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Lippi Giuseppe - - 2011
Historically, humans have long sought to enhance their "athletic" performance to increase body weight, aggressiveness, mental concentration and physical strength, contextually reducing fatigue, pain, and improving recovery. Although regular training is the mainstay for achieving these targets, the ancillary use of ergogenic aids has become commonplace in all sports. The ...
Yuce Murat - - 2011
Interatrial block (IAB), a frequently overlooked conduction delay between the atria, is defined as prolonged P-wave on the electrocardiogram (ECG). Previously, IAB has been shown to be an indicator of dilated and impaired left atrial function, and a predictor of both atrial fibrillation and embolic stroke. The study aim was ...
Jiao Tong - - 2012
In the development of tissue-engineered heart valves based on allograft decellularized extracellular matrix scaffolds, the material properties of the implant should be ideally comparable to the native semilunar valves. This investigation of the viscoelastic properties of the three functional aortic/pulmonary valve tissues (leaflets, sinus wall, and great vessel wall) was ...
Li Yingji - - 2011
Rationale: As powerful vasodilators, prostacyclin analogs are presently the mainstay for the treatment of severe pulmonary arterial hypertension. Although the hemodynamic effects of prostacyclin analogs are well known, the molecular mechanism of their acute effects on pulmonary vascular tone and systemic vascular tone is poorly understood. Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) ...
Soehnlein Oliver - - 2011
Percutaneous transluminal angioplasty with stent implantation is used to dilate arteries narrowed by atherosclerotic plaques and to revascularize coronary arteries occluded by atherothrombosis in myocardial infarction. Commonly applied drug-eluting stents release antiproliferative or anti-inflammatory agents to reduce the incidence of in-stent stenosis. However, these stents may still lead to in-stent ...
Watanabe Go - - 2011
This report describes the novel parachute technique of open distal anastomosis at the aortic arch replacement. Two Teflon felt cylindrical collars were initially placed on the anastomotic site of the descending aorta. All four to five outer loops of the stitches used in the parachute technique were tracked by the ...
Wuest W - - 2011
OBJECTIVES: Transcatheter Aortic Valve Implantation (TAVI) is an alternative to surgical valve replacement in high risk patients. Angiography of the aortic root, aorta and iliac arteries is required to select suitable candidates, but contrast agents can be harmful due to impaired renal function. We evaluated ECG-triggered high-pitch spiral dual source ...
Morin Caroline - - 2011
The aim of this study was to investigate the effect of docosahexaenoic acid monoacylglyceride (MAG-DHA) on human pulmonary arterial tone. Tension measurements on pulmonary arterial tissues demonstrated that MAG-DHA reduced U-46619-induced tone, which is highly sensitive to the H-1152 inhibitor. Results also showed that MAG-DHA treatments decreased RhoA activity levels ...
Villalta Jacqueline D - - 2011
PURPOSE: Selective transarterial embolization for renal angiomyolipomas is effective in preventing or limiting hemorrhage and preserving normal parenchyma. Data are insufficient regarding the safety and efficacy of embolic agents. We compared transarterial embolization of angiomyolipomas using embolic agents of different sizes. MATERIALS AND METHODS: We performed a retrospective review of ...
Owen Richard J - - 2011
INTRODUCTION: This study evaluated the safety, effectiveness, and biodegradation of a new embolic agent, Occlusin™ 503 Artificial Embolization Device (OCL 503). The agent consists of biodegradable poly-lactic-co-glycolic acid microspheres (150-212 μm) coated with type I bovine collagen and was compared with Embosphere(®) Microspheres (300-500 μm) in this controlled study of uterine artery ...
Al Mheid Ibhar I Emory University School of Medicine, Atlanta, Georgia 30322, - - 2011
The primary objective of this study was to elucidate mechanisms underlying the link between vitamin D status and cardiovascular disease by exploring the relationship between 25-hydroxyvitamin D (25-OH D), an established marker of vitamin D status, and vascular function in healthy adults. Mechanisms underlying vitamin D deficiency-mediated increased risk of ...
Saver J L - - 2011
Summary.  Background: The first generation of clinical reperfusion treatment, intravenous (IV) fibrinolysis with tissue plasminogen activator (tPA), was a transformative breakthrough in stroke care, but is far from ideal. Objectives: To survey emerging strategies to increase the efficacy and safety of cerebral reperfusion therapy. Methods: Narrative review. Results and Conclusions: Innovative IV pharmacologic reperfusion ...
