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Schiavone A A Wolfson School of Mechanical and Manufacturing Engineering, Loughborough University, LE11 3TU Loughborough, - - 2014
Finite-element simulations have been carried out to study the effects of material choice, drug eluting coating and cell design on the mechanical behaviour of stents during deployment inside a stenotic artery. Metallic stents made of materials with lower yield stress and weaker strain hardening tend to experience higher deformation and ...
Chancellor William W Division of Pediatric and Congenital Heart Surgery, The Children's Heart Center, University of Mississippi Medical Center, Jackson, - - 2014
Outcomes for truncus arteriosus repair are impacted significantly by the severity of truncal valve dysfunction. When satisfactory repair of the regurgitant truncal valve is unattainable, replacement is required. Given our experience in children with stentless porcine xenografts in the aortic position and the incidence of early valve failure for aortic ...
Querzoli Giorgio G DICAA-Università di Cagliari, Cagliari, Italy. Electronic address: - - 2014
Aortic root dilation and propensity to dissection are typical manifestations of the Marfan Syndrome (MS), a genetic defect leading to the degeneration of the elastic fibres. Dilation affects the structure of the flow and, in turn, altered flow may play a role in vessel dilation, generation of aneurysms, and dissection. ...
Gunning Paul S PS Biomechanics Research Centre (BMEC), Department of Biomedical Engineering, National University of Ireland Galway, Galway, - - 2014
Self expanding Transcatheter Aortic Valve Replacements (TAVR) can conform to the geometry of the aortic annulus and the calcified leaflet complex, which may result in leaflet distortion and altered leaflet kinematics, but such changes have not yet been characterized. In this study we developed a computational model to investigate the ...
Iannone Lucio - - 2014
The nitric oxide synthase (NOS) inhibitor, asymmetric dimethylarginine (ADMA), contributes to the pathogenesis of pulmonary hypertension. Reduced levels of the enzymes metabolising ADMA, dimethylarginine dimethylaminohydrolases (DDAH1 and DDAH2) and increased levels of miRNA-21 are linked to disease pathology, but the mechanisms are not understood. Here we studied the potential role ...
Yamanaka Katsuhiro K Division of Cardiovascular Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, - - 2014
A 67-year old man with ascending aortic aneurysm was referred because of a quadricuspid aortic valve. He underwent aortic root replacement with a valve-sparing technique. Under deep hypothermic circulatory arrest, replacement of the ascending aorta was successfully performed. The postoperative course was uneventful without recurrence of aortic regurgitation.
Karimi Alireza A School of Mechanical Engineering, Iran University of Science and Technology, 16846, Tehran, Iran, - - 2014
The stresses induced on plaque wall during stent implantation inside a stenotic artery are associated with plaque rupture. The stresses in the plaque-artery-stent structure appear to be distinctly different for different plaque types in terms of both distribution and magnitude. In this study, a nonlinear finite element simulation was executed ...
Sharma Vishakha - - 2014
Recent work on the venation patterning and morphogenesis of leaf/leaflet has posed the question how different are these in tendrils, which are another type of vegetative lateral organ. Here, the venation patterns of leaflets, stipules and tendrils were compared in the model species, P. sativum. Unlike reticulated venation in leaflets ...
Pereira Vitor Hugo VH Cardiology Department, Alto Ave Hospital Center, Guimarães, Portugal, - - 2014
The image shows a pseudoaneurysm of the mitral-aortic intervalvular fibrosa and a fistula between the non-coronary sinus and the left atrium.
Slachman Frank N FN Dignity Health Medical Foundation, Sacramento, California. Electronic address: - - 2014
An acellular, noncrosslinked, extracellular-matrix bioscaffold patch was used for aortic root reconstruction after aortic valve replacement in a 90-year-old woman. After her death 3 years later, histologic examination showed constructive remodeling and host-tissue regeneration at the site of the extracellular matrix bioscaffold patch.
