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Wang Mingyi - - 2010
Age-associated arterial alterations in cells, matrix, and biomolecules are the foundation for the initiation and progression of cardiovascular diseases in older persons. This review focuses on the latest advances on the intertwining of aging and disease within the arterial wall at the cell and molecular levels. Endothelial dysfunction, vascular smooth ...
Miyaki Asako - - 2010
AIM: Obesity is a strong risk factor for cardiovascular morbidity and mortality. In addition, decreased central arterial distensibility is recognized as an independent risk factor for cardiovascular disease (CVD). Obese subjects exhibit low arterial distensibillity; however, the mechanism responsible for the decrease in arterial distensibility in obese subjects has not ...
Momiyama Yukihiko - - 2010
Limited correlations between C-reactive protein (CRP) and coronary artery disease (CAD) have been reported. Recently, MRI became a useful tool for non-invasively evaluating atherosclerotic plaques in thoracic and abdominal aortas. To elucidate the associations between plasma CRP levels and the severities of coronary and aortic atherosclerosis, we performed aortic black-blood ...
Tzortzis Stavros - - 2010
Coronary microcirculation is disturbed in patients with arterial hypertension. Carotid intima-media thickness (IMT) and arterial stiffness are markers of subclinical atherosclerosis with prognostic significance. We investigated whether the combination of increased carotid IMT and arterial stiffness has a greater predictive value for the presence of impaired coronary flow reserve (CFR) ...
Washida Naoki - - 2010
AIM: Cerebrovascular disease (CVD) is a major determinant of the prognosis in end-stage renal diseases (ESRD). The purpose of this study was to examine whether factors associated with arterial stiffness contributed to the development of CVD in patients with ESRD. METHODS: CVD (lacunes and carotid/intracranial artery stenosis) was evaluated with ...
Gosse Philippe - - 2010
INTRODUCTION: Stiffness of the large arteries plays a role in the development of left ventricular hypertrophy (LVH), although there are few data on this relation in the general population. The cohort of the Prognostic Indicator of Cardiovascular and Cerebrovascular Events study is a representative population of 65-year-old individuals in which ...
Brosh David - - 2010
AIMS: Previous studies indicated that fluctuations in photoplethysmograph (PPG) amplitude may predict coronary artery disease (CAD). The respiratory modulation response (RMR) is derived from spectral analysis of the PPG signal during instructed breathing. We sought to evaluate the RMR obtained from the fingertip as a predictor of significant CAD. METHODS ...
Wang YuPeng - - 2010
BACKGROUND: It is currently thought that pulmonary embolism and deep vein thrombosis are different manifestations of the same pathological process of venous thromboembolism. Venous thromboembolism has a negative correlation with high-density lipoprotein cholesterol. HYPOTHESIS: Pulmonary embolism has a negative correlation with the level of high-density lipoprotein cholesterol. METHODS: A total ...
Willenberg Torsten - - 2010
PURPOSE: To report an angiographic investigation of midterm atherosclerotic disease progression in below-the-knee (BTK) arteries of claudicants. METHODS: Angiograms were performed in 58 consecutive claudicants (35 men; mean age 68.3+/-8.7 years) with endovascular treatment of femoropopliteal arteries in 58 limbs after a mean follow-up of 3.6+/-1.2 years. Angiograms were reviewed ...
Li Yuanshi - - 2010
OBJECTIVE: Angiotensin II plays an important role in the pathogenesis of atherosclerosis. This study was designed to examine the effect of valsartan, an angiotensin receptor blocker, on atherosclerotic lesions in pulmonary arteries of rabbits with atherosclerosis induced by a high-cholesterol (HC) diet. METHODS: Male New Zealand rabbits were randomly divided ...
Chiers K - - 2010
Atherosclerosis is an uncommon lesion in animals and particularly in dogs. Prominent atherosclerotic lesions of the coronary arteries are described in three dogs. These comprised an expansion of the tunica media by the accumulation of foam cells and/or cholesterol crystals, with subsequent narrowing of the vascular lumen. Immunohistochemical analysis revealed ...
Choi Seong-Woo - - 2011
To evaluate the association between hemoglobin A(1c) (HbA(1c)), carotid atherosclerosis, arterial stiffness, and peripheral arterial disease (PAD) in Korean type 2 diabetic patients. A total of 370 type 2 diabetic patients registered with the public health center in Gokseng-gun, Korea, participated in this study. Following an overnight fast, venous blood ...
Ix Joachim H JH Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, San Diego, California 92161, USA. - - 2010
This study sought to determine the association of high ankle brachial index (ABI) measurements with left ventricular (LV) mass, and to compare its strength with that of low ABI with LV mass. Arterial stiffness leads to LV mass through nonatherosclerotic pathways in mice. In humans, a high ABI indicates stiff ...
