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Badier-Commander C - - 2000
Primary varicose veins are functionally characterized by venous back-flow and blood stagnation in the upright position. Dilatation and tortuosity provide evidence for progressive venous wall remodelling, with disturbance of smooth muscle cell/extracellular matrix organization. Affected areas are not uniformly distributed, some areas being hypertrophic, whereas others are atrophic or unaffected. ...
Kirsch D - - 2000
Conflicting theories on the development of primary varicosis have led to the molecular biological investigation of the vein wall or, more accurately, of the extracellular matrix. It was the aim of this study to quantify matrix expression and to compare pathological changes in the vein wall with valve-orientated staging of ...
Cappelli M - - 2000
This report describes the results of our 3-year experience using ambulatory conservative hemodynamic management (ACHM) for lower extremity venous insufficiency involving the greater saphenous vein (GSV), with specific analysis of recurrence due to neoformation of vessels. We performed 289 ACHM procedures in 259 consecutive patients with GSV-related varicose veins. Follow-up ...
Olapade-Olaopa E O - - 2000
Primary lower limb varicosities classically arise from incompetence of the junction of the superficial and the deep venous systems with retrograde flow into the saphenous veins. However, some patients with superficial varicosities have no demonstrable incompetence of the saphenofemoral or saphenopopliteal junctions. In this study, we examined 52 limbs with ...
Kim Y G - - 2000
BACKGROUND: Ambulatory phlebectomy (AP) is a popular outpatient procedure for the removal of varicose veins. One of the major obstacles of AP is the disappearance and shift of the veins to be removed when the patient is positioned horizontally. OBJECTIVE: We aimed to verify the usefulness of preoperative placement of ...
Hosny G A - - 2000
The authors report avascular necrosis of the talus, after a Dennyson-Fulford subtalar arthrodesis. Vascular and neuropathic causes are discussed.
Haviarová Z - - 1999
The results of the works dealing with alterations of the connective tissue in varicose vein wall are not ambiguous, so the exact cause of the vein dilatation has still not been established. We were determining the collagen and elastin amounts in human varicose vein wall in comparison with non-dilated long ...
Nemcova S - - 1999
Experiments were designed to determine the production of prostacyclin and thromboxane and the activation of cyclic nucleotides in human varicose and nonvaricose veins and to determine whether these second messenger pathways were differentially activated by the venotropic extract of Ruscus aculeatus. The experiments were designed to characterize the activity of ...
Sandri J L - - 1999
Treatment of chronic venous valvular insufficiency requires understanding of the hemodynamics of perforating veins. To preserve normal veins or veins that can function normally once primary sources of valvular insufficiency are removed, a better understanding of the diameter-reflux relationship is desirable. We measured reflux and diameters in 500 perforating veins ...
Otley C C - - 1999
BACKGROUND: Tethering of varicose veins by periadventitial connective tissue can limit the length of vein segment that can be avulsed during ambulatory phlebectomy. A thin, malleable blunt probe is described which can dissect connective tissue adhesions surrounding varicose veins. This probe can be used as an endoluminal probe to localize ...
Durkin M T - - 1999
A prospective, randomised trial was carried out to examine the efficacy of perforate invagination (PIN, Credenhill Ltd, Derbyshire, UK) stripping of the long saphenous vein (LSV) in comparison to conventional stripping (Astratech AB, Sweden) in the surgical management of primary varicose veins. Eighty patients with primary varicosities secondary to sapheno-femoral ...
Yamaki T - - 1999
A case of acute pulmonary embolism following high ligation and compression sclerotherapy for varicose veins is reported. A 54-year-old women developed superficial varicosities and stasis pigmentation on her left leg 1 year prior to her first visit to hospital. No deep vein thrombosis was detected by ascending phlebography performed 3 ...
Loesch A - - 1998
The endothelium is recognized as a major source of endothelin in the vasculature. In this report we show for the first time that endothelin can be demonstrated with immunoelectronmicroscopy in perivascular nerves. About 36% of the axon profiles (varicosity/intervaricosity) examined in the rat basilar artery showed immunolabelling with a polyclonal ...