Nishimura Yusuke Y Division of Neurosurgery, St. Michael's Hospital, University of Toronto, Ontario, Canada; - - 2014
The authors describe a case of a 79-year-old man with a lumbar spinal dural arteriovenous fistula (DAVF) and isthmic spondylolisthesis at the same level. The patient's thoracic spine MRI study demonstrated swelling and increased T2 signal in the spinal cord and regional dilated perimedullary vessels. Lumbar spine MRI showed L-4 ...
Kamiyama Junko J Department of Emergency and Critical Care Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, - - 2014
Endothelin-1 (ET-1) is a mediator of various physiological and pathological processes, including vascular inflammation, cell proliferation and vasoconstriction. Attenuation of ET action using ET-1 antagonists reduces pulmonary vascular leakage and inflammation in several models of lung injuries and experimental acute respiratory distress syndrome (ARDS). Based on these earlier reports, the ...
Weymann Alexander A Department of Cardiac Surgery, Heart and Marfan Center - University of Heidelberg, INF 110, 69120 Heidelberg, - - 2014
In 1967, Donald Ross transferred the patient's own pulmonary valve into the aortic root. Although results of this technique were encouraging, the Ross procedure did not gain widespread popularity until the late 1980s when surgeons started to implant the pulmonary autograft as a freestanding full root replacement with reimplantation of ...
Wang Ruoya - - 2014
Quantifying arterial residual deformations is critical for understanding the stresses and strains within the arterial wall under physiological or pathophysiological loading conditions. This study presents novel findings on residual shear deformations in the left anterior descending coronary artery. Residual shear deformations were most evident when thin, long axial strips were ...
Yamaguchi Hiroki H Department of Cardiovascular Surgery, New Tokyo Hospital, Chiba, Japan. Electronic address: - - 2014
A 33-year-old man presented with severe aortic insufficiency due to a prolapsed bicuspid aortic valve. The ventriculoaortic junction was dilated to 29 mm without root dilatation, and external ring annuloplasty was performed using a Gelweave (Terumo, Tokyo, Japan) graft to reduce the size to 22 mm. The leaflets were repaired ...
Callanan A A Institute for Bioengineering, School of Engineering, The University of Edinburgh, Edinburgh EH9 3JL, UK; Centre for Applied Biomedical Engineering Research, Department of Mechanical, Aeronautical and Biomedical Engineering and the Materials and Surface Science Institute, University of Limerick, Ireland. Electronic address: - - 2014
Deployment of stent-grafts, derived from synthetic biomaterials, is an established minimally invasive approach for effectively treating abdominal aortic aneurysms (AAAs). However, a notable disadvantage associated with this surgical technique is migration of the deployed stent-graft due to poor biocompatibility and inadequate integration in vivo. Recently, tissue-engineered extracellular matrices (ECMs) have ...
Koyama Masayuki M Sapporo Medical University School of - - 2014
Pulmonary arterial hypertension (PAH) is characterized by vasoconstriction and vascular remodeling of the pulmonary artery (PA). Recently, endoplasmic reticulum (ER) stress and inappropriate adaptation through the unfolded protein response (UPR) have been disclosed in various types of diseases. Here we examined whether ER stress is involved in the pathogenesis of ...
Atkins Samantha K SK Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN, - - 2014
The type-I bicuspid aortic valve (BAV), which differs from the normal tricuspid aortic valve (TAV) most commonly by left-right coronary cusp fusion, is frequently associated with secondary aortopathies. While BAV aortic dilation has been linked to a genetic predisposition, hemodynamics has emerged as a potential alternate etiology. However, the link ...
El Arid Jean-Marc JM Cardiovascular Surgery Department, Lille University Hospital, - - 2014
The reimplantation technique for valve-sparing aortic root replacement is increasingly used to treat aortic root pathology. The systematic approach described by El Khoury in 2009 and modified in 2011 using the Valsava graft is simple and reproducible. However, in-conduit suturing of the aortic valve annulus and small rim of sinus ...
