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Oklu Rahmi R Division of Vascular Imaging and Intervention, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, 290 Gray/Bigelow, Boston, MA 02114, USA. - - 2012
Despite the high prevalence of varicose veins and the recent surge in research on the condition, the precise mechanisms underlying their development remain uncertain. In the past decade, there has been a shift from initial theories based on purely mechanical factors to hypotheses pointing to complex molecular changes causing histologic ...
Kamenskiy Alexey V - - 2012
The mechanical environment and properties of the carotid artery play an important role in the formation and progression of atherosclerosis in the carotid bifurcation. The purpose of this work was to measure and compare the range and variation of circumferential stress and tangent elastic moduli in the human common (CCA), ...
Zhang Ran - - 2011
Recent studies suggested that reactive oxygen species derived from nicotinamide adenine dinucleotide phosphate (NAD(P)H) oxidase is of functional importance in modulating vascular tone, and we have previously detected excessive superoxide production in tail-suspended hindlimb unweighting (HU) rat cerebral and carotid arteries. HU rat was a widely used model to simulate ...
Chan Vincent - - 2011
ContextThere is little evidence guiding heart valve prosthesis selection in patients with end-stage renal disease (ESRD) on dialysis.ObjectivesTo perform: 1) a systematic review of studies examining valve replacement in patients with ESRD on dialysis; and 2) a quantitative meta-analysis comparing survival and valve-related outcomes following valve replacement with bioprostheses versus ...
Conrad Kirk P - - 2011
Administering relaxin to conscious rats and humans elicits systemic and renal vasodilation. The molecular mechanisms vary according to the duration of relaxin exposure-so-called "rapid" (within minutes) or "sustained" (hours to days) vasodilatory responses-both being endothelium-dependent. Rapid responses are mediated by G(αi/o) protein coupling to phosphoinositol-3 kinase/Akt (protein kinase B)-dependent phosphorylation ...
Möhlenbruch M - - 2011
PURPOSE: The aim of the study was to examine the effects of mechanical thrombectomy using the Solitaire stent in patients with thromboembolic occlusions of the intracranial carotid artery bifurcation (carotid T) or middle cerebral artery (MCA) and to compare the results with a historical cohort treated with local intraarterial thrombolysis ...
Ducic Ivica - - 2011
Recent evidence has shown that some cases of occipital neuralgia are attributable to musculofascial compression of the greater occipital nerve and improve with neurolysis. A mechanical interaction at the intersection of the nerve and the occipital artery may also be capable of producing neuralgia, although that mechanism remains one theoretical ...
Muda Ahmad Sobri - - 2011
Endovascular treatment of wide-necked aneurysms poses a challenge for the endovascular therapist. The Y-stent-assisted technique has been used for stent-assisted coil embolisation for wide-necked bifurcation aneurysms. This technique has been described for basilar tip aneurysms and middle cerebral artery bifurcation aneurysms using Neuroform and Enterprise stents. We report 2 cases ...
Washington Christopher B - - 2011
The purpose of this study is to evaluate the potential correlation between peak wall stress (PWS) and abdominal aortic aneurysm (AAA) morphology and how it relates to aneurysm rupture potential. Using in-house segmentation and meshing software, six 3-dimensional (3D) AAA models from a single patient followed for 28 months were ...
Summer Ross R The Pulmonary Center, Boston University School of Medicine, Boston, MA, - - 2011
Pulmonary arterial hypertension (PAH) is a condition of unknown etiology whose pathological features include increased vascular resistance, perivascular inflammatory cell infiltration and pulmonary arteriolar remodeling. Although risk factors for PAH are poorly defined, recent studies indicate that obesity may be an important risk factor for this condition. The mechanisms leading ...
d'Uscio Livius V - - 2011
In the present study, we used the hph-1 mouse, which displays GTP-cyclohydrolase I (GTPCH I) deficiency, to test the hypothesis that loss of tetrahydrobiopterin (BH(4)) in conduit and small arteries activates compensatory mechanisms designed to protect vascular wall from oxidative stress induced by uncoupling of endothelial nitric oxide synthase (eNOS). ...
Ozkok Abdullah - - 2011
Bronchial artery embolization (BAE) is a widely used modality of treatment for massive hemoptysis which has well known complications such as chest pain, groin hematoma and transverse myelitis but systemic embolization of the material used in the procedure is very rare and was reported only four times in the literature ...