Marder Victor J - - 2011
Plasmin is a direct-acting thrombolytic with a better safety profile than recombinant tissue-type plasminogen activator (rtPA) in animal models. With the application of retrieval devices for managing acute ischemic stroke, extracted thromboemboli are available for ex vivo examination. We ask whether such thrombi are amenable to plasmin thrombolysis and whether ...
Kerber Charles W CW UCSD Medical Center, San Diego, California 92103-8756, USA. - - 2012
Following satisfactory benchtop testing of a new liquid embolic agent, animal implant studies were performed. Elastase aneurysms were created in the right common carotid artery of New Zealand rabbits under approved institutional guidelines. Using direct fluoroscopic control and commercially available microcatheters, the device was introduced into the aneurysms. At 2 ...
Nassar Taher - - 2011
The concentration of urokinase plasminogen activator (uPA) is elevated in pathological settings such as acute lung injury, where pulmonary arterial contractility and permeability are disrupted. uPA limits the accretion of fibrin after injury. Here we investigated whether uPA also regulates pulmonary arterial contractility and permeability. Contractility was measured using isolated ...
Brenner Benjamin - - 2011
The incidence of venous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism, is increasing and the disease has been found to account for over 500,000 annual deaths in the European Union. VTE is associated with increased mortality and may lead to serious long-term complications. Unfractionated heparin (UFH), low molecular ...
Giordano Arturo - - 2011
The current management of the stenosis of the coronary arteries relies on the insertion of a metal mesh tube, namely stent, into the obstructed vessel. Coronary stents have been envisaged to reduce the restenosis after balloon angioplasty. Nonetheless, one of the major complications after successful revascularization is the late in-stent ...
Di Minno Matteo Nicola Dario - - 2011
The aim of this narrative review is to assess the potential association between arterial and venous thrombotic events. Several studies have suggested that the major cardiovascular risk factors, alone or in combination (e.g. in the metabolic syndrome), are significantly associated with venous thromboembolism (VTE). Recent evidence also suggests that microalbuminuria ...
Curtis J - - 2011
Group B Streptococcus is the most common cause of bacterial infection in the newborn. Our aim was to purify and identify molecules produced by the bacterium, which cause pulmonary hypertension. Guided by bioassays performed in neonatal lambs, we utilized standard biochemical techniques for the purification of these bioactive compounds. The ...
Spiotta Alejandro M - - 2011
Introduction Carotid sacrifice remains a valuable tool in the treatment of select vascular lesions. Neurointerventionalists have relied on coil embolization as their primary means of carotid sacrifice, a procedure that can be lengthy and expensive with long fluoroscopy times. We investigated a novel technique for carotid sacrifice in a swine ...
Carnevale Daniela - - 2011
Aortic dissection, occuring following a separation of the layers constituting the complex vascular walls, leads to the formation of a "false" lumen and disrupts the regulation of aortic wall homeostasis and function. This clinical condition still represents an important health problem and is associated with high mortality. Its natural history ...
Lazo-Langner Alejandro - - 2011
To the Editor: In their recent article (Nov. 25 issue), Wong and Scott did not discuss the potential role of anticoagulants, particularly low-molecular-weight heparins, in the treatment of retinal-vein occlusion, a common condition for which there is no universally accepted therapy.(1) Although the pathophysiology of retinal-vein occlusion is related to ...
- - 2011
To the Editor: In their recent article (Nov. 25 issue), Wong and Scott did not discuss the potential role of anticoagulants, particularly low-molecular-weight heparins, in the treatment of retinal-vein occlusion, a common condition for which there is no universally accepted therapy.(1) Although the pathophysiology of retinal-vein occlusion is related to ...
Wang Y - - 2011
We sought to assess the feasibility of using thermosensitive chitosan/β-glycerophosphate forembolotherapy. The renal arteries in nine rabbits were embolized with chitosan/β-glycero-phosphate. The animals were studied angiographically and sacrificed at one week (n = 3), four weeks (n = 3), and eight weeks (n = 3) after embolotherapy. Histology was obtained ...
Singla Navneet - - 2011
Intracranial aneurysms have been described in patients with Neurofibromatosis (NF)- 1, but not with NF-2 apart from one instance of a middle meningeal artery aneurysm (Louis DN, Ramesh V, Gusella JF. Neuropathology and molecular genetics of neurofibromatosis 2 and related tumors.(1) We report a case of NF-2 and ruptured posterior ...