Sakamoto Kisaburo K Department of Cardiovascular Surgery, Mt. Fuji Shizuoka Children's Hospital, Sizuoka City, Japan. Electronic address: - - 2014
A 1-year-old boy weighing 10.4 kg underwent successful biventricular repair for transposition of the great arteries, a ventricular septal defect, and a left ventricular outflow tract (LVOT) obstruction with moderate pulmonary stenosis of the bicuspid pulmonary valve (z score of -4.4 for the pulmonary valve) by means of a modified Nikaidoh ...
Di Eusanio Marco M Cardiac Surgery Division, Department of Experimental Diagnostic and Specialty Medicine, Sant'Orsola Malpighi Hospital, Alma Mater Studiorum - University of Bologna, 40123 Bologna, Italy. Electronic address: - - 2014
Most usually, the aortic tunnels empty into the left ventricle. Very rarely, they open to the left atrium. The essence of the aortic tunnels is that they bypass the hinges of the valvar leaflets within the aortic root. We have recently encountered an aorto-left atrial tunnel satisfying this criterion.
Mahesh Balakrishnan B Department of Cardiothoracic Surgery, Papworth Hospital, Cambridge, - - 2014
A 45-year old woman with then unknown Loeys-Dietz syndrome (LDS) presented in 2007 with aneurysms involving the entire thoraco-abdominal aorta, but sparing the aortic root and valve. She underwent debranching of the aortic arch, followed by stenting of entire distal ascending aorta, arch and descending aorta. Two years later, a ...
De Boo Diederick W - - 2014
A 71-year-old man initially presented with an asymptomatic, incidentally detected ascending aortic pseudoaneurysm 25 years following aortic root repair with mechanical aortic valve replacement. This pseudoaneurysm was previously treated with coil embolization but due to coil impaction it reopened 8 years later. Endovascular closure of the pseudoaneurysm was achieved with ...
Kida Naoki N a Department of Biomechanics , Institute for Frontier Medical Sciences, Kyoto University , 53 Kawahara-cho, Shogoin, Sakyo , Kyoto 606-8507 , - - 2014
In this study, for predicting arterial function and pathogenesis from a mechanical viewpoint, we develop a continuum mechanical model of an arterial wall that embodies residual and active stresses following a traditional anisotropic passive constitutive law. The residual and active stresses are incorporated into finite element methods based on a ...
Kuwauchi Shintaro S Division of Cardiovascular Surgery, Cardiovascular Center, St. Luke's International Hospital, Tokyo, Japan. Electronic address: - - 2014
We describe here an initial successful case of valve-sparing surgery using reimplantation technique in a 24-year-old male with aortic root dilatation with truncal valve insufficiency after common arterial trunk repair. Concomitant right ventricular outflow tract reconstruction with expanded polytetrafluoroethylene was also successfully performed. He was discharged home on postoperative day 10 ...
Hess Philip P Division of Thoracic and Cardiovascular Surgery, University of Florida, Gainesville, - - 2014
Aortic valve-sparing reimplantation remains an effective technique for repair of aortic root aneurysms. Studies indicate that the Florida Sleeve procedure is dimensionally stable and durable in the early postoperative period; however, our technique has evolved. We describe a 10-year institutional experience and the technical update of the Florida Sleeve repair ...
Rodgers Valérie V Cardiology Service, Centre Hospitalier de l'Université de Montréal, Montréal, Québec, - - 2014
We report the case of a contained rupture of the aortic annulus after transcatheter aortic valve implantation. The landing zone tear extended cranially to the aortic root and caudally into the perimembranous septum, creating a restrictive ventricular septal defect and severe paravalvular regurgitation into both ventricles, but no pericardial effusion ...
Ghavidel Alireza Alizadeh AA Heart Valve Disease Research Center, Iran University of Medical Science, Tehran, Iran; Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Science, Tehran, Iran. Electronic address: - - 2014
We describe a simple technique for aortic root replacement in destructive prosthetic aortic valve endocarditis wherein the fragile aortic annulus tissue is not suitable for suture placement. Therefore, we first reconstructed the intervalvular part with a nontreated pericardial patch and then implanted the aortic composite graft on the aortic root ...
