Search Results
Results 301 - 350 of 1343
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Coskun Ugur - - 2009
BACKGROUND: Since cardiovascular diseases are associated with high mortality and generally undiagnosed before the onset of clinical findings, there is a need for a reliable tool for early diagnosis. Carotid intima-media thickness (CIMT) is a non-invasive marker of coronary artery disease (CAD) and is widely used in practice as an ...
Nathan David G - - 2009
Cholesterol levels and not inflammatory markers are the major variables that pose a risk of coronary artery disease. Diabetes greatly increases the risk at any cholesterol level. Coronary artery disease and cancer are linked by a common protein - an apoptotic protein that also functions as a regulator of insulin ...
Meng Xiao - - 2009
PURPOSE: Several studies have shown arterial stiffness changes associated with coronary artery disease (CAD). Recently, statins were reported to improve arterial stiffness. The aim of the study was to evaluate the effect of atorvastatin on arterial stiffness in CAD patients using pulse wave velocity (PWV). METHODS: We evaluated 63 patients ...
Hoseini Vida Nesar - - 2009
BACKGROUND: It has been shown that microalbuminuria is an independent risk factor for cardiovascular diseases in diabetics, hypertensive patients and in the general population. However, few data has addressed the correlation of microalbuminuria with the severity of coronary artery disease (CAD). The aim of the study was to assess the ...
Riccioni Graziano - - 2009
Carotid artery intima-media thickness measured by ultrasound has been shown to be correlated with the presence of cardiovascular disease and is now accepted and used as a surrogate marker for atherosclerotic disease, an important organ damage of hypercholesterolemia. In particular, statins reduce ischemic heart disease, improve endothelial function, reduce pro-inflammatory ...
Ho Hung-Chi - - 2009
AIM: Atherosclerosis is a systemic disease with focal cardiovascular events. Although the accelerated development of peripheral arterial disease in diabetic patients is well known, the pathogenic mechanism of site-specific susceptibility to glycemia is uncertain. OBJECTIVE: To investigate the association of fasting and post-challenge glucose levels with intima-media thickness (IMT) at ...
Linhartova Katerina - - 2009
Calcific aortic stenosis (AS) is an atherosclerosis-related process and the most common cause of valve disease requiring surgery. To assess the association of inflammatory markers with AS in advanced atherosclerosis. Consecutive patients with coronary artery disease (CAD) associated with AS were prospectively identified (mean transvalvular aortic gradient of 30 mmHg ...
Greene E R - - 2009
Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease that is atherogenic. Decreased arterial distensibility (AD) is a risk factor for cardiovascular disease, and this precursor may be associated with SLE. Accordingly, we tested the hypothesis that patients with SLE will have significantly (p < 0.05) decreased AD when compared ...
Casella Ivan Benaduce - - 2009
To compare common carotid intima-media thickness (IMT) between the two major Brazilian ethnic groups (those of African descent and those of European descent) among individuals with one or more risk factors for atherosclerotic disease. Two hundred and six patients with one or more risk factors for atherosclerotic disease were evaluated ...
Bampi Angela Bacelar Albuquerque - - 2009
Non-invasive detection of atherosclerosis is critical for its prevention. To correlate non-invasively detectable indicators of coronary atherosclerosis, or Coronary Artery Disease (i.e., classical risk factors, hs-CRP test results, carotid intima-media thickness, endothelial function, ankle-brachial index and calcium score by computed tomography) with the extent of coronary disease assessed by the ...
Agabiti-Rosei Enrico - - 2009
Arterial stiffness plays a key role in the pathophysiology of the cardiovascular system. Some indices of arterial stiffness (pulse wave velocity, augmentation index, characteristics of central blood pressure waveform) may be presently calculated and evaluated in the clinical setting. Age and blood pressure are the two major clinical determinants of ...
Mäki-Petäjä Kaisa M KM Clinical Pharmacology Unit, University of Cambridge, Addenbrooke's Hospital, BOX 110, Cambridge, CB2 0QQ, UK. - - 2009
Arterial stiffness is a powerful predictor of cardiovascular outcome in various patient groups as well as in general population, and can directly accelerate the atherosclerotic process. Arterial stiffness is regulated by numerous factors. Traditionally, mean arterial pressure and structural changes in the components of arterial wall were thought to be ...