Goldman R D - - 1998
Little information is available concerning lamins in the nucleus of germinal cells. In this paper we briefly describe and compare the organization of A- and B-type lamins in several mammalian spermatozoa. Nuclear lamin B is localized primarily in the postacrosomal sheath of human, bull and rabbit spermatozoa; lamin A/C is ...
Sadick N S - - 1998
BACKGROUND: In recent years, the transition from radical surgery for the treatment of primary varicose veins has been modified from the previously described high ligation with complete stripping of the greater or lesser saphenous vein. OBJECTIVE: The purpose of the herewith-described technique is to present a less invasive technique that ...
Green D - - 1998
Although sclerotherapy is an established procedure to treat ectatic veins, a wide disparity remains in the reported rates of success, especially for larger varicose veins. This article reviews the venous anatomy of the lower extremity and outlines the indications for sclerotherapy. The historical basis for treatment techniques is explored. The ...
Whitfield J F - - 1997
Parathyroid hormone (PTH), hPTH-(1-84), and its hPTH-(1-34), hPTH-(1-31)NH2, and hPTH-(1-30)NH2 fragments reduced the tail artery pressure in anesthetized female Sprague-Dawley rats by 42.4-67.1% within about 1 minute after injection into a femoral vein, but reduced the pressure by only 8.5-36.2% 2-19 minutes after subcutaneous injection. hPTH-(1-84) and hPTH-(1-34) stimulate both ...
Waksman Y - - 1997
Our present study was to determine the collagen subtype pattern in the greater saphenous vein of the lower limb, obtained from 21 normal (macroscopically and ultrastructurally non-varicose vein segments from non-varicose subjects) and 37 varicose subjects, and to compare affected (macroscopically and ultrastructurally varicose segments from varicose veins) vs. non-affected ...
Crotty T P - - 1996
The first section of this paper reviews the clinical, histochemical and histological features of the varicosity in the early stage of human varicose veins. The second section demonstrates that many of those features have been duplicated in acute experiments where noradrenaline perfused the vasa venarum of an isolated in situ ...
Englund R - - 1996
BACKGROUND: Most studies of recurrent varicose veins have been based on the findings clinically, at operation, or on phlebography. Occasionally these findings have been compared with Doppler findings produced by hand-held continuous-wave Doppler. Duplex scanning is a more refined approach to the assessment of recurrent varicose veins. METHODS: 202 patients ...
Smithson I L - - 1996
We studied the distribution of NADPH-d-reactive sympathetic preganglionic neurons (SPNs) and tyrosine hydroxylase (TH) immunoreactive fibers at T1, T4, T8, and T10 of human thoracic cord. NADPH-d-reactive SPNs were present at all segments. TH-immunoreactive fibers were distributed within the NADPH-d neuropil and appeared to contact SPNs. These interactions may be ...
Yamada T - - 1996
BACKGROUND: This study shows increased infiltration of mast cells in the walls of varicose veins in the lower limbs as an explanation of the pathogenesis of varix formation. METHODS: Great saphenous veins exhibiting varicosity were histologically examined after vein stripping surgery, and the numbers of mast cells in the varicose ...
Fischer R - - 1996
We report on a 56-year-old woman with bilateral chronic venous insufficiency, a cavernous hemangioma at the right thigh and an aneurysm of the left femoral vein, without bone or soft tissue hypertrophy. Histopathology revealed a mucoid degeneration of the media musculature of the venous wall. Such a finding has not ...
Venturi M - - 1996
Alterations of the connective tissue in the varicose vein wall have been noted by several investigators; however, the cause of the vein dilatation has still not been established. The aim of this study was to find a biochemical explanation to the development of varices by evaluating sensitive biochemical markers of ...
Cornu-Thenard A - - 1995
BACKGROUND: The usual method of injection of sclerosing agents is based simply on clinical recognition and visualization of the varicose vein. OBJECTIVE: The authors present an original technique for sclerosing injections, named Doppler sclerotherapy. The purpose is to allow more accurate sclerotherapy in situations where varicose veins (usually greater than ...
