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Vlajković Slobodan S Faculty of Medicine, Department of Anatomy, University of Niš, 81 Dr Zoran Đinđić Blvd., Niš, 18000, Serbia, - - 2014
The posterior cerebral artery (PCA), as a paired terminal branch of the basilar artery, runs through four segments (P1 to P4) to the inferior and medial surfaces of the occipital and a part of the temporal lobes. There are many PCA variants in its course. The literature data indicated that ...
Oliveira Magaldi Marcelo M *Department of Surgery and §School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; ‡Neurosurgery Research Laboratory and ¶Division of Neurological Surgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, - - 2014
Neurosurgery, a demanding specialty, involves many microsurgical procedures that require complex skills, including open surgical treatment of intracranial aneurysms. Simulation or practice models may be useful for acquiring these skills before trainees perform surgery on human patients. To describe a human placenta model for the creation and clipping of aneurysms. ...
Burke Steven K SK *Research and Development, Proteon Therapeutics, Inc, Waltham, MA; †Biopta Ltd, Glasgow, United Kingdom; and ‡University of Texas at Tyler, Tyler, - - 2014
At physiologic pressures, elastic fibers constrain artery diameter. Local treatment of atherosclerotic arteries with PRT-201, a recombinant type I elastase, could result in fragmentation and removal of elastin fibers and increased vessel diameter. To investigate the use of PRT-201 as a treatment for human atherosclerotic arteries. Arteries were harvested from ...
Brinjikji W W From the Department of Radiology, Mayo Clinic, Rochester, Minnesota. - - 2014
Recanalization of intracranial aneurysms following endovascular coiling remains a frustratingly common occurrence. An understanding of the molecular and histopathologic mechanisms of aneurysm healing following coil embolization is essential to improving aneurysm occlusion rates. Histopathologic studies in coiled human and experimental aneurysms suggest that during the first month postcoiling, thrombus formation ...
Cavasin Maria A - - 2014
BackgroundPatients with pulmonary arterial hypertension (PAH) are treated with vasodilators, including endothelin receptor antagonists (ERAs), phosphodiesterase-5 (PDE-5) inhibitors, soluble guanylyl cyclase activators, and prostacyclin. Despite recent advances in pharmacotherapy for individuals with PAH, morbidity and mortality rates in this patient population remain unacceptably high. Here, we tested the hypothesis that ...
Naito Michiko M Department of Anatomy, Nihon University School of Medicine, Tokyo, - - 2014
To understand anomalies in Chiari's network better, we assessed the topographical anatomy of the fetal inferior vena cava (IVC), coronary sinus, and atria. We examined sagittal serial paraffin sections of 15 human fetuses of crown-rump length 24-36 mm, corresponding to a gestational age of 8 weeks. Although their outflow tract ...
Bertl Kristina K Division of Oral Surgery, Bernhard Gottlieb School of Dentistry, Medical University of Vienna, Sensengasse 2a, 1090, Vienna, Austria, - - 2014
CT assessment of the entire course of the inferior alveolar artery (IAA) within the mandibular canal. After contrast medium injection (180 or 400 mg/ml iodine concentration) into the external carotid arteries of 15 fresh human cadaver heads, the main IAA's position in the canal (cranial, buccal, lingual or caudal) was assessed ...
Yang Yang-Ming YM Department of Cell Biology & Anatomy, New York Medical College, Valhalla, New - - 2014
Chronic hypoxia typically elicits pulmonary hypertension (PH) in mice with a male-dominant phenotype. There is an opposite sex-bias in human PH with higher prevalence in women, but greater survival (the "estrogen paradox"). We investigated the involvement of STAT5a/b species, previously established to mediate sexual dimorphism in other contexts, in the ...
Kutkut Issa I Department of Pathology and Immunology, University of Geneva and Geneva University Hospitals, Geneva, Switzerland; Department of Medical Specializations - Cardiology, University of Geneva and Geneva University Hospitals, Geneva, - - 2014
Atherosclerosis is a chronic inflammatory disease of large- to medium-sized arteries and is the main underlying cause of death worldwide. The lymphatic vasculature is critical for processes that are intimately linked to atherogenesis such as the immune response and cholesterol metabolism. However, whether lymphatic vessels truly contribute to the pathogenesis ...
