Search Results
Results 401 - 450 of 536
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Kitamura M - - 1986
The combined antitumor effects of local hyperthermia and a simultaneous injection of bleomycin suspended in sesame oil (BLM-sesame oil) into the proper hepatic artery were studied in a model of liver cancer in rabbits. Fourteen days after inoculation of VX2 carcinoma into the left anterior lobe, 107 rabbits were used ...
Cercek B - - 1986
The effect of pretreatment with heparin on lysis of arterial thrombi by tissue-type plasminogen activator (rt-PA) was studied in 19 dogs. Copper coil-induced carotid artery thrombi were weighed, inserted into the femoral arteries, and exposed to a 15 min infusion of rt-PA at 10 micrograms/kg/min either with (n = 6 ...
Fong H - - 1986
To study the effectiveness of low-dose thrombolytic therapy the authors report their experience with local, low-dose, intra-arterial streptokinase infused at a rate of 5000 units/h in four patients with occluded vein grafts and eight with peripheral arterial occlusions presenting with limb-threatening ischemia. The patients had had symptoms for 4 hours ...
Belkin M - - 1986
This study is a retrospective comparison of the results in 25 low-dose, intra-arterial streptokinase and 12 low-dose intra-arterial urokinase infusions for thromboembolic disease. Intra-arterial streptokinase was successful in 50% of infusions and was marked by significant abnormalities in the coagulation criteria. There was a high incidence of major and minor ...
Cormack G C - - 1986
The anatomical territories of individual vessels supplying the skin and subcutaneous tissues have been measured in specimens of cadaver skin following intra-arterial whole-body barium sulphate injection. An attempt has been made to correlate these area measurements with measurements of the diameters of individual vessels. A method has also been devised ...
Wright K C - - 1986
To simulate the intra-arterial infusion of chemotherapy, ink was infused at a steady rate through a vascular catheter inserted in a transparent tube carrying water at a rate similar to that of arterial blood. The ink ran in one or two discrete streams for 10 to 15 cm before mixing ...
Pernes J M - - 1986
Thirty-five patients hospitalized for recent angiographically documented arterial occlusion in the legs (27 femoropopliteal arteries and eight grafts) benefited from local fibrinolytic therapy delivered at the site of the occlusion with a 4- or 5-F catheter. This therapy combined a continuous urokinase (UK) infusion of 1,000 U/kg/hour and a lysyl ...
Lewis P J - - 1986
Peripheral ischemia, secondary to ergotamine tartrate and caffeine suppositories is reported in a 48-year-old female. Lower extremity pre-gangrenous changes were unresponsive to surgical sympathectomy, calcium channel blockade, intra-arterial vasodilators and systemic anticoagulation. A dramatic clinical and radiological reversal of the vasospasm was obtained with intravenous sodium nitroprusside when surgical amputation ...
Hirai M - - 1986
The purpose of this study was to compare the haemodynamic effects of intra-arterial and intravenous prostaglandin E1 (PGE1) both injected and infused into ischaemic legs. Continuous intra-arterial infusion of PGE1 induced a significantly greater increase in skin temperature and blood flow than did intravenous drip infusion. Furthermore, intra-arterial infusion caused ...
Théron J - - 1986
Early experience shows that: Superselective intra-arterial catheterization above the ophthalmic artery minimizes the orbital complications. Catheterization in a distal branch may lead to the non-infusion of a part of the tumor territory. A much higher concentration of the drug is achieved by superselective intra-arterial infusion than by intravenous injection. Longer ...
Simon O - - 1986
Three pigs of 34 kg live weight were fitted with a re-entrant cannula in the duodenum, and with two catheters placed in the jugular vein and carotid artery. They were fed 1.2 kg/d of wheat-dried-skimmed milk diet. Digesta from the proximal duodenal cannula were collected for 12 h on 2 ...
Schulenburg C E - - 1985
Two patients are described who suffered severe complications after inadvertent intra-arterial administration of diazepam. The effects of intra-arterial diazepam are discussed and the prevention of this disaster is emphasized.