Kanter A - - 1995
BACKGROUND: It has been suggested that arteriovenous anastomoses (AVA) may contribute to the etiology of varicose vein disease. Duplex ultrasound has recently assumed a major role in the diagnosis of venous disease. This noninvasive method can serve as a research tool to better elucidate the role of AVA, and as ...
Madson D I - - 1995
The persistence of the sciatic artery is an unusual occurrence, with an angiographically demonstrated incidence of 0.06%. There have been 71 cases previously reported. We report an additional case in a 14-year-old boy who presented with a chief complaint of unsightly varices. The involved right limb was notably shorter than ...
Reghunandanan R - - 1995
In 20 varicose vein patients, aged twenty-five to forty-five years, and suffering the disease for more than two years, pulse wave velocity (PWV) of the femoral-dorsalis pedis artery of the lower limbs was measured and compared with that of 20 age-matched normal subjects. Blood pressure and fasting serum total cholesterol ...
Weiss R A - - 1995
BACKGROUND: Doppler examination of varicosities is an essential part of accurate venous diagnosis prior to treatment. Doppler examination is the most fundamental of diagnostic techniques and must be familiar to all dermatologic surgeons treating the venous system of the leg. Those physicians presently concentrating primarily on telangiectasia will find their ...
Staubesand J - - 1995
A macroscopic anatomical investigation was carried out on 67 embalmed dissecting-room legs in order to determine the position, course, and origin of so-called Cockett's perforating veins. This information was considered to be of particular importance because of the frequency with which varicoses in this region are treated with sclerosing agents ...
Phillips G W - - 1995
Ninety-three legs in 68 consecutive patients presenting for preoperative assessment of varicose veins were examined by a combination of ascending venography with varicography and also by colour duplex ultrasound. Ninety-one to ninety-two per cent of incompetent sapheno-femoral and sapheno-popliteal communications were demonstrated by ascending venography/varicography and 92-95% by ultrasound. Ascending ...
Stonebridge P A - - 1995
The varicograms of 128 legs were reviewed by a panel of two vascular surgeons and a radiologist with a specialist vascular interest. Varicography effectively elucidates the anatomical basis of recurrence. Recurrent varicose veins were associated with (i) technically unsatisfactory surgery at the saphenofemoral junction (66 per cent) and (ii) failure ...
Somjen G M - - 1995
BACKGROUND: A number of informative and detailed scientific communications have been published in recent years on the functional anatomy of the lower extremity venous system. OBJECTIVE: This paper is aimed at providing basic anatomic information for physicians interested in phlebology. It also highlights the new research areas and the changing ...
Quigley F G - - 1994
Varicose veins are a common clinical finding with a high recurrence rate following treatment with either surgery or sclerotherapy. Patterns of incompetence in 100 limbs with recurrent varicose veins were determined using duplex ultrasonography. Saphenofemoral or recurrent groin tributary incompetence was present in 44 limbs, an incompetent long saphenous remnant ...
Welch H J - - 1994
Primary varicose veins of the upper extremity are extremely rare. We present three cases and discuss cause, diagnosis, and treatment. Three patients, a 23-year-old man, a 31-year-old woman, and a 39-year-old man, were referred with symptomatic varicose veins of the arm. None of the patients had lower extremity varicosities. Diagnosis ...
Dodge J T - - 1994
The density and nerve varicosity-smooth muscle cell separation of rabbit cerebral and ear arterial beds were compared. The rabbit middle cerebral artery and three of its successive branches and a comparable-sized ear artery and two branches were perfusion-fixed for electron microscopy and analyzed by quantitative morphometric procedures. The purpose was ...
Abu-Own A - - 1994
Duplex ultrasonography was used to assess patients with primary varicose veins to determine whether varicosities of the long saphenous vein (LSV) occurred without saphenofemoral junction (SFJ) incompetence. Some 167 consecutive patients with the clinical diagnosis of primary varicose veins were investigated. Of 190 limbs with LSV reflux 63 had no ...
Goldman M P - - 1994
Varicose veins are superficial vessels that are abnormally twisted, lengthened, or dilated and are usually caused by inefficient or defective valves within the vein. They represent a medical condition accompanied by symptoms deserving treatment. Varicose veins are a manifestation of venous disease that may precede later severe complications. Varicosities cause ...
