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Weymann Alexander A Department of Cardiac Surgery, Heart and Marfan Center - University of Heidelberg, INF 110, 69120 Heidelberg, - - 2014
In 1967, Donald Ross transferred the patient's own pulmonary valve into the aortic root. Although results of this technique were encouraging, the Ross procedure did not gain widespread popularity until the late 1980s when surgeons started to implant the pulmonary autograft as a freestanding full root replacement with reimplantation of ...
Wang Ruoya - - 2014
Quantifying arterial residual deformations is critical for understanding the stresses and strains within the arterial wall under physiological or pathophysiological loading conditions. This study presents novel findings on residual shear deformations in the left anterior descending coronary artery. Residual shear deformations were most evident when thin, long axial strips were ...
Yamaguchi Hiroki H Department of Cardiovascular Surgery, New Tokyo Hospital, Chiba, Japan. Electronic address: - - 2014
A 33-year-old man presented with severe aortic insufficiency due to a prolapsed bicuspid aortic valve. The ventriculoaortic junction was dilated to 29 mm without root dilatation, and external ring annuloplasty was performed using a Gelweave (Terumo, Tokyo, Japan) graft to reduce the size to 22 mm. The leaflets were repaired ...
Callanan A A Institute for Bioengineering, School of Engineering, The University of Edinburgh, Edinburgh EH9 3JL, UK; Centre for Applied Biomedical Engineering Research, Department of Mechanical, Aeronautical and Biomedical Engineering and the Materials and Surface Science Institute, University of Limerick, Ireland. Electronic address: - - 2014
Deployment of stent-grafts, derived from synthetic biomaterials, is an established minimally invasive approach for effectively treating abdominal aortic aneurysms (AAAs). However, a notable disadvantage associated with this surgical technique is migration of the deployed stent-graft due to poor biocompatibility and inadequate integration in vivo. Recently, tissue-engineered extracellular matrices (ECMs) have ...
Koyama Masayuki M Sapporo Medical University School of - - 2014
Pulmonary arterial hypertension (PAH) is characterized by vasoconstriction and vascular remodeling of the pulmonary artery (PA). Recently, endoplasmic reticulum (ER) stress and inappropriate adaptation through the unfolded protein response (UPR) have been disclosed in various types of diseases. Here we examined whether ER stress is involved in the pathogenesis of ...
Atkins Samantha K SK Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN, - - 2014
The type-I bicuspid aortic valve (BAV), which differs from the normal tricuspid aortic valve (TAV) most commonly by left-right coronary cusp fusion, is frequently associated with secondary aortopathies. While BAV aortic dilation has been linked to a genetic predisposition, hemodynamics has emerged as a potential alternate etiology. However, the link ...
El Arid Jean-Marc JM Cardiovascular Surgery Department, Lille University Hospital, - - 2014
The reimplantation technique for valve-sparing aortic root replacement is increasingly used to treat aortic root pathology. The systematic approach described by El Khoury in 2009 and modified in 2011 using the Valsava graft is simple and reproducible. However, in-conduit suturing of the aortic valve annulus and small rim of sinus ...
Sakamoto Kisaburo K Department of Cardiovascular Surgery, Mt. Fuji Shizuoka Children's Hospital, Sizuoka City, Japan. Electronic address: - - 2014
A 1-year-old boy weighing 10.4 kg underwent successful biventricular repair for transposition of the great arteries, a ventricular septal defect, and a left ventricular outflow tract (LVOT) obstruction with moderate pulmonary stenosis of the bicuspid pulmonary valve (z score of -4.4 for the pulmonary valve) by means of a modified Nikaidoh ...
Di Eusanio Marco M Cardiac Surgery Division, Department of Experimental Diagnostic and Specialty Medicine, Sant'Orsola Malpighi Hospital, Alma Mater Studiorum - University of Bologna, 40123 Bologna, Italy. Electronic address: - - 2014
Most usually, the aortic tunnels empty into the left ventricle. Very rarely, they open to the left atrium. The essence of the aortic tunnels is that they bypass the hinges of the valvar leaflets within the aortic root. We have recently encountered an aorto-left atrial tunnel satisfying this criterion.
Mahesh Balakrishnan B Department of Cardiothoracic Surgery, Papworth Hospital, Cambridge, - - 2014
A 45-year old woman with then unknown Loeys-Dietz syndrome (LDS) presented in 2007 with aneurysms involving the entire thoraco-abdominal aorta, but sparing the aortic root and valve. She underwent debranching of the aortic arch, followed by stenting of entire distal ascending aorta, arch and descending aorta. Two years later, a ...