Stewart Ralph A H - - 2011
There is currently limited evidence on the safety and efficacy of novel oral anticoagulants in patients with mechanical heart valves. This case report describes a patient with a St Jude aortic valve replacement who suffered valve thrombosis and an embolic stroke when anti-coagulated with the direct thrombin inhibitor dabigatran etexilate.
Pilo C - - 2011
A post-mortem survey was carried out on 46 Sardinian horses to evaluate the presence of Strongylus vulgaris and associated pathology. Horses were from local farms and had been treated with broad-spectrum anthelmintics at least 3 times a year. Examination of the cranial mesenteric arterial system (CMAS) showed parasite-induced lesions in ...
Bolduc Virginie - - 2011
The cardiac cycle imposes a mechanical stress that dilates elastic carotid arteries, while shear stress largely contributes to the endothelium-dependent dilation of downstream cerebral arteries. In the presence of dyslipidemia, carotid arteries stiffen while the endothelial function declines. We reasoned that stiffening of carotid arteries would be prevented by reducing ...
Thompson Jennifer Anne - - 2011
This study examined perturbed aortic development and subsequent wall stiffening as a mechanism for programming of cardiovascular disease. Placental insufficiency was induced in pregnant guinea pigs at mid-gestation by uterine artery ligation. Near term, fetuses were sacrificed and defined as normal birth weight (NBW), low birth weight (LBW) and intrauterine ...
Muscogiuri Giovanna - - 2011
One of the critical points in the pathogenesis of aortic aneurysms (AAs) is the disruption of the balance between vascular extracellular matrix (ECM) deposition and degradation. AAs are common features in some genetically determined diseases of the connective tissue, such as Marfan and Ehlers-Danlos. Acquired factors determining an enhanced inflammatory ...
Zheng Qichang - - 2011
Chronic allograft vasculopathy (CAV) remains a major obstacle for long-term survival of grafts even though therapeutic strategies have improved considerably in recent years. CAV is characterized by concentric and diffuse neointimal formation, medial apoptosis, infiltration of lymphocyte or inflammatory cells, and deposition of extracellular matrix both in arteries and veins. ...
Rachev Alexander - - 2011
The study provides a pathway to design a mechanics-matching vascular graft for an end-to-end anastomosis to a host artery. For functional equivalence, we submit that the graft and a host artery should have equal inner deformed diameters, equal pressure-radius module, and experience equal axial forces when subjected to mean arterial ...
Singh Sanjeev - - 2011
Abstract  A rare association of supracardiac total anomalous pulmonary venous connection (TAPVC) along with severe rheumatic mitral regurgitation is presented. The patient, a 28-year-old female, underwent successful repair of the TAPVC along with pericardial patch closure of the atrial septal defect and replacement of the mitral valve with a mechanical ...
Mavrogenis Andreas F - - 2011
Aneurysmal bone cysts are rarely located in the scapula and are especially rare in the acromion. We present an 8-year-old boy with a large aneurysmal bone cyst of the acromion that achieved curative treatment with one selective transcatheter arterial embolization. Five years after the procedure, healing of the lesion and ...
Sommer Gerhard - - 2012
Human arteries with non-atherosclerotic intimal thickening consist of three distinct layers: adventitia, media and intima. From a series of axial extension and inflation tests on intact and layer-dissected human carotid arteries (adventitia and media-intima composite), a 3D structurally-based strain-energy function (SEF) is calibrated, and a set of five material parameters ...
Coen Matteo - - 2011
The arterial adventitia has been long considered an essentially supportive tissue; however, more and more data suggest that it plays a major role in the modulation of the vascular tone by complex interactions with structures located within intima and media. The purpose of this review is to summarize these data ...
Tian Lian L Department of Mechanical Engineering, University of Colorado, Boulder, Colorado, - - 2011
Understanding how arterial remodeling changes the mechanical behavior of pulmonary arteries (PAs) is important to the evaluation of pulmonary vascular function. Early and current efforts have focused on the arteries' histological changes, their mechanical properties under in vitro mechanical testing, and their zero-stress and no-load states. However, the linkage between ...
Nakazawa Gaku - - 2011
Although, the first-generation drug eluting stents (DES) have significantly reduced rates of restenosis compared to bare metal stents (BMS), an increased risk of late stent thrombosis (LST) has emerged as a major concern. Pathologic studies of patients dying from late DES thrombosis demonstrates delayed arterial healing characterized by persistent fibrin ...
