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Frise Matthew C MC Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, - - 2014
The human pulmonary circulation loses its natural distensibility under sustained hypoxia, leading to pulmonary arterial hypertension and a much higher workload for the right ventricle. The hypoxia-inducible factor (HIF) pathway is implicated in this pulmonary vascular response to continued hypoxia by animal studies, and additionally by rare human diseases where ...
Currigan Dale A DA From the Cardiovascular Therapeutics Unit, Department of Pharmacology and Therapeutics, The University of Melbourne, Victoria, Australia (D.A.C., R.J.A.H., C.E.W., J.A.A., P.F.S.) and Department of Anaesthesia and Pain Medicine, Royal Melbourne Hospital, Parkville, Australia (D.A.C., - - 2014
Vasopressor drugs, commonly used to treat systemic hypotension and maintain organ perfusion, may also induce regional vasoconstriction in specialized vascular beds such as the lung. An increase in pulmonary vascular tone may adversely affect patients with pulmonary hypertension or right heart failure. While sympathomimetics constrict pulmonary vessels, and vasopressin does ...
Vergallo Rocco R Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, - - 2014
-Despite the exposure of the entire vasculature to the atherogenic effects of systemic risk factors, atherosclerotic plaques preferentially develop at sites with disturbed flow. This study aimed at exploring in vivo the relationship between local endothelial shear stress (ESS) and coronary plaque characteristics in humans, using computational fluid dynamics and ...
Model Lynn S LS Department of Surgery, Yale School of Medicine, New Haven, Connecticut ; Vascular Biology and Therapeutics Program, Yale School of Medicine, New Haven, - - 2014
Vein graft adaptation to the arterial environment is characterized by loss of venous identity, with reduced Ephrin type-B receptor 4 (Eph-B4) expression but without increased Ephrin-B2 expression. We examined changes of vessel identity of human saphenous veins in a flow circuit in which shear stress could be precisely controlled. Medium ...
Dorfmüller Peter P Paris-South University, Faculty of Medicine, Kremlin-Bicêtre, France Dept of Pathology, Centre Chirurgical Marie Lannelongue, Le Plessis-Robinson, France INSERM U999, Pulmonary Hypertension, Pathophysiology and Novel Therapies, Centre Chirurgical Marie Lannelongue, Le Plessis-Robinson, France Both authors contributed equally to this study - - 2014
Limited numbers of operated patients with chronic thromboembolic pulmonary hypertension (CTEPH) are refractory to pulmonary endarterectomy (PEA) and experience persistent pulmonary hypertension (PH). We retrospectively assessed lung histology available from nine patients with persistent PH (ineffective PEA (inPEA) group) and from eight patients transplanted for distal CTEPH inaccessible by PEA ...
Vincent Stéphane D SD Department of Developmental Biology & Stem Cell Biology, CNRS URA 2578, Institut Pasteur, Paris, - - 2014
Congenital heart defects affect at least 0.8% of newborn children and are a major cause of lethality prior to birth. Malformations of the arterial pole are particularly frequent. The myocardium at the base of the pulmonary trunk and aorta and the arterial tree associated with these great arteries are derived ...
Lindskog Henrik H Laboratory for Accelerated Vascular Research, Division of Vascular Surgery, Department of Surgery, University of California, San Francisco, CA 94143, - - 2014
Coordinated arterial-venous differentiation is crucial for vascular development and function. The origin of the cardinal vein (CV) in mammals is unknown, while conflicting theories have been reported in chick and zebrafish. Here, we provide the first molecular characterization of endothelial cells (ECs) expressing venous molecular markers, or venous-fated ECs, within ...
Kim Jong Hun - - 2014
The anterior commissure defect of tricuspid valve may leave remnant regurgitation with inadequate leaflet coaptation after simple patch closure of the defect. A 19-year-old man underwent commissuroplasty for the anterior commissure defect caused by tricuspid valve endocarditis. Significant remnant regurgitation after patch closure of the anterior commissure defect was successfully ...
Wandall-Frostholm Christine C Department of Biomedicine, Aarhus University, Aarhus, - - 2014
In vascular biology, endothelial KCa2.3 and KCa3.1 channels contribute to arterial blood pressure regulation by producing membrane hyperpolarization and smooth muscle relaxation. The role of KCa2.3 and KCa3.1 channels in the pulmonary circulation is not fully established. Using mice with genetically encoded deficit of KCa2.3 and KCa3.1 channels, this study ...
Petre Izabella I Department of Obstetrics and Gynecology, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania; - - 2014
The placental development is a complex process, in which any disturbance can induce changes with grave consequences for the offspring. Villi and villous vascularization development is in, and underdevelopment can lead to villous placental insufficiency. This paper aims to analyze the arterial and venous vasculature of the placenta, both macroscopic ...