Kimura Taizo T 1] Department of Molecular Cardiovascular Biology, Yamaguchi University School of Medicine [2] Division of Cardiology, Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine [3] Division of Cardiovascular Medicine, Medical Science for Control of Pathological Processes, Graduate School of Comprehensive Human Science, University of - - 2014
Acute aortic dissection (AAD) is caused by the disruption of intimomedial layer of the aortic walls, which is immediately life-threatening. Although recent studies indicate the importance of proinflammatory response in pathogenesis of AAD, the mechanism to keep the destructive inflammatory response in check is unknown. Here, we report that induction ...
Berdajs Denis - - 2014
During the past decades, replacement of the aortic valve (AVR) was considered a straightforward treatment of aortic valve disease. The technique is simple, with a relatively low perioperative mortality and morbidity (3-5%) and, as such, does not require a detailed knowledge of aortic root anatomy. However, with the renaissance of ...
Kefayati Sarah S Department of Physics and Astronomy, University of Western Ontario, London, ON, - - 2014
Atherosclerotic disease, and the subsequent complications of thrombosis and plaque rupture, has been associated with local shear stress. In the diseased carotid artery, local variations in shear stress are induced by various geometrical features of the stenotic plaque. Greater stenosis severity, plaque eccentricity (symmetry) and plaque ulceration have been associated ...
François Katrien K Cardiac Centre, Department of Cardiac Surgery, University Hospital Ghent, Ghent, Belgium. Electronic address: - - 2013
Aortic root dilatation remains of concern late after repair for tetralogy of Fallot (ToF). We have previously demonstrated that the aortic root size decreases progressively after early correction. To test whether the aortic wall changes are intrinsic or acquired, a histologic study was performed of infants at early repair. From ...
Villa Emmanuel - - 2013
Aortic root replacement with biological conduit (homograft, autograft, or xenograft) is a valuable tool, but biological valves are often prone to degeneration. Reoperations usually require root removal and repetition of the Bentall procedure to maintain the same orifice area. A less radical option is to limit replacement to the valve. ...
Fujimoto M - - 2013
BACKGROUND AND PURPOSE:A recent randomized clinical trial on intracranial atherosclerosis was discontinued because of the higher frequency of stroke and death in the angioplasty and stent placement group than in the medical treatment group. An in-depth understanding of the relationship between biologic responses and flow dynamics is still required to ...
Kasdi Reda - - 2013
Acute valve-sparing procedures are effective in the treatment of aortic root dilation when there is no valve pathology. In this review, we discuss the role of aortic valve-sparing procedures in the presence of connective tissue disorders such as scleroderma.
Heo Woon - - 2013
Despite marvelous advances in repair for acute type A aortic dissection over past decades, it remains challenging to repair the aortic root when aortic dissection extended to the sinuses causes the fragile root because of its thinner layers, which are susceptible to suture trauma. Here, we describe a modified Florida ...
Pavlidis Antonios N - - 2013
Vessel perforation is an undesirable and life-threatening complication during vein graft angioplasty. We report on a case of vein graft rupture during angioplasty, which was successfully managed with deployment of a polytetrafluoroethylene-covered stent.
Nishida Hidefumi - - 2013
The Medtronic freestyle aortic root bioprosthesis (Medtronic, Inc., Minneapolis, MN, USA) is a stentless valve with an effective orifice area that is larger than that observed on other bioprostheses. However, there have been sporadic reports of structural valve deterioration (SVD), such as aortic root wall rupture, leaflet tearing, and pseudoaneurysm ...
Behranwala Ali Asgar AA Department of Cardiovascular Thoracic Surgery, Jaslok Hospital and Research Centre, Mumbai, - - 2013
Acute aortic dissection after aortic valve replacement is rare. A 57-year-old man presented with an acute type A aortic dissection 1 year after aortic valve replacement, which originated from the previous aortotomy site. He underwent a Bentall procedure. Postoperatively, he developed complete heart block requiring permanent pacemaker implantation. During aortic ...
