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Whitfield J F - - 1997
Parathyroid hormone (PTH), hPTH-(1-84), and its hPTH-(1-34), hPTH-(1-31)NH2, and hPTH-(1-30)NH2 fragments reduced the tail artery pressure in anesthetized female Sprague-Dawley rats by 42.4-67.1% within about 1 minute after injection into a femoral vein, but reduced the pressure by only 8.5-36.2% 2-19 minutes after subcutaneous injection. hPTH-(1-84) and hPTH-(1-34) stimulate both ...
Waksman Y - - 1997
Our present study was to determine the collagen subtype pattern in the greater saphenous vein of the lower limb, obtained from 21 normal (macroscopically and ultrastructurally non-varicose vein segments from non-varicose subjects) and 37 varicose subjects, and to compare affected (macroscopically and ultrastructurally varicose segments from varicose veins) vs. non-affected ...
Crotty T P - - 1996
The first section of this paper reviews the clinical, histochemical and histological features of the varicosity in the early stage of human varicose veins. The second section demonstrates that many of those features have been duplicated in acute experiments where noradrenaline perfused the vasa venarum of an isolated in situ ...
Englund R - - 1996
BACKGROUND: Most studies of recurrent varicose veins have been based on the findings clinically, at operation, or on phlebography. Occasionally these findings have been compared with Doppler findings produced by hand-held continuous-wave Doppler. Duplex scanning is a more refined approach to the assessment of recurrent varicose veins. METHODS: 202 patients ...
Smithson I L - - 1996
We studied the distribution of NADPH-d-reactive sympathetic preganglionic neurons (SPNs) and tyrosine hydroxylase (TH) immunoreactive fibers at T1, T4, T8, and T10 of human thoracic cord. NADPH-d-reactive SPNs were present at all segments. TH-immunoreactive fibers were distributed within the NADPH-d neuropil and appeared to contact SPNs. These interactions may be ...
Yamada T - - 1996
BACKGROUND: This study shows increased infiltration of mast cells in the walls of varicose veins in the lower limbs as an explanation of the pathogenesis of varix formation. METHODS: Great saphenous veins exhibiting varicosity were histologically examined after vein stripping surgery, and the numbers of mast cells in the varicose ...
Fischer R - - 1996
We report on a 56-year-old woman with bilateral chronic venous insufficiency, a cavernous hemangioma at the right thigh and an aneurysm of the left femoral vein, without bone or soft tissue hypertrophy. Histopathology revealed a mucoid degeneration of the media musculature of the venous wall. Such a finding has not ...
Venturi M - - 1996
Alterations of the connective tissue in the varicose vein wall have been noted by several investigators; however, the cause of the vein dilatation has still not been established. The aim of this study was to find a biochemical explanation to the development of varices by evaluating sensitive biochemical markers of ...
Cornu-Thenard A - - 1995
BACKGROUND: The usual method of injection of sclerosing agents is based simply on clinical recognition and visualization of the varicose vein. OBJECTIVE: The authors present an original technique for sclerosing injections, named Doppler sclerotherapy. The purpose is to allow more accurate sclerotherapy in situations where varicose veins (usually greater than ...
Kanter A - - 1995
BACKGROUND: It has been suggested that arteriovenous anastomoses (AVA) may contribute to the etiology of varicose vein disease. Duplex ultrasound has recently assumed a major role in the diagnosis of venous disease. This noninvasive method can serve as a research tool to better elucidate the role of AVA, and as ...
Madson D I - - 1995
The persistence of the sciatic artery is an unusual occurrence, with an angiographically demonstrated incidence of 0.06%. There have been 71 cases previously reported. We report an additional case in a 14-year-old boy who presented with a chief complaint of unsightly varices. The involved right limb was notably shorter than ...
Reghunandanan R - - 1995
In 20 varicose vein patients, aged twenty-five to forty-five years, and suffering the disease for more than two years, pulse wave velocity (PWV) of the femoral-dorsalis pedis artery of the lower limbs was measured and compared with that of 20 age-matched normal subjects. Blood pressure and fasting serum total cholesterol ...