De Boo Diederick W - - 2014
A 71-year-old man initially presented with an asymptomatic, incidentally detected ascending aortic pseudoaneurysm 25 years following aortic root repair with mechanical aortic valve replacement. This pseudoaneurysm was previously treated with coil embolization but due to coil impaction it reopened 8 years later. Endovascular closure of the pseudoaneurysm was achieved with ...
Kida Naoki N a Department of Biomechanics , Institute for Frontier Medical Sciences, Kyoto University , 53 Kawahara-cho, Shogoin, Sakyo , Kyoto 606-8507 , - - 2014
In this study, for predicting arterial function and pathogenesis from a mechanical viewpoint, we develop a continuum mechanical model of an arterial wall that embodies residual and active stresses following a traditional anisotropic passive constitutive law. The residual and active stresses are incorporated into finite element methods based on a ...
Kuwauchi Shintaro S Division of Cardiovascular Surgery, Cardiovascular Center, St. Luke's International Hospital, Tokyo, Japan. Electronic address: - - 2014
We describe here an initial successful case of valve-sparing surgery using reimplantation technique in a 24-year-old male with aortic root dilatation with truncal valve insufficiency after common arterial trunk repair. Concomitant right ventricular outflow tract reconstruction with expanded polytetrafluoroethylene was also successfully performed. He was discharged home on postoperative day 10 ...
Hess Philip P Division of Thoracic and Cardiovascular Surgery, University of Florida, Gainesville, - - 2014
Aortic valve-sparing reimplantation remains an effective technique for repair of aortic root aneurysms. Studies indicate that the Florida Sleeve procedure is dimensionally stable and durable in the early postoperative period; however, our technique has evolved. We describe a 10-year institutional experience and the technical update of the Florida Sleeve repair ...
Ghavidel Alireza Alizadeh AA Heart Valve Disease Research Center, Iran University of Medical Science, Tehran, Iran; Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Science, Tehran, Iran. Electronic address: - - 2014
We describe a simple technique for aortic root replacement in destructive prosthetic aortic valve endocarditis wherein the fragile aortic annulus tissue is not suitable for suture placement. Therefore, we first reconstructed the intervalvular part with a nontreated pericardial patch and then implanted the aortic composite graft on the aortic root ...
Kimura Taizo T 1] Department of Molecular Cardiovascular Biology, Yamaguchi University School of Medicine [2] Division of Cardiology, Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine [3] Division of Cardiovascular Medicine, Medical Science for Control of Pathological Processes, Graduate School of Comprehensive Human Science, University of - - 2014
Acute aortic dissection (AAD) is caused by the disruption of intimomedial layer of the aortic walls, which is immediately life-threatening. Although recent studies indicate the importance of proinflammatory response in pathogenesis of AAD, the mechanism to keep the destructive inflammatory response in check is unknown. Here, we report that induction ...
François Katrien K Cardiac Centre, Department of Cardiac Surgery, University Hospital Ghent, Ghent, Belgium. Electronic address: - - 2013
Aortic root dilatation remains of concern late after repair for tetralogy of Fallot (ToF). We have previously demonstrated that the aortic root size decreases progressively after early correction. To test whether the aortic wall changes are intrinsic or acquired, a histologic study was performed of infants at early repair. From ...
Villa Emmanuel - - 2013
Aortic root replacement with biological conduit (homograft, autograft, or xenograft) is a valuable tool, but biological valves are often prone to degeneration. Reoperations usually require root removal and repetition of the Bentall procedure to maintain the same orifice area. A less radical option is to limit replacement to the valve. ...
Fujimoto M - - 2013
BACKGROUND AND PURPOSE:A recent randomized clinical trial on intracranial atherosclerosis was discontinued because of the higher frequency of stroke and death in the angioplasty and stent placement group than in the medical treatment group. An in-depth understanding of the relationship between biologic responses and flow dynamics is still required to ...
Kasdi Reda - - 2013
Acute valve-sparing procedures are effective in the treatment of aortic root dilation when there is no valve pathology. In this review, we discuss the role of aortic valve-sparing procedures in the presence of connective tissue disorders such as scleroderma.
Heo Woon - - 2013
Despite marvelous advances in repair for acute type A aortic dissection over past decades, it remains challenging to repair the aortic root when aortic dissection extended to the sinuses causes the fragile root because of its thinner layers, which are susceptible to suture trauma. Here, we describe a modified Florida ...
Pavlidis Antonios N - - 2013
Vessel perforation is an undesirable and life-threatening complication during vein graft angioplasty. We report on a case of vein graft rupture during angioplasty, which was successfully managed with deployment of a polytetrafluoroethylene-covered stent.
Nishida Hidefumi - - 2013
The Medtronic freestyle aortic root bioprosthesis (Medtronic, Inc., Minneapolis, MN, USA) is a stentless valve with an effective orifice area that is larger than that observed on other bioprostheses. However, there have been sporadic reports of structural valve deterioration (SVD), such as aortic root wall rupture, leaflet tearing, and pseudoaneurysm ...