Hodis Howard N - - 2009
Although plasma total homocysteine (tHcy) levels are associated with cardiovascular disease, it remains unclear whether homocysteine is a cause or a marker of atherosclerotic vascular disease. We determined whether reduction of tHcy levels with B vitamin supplementation reduces subclinical atherosclerosis progression. In this double-blind clinical trial, 506 participants 40 to ...
Claridge M W - - 2009
BACKGROUND AND AIMS: It is widely accepted that subjects with vascular disease have increased arterial stiffness and intima-media thickness (IMT) when compared with healthy controls. The aim of this study was to investigate indices of arterial stiffness and IMT in the common carotid arteries (CCAs) of subjects with and without ...
Kocak H - - 2009
BACKGROUND AND AIM: Carotid artery intima-media thickness (CIMT) and brachial artery flow-mediated dilation percentage (FMD%) are two commonly used parameters for detecting subclinical atherosclerosis. However, studies investigating the relationship between CIMT and brachial artery FMD% in different populations have produced conflicting results. The aim of this study was to determine ...
Bernier Angelina V AV Division of Pediatric Endocrinology and Glycogen Storage Disease Program, Department of Pediatrics, University of Florida, Gainesville, FL 32610-0296, - - 2009
To determine cardiovascular disease risk in a larger cohort of patients with glycogen storage disease (GSD) I through the use of noninvasive measures of arterial function and anatomy. Carotid intima media thickness (IMT), radial artery tonometry, and brachial artery reactivity were performed in 28 patients with GSD I (13F/15M, mean ...
Tsuchida Masayuki - - 2009
In 1982, a 49-year-old Japanese woman had been referred to our hospital for further investigation of her hypercholesterolemia. She was diagnosed as heterozygous familial hypercholesterolemia, because of Achilles tendon xanthoma and a family history of primary hypercholesterolemia. Three years later, she had chest pain on effort and angina pectoris was ...
Roos Marcel - - 2009
AIM: To evaluate the association between fetuin-A level (AHSG), its encoding gene (Thr256Ser) and arterial function in subjects with normal kidney function. INTRODUCTION: The aortic pulse wave velocity (aPWV) is a predictor for cardiovascular mortality. Fetuin-A is a calcification inhibitor and correlates negatively with increased vascular stiffness in dialysis patients. ...
Erdemir Aydin - - 2009
The aim of this study is to evaluate the carotid artery intima media thickness and serum lipids in pediatric patients with epilepsy treated with valproic acid. The study included 44 pediatric epileptic and 40 healthy children. Intima media thickness of left common carotid artery and fasting lipid profile (total cholesterol, ...
Benetos A - - 2009
SUMMARY: The role of body composition on arterial stiffness and osteoporosis remains unclear, especially in the elderly male population. Our results indicate that elderly men with high lean mass and low fat mass exhibit the best arterial and bone profile with the lowest arterial stiffness and the highest bone mineral ...
Schmidt C - - 2009
OBJECTIVES: The aim of the present study was to investigate the relationship between atherosclerotic progression rate as measured by carotid artery IMT during very long-term follow-up in clinically healthy men and a number of baseline risk factors of potential importance for atherosclerosis progression including apoA-I, apoB, apoB/apoA-I ratio, other lipid ...
Georgiev Antonio - - 2008
In the etiology of coronary artery disease there are many factors involved as a result of the complex interaction between genetic predisposition and environmental influences. The lipoprotein lipase (LPL) plays a very important role in lipid metabolism. It hydrolyzes the triglycerides in hylomicrones and very low density lipoproteins - VLDL. ...
Lim Geok-Hoon - - 2008
The endoscopic features of cholesterol atheroembolism affecting the colon have not been extensively described in the literature, owing to the rarity of this entity. We report a middle-aged man who presented with hematochezia after recent coronary artery bypass graft surgery. Colonoscopy revealed ulcerative skip lesions with overlying slough resembling pseudomembranes ...
Schnabel Renate - - 2008
Selenium is a central determinant of antioxidative glutathione peroxidase 1 (GPx-1) expression and activity. The relevance of selenium supplementation on GPx-1 in coronary artery disease (CAD) needs to be established. We assessed the effect of selenium supplementation on GPx-1 in cell culture and on endothelial function in a prospective clinical ...
Guzik Tomasz J - - 2008
This study sought to examine the expression and activity of the calcium-dependent nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) in human atherosclerotic coronary arteries. The NOX-based NADPH oxidases are major sources of reactive oxygen species (ROS) in human vessels. Several NOX homologues have been identified, but their relative contribution to ...