Friedlander Arthur H - - 2010
BACKGROUND: Atherosclerosis may be initiated/accelerated by chronic dental infection (CDI). Noninvasively visualizing the carotid arteries is an accepted surrogate marker for determining coronary artery atherosclerosis (CAA). We hypothesized that 36 individuals with radiographic carotid atheromas would have more radiographic CDI than risk-matched individuals without atheromas. METHODS: We determined the arithmetic ...
Miettinen T A - - 2011
It is not known whether dietary intake of plant stanols or sterols changes the composition of arterial sterols. Therefore, we compared serum and carotid artery cholesterol and non-cholesterol sterols after plant stanol (staest) or sterol (steest) ester feeding in endarterectomized patients. Elderly statin-treated asymptomatic patients undergoing carotid endarterectomy were randomized ...
Ahmadi Naser - - 2010
BACKGROUND: Atherosclerotic changes within the coronary artery wall can affect vessel distensibility. OBJECTIVE: This study evaluated the relationship between the coronary distensibility index (CDI) and the severity of coronary artery disease (CAD) measured by computed tomographic angiography (CTA). METHODS: One hundred thirteen subjects, age 63 +/- 10 years, 32% women, ...
Vlachopoulos Charalambos - - 2010
Increased levels of interleukin-18 (IL-18) have been related to plaque progression and vulnerability and cardiovascular outcomes. Arterial functional and structural characteristics and endothelial/inflammatory activation are important determinants of cardiovascular performance and predictors of risk. We investigated whether IL-18 is a determinant of global arterial function and early structural changes in ...
Freedman Barry I BI Section on Nephrology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157-1053, USA. - - 2010
Inverse associations are reported between circulating 25-hydroxyvitamin D and visceral adiposity. The effects of vitamin D levels on atherosclerosis are unknown. The objective of this study was to test for relationships between vitamin D, adiposity, bone density, and atherosclerosis in African-Americans. Circulating 25-hydroxyvitamin D, 1,25 dihydroxyvitamin D, intact PTH, C-reactive ...
Choi H-Y - - 2010
BACKGROUND: Perforating artery territorial infarction (PAI) is usually a small artery disease (SAD). However, it may also result from branch artery occlusion or arterial embolism from the proximal atherosclerotic lesions. We hypothesized that patients with PAI caused by a SAD may have a distinct pattern of systemic artery involvement from ...
Pasquali Sara K - - 2010
Children who have undergone the arterial switch operation (ASO) are at risk for premature coronary artery disease due to coronary re-implantation. Obesity may also pose cardiovascular risk. The purpose of this study was to evaluate comorbidities and markers of early cardiovascular disease in obese ASO patients. Obese [body mass index ...
Peng Dao-Quan - - 2010
Recent studies indicated that soluble OX40 ligand (OX40L) levels were increased in acute coronary syndrome. But the association between sOX40L and carotid intima-media thickness (IMT) has not been evaluated. We measured plasma soluble OX40L (sOX40L) and Interleukin-10 (IL-10) levels in 35 patients with stable angina pectoris, 30 patients with risk ...
Moazeni Esmaeil - - 2010
In order to develop a niosome-encapsulated ciprofloxacin (CPFX) HCl formulation for pulmonary delivery, the feasibility of encapsulation of CPFX in niosomes, its stability and nebulization capability was evaluated. Various combinations of nonionic surfactants with cholesterol were used to prepare the formulations. The in vitro deposition data of the niosomal formulations ...
Gedikli Omer - - 2010
The Seventh Report of the Joint National Committee on the Prevention, Detection, Evaluation, and Treatment of High Blood Pressure classifies blood pressure (BP) as normal, prehypertension, and hypertension. Although it has been shown that there is a relationship between hypertension and arterial stiffness, there is not sufficient data about arterial ...
Abdel-Azeez Hala Abdel-Hameed - - 2010
Osteopontin (OPN), a bone-related protein, is present within the atherosclerotic plaques, most strikingly in calcified plaques. Valvular calcifications are accepted as a part of the spectrum of atherosclerosis and are associated with atherosclerotic calcification in the coronary arteries. The study aimed to evaluate the association of plasma OPN with the ...
Hadgu Akberet - - 2010
The authors report a case of a 48-year-old male smoker who presented with respiratory distress and constitutional symptoms along with gynaecomastia and multiple pulmonary nodules. Based on normal physical and ultrasound findings of the testes, presence of markedly elevated serum β human chorionic gonadotrophin (HCG) and biopsy findings of the ...