Hochberg F H - - 1985
The rationale for, methodology of, and experience with intra-arterial BCNU infusion therapy of malignant glioma are described. This approach achieves tumor levels of drug four times greater than equal doses infused intravenously, and has been used to treat 79 patients over the course of 4 years. The drug was given ...
Bratanow N - - 1985
Intra-arterial PO2 (PiO2) was polarographically monitored in ten critically ill patients during induction of anesthesia, the intraoperative period, extubation, and the immediate postoperative period; 147 PiO2 values were then paired with simultaneous measurements of PaO2. Mean PiO2 closely followed mean PaO2 over a wide range of values (r = .97), ...
Du Toit D F - - 1985
A case of gangrene of the hand following inadvertent intra-arterial injection of a pyrazole derivative (Tomanol) is presented. Gangrene of the hand and superficial sloughing of the distal arm necessitated a forearm amputation. Because of the serious sequelae, precautions must be taken to avoid inadvertent intra-arterial injections and due consideration ...
Walker W J - - 1985
Twenty-six unselected patients presenting with acute arterial ischaemia of a limb were treated with low-dose intra-arterial streptokinase under the joint care of a radiologist and a vascular surgeon. The results are reported and complications described. It is suggested that co-operative radiological and surgical management is essential and a shortened protocol ...
Teplick S K - - 1985
Percutaneous transcholecystic cholangiography was performed in three patients with normal-sized bile ducts and suspected obstructive jaundice, and it was performed 14 times in eight normal dogs. In every instance there was good demonstration of both the intra- and extrahepatic biliary tree. There were no significant clinical complications. Transcholecystic cholangiography is ...
Pritchard S L - - 1985
We describe three pediatric patients in whom locally infused streptokinase at a dose of 50 U/kg/hr was used successfully to treat thrombosis in a major artery, a major vein, and a systemic-to-pulmonary arterial graft. Complications, including hemorrhage and distal embolization, were minimized by careful monitoring of the coagulation status of ...
Schanzer H - - 1985
In order to elucidate whether tissue damage produced on occasion by intramuscular injection of long-acting penicillin is due to accidental intra-arterial injection or vasospasm, two types of experiments were carried out in rabbits. In the first set of experiments, six New Zealand White rabbits were given intra-arterial injections of 0.4 ...
Baker S R - - 1985
We have evaluated the use of the completely implantable infusaid pump in 22 patients with advanced cancer confined to the head and neck. Unilateral head lesions are treated with a single-catheter pump infusing the external carotid artery. A dual-catheter pump is used for midline or bilateral head lesions (both external ...
Quinones-Baldrich W J - - 1985
This article describes our initial experience with intraoperative infusion of the fibrinolytic agent streptokinase. Five patients with various complications of atherosclerosis manifested by limb-threatening ischemia were treated by balloon-catheter thromboembolectomy followed by intra-arterial streptokinase infusion. In each patient viability of the involved extremity was questionable after removal of all thrombus ...
Sved A F - - 1985
The effects of specific treatments of the caudal ventrolateral medulla (CVLM) on vasopressin (AVP) release and arterial pressure (AP) were examined in urethane-anesthetized rabbits. Electrical stimulation of the CVLM for 5 minutes did not increase plasma AVP; it did however elicit an acute fall in arterial pressure. Similarly, stimulation of ...
Mauser M - - 1985
Recovery of adenosine triphosphate after myocardial ischemia is limited by the slow adenine nucleotide de novo synthesis and the availability of precursors of the nucleotide salvage pathways. We determined the adenine nucleotide de novo synthesis in the dog by infusion of [14C]glycine and the acceleration of adenine nucleotide built up ...
Arnoczky S P - - 1985
The blood supply to the knee arises from a vascular plexus that surrounds the joint. The descending genicular artery, the medial and lateral inferior genicular arteries, the medial and lateral superior genicular arteries, the middle genicular artery, and the anterior and posterior tibial recurrent arteries contribute vessels that supply the ...
Corser G - - 1985
A patient presented with a painful, oedematous, cyanosed hand having injected a solution of diamorphine and methylphenidate into his radial artery. Treatment was started with heparin and vasodilators. Benefit from this was limited and a course of intra-arterial urokinase was instituted. This gave almost total resolution of the injury. The ...