Josue Diaz-Delgado DD 1  Veterinary Histology and Pathology, Institute of Animal Health, Veterinary School, University of Las Palmas de Gran Canaria, Trasmontaña s/n, Arucas 35413, Las Palmas de Gran Canaria, - - 2014
Abstract Wohlfahrtiimonas chitiniclastica is a rare cause of fatal septicemia in humans, and recently reported in a white-tailed deer (Odocoileus virginianus). We describe fatal septicemia associated with W. chitiniclastica in a short-beaked common dolphin (Delphinus delphis) with fibrinosuppurative and necrotizing pulmonic, aortic, and mitral valve endocarditis.
Wilkins Martin R MR Department of Medicine, Imperial College London, London, United Kingdom - - 2014
-Human variation in susceptibility to hypoxia-induced pulmonary hypertension is well recognized. High-altitude residents who do not develop pulmonary hypertension may host protective gene mutations. -Exome sequencing was conducted on 24 unrelated Kyrgyz highlanders living 2400 to 3800m above sea level, 12 (ten male, mean age 54yrs) with an elevated mean ...
Bellini Chiara C Department of Biomedical Engineering, Yale University, New Haven, CT, 06511, USA. Electronic address: - - 2014
Genetic studies in patients reveal that mutations to genes that encode contractile proteins in medial smooth muscle cells can cause thoracic aortic aneurysms and dissections. Mouse models of such mutations, including Acta2(-/-) and Myh11(R247C/R247C), surprisingly do not present with any severe vascular phenotype under normal conditions. This observation raises the ...
Tsamis Alkiviadis A Departments of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States; Center for Vascular Remodeling and Regeneration, University of Pittsburgh, Pittsburgh, PA, United States; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, United - - 2014
We recently reported a mechanistic model to link micro-architectural information to the delamination strength (Sd) of human ascending thoracic aorta (ATA). That analysis demonstrated that the number density (N) and failure energy (Uf) of the radially-oriented collagen fibers contribute to the Sd of both aneurysmal (ATAA) and non-aneurysmal (CTRL-ATA) aortic ...
Wong Daniel J DJ Vascular Biology and Therapeutics (VBT) Program and the Department of Surgery, Yale University School of Medicine, New Haven, - - 2014
Vein bypass is an essential therapy for patients with advanced peripheral and coronary artery disease despite development of neointimal hyperplasia. We have shown that stimulation of the receptor tyrosine kinase ephrin type-B receptor 4 (Eph-B4) with its ligand ephrin-B2 prevents neointimal hyperplasia in murine vein grafts. This study determines whether ...
Lin Li-Hsien LH Department of Neurology, University of Iowa, Iowa City, IA 52242, USA. Electronic address: - - 2014
Extracellular acidification activates a family of proteins known as acid-sensing ion channels (ASICs). One ASIC subtype, ASIC type 1 (ASIC1), may play an important role in synaptic plasticity, memory, fear conditioning and ischemic brain injury. ASIC1 is found primarily in neurons, but one report showed its expression in isolated mouse ...
Kamenskiy Alexey V AV Department of Surgery, University of Nebraska Medical Center, Omaha, NE. Electronic address: - - 2014
Surgical and interventional therapies for Peripheral Artery Disease (PAD) are notorious for high rates of failure. Interactions between the artery and repair materials play an important role, but comprehensive data describing the physiological and mechanical characteristics of human femoropopliteal arteries are not available. Fresh femoropopliteal arterieswere obtainedfrom 70 human subjects ...
Ibrahim Mohsen M Department of Surgery, Washington University School of Medicine, St. Louis, Missouri; Department of Thoracic Surgery, Sapienza University, Rome, - - 2014
There is accumulating evidence that extracellular adenosine triphosphate (eATP) promotes many of the underlying mechanisms that exacerbate acute lung injury. However, much of these data are from inbred rodent models, indicating the need for further investigation in higher vertebrates to better establish clinical relevance. To this end we evaluated a ...
Kotoulas Christophoros C 1 Department of Cardiothoracic Surgery, Army General Hospital of Athens, Athens, Greece ; 2 School of Medicine, University of Patras, Patras, - - 2014
The importance of the role of bronchial arteries is notable in modern days thoracic surgery. The significance of their anastomoses with adjusted structures has not yet been sufficiently rated, especially in cases of haemoptysis, heart-lung transplantations and treatment of aneurysms of the thoracic aorta. The need of a thorough study ...