Baumann P Q - - 1994
The accuracy of using other free pools in lieu of tRNA for calculation of tissue protein synthesis in liver (L), skeletal muscle (SM), and heart (H) was assessed in six adult miniature swine using L-[1-13C]leucine and L-[ring-2H5]phenylalanine as tracers. L leucyl-tRNA enrichment was higher than arterial plasma leucine and ketoisocaproate ...
Crotty T P - - 1994
A hypothesis is presented on the origin of PSD, the dilatation which occurs in an artery distal to a site of stenosis. The fact that turbulent flow is associated with both PSD and with experimentally induced varicosities suggested that similar mechanisms are involved. That is the basis for a proposal ...
Chen M F - - 1994
Recently, we developed a new method of radionuclide venography of lower limbs, namely SC-RNV, by subcutaneous injection of Tc-99m pertechnetate at acupuncture points K-3. In this study, we applied this method to evaluate the venous drainage of lower limbs in a patient with severe varicose veins and edematous swelling of ...
McBride K D - - 1993
Initial experience with a new technique, using an inflatable compression device during ascending phlebography, is described. This method is compared with standard varicography in a small series of patients with recurrent varicose veins. In this pilot study, 13 patients had 17 limbs examined by the new method and 14 limbs ...
Fratila A - - 1993
Percutaneous Minisurgical Phlebectomy is a safe and effective form of permanent treatment for side-branch varicosis in addition to other varicose veins (except the proximal part of the long saphenous vein) by means of multiple 1 to 2 mm incisions. The operation is performed using local anaesthesia in the outpatient department. ...
Raymond-Martimbeau P - - 1993
Advanced sclerotherapy of varicose veins is described in this article using duplex ultrasonographic guidance in three phases of the process. In the presclerotherapeutic stage, patency and competency of the deep venous system are evaluated, location and morphology of the highest point of reflux are determined, luminal and parietal diameters of ...
Marley W M - - 1993
The protocol for clinical examination and diagnostic evaluation of patients with varicose veins is described in this article. The specific techniques of sclerotherapy for treatment of the saphenofemoral junction, sapheno-popliteal junction, incompetent perforators, and truncular and reticular varices is outlined. Recommended dosages for both saphenous and nonsaphenous varicose veins are ...
Lowell R C - - 1992
Experiments were designed to study functional changes in superficial leg veins of patients with primary varicosity. Excess segments were taken from 19 patients undergoing elective vein resection. Excess segments of greater saphenous veins taken from 13 patients undergoing coronary or lower extremity arterial bypass were used as controls. These rings, ...
Thibault P K - - 1992
Treatment options following duplex evaluation of recurrent varicose veins are discussed and a method of injecting incompetent perforating veins using ultrasound guidance is described. The results of duplex evaluation 6 months postinjection using this technique are presented. These early results indicate that sclerosant injection employing ultrasound guidance is an effective ...
Moritz A - - 1992
Varicose veins are generally deemed inappropriate graft material for arterial reconstructions despite their physiologic flow surface because of their large and irregular caliber. Size reduction by threading such veins in constricting tubes may create bypass grafts of suitable caliber as long as redundant wall material does not cause stenoses. Sixteen ...
Hinrichs W L - - 1992
A previous study showed that microporous, compliant and (bio)degradable vascular prostheses prepared from a polyurethane/poly(L-lactic acid) mixture can function as a temporary scaffold for the regeneration of small-calibre arteries. In this study the mechanism of fragmentation of vascular prostheses made of polyurethane, copolyesterether and blends of either polyurethane or copolyesterether ...
Funderburgh J L - - 1991
A glycoprotein reactive with antibodies against corneal keratan sulfate proteoglycan (KSPG) was purified 300-fold from extracts of bovine aorta using DEAE ion-exchange, gel-filtration, hydrophobic interaction, and reverse-phase chromatographic separations. The intact glycoprotein was 70-80 kDa on sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Deglycosylation with endo-beta-galactosidase and N-glycanase reduced the size to ...
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