Okamoto Y - - 1985
Cisplatin (CDDP) was microencapsulated with ethylcellulose, and microcapsules (CDDP-mc) were infused into the maxillary arteries of patients with various head and neck carcinomas. We then found that the CDDP level in the circulating blood was significantly lower than that in patients administrated intravenous non-excapsulated CDDP. However, significantly high concentrations of ...
Kusano S - - 1985
Selective renal artery embolization with absolute ethanol was performed without balloon occlusion in a series of 11 healthy mongrel dogs. Electrocardiogram, blood ethanol level, heart rate, and blood pressure of the aorta and pulmonary artery were monitored. Ventricular extrasystoles and/or ventricular fibrillation occurred in six of the 11 dogs, to ...
Pierpont G L - - 1985
Because arterial cannulation assists in management of critically ill patients (pts), we assessed the utility of extending intra-arterial monitoring to hospitalized patients suffering in-hospital cardiopulmonary arrest outside of intensive care wards. A totally self-contained, readily portable system for rapid insertion of emergency intra-arterial lines was evaluated in 16 pts from ...
Kapp J P - - 1985
The chemotherapeutic agents 1-3 bis(2-chloroethyl)-1-nitrosourea (BCNU) and cis-diamminedichloroplatinum II (cisplatin) have both shown activity against malignant glioma, especially when given by arterial infusion. The combination of these agents given by this method is logical because their individual major toxicities are directed at different organ systems, and because of their differences ...
Cooper A M - - 1985
Volumetric infusion pumps are widely used for intravenous infusions. We have extended their use to the intra-arterial infusion of drugs. An in vitro evaluation of the performance of such devices, under experimental conditions comparable to an intra-arterial infusion, was carried out. The results obtained confirmed the accuracy of volumetric infusion ...
Saito H - - 1985
The development of the intra-intestinal artery in the Australian lungfish, Neoceratodus forsteri was studied by dye injection. The right arterior wall of the midgut changes to become the valvular wall of the original part of the spiral valve owing to the shift of the foregut towards the posterior and the ...
Diaz-Flores L - - 1985
The histopathological data presented support a new concept for the origin of the cells which cause intimal thickening of arteries. Arterial segments, isolated between ligatures, when examined by intravascular contrast techniques, showed penetration of vasa-vasora and formation of intra-arterial granulation tissue which produced myointimal thickening. Transitional forms between pericytes and ...
Bovino J A - - 1984
During fluorescein angiography, sodium fluorescein dye intended for intravenous use was inadvertently injected into an artery in the antecubital fossa. An immediate and dramatic orange discoloration of the skin distal to the injection combined with intense burning pain of the right forearm and hand were noted. The patient was treated ...
Mentzer S - - 1984
Technical advances that have provided reliable long-term vascular access are described in the setting of pulse and continuous venous chemotherapy infusion and for regional arterial drug delivery. Despite dramatic improvement in the morbidity of such access procedures, it is important to remember that their value still depends upon the effectiveness ...
Wallace S - - 1984
Transcatheter intra-arterial therapy for the cancer patient encompasses infusion of chemotherapy and embolization. Intra-arterial infusion of chemotherapeutic agents has been resurrected because of the availability of new drugs, combinations of drugs, and the capability of percutaneous selective catheter placement. Intra-arterial infusion has been effective in patients with carcinomas of the ...
Moore T C - - 1984
Shock and arterial insufficiency have been observed to be associated with increased levels of sepsis and mortality. As the vast majority of small recirculating lymphocytes reach lymph nodes in arterial blood, the haemodynamic components of lymph node function would appear to be of importance. Lymphocyte traffic in sheep, as mirrored ...
Goldberg I - - 1984
A case of inadvertent intra-arterial self-injection of crushed codeine tablets in an 37-year-old man, resulting in gangrene of an upper extremity, is presented. The problem studied was whether the gangrene was caused by the codeine or by one of the excipients found in the tablets. The cause of the gangrene ...
Alguire P C - - 1984
A drug addict experienced a necrotizing cellulitis of his scrotum and medial thigh after an injection of heroin into his left femoral artery. It is proposed that the arterial injection was directly responsible for producing the low tissue oxygen tension necessary for the synergistic growth of aerobic and anaerobic bacteria ...