Muramatsu Takashi T Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Cardiology, Fujita Health University Hospital, Toyoake, - - 2014
Despite the frequent use of spectral analysis of intravascular ultrasound radiofrequency data (VH(®) IVUS) in clinical studies, the assessment for reproducibility using this with high frequency IVUS remains unexplored. The aim of this study was to examine the reproducibility of VH IVUS using 45-MHz rotational IVUS in ex vivo human ...
de Kerchove Laurent L Pôle de Recherche Cardiovasculaire, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium; Division of Cardiothoracic and Vascular Surgery, Cliniques Universitaires Saint-Luc, Brussels, Belgium. Electronic address: - - 2014
To enhance the reproducibility of aortic valve-sparing reimplantation and annuloplasty, we analyzed the topographic relationship between the ventriculoaortic junction (VAJ), basal ring (BR), and sinotubular junction (STJ). The root base thickness is also quantified. Fifty-eight fresh human aortic valves were analyzed. The root was dissected to the limit where the ...
Frise Matthew C MC Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, - - 2014
The human pulmonary circulation loses its natural distensibility under sustained hypoxia, leading to pulmonary arterial hypertension and a much higher workload for the right ventricle. The hypoxia-inducible factor (HIF) pathway is implicated in this pulmonary vascular response to continued hypoxia by animal studies, and additionally by rare human diseases where ...
Currigan Dale A DA From the Cardiovascular Therapeutics Unit, Department of Pharmacology and Therapeutics, The University of Melbourne, Victoria, Australia (D.A.C., R.J.A.H., C.E.W., J.A.A., P.F.S.) and Department of Anaesthesia and Pain Medicine, Royal Melbourne Hospital, Parkville, Australia (D.A.C., - - 2014
Vasopressor drugs, commonly used to treat systemic hypotension and maintain organ perfusion, may also induce regional vasoconstriction in specialized vascular beds such as the lung. An increase in pulmonary vascular tone may adversely affect patients with pulmonary hypertension or right heart failure. While sympathomimetics constrict pulmonary vessels, and vasopressin does ...
Vergallo Rocco R Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, - - 2014
-Despite the exposure of the entire vasculature to the atherogenic effects of systemic risk factors, atherosclerotic plaques preferentially develop at sites with disturbed flow. This study aimed at exploring in vivo the relationship between local endothelial shear stress (ESS) and coronary plaque characteristics in humans, using computational fluid dynamics and ...
Model Lynn S LS Department of Surgery, Yale School of Medicine, New Haven, Connecticut ; Vascular Biology and Therapeutics Program, Yale School of Medicine, New Haven, - - 2014
Vein graft adaptation to the arterial environment is characterized by loss of venous identity, with reduced Ephrin type-B receptor 4 (Eph-B4) expression but without increased Ephrin-B2 expression. We examined changes of vessel identity of human saphenous veins in a flow circuit in which shear stress could be precisely controlled. Medium ...
Dorfmüller Peter P Paris-South University, Faculty of Medicine, Kremlin-Bicêtre, France Dept of Pathology, Centre Chirurgical Marie Lannelongue, Le Plessis-Robinson, France INSERM U999, Pulmonary Hypertension, Pathophysiology and Novel Therapies, Centre Chirurgical Marie Lannelongue, Le Plessis-Robinson, France Both authors contributed equally to this study - - 2014
Limited numbers of operated patients with chronic thromboembolic pulmonary hypertension (CTEPH) are refractory to pulmonary endarterectomy (PEA) and experience persistent pulmonary hypertension (PH). We retrospectively assessed lung histology available from nine patients with persistent PH (ineffective PEA (inPEA) group) and from eight patients transplanted for distal CTEPH inaccessible by PEA ...
Sáez Pablo P Group of Applied Mechanics and Bioengineering, Aragón Institute of Engineering Research, University of Zaragoza, Spain ; CIBER-BBN. Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina, - - 2014
Arterial hypertension is a chronic medical condition associated with an elevated blood pressure. Chronic arterial hypertension initiates a series of events, which are known to collectively initiate arterial wall thickening. However, the correlation between macrostructural mechanical loading, microstructural cellular changes, and macrostructural adaptation remains unclear. Here, we present a microstructurally ...
Mokoena Taole T Department of Surgery, School of Medicine, University of Pretoria, South Africa, and Pretoria Academic Hospital Complex. - - 2014
Lower limb varicose veins are a common complication of bipedal human movement and deep-vein thrombosis. However, they may have unusual causes, e.g. forming as collaterals around an obstruction or resulting from vascular malformations. Surgery in these cases can be inappropriate or harmful. Five cases of lower limb varicose veins in ...