Georgakarakos E - - 2013
The hemodynamic consequences of misaligned stent-grafts (SG) in fenestrated endografts (EG) have not been adequately studied. Our aim was to study the hemodynamic effects of positional variations of SG, investigating the potential influence on the total displacement forces acting on the EG and the shear stress values at the stented ...
Kim Dong Hee - - 2013
A 74-year-old man was diagnosed with aortic root aneurysm and two-vessel coronary disease. Echocardiographic assessment revealed an enlarged sinus of Valsalva 60 mm in diameter with mild aortic regurgitation. Florida sleeve repair was performed using a vascular graft combined with coronary artery bypass grafting. The postoperative course was uncomplicated and ...
Sahin Muslum - - 2013
Pseudoaneurysm of the aortic root is a rare condition and potentially fatal if not treated. It may occur in different etiologies. In this case, we aim to show an aortic pseudoaneurysm arising from the aorta-saphenous vein graft anastomosis.
Wang Lian - - 2013
Ginkgo biloba extract (EGb 761) is widely used to treat cerebral disorders. Clinical trials have demonstrated therapeutic benefits of EGb 761 in various vascular diseases. Because the potential pathophysiological mechanisms appear similar to those involved in aneurysmal degeneration, we postulated that EGb 761 might affect the development and progression of ...
Loukas Marios - - 2013
The aortic root is the anatomical bridge between the left ventricle and the ascending aorta. It is made up of the aortic valve leaflets, which are supported by the aortic sinuses (of Valsalva), and the interleaflet triangles interposed between the basal attachments of the leaflets. As such, it possesses significant ...
Takamizawa Keiichi - - 2013
It is well known that arteries are subject to residual stress. In earlier studies, the residual stress in the arterial ring relieved by a radial cut has been considered in stress analysis. However, it has been found that axial strips sectioned from arteries also curled into arcs, showing that the ...
Viswanathan Uma - - 2013
The occurrence of a brachial plexus united into a single cord is very rare. During routine dissection of an elderly female cadaver, the brachial plexus united into a single cord was observed bilaterally. On the left side, C4, C5, and C6 roots combined to form the upper trunk, the C7 ...
Crooke Philip S PS From the *Department of Mathematics, Vanderbilt University, Nashville, TN USA; †BioStable Science and Engineering, Inc, Austin, TX USA; ‡German Heart Center Munich, Munich, Germany; and §Department of Cardiac Surgery, Vanderbilt University, Nashville, TN - - 2013
A full geometric annuloplasty ring could facilitate aortic valve repair. The purpose of this report was to document the design of such a ring using mathematical analyses of normal human aortic valve computed tomographic angiograms. One-millimeter axial slices of high-resolution computed tomographic angiograms from 11 normal aortic roots were used ...
Mao Sun-Zhong - - 2013
Hypoxic pulmonary arterial hypertension (PAH) is a disabling disease with limited treatment options. Hypoxic pulmonary vascular remodeling is a major cause of hypoxic PAH. Pharmacological agents that can inhibit the remodeling process may have great therapeutic value. To examine the effect of intermedin (IMD), a new calcitonin gene-related peptide family ...
Goldstone Andrew B - - 2013
Delayed pulmonary autograft failure is the principal limitation of the Ross procedure. Although reoperation typically includes replacement of the neoaortic valve, strategies for autograft valve preservation are becoming increasingly employed. However, leaflet prolapse and asymmetry are deterrents to valve preservation in this technically complex surgical population. The present report illustrates ...
Kim Rebeca J - - 2013
Acute left main coronary occlusion secondary to a periaortic root hematoma secondary to annular rupture during transcatheter heart valve deployment. © 2013 Wiley Periodicals, Inc.
Yim Eugene Sun - - 2013
Two professional athletes in the US National Basketball Association required surgery for aortic root dilation in 2012. These cases have attracted attention in sports medicine to the importance of aortic root disease in athletes. In addition to aortic root dilation, other forms of aortic disease include anomalous coronary artery, bicuspid ...
Vola Marco - - 2013
The case is reported of a surgical aortic valvular stenosis with a severely calcified ascending aortic root in a 76-year-old woman. The morphology and size of the aortic annulus were unsuitable for transcatheter aortic valve implantation (TAVI); thus, surgery was scheduled. Aortic calcifications allowed a transverse aortotomy 4 cm superior ...
Meng H - - 2013
Increasing detection of unruptured intracranial aneurysms, catastrophic outcomes from subarachnoid hemorrhage, and risks and cost of treatment necessitate defining objective predictive parameters of aneurysm rupture risk. Image-based computational fluid dynamics models have suggested associations between hemodynamics and intracranial aneurysm rupture, albeit with conflicting findings regarding wall shear stress. We propose ...