Lindsay Mark E ME Massachusetts General Hospital Thoracic Aortic Center, Departments of Medicine and Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts - - 2014
Gene identification in human aortic aneurysm conditions is proceeding at a rapid pace and the integration of pathogenesis-based management strategies in clinical practice is an emerging reality. Human genetic alterations causing aneurysm involve diverse gene products including constituents of the extracellular matrix, cell surface receptors, intracellular signaling molecules, and elements ...
So Tetsuya T Department of Thoracic Surgery, Shinkomonji Hospital, Kitakyushu 800-0057, Japan - - 2014
We present a case of a human pulmonary dirofilariasis in a 59-year-old man. At the medical examination, a chest computed tomography (CT) revealed a mass, measuring 18 × 15 mm in diameter, with an irregular margin on the bottom of the right lower lobe. We could not neglect the possibility ...
Hou Xuhui X Department of Vascular Surgery, China-Japan Friendship Hospital of Jilin University, Changchun 130031, Jilin Province, - - 2013
It is necessary to investigate the longitudinal tensile mechanical characteristics of the middle cerebral artery and the fetal umbilical vein prior to applying fetal umbilical vein transplantation for repair of injured middle cerebral artery. Fifteen fresh fetal umbilical vein specimens and 15 normal human fresh cadaver middle cerebral artery specimens ...
Aksüt Mehmet - - 2013
After repair of atrial septal defects with or without patch, residual shunt, shrinkage, haemolysis and thromboembolic complications may occur. Even though the pericardium is quite a suitable material for the closure of atrial septal defects, the external surface of the pericardium is not smooth and may be a nidus for ...
Sannier Aurélie A Department of Pathology, Hôpital Avicenne, AP-HP, Université Paris 13, Bobigny, - - 2013
Lymph vessels play an important role in tumor progression. Pulmonary adenocarcinomas, accounting for half of non-small-cell lung carcinomas, compose a spectrum of histological types, exclusively or without a lepidic growth pattern (LGP) along preserved interalveolar septa. In that context, this study was designed to investigate the lymphatic vascular pattern associated ...
Saiki Kazunobu K Unit of Translational Medical Science, Department of Macroscopic Morphology, Nagasaki University, Graduate School of Biomedical Science, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan. - - 2013
We measured the calibers of the left and right internal jugular veins (IJV) and sizes of the left and right transverse sinuses (TS) in 91 cadavers, compared them between the left and right sides, and also evaluated the drainage patterns of the superior sagittal sinus (SSS) and straight sinus (=rectal ...
Cornett Bridget B The Perinatal Institute Division of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Cincinnati Children's Hospital Medical Center Research Foundation, Cincinnati, OH 45229, - - 2013
Wntless (Wls), a gene highly conserved across the animal kingdom, encodes for a transmembrane protein that mediates Wnt ligand secretion. Wls is expressed in developing lung, wherein Wnt signaling is necessary for pulmonary morphogenesis. We hypothesize that Wls plays a critical role in modulating Wnt signaling during lung development and ...
Mahimarangariah Jayaranganath - - 2013
Sinus of Valsalva aneurysms are commonly associated with ventricular septal defects. We describe a 14 year old boy who presented with Rupture of Right Sinus Of Valsalva (RSOV) into the right ventricular outflow tract (through two openings) along with a residual ventricular septal defect (VSD), four years after surgical closure ...
Kulkarni Ananta A AA Department of Plastic Surgery, Dr D.Y.Patil Hospital & Research Centre, Sector -5, Nerul, NaviMumbai, Maharashtra 400 706 - - 2013
Commonly, a groin defect is reconstructed with flaps from ipsilateral thigh or lower abdomen. Here we present a case report of use of a pedicled flap from the posterior scrotum based on posterior scrotal artery to cover a groin defect exposing femoral vessels. Posterior scrotal artery, to best of our ...
Abed Saif F - - 2012
: The cranio-orbital foramen is an osseous anatomical landmark located adjacent to the superior orbital fissure. It is a potential source of hemorrhage during deep orbital dissection because it is the location of an anastomosis between the lacrimal artery and the middle meningeal artery. The purpose of this study was ...
Uchino Akira - - 2012
INTRODUCTION: Duplicate origin of the middle cerebral artery (MCA) is rare and has been misdiagnosed or confused as fenestration of the proximal M1 segment of the MCA. The condition is not a true fenestration and occurs when two MCA branches arise separately from the terminal segment of the internal carotid ...
