden onset of vision loss was admitted to hospital. Her brain MRI showed abnormal T2-signal hyperintensity and visual evoked potential revealed prolonged P100 latency. Consequently, optic neuritis was diagnosed. A review on history of dizziness, falling, and weak pulses ...
Song Ming - - 2011
OBJECTIVES: With rapid advances in endoscopic neurosurgery, it has become possible to treat some lesions located in the anterior skull base through a transnasal approach. This anatomic study was undertaken to describe the area of surgical exposure of the anterior skull base afforded by transnasal approaches with an endoscope, as ...
Lee Yeong Yeh - - 2011
We report a 33-year-old Malay woman presented with acute left dense hemiparesis and an NIHSS score of 11/15. Computed tomography (CT) scan brain showed a massive right middle cerebral artery (MCA) territory infarct. The right internal carotid artery (ICA) and right proximal MCA were shown occluded from digital substraction angiography ...
Tanaka H - - 2010
The lipid metabolism of varicose veins (VVs) remains unknown. To elucidate the pathogenesis of VV, we utilized the novel technique of imaging mass spectrometry (IMS). We obtained VV tissues from 10 limbs of 10 VV patients who underwent great saphenous vein stripping. As control vein samples, we harvested segmental vein ...
Rass Knuth - - 2010
BACKGROUND: Endovenous laser treatment (EVLT) is a minimally invasive procedure to ablate varicose veins. The venous arterial flow index (VAFI) represents a quantitative duplex ultrasound parameter to characterize venous hemodynamics, which has not been investigated in EVLT so far. OBJECTIVE: To analyze the hemodynamic improvement of EVLT of the great ...
Mehta Vandana - - 2010
The variations in the pattern of distribution of superior thyroid artery assume paramount importance for neck surgeons, in view of its vital topographical relationship to the external laryngeal nerve. In this study, we report an unusual variation in the arterial supply of the thyroid gland, which was detected during a ...
Gupta Rishi - - 2011
We present a 56-year-old man who presented with bilateral vertebral artery occlusions and recurrent transient ischemic attacks and strokes despite maximal medical therapy. A long-segment extracranial right vertebral occlusion was noted and successfully reconstructed with four drug-eluting stents. The patient has been symptom free for 3 months and does not ...
Aravind B - - 2010
Imbalance of matrix metalloproteinase enzymes (MMP) and their inhibitors (TIMPs) may contribute to the development of varicose veins. We hypothesised that, histological changes in varicose vein wall correlate with alterations in expression of MMP/TIMP. Varicose veins (n=26) were compared with great saphenous vein (GSV) segments (n=11) from arterial bypass, and ...
Rabe Eberhard - - 2010
BACKGROUND: Sclerotherapy involves the injection of a sclerosing agent for the elimination of intracutaneous, subcutaneous, and transfascial varicose veins. OBJECTIVE: To update guidelines for sclerotherapy of varicose veins. METHODS: The guidelines for sclerotherapy of varicose veins of the German Society of Phlebology were updated and modified through a review of ...
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