Weiss R A - - 1995
BACKGROUND: Doppler examination of varicosities is an essential part of accurate venous diagnosis prior to treatment. Doppler examination is the most fundamental of diagnostic techniques and must be familiar to all dermatologic surgeons treating the venous system of the leg. Those physicians presently concentrating primarily on telangiectasia will find their ...
Staubesand J - - 1995
A macroscopic anatomical investigation was carried out on 67 embalmed dissecting-room legs in order to determine the position, course, and origin of so-called Cockett's perforating veins. This information was considered to be of particular importance because of the frequency with which varicoses in this region are treated with sclerosing agents ...
Phillips G W - - 1995
Ninety-three legs in 68 consecutive patients presenting for preoperative assessment of varicose veins were examined by a combination of ascending venography with varicography and also by colour duplex ultrasound. Ninety-one to ninety-two per cent of incompetent sapheno-femoral and sapheno-popliteal communications were demonstrated by ascending venography/varicography and 92-95% by ultrasound. Ascending ...
Stonebridge P A - - 1995
The varicograms of 128 legs were reviewed by a panel of two vascular surgeons and a radiologist with a specialist vascular interest. Varicography effectively elucidates the anatomical basis of recurrence. Recurrent varicose veins were associated with (i) technically unsatisfactory surgery at the saphenofemoral junction (66 per cent) and (ii) failure ...
Somjen G M - - 1995
BACKGROUND: A number of informative and detailed scientific communications have been published in recent years on the functional anatomy of the lower extremity venous system. OBJECTIVE: This paper is aimed at providing basic anatomic information for physicians interested in phlebology. It also highlights the new research areas and the changing ...
Quigley F G - - 1994
Varicose veins are a common clinical finding with a high recurrence rate following treatment with either surgery or sclerotherapy. Patterns of incompetence in 100 limbs with recurrent varicose veins were determined using duplex ultrasonography. Saphenofemoral or recurrent groin tributary incompetence was present in 44 limbs, an incompetent long saphenous remnant ...
Welch H J - - 1994
Primary varicose veins of the upper extremity are extremely rare. We present three cases and discuss cause, diagnosis, and treatment. Three patients, a 23-year-old man, a 31-year-old woman, and a 39-year-old man, were referred with symptomatic varicose veins of the arm. None of the patients had lower extremity varicosities. Diagnosis ...
Dodge J T - - 1994
The density and nerve varicosity-smooth muscle cell separation of rabbit cerebral and ear arterial beds were compared. The rabbit middle cerebral artery and three of its successive branches and a comparable-sized ear artery and two branches were perfusion-fixed for electron microscopy and analyzed by quantitative morphometric procedures. The purpose was ...
Abu-Own A - - 1994
Duplex ultrasonography was used to assess patients with primary varicose veins to determine whether varicosities of the long saphenous vein (LSV) occurred without saphenofemoral junction (SFJ) incompetence. Some 167 consecutive patients with the clinical diagnosis of primary varicose veins were investigated. Of 190 limbs with LSV reflux 63 had no ...
Goldman M P - - 1994
Varicose veins are superficial vessels that are abnormally twisted, lengthened, or dilated and are usually caused by inefficient or defective valves within the vein. They represent a medical condition accompanied by symptoms deserving treatment. Varicose veins are a manifestation of venous disease that may precede later severe complications. Varicosities cause ...
Baumann P Q - - 1994
The accuracy of using other free pools in lieu of tRNA for calculation of tissue protein synthesis in liver (L), skeletal muscle (SM), and heart (H) was assessed in six adult miniature swine using L-[1-13C]leucine and L-[ring-2H5]phenylalanine as tracers. L leucyl-tRNA enrichment was higher than arterial plasma leucine and ketoisocaproate ...
Crotty T P - - 1994
A hypothesis is presented on the origin of PSD, the dilatation which occurs in an artery distal to a site of stenosis. The fact that turbulent flow is associated with both PSD and with experimentally induced varicosities suggested that similar mechanisms are involved. That is the basis for a proposal ...