Gümüş Hatice - - 2012
Abstract Purpose: Renal artery variations are important for clinical reasons. The aim of this study is to determine the originating level and variations of renal arteries with 64-channel multidetector computed tomography (MDCT). Materials and methods: In a university hospital, 820 patients who underwent MDCT angiography of the abdominal aorta were ...
Xu Keli - - 2012
Notch signaling plays an essential role in development and homeostasis of multiple organs including the lung. Dysregulation of Notch signaling has been implicated in various lung diseases including lung cancer. Here we review functions of Notch signaling in coordinating events during lung development, such as early proximodistal fate generation and ...
Thomas Daniel B - - 2011
Insulation and vascular heat-retention mechanisms allow penguins to forage for a prolonged time in water that is much cooler than core body temperature. Wing-based heat retention involves a plexus of humeral arteries and veins, which redirect heat to the body core rather than to the wing periphery. The humeral arterial ...
Morales Maria E - - 2011
Abstract Akodonema luzsarmientae n.g. n.sp. (Nemata: Metastrongyloidea) is described from the pulmonary arteries and heart from several individuals of Akodon mollis "soft grass mouse" (Rodentia: Cricetidae) collected in the region of Ancash, Peru. The new genus and species is distinguished by having a dorsal ray consisting of only two small ...
Gardner Scott L - - 2011
Abstract Akodonema luzsarmientae n.g. n.sp. (Nemata: Metastrongyloidea) is described from the pulmonary arteries and heart from several individuals of Akodon mollis "soft grass mouse" (Rodentia: Cricetidae) collected in the region of Ancash, Peru. The new genus and species is distinguished by having a dorsal ray consisting of only two small ...
Hlaing K P - - 2011
The cystic artery (CA) is known to exhibit variations in its origin and branching pattern. This is attributed to the developmental changes occurring in the primitive ventral splanchnic arteries. During routine dissection of a male cadaver, we observed that the CA originated from the middle hepatic artery (MHA) at a ...
Jadhav S D - - 2011
Carotid arteries and their branches exhibit a wide range of variations. However, variations in the origin of the thyrolingual trunk from the common carotid artery are rare. We observed a case of thyrolingual trunk arising from the bifurcation point of the right common carotid artery during a routine dissection class ...
Ansari Saeed - - 2011
This article describes a straightforward method to measure the dimensions and identify morphological variations in the cerebral arterial circle using the general-purpose software program Osiris. This user-friendly and portable program displays, manipulates, and analyzes medical digital images, and it has the capability to determine morphometric properties of selected blood vessels ...
Prakash Prakash - - 2011
Background: Vascular variations regarding the branching pattern of the aorta are important in different laparoscopic surgeries, liver and kidney transplantation, oncologic resections, and various interventional radiological procedures in the abdominal region. The present work was undertaken on cadavers to examine the prevalence of vascular patterns of the important branches of ...
Kayalvizhi I - - 2011
A rare association of accessory testicular artery along with double renal arteries and accessory renal vein was observed unilaterally on the left side. In addition, the left inferior phrenic artery was arising from the left gastric branch of the coeliac trunk. This was observed in the dissection of an adult ...
Ghatak Tanmoy - - 2011
Erroneous positioning of central venous catheters in small tributaries of large central veins is a rare occurrence. We describe two such unusual incidents involving cannulation of the small tributaries of left brachiocephalic vein. Malposition was suspected when the central venous waveform could not be obtained despite all attempts. Unusual central ...
Ishihara H - - 2011
A 32-year-old woman hospitalized for subarachnoid hemorrhage showed rare arterial variation on the right side with anomalous origins of the vertebral artery, aberrant subclavian artery and persistent trigeminal artery. Angiography showed the right vertebral artery to originate from the right common carotid artery, the right subclavian artery to arise separately ...
Gill Ryan M - - 2011
Correct classification of nonalcoholic steatohepatitis (NASH) liver biopsies is of critical importance and relies on correct orientation to microscopic liver architecture. Centrizonal arteries can cause central zones to be mistaken for portal tracts, especially in the setting of centrizonal ductular reaction, and result in either missed diagnosis or inaccurate staging ...
Aragão José Aderval - - 2011
PURPOSE: The aim of the present study was to determine the frequency of occurrence of multiple renal arteries in human fetuses. METHODS: Sixty kidneys from human fetuses (32 males and 28 females) were used, fixed and kept in 10% formol solution. The fetal age was estimated from the hallux-calcaneus length ...