Bosevski Marijan - - 2010
Objective of our study was to estimate the metabolic syndrome (MSy)' components in type 2 diabetic subjects (T2D) with symptomatic coronary artery disease (CAD): arterial hypertension, waist circumference, triglyceridemia and plasma level of HDL, in order to define their clinical role in angina severity status. Second objective was to compare ...
Yu J - - 2010
The aim of this study was to assess the effect of rosiglitazone on endothelial function of the coronary arteries and on plasma levels of inflammatory markers in diabetic patients with coronary artery disease (CAD). Fifty-six patients with type 2 diabetes and CAD were randomized to receive either rosiglitazone (4 mg/day) ...
Choi Seong-Woo - - 2010
BACKGROUND: To evaluate the association between albuminuria, carotid atherosclerosis, arterial stiffness, and peripheral arterial disease (PAD) in Korean type 2 diabetic patients. METHODS: In total, 673 type 2 diabetic patients registered with the public health center participated. Following an overnight fast, venous blood and urine samples were collected and analyzed. ...
Sumino Hiroyuki - - 2010
The beneficial effects of raloxifene, a selective estrogen receptor modulator, on cardiovascular risks and events have been investigated. Brachial arterial flow-mediated vasodilatation (FMD), carotid intima-media thickness (IMT), and pulse wave velocity (PWV) have been widely used in clinical settings as surrogate markers of atherosclerosis. This study investigated the simultaneous effects ...
Karangelis D E - - 2010
Cardiovascular disease is the largest cause of death in Western societies and it primarily results from atherosclerosis of large and medium-sized vessels. Atherosclerosis leads to myocardial infarction, when it occurs in the coronary arteries, or stroke, when it occurs in the cerebral arteries. Pathological processes involved in macrovascular disease include ...
Yildirim Nesligul - - 2010
Coronary artery ectasia (CAE) is defined as localized or diffuse dilation of the coronary arteries. There are scarce data about the role of dendritic cells in CAE development. In this study we investigated the activation markers on the surface of monocyte-derived dendritic cells (mDCs) in coronary artery disease (CAD) patients ...
Koc Mevlut - - 2010
Limited, controversial data exist regarding changes in high-sensitivity C-reactive protein (hs-CRP) levels over short times and the importance of detecting these changes in patients who have coronary artery disease (CAD). We investigated the variation of hs-CRP levels and their association with the severity of CAD in patients with stable CAD.We ...
Yildiz Mustafa - - 2010
The pulse wave velocity (PWV), as an indicator of arterial distensibility, may play an important role in the stratification of patients based on the cardiovascular risk. PWV inversely correlates with arterial distensibility and relative arterial compliance. Decreased arterial distensibility alters arterial blood pressure and flow dynamics, and disturbes coronary perfusion. ...
Kalay Nihat N Department of Cardiology, Erciyes University Medical Faculty, Kayseri, Turkey. - - 2010
Endothelial dysfunction plays a crucial role in the process of atherosclerotic diseases and has been accepted as an early stage of atherosclerosis. Carotid intima-media-thickness (CIMT) and flow-mediated-dilatation (FMD) of the brachial artery have been recommended as noninvasive methods to assess endothelial structure and function. Angiographic properties of patients with acute ...
Heffernan Kevin S KS The Vascular Function Study Group, The Hypertrophic Cardiomyopathy Center, Tufts Medical Center, Boston, Massachusetts, - - 2010
Patients with hypertrophic cardiomyopathy (HC) have coronary microvascular dysfunction, which is an independent predictor of adverse left ventricular remodeling, systolic dysfunction, and mortality in these patients. Whether these defects in vasomotor function are localized to the coronary arteries or whether systemic vasomotor dysfunction is present in patients with HC has ...
Kim Beom Jin - - 2010
BACKGROUND: Colorectal neoplasia and cardiovascular disease appear to share common risk factors. This study aimed to investigate the association between the thickness of the intima-media complex (IMT) or carotid artery stenosis (CAS) on carotid artery ultrasonography and the presence of colorectal adenomas in middle-aged asymptomatic men. METHODS: This study was ...
Shoji Tetsuo - - 2010
OBJECTIVE: Both arterial thickness and stiffness are predictors of cardiovascular disease (CVD). Although these arterial changes develop in parallel, no study has ever tested a hypothesis that arterial stiffness can predict mortality from CVD independent of arterial thickness. This study tested this possibility. METHODS: This was an observational cohort study ...