Chen M F - - 1994
Recently, we developed a new method of radionuclide venography of lower limbs, namely SC-RNV, by subcutaneous injection of Tc-99m pertechnetate at acupuncture points K-3. In this study, we applied this method to evaluate the venous drainage of lower limbs in a patient with severe varicose veins and edematous swelling of ...
McBride K D - - 1993
Initial experience with a new technique, using an inflatable compression device during ascending phlebography, is described. This method is compared with standard varicography in a small series of patients with recurrent varicose veins. In this pilot study, 13 patients had 17 limbs examined by the new method and 14 limbs ...
Fratila A - - 1993
Percutaneous Minisurgical Phlebectomy is a safe and effective form of permanent treatment for side-branch varicosis in addition to other varicose veins (except the proximal part of the long saphenous vein) by means of multiple 1 to 2 mm incisions. The operation is performed using local anaesthesia in the outpatient department. ...
Raymond-Martimbeau P - - 1993
Advanced sclerotherapy of varicose veins is described in this article using duplex ultrasonographic guidance in three phases of the process. In the presclerotherapeutic stage, patency and competency of the deep venous system are evaluated, location and morphology of the highest point of reflux are determined, luminal and parietal diameters of ...
Marley W M - - 1993
The protocol for clinical examination and diagnostic evaluation of patients with varicose veins is described in this article. The specific techniques of sclerotherapy for treatment of the saphenofemoral junction, sapheno-popliteal junction, incompetent perforators, and truncular and reticular varices is outlined. Recommended dosages for both saphenous and nonsaphenous varicose veins are ...
Lowell R C - - 1992
Experiments were designed to study functional changes in superficial leg veins of patients with primary varicosity. Excess segments were taken from 19 patients undergoing elective vein resection. Excess segments of greater saphenous veins taken from 13 patients undergoing coronary or lower extremity arterial bypass were used as controls. These rings, ...
Thibault P K - - 1992
Treatment options following duplex evaluation of recurrent varicose veins are discussed and a method of injecting incompetent perforating veins using ultrasound guidance is described. The results of duplex evaluation 6 months postinjection using this technique are presented. These early results indicate that sclerosant injection employing ultrasound guidance is an effective ...
Moritz A - - 1992
Varicose veins are generally deemed inappropriate graft material for arterial reconstructions despite their physiologic flow surface because of their large and irregular caliber. Size reduction by threading such veins in constricting tubes may create bypass grafts of suitable caliber as long as redundant wall material does not cause stenoses. Sixteen ...
Hinrichs W L - - 1992
A previous study showed that microporous, compliant and (bio)degradable vascular prostheses prepared from a polyurethane/poly(L-lactic acid) mixture can function as a temporary scaffold for the regeneration of small-calibre arteries. In this study the mechanism of fragmentation of vascular prostheses made of polyurethane, copolyesterether and blends of either polyurethane or copolyesterether ...
Funderburgh J L - - 1991
A glycoprotein reactive with antibodies against corneal keratan sulfate proteoglycan (KSPG) was purified 300-fold from extracts of bovine aorta using DEAE ion-exchange, gel-filtration, hydrophobic interaction, and reverse-phase chromatographic separations. The intact glycoprotein was 70-80 kDa on sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Deglycosylation with endo-beta-galactosidase and N-glycanase reduced the size to ...
Hirai M - - 1991
Venous hemodynamics were evaluated by plethysmography in normal subjects and patients with venous disorders of the lower extremity, to clarify the pathophysiology of chronic venous insufficiency (CVI) due to primary varicose veins. Expelled volume during five active dorsiflexions of the feet and venous recovery time were calculated to evaluate muscle ...
Hanrahan L M - - 1991
The nature and distribution of venous disease surrounding the development of varicose veins and its treatment is controversial. Using duplex ultrasonography, we evaluated 54 lower extremities in 32 patients with varicose veins who were symptomatic and had obvious varicose veins by clinical examination. Twenty-eight percent had greater saphenous trunk incompetence, ...
Mashiah A - - 1991
We studied varices of the lower limb by scanning electron microscope (SEM) in 29 women who had undergone surgery under local anesthesia for symptomatic varicose veins. Their ages ranged between 19 and 42 years (average 30). They were all diagnosed as having incompetence of the valve at the saphenofemoral junction. ...