Park Hyo Eun - - 2011
Coronary artery calcium score (CACS) is a strong predictor of coronary heart disease and provides incremental prognostic information beyond traditional risk factors. The difference in prevalence and distribution of CACS in different ethnic groups has been reported with conflicting results. We aimed to investigate the prevalence and distribution of CACS ...
Yim Deane L S - - 2011
We report the case of an adolescent who was presented with long-standing exertional symptoms, and was diagnosed with an anomalous right coronary arterial origin arising above the commissural junction between the left and right aortic sinus, with inter-arterial and intramural compression. The precise origin of this lesion outside the aortic ...
Pijnenborg R - - 2011
In contrast to baboon or rhesus macaque, trophoblast invasion in the human placental bed occurs by the interstitial as well as the endovascular route and reaches as deep as the inner myometrium. We here describe two rare specimens of gorilla placenta. In the light of recent findings in the chimpanzee, ...
Chu Yinzhu - - 2011
The purpose of this study was to test the morphology and haemodynamics of the renal artery in the rabbit as evaluated by conventional and contrast-enhanced ultrasonography (CEUS). The morphology and haemodynamics of the rabbit renal artery, including the diameter, which were measured using B-mode ultrasonography (US), colour Doppler US and ...
Ongeti Kevin W - - 2011
Variant anatomy of the superior thyroid artery is important during surgical procedures, interpretation of angiograms, and interventional radiography in the neck. Pattern of the variations shows population differences but there is no data from the Kenyan population. This study therefore investigated the variations in origin of the superior thyroid artery ...
Iwai Toshinori - - 2011
It is well-known that the branches of the external carotid artery (ECA) can show anatomical variation, but it is extremely rare that thyrolingual trunk originates from common carotid artery (CCA). Here we report a case of the thyrolingual trunk arising from the CCA on the right side in a 73-year-old ...
Sañudo José R - - 2011
INTRODUCTION AND HYPOTHESIS: The aim of this work is to analyse the variability of the obturator artery (oa), unify previous criteria and propose a simple classification for clinical use. METHODS: A sample of 119 adult human embalmed cadavers was used. Origin and course of the oa in relation with the ...
Aydın Mennan Ece - - 2011
The superior cerebellar artery is the most consistent branch of the basilar artery and arises near the bifurcation of the basilar artery. A bilateral origin of the superior cerebellar arteries from the posterior cerebral arteries has been rarely reported in the literature. Reporting variations in brain vessels is important for ...
Kumar Saurabh - - 2011
Omega-3 polyunsaturated fatty acids in fish oils may have antifibrillatory effects; however, their electrophysiologic effects in paroxysmal atrial fibrillation (PAF) remain unknown. The aim of this study was to investigate the effects of chronic fish oil supplementation on human pulmonary vein (PV) and left atrial electrophysiology in PAF. Patients with ...
Hassan A - - 2011
The aim of this study was to assess vascular disturbances in the testis of infertile males associated with varicocele. In total, 124 consecutive male subjects were divided into the following groups: healthy fertile controls (n = 10), Gp1 (n = 28); infertile males with subclinical varicocele, Gp2 (n = 26); infertile males with grade I left ...
Park Eun-Ah - - 2011
We wanted to describe the three-dimensional (3D) anatomic variations of the femoral vein (FV) and popliteal vein (PV) in relation to the accompanying artery using CT venography. We performed a retrospective review of 445 bilateral (890 limbs) lower limb CT venograms. After the 3D relationship between the FV and PV ...
Khorgami Zhamak - - 2011
Vascular anastomosis is commonly done by hand-sewn methods which not only are slow in pace, but also need experiences in surgeons' hands. As the old techniques are replaced by the new ones all the time, it is sensed that a new sutureless approach should be welcomed in the field of ...
Palmieri Breno José - - 2011
To investigate the prevalence and distribution of renal arteries and their branches in vivo, correlating the particularities found in them with sex and laterality. Two hundred renal pedicles were studied by CT angiography and its arteries analyzed according to number, position of origin, size, length and trajectory in relation to ...
Barrow Daniel L - - 2011
BACKGROUND:: Intraoperative rupture of an intracranial aneurysm is a potentially devastating but avoidable and manageable complication of aneurysm surgery. OBJECTIVE:: To describe a surgical technique that the authors have used successfully to repair a tear at the neck of an intracranial aneurysm. The technique and alternative options for managing this ...
Li Yuhui - - 2011
A 39-year-old woman presented with left visual disturbance and diplopia. Magnetic resonance imaging revealed a well-enhanced tumor in the left tentorium, cavernous sinus, and suprasellar region. Angiography demonstrated an abnormal origin of the ophthalmic artery from the anterior cerebral artery. The tumor was partially removed by left frontotemporal craniotomy with ...
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