Foley Robert N - - 2009
Phosphorus levels correlate with atherosclerosis in both animal models and humans with advanced chronic kidney disease, but whether this relationship exists among individuals with normal kidney function is unknown. This study aimed to determine whether an association exists between phosphorus levels and coronary artery calcium levels in a community-based cohort ...
Walsham Anna C - - 2008
PURPOSE: To validate a computer-aided detection (CAD) tool for the detection of pulmonary arterial filling defects at computed tomographic pulmonary angiography (CTPA) and to assess its benefit for readers of different levels of experience. METHODS: One hundred consecutive CTPA studies were retrospectively evaluated by a chest radiologist for presence of ...
Vicari Enzo - - 2008
AIM: To evaluate whether the response to sildenafil administration in patients with arterial erectile dysfunction (ED) was related to their peak systolic velocity (PSV), peripheral atherosclerosis, cardiovascular risk factors (RF) and/or comorbidities at low cardiovascular risk. METHODS: We enrolled 97 patients with 1-2 RF and comorbidities, combined with arterial ED ...
Alaee Abdultasool - - 2008
The purpose of this study was to investigate role of predictive value of carotid artery ultrasonography on the basis of intima-media thickness in coronary artery disease. Ultrasonography and quantitative coronary angiography were achieved for assessment carotid and coronary artery diseases in 80 consecutive patients (mean age 57.37 years) with chest ...
Vyssoulis Gregory P - - 2010
BACKGROUND: Arterial stiffness and wave reflections are independent predictors of cardiovascular disease. Metabolic syndrome (MS) is related to increased aortic stiffness in several populations. However, it is unclear whether the association of MS with aortic stiffness differs according to the considered definition. Moreover, data regarding the association of wave reflections ...
Rampersaud Evadnie E Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland, Baltimore, Maryland 21201, - - 2008
Coronary artery calcification (CAC) and common carotid artery intima-media thickness (CIMT) are measures of subclinical vascular disease. This 2000-2006 study aimed to characterize the associations among coronary artery disease risk factors, CAC quantity, and CIMT and to estimate shared genetic and environmental contributions to both CAC and CIMT among 478 ...
El-Gendi Salwa S - - 2008
To evaluate the role of non-traditional biochemical markers, and carotid and femoral Doppler in early detection of atherosclerosis in asymptomatic cardiovascular risk patients. This study was conducted on 72 patients with various cardiovascular risk factors (22 diabetic, 15 hypertensive, 20 smokers, and 15 obese), in addition to 18 healthy controls. ...
Izuhara Masayasu - - 2008
BACKGROUND: The cardio-ankle vascular index (CAVI) has been recently reported as a new index of aortic stiffness, which is less influenced by blood pressure than pulse wave velocity (PWV). The present study investigated the relationship between the levels of CAVI and carotid and coronary arteriosclerosis. METHODS AND RESULTS: The 443 ...
Kopeć Grzegorz - - 2009
Aortic stiffening is the most important determinant of elevated systolic blood pressure which in turn is the main contributor to the burden of disease attributable to hypertension. Endothelial function may affect arterial stiffening as has been shown for carotid-aorto-femoral segments in healthy humans or subjects with cardiovascular risk factors. We ...
Hu Teng - - 2008
There is evidence for two subpopulations among circulating endothelial progenitor cells (EPCs), i.e., CD34(+)-EPCs and CD14(+)-EPCs. Prior studies on the relationship between the level of EPCs and coronary artery disease (CAD), either did not distinguish between the two types of EPCs or studied only CD34(+)-EPCs. We therefore investigated whether the ...
Güneş Yilmaz - - 2008
BACKGROUND: Coronary artery disease (CAD) is a leading cause of death and prevention and early detection of CAD are major goals of healthcare. Although ultrasound methods allow valid and repeatable detection of structure and function of cardiovascular system, a rapid ultrasonographic method for the prediction of CAD has not yet ...
Largo Raquel - - 2008
OBJECTIVE: To determine whether systemic inflammation induced by chronic antigen-induced arthritis (AIA) accelerates vascular lesions in rabbits with atherosclerosis. METHODS: Two models of atherosclerosis and chronic AIA were combined. Atherosclerosis was induced by coupling a hyperlipemic diet with an endothelial lesion at the femoral arteries, while chronic AIA was induced ...