Chen Liang-Wan - - 2013
We describe an alternative valve-sparing aortic root replacement technique for patients with root aneurysms accompanied by aortic valve insufficiency. Aortic root reduction plasty was accomplished by plication and exclusion of parts of the sinus walls. Subsequently, 3 teardrop-shaped patches compatible with the sizes and shapes of the corresponding plicated sinuses ...
Rouchaud Aymeric - - 2013
INTRODUCTION: Coiling is the gold standard for the treatment of intracranial aneurysms. However, some issues associated with endovascular treatment limit its long-term efficiency. Recanalization with coil compaction is certainly the most important. New approaches may be considered to promote thrombus colonization by mesenchymal cells and aneurysm healing. In the present ...
Al-Jarallah Aishah - - 2013
OBJECTIVES: To examine the effects of pomegranate extract on inflammation and oxidative stress and the development of spontaneous occlusive coronary artery atherosclerosis in the SR-BI/apoE double knockout mouse model of coronary heart disease. METHODS AND RESULTS: SR-BI/apoE double KO mice were treated for two weeks with pomegranate extract via drinking ...
Sakaguchi Taichi - - 2013
We report a case of aortic wall rupture in a patient with a Medtronic Freestyle stentless bioprosthesis (Medtronic Inc, Minneapolis, MN) after full root implantation. A 68-year-old man who underwent aortic root replacement with a Freestyle bioprosthesis 12 years prior was found to have a large pseudoaneurysm originating from the ...
Kim Chul Young - - 2013
Bioassay-guided fractionation of the methanol extract from the root of Sophora flavescens led to the isolation of eight known prenylated flavonoids responsible for the vasorelaxation activity in porcine coronary arteries. Among them, kushenol N and 5-methylsophoraflavanone B strongly induced the relaxation of porcine coronary arteries with respective ED(50) values of ...
Maselli Daniele - - 2013
OBJECTIVES: We sought to evaluate the effects of the reimplantation type versus the remodeling type of aortic valve-sparing technique on the geometry of the same aortic root. METHODS: Fifteen fresh isolated porcine hearts with normal aortic valves and a standard aortoventricular junction size of 23 mm were processed. An aortic ...
Enomoto Yoshinori - - 2013
We describe aortic root dilatation, severe aortic regurgitation, and pulmonary artery stenosis that were accidentally diagnosed 23 years after the arterial switch operation for transposition of the great arteries in situs inversus. We successfully performed the modified Bentall procedure and pulmonary artery reconstruction. The pathology of the dilated aortic root ...
Iskandar Aline - - 2013
BACKGROUND: The aorta is exposed to hemodynamic stress during exercise, but whether or not the aorta is larger in athletes is not clear. We performed a systematic literature review and meta-analysis to examine if athletes demonstrate increased aortic root dimensions when compared to non-athlete controls. METHODS AND RESULTS: We searched ...
Hoshino Yasuto - - 2013
OBJECTIVES: We examined the mechanism of coronary artery spasm related to oxidant stress with aging in senescence marker protein-30 (SMP30)-deficient mice because SMP30 decreases with aging and SMP30 knockout (KO) mice show a short life with increased oxidant stress. METHODS: To examine the effect of SMP30 on coronary artery vasomotor ...
Tucker Adam - - 2013
Up to 150 words summarising the case presentation and outcome (this will be freely available online). A Marfan case with dilated aortic root and prolapsed leaflets underwent aortic repair. The non-coronary leaflet-measured effective height was 7 mm (prolapsing) and was lifted up to 10 mm with a centrally placed plicating ...
Asanuma Tatsuya - - 2013
Simulation studies have been performed in attempts to elucidate the signifi cance of shear and tissue stresses in the progression and rupture of coronary artery plaques, but few studies have analyzed both stresses simultaneously. We analyzed the distributions of shear stress and tissue stress in a model of coronary artery ...
Fujimoto Motoaki - - 2013
Symptomatic intracranial atherosclerotic stenosis is associated with a high rate of recurrent stroke. Endovascular angioplasty and stenting using the Wingspan(TM) Stent (Stryker) has been used for treatment of this disorder. However, a recent randomized trial (SAMMPRIS Clinical Trial) reported that it was inferior to aggressive medical management. To explore the ...
Angelini Daniel J - - 2013
Both chronic hypoxia and allergic inflammation induce vascular remodeling in the lung, but only chronic hypoxia appears to cause PH. We investigate the nature of the vascular remodeling and the expression and role of hypoxia-induced mitogenic factor (HIMF/FIZZ1/RELMα) in explaining this differential response. We induced pulmonary vascular remodeling through either ...
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