Vincent Stéphane D SD Department of Developmental Biology & Stem Cell Biology, CNRS URA 2578, Institut Pasteur, Paris, - - 2014
Congenital heart defects affect at least 0.8% of newborn children and are a major cause of lethality prior to birth. Malformations of the arterial pole are particularly frequent. The myocardium at the base of the pulmonary trunk and aorta and the arterial tree associated with these great arteries are derived ...
Lindskog Henrik H Laboratory for Accelerated Vascular Research, Division of Vascular Surgery, Department of Surgery, University of California, San Francisco, CA 94143, - - 2014
Coordinated arterial-venous differentiation is crucial for vascular development and function. The origin of the cardinal vein (CV) in mammals is unknown, while conflicting theories have been reported in chick and zebrafish. Here, we provide the first molecular characterization of endothelial cells (ECs) expressing venous molecular markers, or venous-fated ECs, within ...
Kim Jong Hun - - 2014
The anterior commissure defect of tricuspid valve may leave remnant regurgitation with inadequate leaflet coaptation after simple patch closure of the defect. A 19-year-old man underwent commissuroplasty for the anterior commissure defect caused by tricuspid valve endocarditis. Significant remnant regurgitation after patch closure of the anterior commissure defect was successfully ...
Wandall-Frostholm Christine C Department of Biomedicine, Aarhus University, Aarhus, - - 2014
In vascular biology, endothelial KCa2.3 and KCa3.1 channels contribute to arterial blood pressure regulation by producing membrane hyperpolarization and smooth muscle relaxation. The role of KCa2.3 and KCa3.1 channels in the pulmonary circulation is not fully established. Using mice with genetically encoded deficit of KCa2.3 and KCa3.1 channels, this study ...
Petre Izabella I Department of Obstetrics and Gynecology, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania; - - 2014
The placental development is a complex process, in which any disturbance can induce changes with grave consequences for the offspring. Villi and villous vascularization development is in, and underdevelopment can lead to villous placental insufficiency. This paper aims to analyze the arterial and venous vasculature of the placenta, both macroscopic ...
Lindsay Mark E ME Massachusetts General Hospital Thoracic Aortic Center, Departments of Medicine and Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts - - 2014
Gene identification in human aortic aneurysm conditions is proceeding at a rapid pace and the integration of pathogenesis-based management strategies in clinical practice is an emerging reality. Human genetic alterations causing aneurysm involve diverse gene products including constituents of the extracellular matrix, cell surface receptors, intracellular signaling molecules, and elements ...
So Tetsuya T Department of Thoracic Surgery, Shinkomonji Hospital, Kitakyushu 800-0057, Japan - - 2014
We present a case of a human pulmonary dirofilariasis in a 59-year-old man. At the medical examination, a chest computed tomography (CT) revealed a mass, measuring 18 × 15 mm in diameter, with an irregular margin on the bottom of the right lower lobe. We could not neglect the possibility ...
Arichika Shigeta S Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Kyoto University, Kyoto, - - 2014
We aimed to visualize the retinal arterial wall thickness, assisted by noninvasive adaptive optics scanning laser ophthalmoscopy (AO-SLO). The arterial wall thickness was measured and compared between one normal subject and one patient suffering from malignant hypertensive retinopathy. Increased arterial wall thickness was revealed with a newly developed AO-SLO system, ...
Upadhyaya Jasbir D JD Department of Oral Biology, University of Manitoba, Winnipeg, MB, - - 2014
Activation of bitter taste receptors (T2Rs) in human airway smooth muscle cells leads to muscle relaxation and bronchodilation. This finding led to our hypothesis that T2Rs are expressed in human pulmonary artery smooth muscle cells and might be involved in regulating the vascular tone. RT-PCR was performed to reveal the ...
Gunn Andrew J AJ Department of Imaging, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, FND 216, Boston, MA 02114, - - 2014
Background/Objectives. Embolization of the left gastric artery (LGA), which preferentially supplies the gastric fundus, has been shown to produce weight loss in animal models. However, weight loss after LGA embolization in humans has not been previously established. The aim of this study was to evaluate postprocedural weight loss in patients ...
Longchamp Alban A Department of Surgery, Brigham and Women's Hospital/Harvard Medical School; - - 2014
The mainstay of contemporary therapies for extensive occlusive arterial disease is venous bypass graft. However, its durability is threatened by intimal hyperplasia (IH) that eventually leads to vessel occlusion and graft failure. Mechanical forces, particularly low shear stress and high wall tension, are thought to initiate and to sustain these ...