Kablak-Ziembicka Anna - - 2008
Carotid intima-media thickness (CIMT) is an early marker of coronary artery disease (CAD). This study aimed to evaluate CIMT value for CAD prediction in pre-and postmenopausal women referred for coronary angiography with angina-like symptoms and a positive result of the treadmill test. The study comprised 321 women referred for coronary ...
Jalilian Ali - - 2008
Recently another member of the paraoxonase gene family designated paraoxonase-2 has been identified. Paraoxonase-2 has antioxidant properties similar to paraoxonase-1 and paraoxonase-3. However, in contrast to paraoxonase-1 and paraoxonase-3, paraoxonase-2 is not associated with high-density lipoprotein and may only exert its antioxidant function at the cellular level. We assessed the ...
Burdick Thomas R - - 2008
This article outlines general concepts of, and strategies for, therapeutic embolization throughout the body, touching on all major arterial distributions. Clinical scenarios that allow or prevent safe embolization of vessels are presented. Specific agents are recommended where appropriate, as are alternate approaches when embolization is not an option. Pre-embolization precautions ...
Samoila Olguta C - - 2008
Extracellular superoxide dismutase (EC-SOD) is the main SOD isoform in the arterial wall contributing to cardiovascular defense against oxidative stress by removing the superoxide anion. In our study, the Thr40Ala and Arg213Gly polymorphic variants of the EC-SOD gene (SOD ( 3 )) were investigated for associations with atherosclerosis and other ...
Eroglu S - - 2009
BACKGROUND AND AIM: Epicardial adipose tissue (EAT), which is thought to be a component of visceral adiposity, is associated with the metabolic syndrome. We aimed to test the hypothesis that echocardiographic EAT thickness can be a marker for the presence and severity of coronary artery disease (CAD). METHOD AND RESULTS: ...
Basarici Ibrahim - - 2008
BACKGROUND: Atherosclerotic coronary artery disease is the leading cause of death worldwide. Oxidative stress is one of the key elements in the pathogenesis of atherosclerosis. Isoprostanes are established markers of oxidative stress. The aim of this study was to investigate the association of urinary 8-isoprostane levels with the presence and ...
Akgullu Cagdas - - 2008
OBJECTIVE: Reduced arterial compliance is an independent predictor of cardiovascular mortality and is commonly encountered in patients with coronary artery disease. Statins may produce cholesterol-independent effects which can result at least in part from direct improvement of the arterial function. In this study, we sought to determine the effect of ...
Nicholls Stephen J - - 2008
Technological advances in arterial wall imaging have provided the opportunity to evaluate the impact of medical therapies on the progression of atherosclerosis in vivo. Arterial imaging has been extensively utilized to determine the impact of high-dose statin therapy. Using multiple imaging modalities in the carotid and coronary territories, rosuvastatin has ...
Fujiwara Takayuki - - 2008
Matrix metalloproteinase (MMP), which is activated by oxidative stress, plays an important role in the development of ventricular remodeling in coronary artery disease. Pravastatin is shown to reduce oxidative stress. We tested the hypothesis that cardiac oxidative stress and MMP activity are reduced in patients with coronary artery disease and ...
Cypiene Alma - - 2008
Systemic sclerosis (SSc) is characterized by thickening and fibrosis of skin and internal organs that is associated with vascular damage. SSc may lead to arterial dysfunction and premature aging of the arteries. However, its relationship with parameters of arterial wall dysfunction has not been fully explored. To determine if carotid-radial ...
Malcom Gray T - - 2009
OBJECTIVE: To examine the associations of the coronary heart disease (CHD) risk factors with lipid composition of arterial tissue in 397 autopsied subjects 15-34 years of age from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study. METHODS AND RESULTS: We measured esterified cholesterol, free cholesterol, and phospholipid in the ...
Myllykangas Liisa - - 2009
We investigated the association between histologically defined atherosclerotic lesions in the carotid arteries and the genetic variants of APOE and LPL in a population-based sample of Finns aged 85 or over. Post-mortem analysis of carotid arteries was performed in 240 subjects. Atherosclerotic lesions were categorized according to the modified American ...
Antoniades Charalambos C Department of Cardiovascular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United - - 2008
This study sought to determine the effects of endogenous tetrahydrobiopterin (BH4) bioavailability on endothelial nitric oxide synthase (eNOS) coupling, nitric oxide (NO) bioavailability, and vascular superoxide production in patients with coronary artery disease (CAD). GTP-cyclohydrolase I, encoded by the GCH1 gene, is the rate-limiting enzyme in the biosynthesis of BH4, ...
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