Protopapas Aristotle D - - 2011
  Background: Pulmonary embolism (PE) is a life-threatening complication, with a deceptive clinical presentation following coronary artery bypass grafting (CABG). Methods: We identified 13 studies on PE in post-CABG patients, spanning a period of 34 years. Results: The overall cumulative incidence of PE following CABG was 1.3% (111 PEs in ...
Rehak M - - 2011
See also Rehak M, Wiedemann P. Retinal vein thrombosis: pathogenesis and management. J Thromb Haemost 2010; 8: 1886-94; Ageno W, Squizzato A, Lazo-Langner A. Retinal vein thrombosis: pathogenesis and management: a rebuttal. This issue, pp 418-9.
Hurjui Loredana - - 2011
The importance of endothelium-derived hyperpolarizing factor (EDHF) in endothelium-dependent relaxation (EDR) is influenced by multiple factors, including vascular territory and caliber, pre-existing tone and its determining factors. Using isometric myography we noticed that in rat mesenteric resistance arteries (RMA2; 2nd order branches) EDHF-mediated relaxation is increased when precontraction is induced ...
Kawamoto Ryuichi - - 2011
INTRODUCTION. Serum high molecular weight (HMW) adiponectin, an adipocytokine, which is a protein secreted specifically by adipose tissue, improves insulin sensitivity and plays an important role in the development of metabolic syndrome and cardiovascular disease (CVD). Pulse wave velocity (PWV) is a noninvasive method of measuring arterial stiffness for the ...
Thomas Joby K - - 2011
Determining the severity of mitral stenosis (MS) is important for both prognostic and therapeutic reasons. The mitral valve area (MVA) can be measured by planimetry, pressure half-time, continuity equation, and proximal isovelocity surface area methods. In this study, we propose a novel yet simple, independent measure of MS severity-the mitral ...
van den Akker Jeroen - - 2011
While inward remodeling of small arteries in response to low blood flow, hypertension, and chronic vasoconstriction depends on type 2 transglutaminase (TG2), the mechanisms of action have remained unresolved. We studied the regulation of TG2 activity, its (sub) cellular localization, substrates, and its specific mode of action during small artery ...
Zou Junjie - - 2011
Nanoparticles possess several advantages as a carrier system for intracellular delivery of therapeutic agents. Rapamycin is an immunosuppressive agent which also exhibits marked antiproliferative properties. We investigated whether rapamycin-loaded nanoparticles(NPs) can reduce neointima formation in a rat model of vein graft disease. Poly(lactic-co-glycolic acid) (PLGA) NPs containing rapamycin was prepared ...
Ljubkovic Marko - - 2010
SCUBA diving is associated with generation of gas emboli due to gas release from the supersaturated tissues during decompression. Gas emboli arise mostly on the venous side of circulation, and they are usually eliminated as they pass through the lung vessels. Arterialization of venous gas emboli (VGE) is seldom reported, ...
Schwaiblmair Martin - - 2010
Several forms of pulmonary disease occur among patients treated with amiodarone, i.e. chronic interstitial pneumonitis, organizing pneumonia, ARDS, a solitary pulmonary mass of fibrosis. The prevalence is estimated to be about 5%. Two major hypotheses of amiodarone-induced pulmonary injury include direct cytotoxicity and a hypersensitivity reaction. Given the frequency and ...
Lakoma Anna - - 2010
OBJECTIVE: The purposes of our study were to retrospectively evaluate the pulmonary circulation parameters of pulmonary transit time and pulmonary blood volume in patients after Ross procedures using time-resolved MR angiography and to investigate associations with right ventricular dysfunction in the same group of patients. MATERIALS AND METHODS: Sixteen patients ...
Diegeler Anno - - 2010
Stenting of the Shelhigh pulmonary conduit was performed 2 years after a Ross procedure because of a stenosis of the distal segment. We used the new Siemens Artis Zeego technology. A precise placement of the stent to release the stenosis within the distal segment simultaneously retaining a competent valve was ...
Akmal M - - 2010
Scientific theories take centuries to come into existence and they keep on evolving. Uncountable intellectual minds work on these theories; some fail to do anything about it; some add a little after tremendous efforts, and some people give remarkable and unforgettable contribution.As far as credit is concerned, the person who ...