Liu Xiao X Key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, - - 2014
Despite the crucial role of nitric oxide (NO) in the homeostasis of the vasculature, little quantitative information exists concerning NO transport and distribution in medium and large-sized arteries where atherosclerosis and aneurysm occur and hemodynamics is complex. We hypothesized that local hemodynamics in arteries may govern NO transport and affect ...
Hou Xuhui X Department of Vascular Surgery, China-Japan Friendship Hospital of Jilin University, Changchun 130031, Jilin Province, - - 2013
It is necessary to investigate the longitudinal tensile mechanical characteristics of the middle cerebral artery and the fetal umbilical vein prior to applying fetal umbilical vein transplantation for repair of injured middle cerebral artery. Fifteen fresh fetal umbilical vein specimens and 15 normal human fresh cadaver middle cerebral artery specimens ...
Aksüt Mehmet - - 2013
After repair of atrial septal defects with or without patch, residual shunt, shrinkage, haemolysis and thromboembolic complications may occur. Even though the pericardium is quite a suitable material for the closure of atrial septal defects, the external surface of the pericardium is not smooth and may be a nidus for ...
Sannier Aurélie A Department of Pathology, Hôpital Avicenne, AP-HP, Université Paris 13, Bobigny, - - 2013
Lymph vessels play an important role in tumor progression. Pulmonary adenocarcinomas, accounting for half of non-small-cell lung carcinomas, compose a spectrum of histological types, exclusively or without a lepidic growth pattern (LGP) along preserved interalveolar septa. In that context, this study was designed to investigate the lymphatic vascular pattern associated ...
Saiki Kazunobu K Unit of Translational Medical Science, Department of Macroscopic Morphology, Nagasaki University, Graduate School of Biomedical Science, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan. - - 2013
We measured the calibers of the left and right internal jugular veins (IJV) and sizes of the left and right transverse sinuses (TS) in 91 cadavers, compared them between the left and right sides, and also evaluated the drainage patterns of the superior sagittal sinus (SSS) and straight sinus (=rectal ...
Cornett Bridget B The Perinatal Institute Division of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Cincinnati Children's Hospital Medical Center Research Foundation, Cincinnati, OH 45229, - - 2013
Wntless (Wls), a gene highly conserved across the animal kingdom, encodes for a transmembrane protein that mediates Wnt ligand secretion. Wls is expressed in developing lung, wherein Wnt signaling is necessary for pulmonary morphogenesis. We hypothesize that Wls plays a critical role in modulating Wnt signaling during lung development and ...
Mahimarangariah Jayaranganath - - 2013
Sinus of Valsalva aneurysms are commonly associated with ventricular septal defects. We describe a 14 year old boy who presented with Rupture of Right Sinus Of Valsalva (RSOV) into the right ventricular outflow tract (through two openings) along with a residual ventricular septal defect (VSD), four years after surgical closure ...
Kulkarni Ananta A AA Department of Plastic Surgery, Dr D.Y.Patil Hospital & Research Centre, Sector -5, Nerul, NaviMumbai, Maharashtra 400 706 - - 2013
Commonly, a groin defect is reconstructed with flaps from ipsilateral thigh or lower abdomen. Here we present a case report of use of a pedicled flap from the posterior scrotum based on posterior scrotal artery to cover a groin defect exposing femoral vessels. Posterior scrotal artery, to best of our ...
Abed Saif F SF Division of Basic Medical Sciences, St. George's University of London, London, England, United Kingdom. - - 2012
The cranio-orbital foramen is an osseous anatomical landmark located adjacent to the superior orbital fissure. It is a potential source of hemorrhage during deep orbital dissection because it is the location of an anastomosis between the lacrimal artery and the middle meningeal artery. The purpose of this study was to ...
Uchino Akira - - 2012
INTRODUCTION: Duplicate origin of the middle cerebral artery (MCA) is rare and has been misdiagnosed or confused as fenestration of the proximal M1 segment of the MCA. The condition is not a true fenestration and occurs when two MCA branches arise separately from the terminal segment of the internal carotid ...
Gümüş Hatice - - 2012
Abstract Purpose: Renal artery variations are important for clinical reasons. The aim of this study is to determine the originating level and variations of renal arteries with 64-channel multidetector computed tomography (MDCT). Materials and methods: In a university hospital, 820 patients who underwent MDCT angiography of the abdominal aorta were ...
Xu Keli - - 2012
Notch signaling plays an essential role in development and homeostasis of multiple organs including the lung. Dysregulation of Notch signaling has been implicated in various lung diseases including lung cancer. Here we review functions of Notch signaling in coordinating events during lung development, such as early proximodistal fate generation and ...
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