Kim Young Il - - 2011
PURPOSE: This study was designed to investigate the effects of stenting across the branching arteries on the patency and stent-tissue responses over the branching arterial orifices. METHODS: Thirteen dogs were observed after placing aortic stents across the celiac arteries (CA), superior mesenteric arteries (SMA), and renal arteries (RA). The animals ...
Menegazzi James J - - 2012
Recently, portable extracorporeal membrane oxygenation (ECMO) machines have become commercially available. This creates the potential to utilize extracorporeal life support (ECLS) for the treatment of sudden cardiac arrest in the emergency department, and potentially in the out-of-hospital setting. We sought to determine the feasibility of installing the ECMO circuit during ...
Gandy Kimberly L - - 2011
Aortic insufficiency (AI) is generally regarded as a contraindication for mechanical circulatory support in children. In the current Berlin EXCOR trial, moderate to severe AI is an exclusion criterion. There are reports in the literature of successful mechanical circulatory support (MCS) in adult patients with significant AI via "aortic exclusion" ...
Sun Tao - - 2011
Aim:To investigate the mechanisms underlying the vasorelaxant effect of formononetin, an O-methylated isoflavone, in isolated arteries, and its antihypertensive activity in vivo.Methods:Arterial rings of superior mesenteric arteries, renal arteries, cerebral basilar arteries, coronary arteries and abdominal aortas were prepared from SD rats. Isometric tension of the arterial rings was recorded ...
Snow Jessica B - - 2011
Intermittent hypoxia (IH) resulting from sleep apnea causes both systemic and pulmonary hypertension. Enhanced endothelin-1 (ET-1)-induced vasoconstrictor reactivity is thought to play a central role in the systemic hypertensive response to IH. However, whether IH similarly increases pulmonary vasoreactivity and the signaling mechanisms involved are unknown. The objective of the ...
Lindgren Isa Maria - - 2011
Prolonged fetal hypoxia leads to growth restriction and can cause detrimental pre- and postnatal alterations. The embryonic chicken is a valuable model to study the effects of prenatal hypoxia, but little is known about its long-term effects on cardiovascular regulation. We hypothesized that chicken embryos incubated under chronic hypoxia would ...
Hammond Stephanie - - 2011
Altered endothelial function may underlie human cardiovascular diseases, including hypertension, diabetes and pre-eclampsia. While much is known about endothelial function in small arteries, very little is known about endothelial responses in small veins isolated from humans. Therefore, we assessed endothelium-dependent responses in omental arteries and veins isolated from healthy pregnant ...
Ferruzzi Jacopo - - 2011
Elastin is the primary component of elastic fibres in arteries, which contribute significantly to the structural integrity of the wall. Fibrillin-1 is a microfibrillar glycoprotein that appears to stabilize elastic fibres mechanically and thereby to delay a fatigue-induced loss of function due to long-term repetitive loading. Whereas prior studies have ...
Wynn Thomas A - - 2011
Pulmonary fibrosis is a highly heterogeneous and lethal pathological process with limited therapeutic options. Although research on the pathogenesis of pulmonary fibrosis has frequently focused on the mechanisms that regulate the proliferation, activation, and differentiation of collagen-secreting myofibroblasts, recent studies have identified new pathogenic mechanisms that are critically involved in ...
Katz Lisa M - - 2011
Objective-To compare responses of equine digital arteries (EDAs) and veins (EDVs) to human-acalcitonin gene-related peptide (hαCGRP), evaluate effect of the endothelium, and characterize receptors and sources of endogenous CGRP. Sample-Palmar digital vessels (5 to 9/experiment) from healthy adult horses killed at an abattoir. Procedures-Vessel rings were mounted under tension in ...
Gopikrishna G - - 2011
Fatal course of re-expansion pulmonary oedema (REPO) is infrequent and very rarely documented in mechanically ventilated patients. We report a case of fatal REPO following tube thoracostomy for a right-sided pneumothorax in an elderly patient of chronic obstructive pulmonary disease (COPD) with respiratory failure on mechanical ventilation.
Keyes Joseph T - - 2011
Murine models of disease are a powerful tool for researchers to gain insight into disease formation, progression, and therapies. The biomechanical indicators of diseased tissue provide a unique insight into some of these murine models, since the biomechanical properties in scenarios such as aneurysm and Marfan syndrome can dictate tissue ...