Chang Hak - - 2010
In the microsurgical reconstruction of the foot, anterior tibial artery-dorsalis pedis artery and posterior tibial artery-plantar artery are mainly used as recipient arterial pedicles. These arteries are the main sources for foot circulation and the preservation of these arterial circulations is very important. Although the end-to-side technique or the flow-through ...
Gutierrez Jose - - 2010
Dolichoectasia is found primarily in aged individual with atherosclerotic disease. It presents with brain stem compression and stroke, which could be ischaemic or haemorrhagic. Even if severe atherosclerosis is thought to play a pivotal role, new evidence suggest that the internal elastic laminae is disrupted, intracranially and extracranially, so multiorganic ...
van Royen Niels - - 2009
In human hearts, an extensive pre-existing collateral network is present. This was shown unequivocally some 50 years ago in a series of very detailed post-mortem angiographic studies. In these studies, it was also observed that the pre-existent collateral vessels enlarge upon closure of an epicardial coronary artery, resulting in large ...
Mah?? Guillaume - - 2009
Proximal claudication remains a difficult diagnosis. The ankle to brachial index may be insensitive in the case of isolated hypogastric lesions. Penile pressure represents an alternative method for proximal arteries. Surprisingly, the accuracy of penile pressure measurement in detecting lesions on the arteries supplying pelvic circulation in patients suffering claudication ...
Chen Yen-Hsing - - 2009
BACKGROUND: The sources of secretion and clearance of plasma urotensin II (UII) in the human circulation remain uncertain and may be relevant to understanding the role of UII in human physiology and cardiovascular disease. METHODS: In 94 subjects undergoing clinically indicated cardiac catheterization, we collected blood samples from arterial and ...
Moore Gaea Schwaebe - - 2009
Venous gas bubbles occur in recreational SCUBA divers in the absence of decompression sickness, forming venous gas emboli (VGE) which are trapped within pulmonary circulation and cleared by the lung without overt pathology. We hypothesized that asymptomatic VGE would transiently increase ventilation-perfusion mismatch due to their occlusive effects within the ...
Kim Youn-Jung - - 2009
BACKGROUND: Methotrexate (MTX) has been widely used for the treatment of inflammatory diseases and rheumatoid arthritis, as well as a variety of tumors. However, MTX-induced pulmonary toxicity is a serious and unpredictable side effect of the therapy, which includes allergic, cytotoxic or immunologic reactions, and is a major clinical problem. ...
Schirmer Stephan H - - 2009
OBJECTIVES: Our aim was to determine cytokine and oxygen gradients over the collateral circulation in humans. BACKGROUND: The molecular background of the maturation of the collateral circulation in response to coronary narrowing is poorly understood in humans, partly because of difficulties in obtaining local samples from the human collateral circulation. ...
Ishido Hirotaka - - 2009
An enlarged thymus adversely affected pulmonary artery development and perfusion in a 4-month-old boy with asplenia syndrome and a single ventricular circulation with aorto-pulmonary shunt. Steroid administration for 4 weeks successfully reduced thymus volume, concomitant with improvement of pulmonary vasculature and perfusion. Given the importance of pulmonary physiology in the ...
Wolkove N - - 2009
Amiodarone is an antiarrhythmic agent commonly used to treat supraventricular and ventricular arrhythmias. This drug is an iodinecontaining compound that tends to accumulate in several organs, including the lungs. It has been associated with a variety of adverse events. Of these events, the most serious is amiodarone pulmonary toxicity. Although ...
Moesgaard J - - 2009
Assessment of pulmonary congestion in left-sided heart failure is necessary for guiding anticongestive therapy. Clinical examination and chest x-ray are semiquantitative methods with poor diagnostic accuracy and reproducibility. To establish reference values, describe reproducibility, and investigate the diagnostic and monitoring properties in relation to pulmonary congestion of new pulmonary gas ...
Endo Shunsuke - - 2009
Anatomical variations of the pulmonary vessels present a potential risk of intraoperative bleeding and damage to pulmonary circulation during pulmonary resection. We present details of a dangerous variation of the superior pulmonary vein associated with thoracoscopic right lower lobectomy that could potentially be divided if there was no preoperative foreknowledge ...
DiStasi, Matthew
Indiana University-Purdue University Indianapolis (IUPUI)
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