Cornu-Thénard A - - 1991
One hundred twenty-five lower limbs with varicose veins were studied clinically, essentially by palpation. Two specialists in venous pathology scored the severity of the varicose veins from 0 to 20. Comparison between the different clinical parameters and the scores of the specialists showed that two systems of clinical quantification gave ...
Crotty T P - - 1991
When noradrenaline, either endogenous or exogenous, is released from the venae venarum of a dog's lateral saphenous vein which is constricted by noradrenaline, it dilates the vein. By limiting the release of the drug to just a section of the vein's venae venarum network it is possible to dilate the ...
Wang T M - - 1991
One hundred and twenty Chinese adults' facial halves were selected for this study. The description of the mandibular ramus of the facial nerve was presented under 4 items: (1) the relationship with the lower border of the mandible, (2) the number of its rami, (3) the relationship with the retromandibular ...
Sadick N S - - 1991
The author reports the results of a double-blind, paired-comparison study using saline sclerosant plus or minus heparin additive. The study was designed to elucidate the effects of increasing concentrations of hypertonic saline with regard to vessel diameter, clinical efficacy, complications, and discomfort. Six hundred women with bilaterally symmetrical starburst telangiectasias ...
Maurel E - - 1990
Various types of collagen (I, III, IV, V) were identified in normal and varicose human saphenous veins using pepsin digestion and cyanogen bromide digestion followed by SDS-polyacrylamide gel electrophoresis. Varicose veins were found to have a higher collagen content than normal veins. This is consistent with the morphological fibrosis which ...
Goren G - - 1990
This study was conducted to correlate the clinical presentations of uncomplicated primary varicose veins with the topographic and anatomic source of reflux (escape points). One-hundred sixty-three patients with primary varicose veins (144 females, 19 males; 96 unilateral, 67 bilateral) in 230 involved limbs were examined. The origin and extent of ...
Almgren B - - 1989
Deep venous valvular incompetence (DVI) of primary, non-thrombotic origin has received little interest compared with secondary, postthrombotic DVI. In this study both limbs of 308 patients with untreated or surgically treated varicose veins in at least one limb were examined with Doppler ultrasound for signs of deep vein reflux. Ascending ...
Murata K - - 1989
The constituents of heparan sulfate isomers in human arteries were analysed at the disaccharide unit by high-performance liquid chromatography. Heparitinases I and II facilitated differentiation of six unsaturated disaccharides from heparan sulfate isomers. The variously sulfated disaccharide components of these heparan sulfate isomers were detected after digestion with heparitinases I ...
Hashizume K - - 1989
In humans and dogs, the plasma contains little free dopamine, and dopamine is almost all present in two isomeric forms of conjugates with sulfate esters, dopamine-3-O-sulfate and dopamine 4-O-sulfate. These two isomers differ in metabolic stability and biological activity. The physiological role of dopamine sulfates is controversial. In the present ...
Clarke H - - 1989
A reduction in the 'elasticity' of the venous system has been proposed as a precursor of venous insufficiency, but the concept remains controversial. This study was designed to develop a method of assessing venous elasticity, and to use this method to investigate the aetiology of varicose veins. Simultaneous measurements of ...
Trigaux J P - - 1989
Varicography, consisting of direct puncture and injection into a varicosity, is the diagnostic procedure of choice in the assessment of varicose veins of the lower limbs. It must be performed in cases of recurrent posterior varicose veins of the leg, after negative ascending phlebography, when looking for possible drainage by ...
Goldman M P - - 1989
The venous anatomy of the leg is described with special reference to the superficial venous system. The histologic and histochemical differences between varicose and normal veins are presented. The pathophysiology of varicose veins is related to congential or acquired abnormalities of the deep venous system, venous valves, and/or fascial or ...
Schultz-Haakh H - - 1989
Varicose veins and venous ailments are common among adult Americans. Treatment procedures vary but are mostly invasive. The current investigation utilizes focused high-intensity ultrasound for producing destruction of the venous wall in experimental dogs and in patients with varicose veins. Results are encouraging and suggest that focused ultrasonic irradiation can ...
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