Balamurugan S - - 2011
Microscope integrated Near infra red Indocyanine green video angiography (NIR ICG VA) has been frequently used in cerebrovascular surgery. It is believed to be a simple and reliable method with acquisition of real time high spatial resolution images. The aim of this review article was to evaluate the efficacy of ...
Qian Jie - - 2011
Recent publications have emphasized the concept that restenosis of a bare metal stent (BMS) is not as clinically benign as previously believed. We present a case of very late stent thrombosis 9 years after implantation of a BMS is described. Optical coherence tomography shows plaque rupture in the stent. These ...
Benfatti Ricardo Adala - - 2011
The blood hypercoagulability in pregnancy increases significantly the incidence of thrombosis of mechanical valves. Acquired supravalvular aortic stenosis is extremely rare. We report the case of an immediate postpartum patient with aortic mechanical prostheses and acquired supravalvular aortic stenosis who underwent emergency heart surgery, with severe hemodynamic instability, using adapted ...
Tsigkas Grigorios - - 2011
Pseudostenosis or 'accordion phenomenon' is a transient angiographic multifocal filling defect observed mostly during percutaneous coronary intervention, mainly in tortuous vessels. We describe a case of a reproducible accordion effect in the right coronary artery accompanied by only a mild clinical syndrome. Optical coherence tomography evaluation of this strange and ...
Bernal Miguel - - 2011
Arterial elasticity has gained importance in recent decades because it has been shown to be an independent predictor of cardiovascular diseases. Several in vivo and ex vivo techniques have been developed to characterize the elastic properties of vessels. In vivo techniques tend to ignore the anisotropy of the mechanical properties ...
Hu Haichuan - - 2011
The reconstruction of the alimentary tract after esophagectomy is usually achieved by either anterior or posterior route through the mediastinum. Previous anatomic studies in comparing the length of both routes applied different methods and yielded inconsistent results. In order to resolve this important debate, we went back to cadavers to ...
Maiellaro-Rafferty Kathryn - - 2011
The causality of the associations between cellular and mechanical mechanisms of abdominal aortic aneurysm (AAA) formation has not been completely defined. Because reactive oxygen species are established mediators of AAA growth and remodeling, our objective was to investigate oxidative stress-induced alterations in aortic biomechanics and microstructure during subclinical AAA development. ...
Ejma Maria - - 2011
Cranial nerve palsy, most commonly trigeminal, abducens, or facial, caused by compression of an ectatic or elongated intracranial artery is a well-known phenomenon. Symptoms of brain stem compression by an abnormal artery have rarely been reported (Tomasello et al. Neurosurgery 56(suppl 1):117-124, 2005). The authors present a 59-year-old woman with ...
Sandoval Elena - - 2011
A 75-year-old patient underwent open repair of a rapidly expanded aneurysm after previous multiple endovascular repair (EVAR) attempts by others. Open surgical reconstruction allowed the explants of all metallic components of implanted stent-grafts. This is still an uncommon phenomenon due to the still low late reintervention rate. Keywords: Abdominal aortic ...
Sallam Mansour M - - 2011
The radial approach is an elegant alternative to femoral access for diagnostic and interventional coronary procedures; this access site is infrequently associated with vascular complications, although less than the femoral approach. We present our experience in management of iatrogenic radial artery perforation in 3 cases; one case managed conservatively through ...
Takeda Shigeki - - 2011
We examined a solitary hematoma in a patient with sporadic cerebral amyloid angiopathy (CAA). The hematoma affected the middle frontal sulcus, cerebral cortex (CC) and subcortical frontal white matter (sfWM). We embedded the hematoma in four paraffin blocks, each of which was cut serially into 6-µm-thick sections. The first section ...
Kayhan Arda - - 2011
BACKGROUND: Developmental abnormalities of the abdominal aorta are exceedingly rare, and the molecular mechanisms underlying these defects are unknown. CASE: We present computed angiographic findings of a 64-year-old female with long-standing hypertension having an abdominal double aorta accompanied by a double inferior vena cava. The abdominal aorta bifurcated into two ...
Idetsu Akihito - - 2011
Solitary profunda femoris artery aneurysm (PFAA) is extremely rare but presents with symptoms related to rupture, distal embolization, or local compression of veins and nerves. We report two surgically treated cases of solitary PFAA. In case 1, a 69-year-old man presented with sudden onset of pain in the left groin. ...
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