Takano Tamaki T Department of Cardiovascular Surgery, Shinshu University School of Medicine, Matsumoto, Nagano, Japan - - 2013
Reoperation on the aortic root is considered to be challenging because of high hospital mortality. Prosthesis-sparing aortic root replacement, in which the aortic prosthesis is preserved during reoperation, and could avoid passing sutures through the weakened aortic annuls after the initial prosthesis has been removed. We report 3 cases of ...
Georgakarakos E - - 2013
The hemodynamic consequences of misaligned stent-grafts (SG) in fenestrated endografts (EG) have not been adequately studied. Our aim was to study the hemodynamic effects of positional variations of SG, investigating the potential influence on the total displacement forces acting on the EG and the shear stress values at the stented ...
Kim Dong Hee - - 2013
A 74-year-old man was diagnosed with aortic root aneurysm and two-vessel coronary disease. Echocardiographic assessment revealed an enlarged sinus of Valsalva 60 mm in diameter with mild aortic regurgitation. Florida sleeve repair was performed using a vascular graft combined with coronary artery bypass grafting. The postoperative course was uncomplicated and ...
Sahin Muslum - - 2013
Pseudoaneurysm of the aortic root is a rare condition and potentially fatal if not treated. It may occur in different etiologies. In this case, we aim to show an aortic pseudoaneurysm arising from the aorta-saphenous vein graft anastomosis.
Wang Lian - - 2013
Ginkgo biloba extract (EGb 761) is widely used to treat cerebral disorders. Clinical trials have demonstrated therapeutic benefits of EGb 761 in various vascular diseases. Because the potential pathophysiological mechanisms appear similar to those involved in aneurysmal degeneration, we postulated that EGb 761 might affect the development and progression of ...
Loukas Marios - - 2013
The aortic root is the anatomical bridge between the left ventricle and the ascending aorta. It is made up of the aortic valve leaflets, which are supported by the aortic sinuses (of Valsalva), and the interleaflet triangles interposed between the basal attachments of the leaflets. As such, it possesses significant ...
Takamizawa Keiichi - - 2013
It is well known that arteries are subject to residual stress. In earlier studies, the residual stress in the arterial ring relieved by a radial cut has been considered in stress analysis. However, it has been found that axial strips sectioned from arteries also curled into arcs, showing that the ...
Viswanathan Uma - - 2013
The occurrence of a brachial plexus united into a single cord is very rare. During routine dissection of an elderly female cadaver, the brachial plexus united into a single cord was observed bilaterally. On the left side, C4, C5, and C6 roots combined to form the upper trunk, the C7 ...
Crooke Philip S PS From the *Department of Mathematics, Vanderbilt University, Nashville, TN USA; †BioStable Science and Engineering, Inc, Austin, TX USA; ‡German Heart Center Munich, Munich, Germany; and §Department of Cardiac Surgery, Vanderbilt University, Nashville, TN - - 2013
A full geometric annuloplasty ring could facilitate aortic valve repair. The purpose of this report was to document the design of such a ring using mathematical analyses of normal human aortic valve computed tomographic angiograms. One-millimeter axial slices of high-resolution computed tomographic angiograms from 11 normal aortic roots were used ...
Mao Sun-Zhong - - 2013
Hypoxic pulmonary arterial hypertension (PAH) is a disabling disease with limited treatment options. Hypoxic pulmonary vascular remodeling is a major cause of hypoxic PAH. Pharmacological agents that can inhibit the remodeling process may have great therapeutic value. To examine the effect of intermedin (IMD), a new calcitonin gene-related peptide family ...
Goldstone Andrew B - - 2013
Delayed pulmonary autograft failure is the principal limitation of the Ross procedure. Although reoperation typically includes replacement of the neoaortic valve, strategies for autograft valve preservation are becoming increasingly employed. However, leaflet prolapse and asymmetry are deterrents to valve preservation in this technically complex surgical population. The present report illustrates ...
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