Zheng Jian Lei - - 2010
YKL-40 is a pro-inflammatory protein highly expressed in atherosclerotic plaques, and is related to prognosis of patients with coronary artery disease (CAD). This study aimed to assess the possible association between YKL-40 and coronary lesion progression in CAD patients. A total of 313 patients with CAD, who underwent percutaneous coronary ...
Mohamed Randa H - - 2010
OBJECTIVE: We tested the association between PON1 polymorphism, PON1 activity, oxidative susceptibility of LDL and coronary artery disease in Egyptians. METHODS: PON1 polymorphism, serum PON1 activity, lipoprotein oxidation susceptibility and lipid profile were measured. RESULTS: Levels of HDL and paraoxonase activity were significantly decreased in CAD patients compared to control ...
Takahashi Mao - - 2010
LR11, an LDL receptor family member, is expressed in intimal smooth muscle cells. It was found that the soluble form of LR11 (sLR11) is detected in serum, and the circulating sLR11 levels are positively correlated with intima-media thickness of carotid arteries in dyslipidemic subjects. To clarify the significance of serum ...
Huang Yan-sheng - - 2009
BACKGROUND: Atherosclerosis is a chronic inflammatory disease. Accumulated evidences suggest a deep involvement of oxidative damage in the development of atherosclerosis, but little is discussed over the relationship between plasma glutathione redox status as the most important intrinsic antioxidant defensive mechanism and the atherosclerosis. METHODS: A total of 132 patients ...
Jha Hem C - - 2009
Coronary artery disease (CAD) is a public health problem accounting for an estimated one-third of deaths overall. A potential link between infectious agents and atherosclerosis has been suggested. Data obtained from several seroepidemiological studies have suggested that infection with Chlamydophila pneumoniae, Helicobacter pylori, cytomegalovirus and herpes simplex virus-1 can initiate ...
Peters Mike J L - - 2010
OBJECTIVE: Preliminary evidence suggests that ankylosing spondylitis (AS) is associated with an increased cardiovascular (CV) risk. We investigated subclinical atherosclerosis and arterial stiffness in patients with AS compared with controls, and identified CV and AS related risk factors for atherosclerotic disease. METHODS: A total of 59 patients with AS who ...
Kim Kye Hun - - 2009
BACKGROUND: The role of velocity vector imaging (VVI) in evaluating arterial stiffness is not well known. We investigated the usefulness of vascular strain analysis by VVI in evaluating arterial stiffness. METHODS: Heart-femoral and brachial-ankle pulse wave velocities (PWVs) were measured as standard parameters of arterial stiffness. Intima-media thickness (IMT), fractional ...
Hsieh Ming-Jer - - 2009
BACKGROUND: Coronary artery disease (CAD) is the most important cause of mortality and morbidity in patients who have undergone carotid artery endovascular or surgical intervention. Metabolic syndrome (MetS) and hyperhomocysteinemia (HHCY) have been reported to be associated with CAD. However, no study has investigated the association between MetS or HHCY ...
Ghatrehsamani Keihan - - 2009
Hepatic lipase (LIPC) and cholesteryl ester transfer protein (CETP) are important components of high-density lipoprotein (HDL) metabolism and reverse cholesterol transport. Therefore, their genes are promising candidate genes for cardiovascular disease. The aim of the present study was to investigate whether combined LIPC -514C/T and CETP I405V polymorphisms correlate with ...
Kwagyan John - - 2009
The objective of this study was to investigate the relationship of flow-mediated dilatation and intima-media thickness (IMT) with coronary risk in African Americans (AAs). Endothelial dysfunction and IMT of carotid arteries are considered early steps in atherosclerotic disease process and have been used as surrogate markers of subclinical atherosclerosis. Data ...
Schindler Thomas H - - 2009
To examine a relationship between alterations of structure and function of the arterial wall in response to glucose-lowering therapy in type 2 diabetes mellitus (DM) after a 1-year follow-up (FU). In DM (n = 22) and in healthy controls (n = 17), coronary artery calcification (CAC) was assessed with electron ...
Seng K - - 2010
PURPOSE: Patients with coronary artery disease (CAD) show a high prevalence for concomitant atherosclerotic peripheral arterial disease (PAD). On the other hand, PAD seems to be an additional risk factor for cardiac events. We evaluated the correlation between arterial pathologies as found in whole-body MR angiography and coronary artery calcification ...
Andersen Rune - - 2010
Long-term survival in Hodgkin lymphoma (HL) survivors is complicated by an increased risk for coronary artery disease (CAD) due to radiation-induced endothelial damage. Our objective was to quantify total coronary artery calcium (CAC) in long-term HL survivors who had survived >or=15 years after treatment and relate it to the presence ...
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