Wolfson R H - - 1984
We treated 27 cases of arterial thromboembolism, including nine thrombosed grafts, with intra-arterial (IA) streptokinase. Complete lysis without significant residual lesions was achieved in eight (30%) of the cases, and partial lysis with sustained improvement was achieved in an additional six cases (22%). Partial lysis revealing inaccessible residual disease in ...
Mann S - - 1984
Between 1973 and 1981 1000 successful studies involving ambulatory monitoring of intra-arterial blood pressure were performed using percutaneous cannulation of the brachial artery. We have reviewed the clinical effects of these studies and 35 other cases where attempted cannulation was unsuccessful. One major complication occurred, when an infected haematoma arising ...
McCracken J A - - 1984
Several substances including prostaglandin F2 alpha, progesterone and 85-krypton have been shown to be transferred from the venous side to the arterial side of the circulation in the ovarian vascular pedicle. Experiments were therefore carried out to study the transfer of three pairs of steroids (progesterone and 20 alpha-dihydroprogesterone, C-21; ...
McGuinness O P - - 1984
The metabolic clearance rate (MCR) and maximal rate of glycerol removal (Rd max) were determined in anesthetized dogs at two time periods after the intravenous administration of either Escherichia coli endotoxin or saline. The nonisotopic method employed in these studies to determine the MCR of glycerol consisted of a constant ...
Bledin A G - - 1984
Arterial catheter tip position and arterial flow was monitored by intra-arterial infusion of 99Tcm macroaggregated albumin in patients treated by intra-arterial chemotherapy. Variations in arterial flow pattern as monitored by macroaggregated albumin perfusion studies were encountered in 16 patients without apparent change in the catheter position as monitored by arteriographic ...
Benabe J E - - 1984
Intra-arterial infusion of vanadate (VO4) in dogs produces a reduction in renal blood flow (RBF), glomerular filtration rate (GFR), urine flow (V), and the fractional excretion of sodium (FENa+). To evaluate the role of Ca2+ in these changes VO4 was infused into the renal artery in the presence of the ...
Virag R - - 1984
The effect of intracavernous injection of papaverine (ICIP) has been investigated in 45 men: 6 normally potent volunteers, 10 psychogenic, and 29 organic impotent males. The first two groups obtained erections within 10 minutes, lasting from 1 to 4 hours, after injection of 80 mg of papaverine. Those belonging to ...
Carlson J A JA - - 1984
Intra-arterial chemotherapy is supported by the rationale that regional infusion more than systemic administration can produce higher regional concentrations of cytotoxic drugs, thereby enhancing tumor kill. The hypothesis that intra-arterial infusion of cis-diamminedichloroplatinum II (DDP) enhances regional drug concentrations in tissue has not been studied. Therefore, 30 New Zealand white ...
Dusting G J - - 1984
The platelet release products thromboxane A2 (TxA2) and serotonin (5-HT) might contribute to coronary vasoconstriction in humans. We have examined the effects of a TxA2-like analogue (U46619), 5-HT, and epoprostenol (PGI2) on the left anterior descending coronary artery of the dog. Changes in diameter were measured by sonomicrometry during perfusion ...
Bremer A M - - 1984
We have used intra-arterial (i.a.) 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) either alone or as part of adjuvant chemotherapy in patients with malignant brain tumors over a 3 year period (1979-1982). The i.a. BCNU technique was used 111 times to infuse 134 arteries in 37 patients. These patients, 28 cases with glial tumor and ...
Jackson D V DV - - 1984
Currently the chemotherapeutic agents available for intra-arterial infusion in metastatic liver cancer are limited to only a few. The recent demonstration of the feasibility of prolonged IV infusion of vincristine led to exploration of hepatic intra-arterial infusion of this agent. A continuous infusion of 0.4 mg total dose was administered ...
Kawagoe K - - 1983
Five cases of recurrent cervical carcinoma with sites of recurrence restricted to the pelvis were treated by intra-arterial infusion of oncostatics via the bilateral internal iliac arteries. One tip of the catheter was positioned in the internal iliac artery, proximal and close to the superior glutea artery, through the arteria ...
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