Regional chemotherapy with Adriamycin via the pulmonary artery produces significantly higher tissue levels in the infused canine lobe than systemic administration. Seven patients with soft tissue sarcomas who had received the maximum dose of Adriamycin and had shown metastatic tumor recurrence to the lungs, received small doses of 10 to ...

Dextran microspheres (Sephadex G25 fine) from 25 to 105 micrometer, labelled with fluorochrome (Lissamine Rhodamine B), in concentrations of 1 and 2 million particles suspended in 2 ml Ficoll 70, were injected into the right common carotid artery of 10 white female rabbits (Danish domestic variety) which were sacrificed at ...

Based o the results of treatment of 28 patients with proved ulnar artery thrombosis, multiple therapeutic regimens, including intra-arterial medications, excision and ligation of the involved segment, environmental modification and biofeedback, sympathectomy, stellate blocks, and excision and vein grafting, and recognizing that no single treatment is suitable for everyone, a ...

A five-year-old boy was operated upon for left-sided cryptorchidism. Failure of uro-genital union was found with the left testis and caput epididymidis intra-abdominally situated, and vas deferens and the rest of the epididymis in the lower part of the inguinal canal. The risk of development of malignancy in an intra-abdominal ...

Angiography was performed in connection with intra-arterial chemotherapy in 110 patients with bronchogenic carcinoma. All tumors were supplied from at least one ipsilateral bronchial artery. A double systemic arterial supply was found in 12 patients, the additional blood supply coming from a second ipsilateral bronchial artery in 3 patients, from ...

Peripheral ischaemia related to the inadvertent intra-arterial injection of crushed tablets in suspension, was seen in five drug addicts. Characteristic clinical, features were observed including pain, discolouration, oedema, immediate and delayed sensory and motor deficits, and pregangrenous and gangrenous changes distal to the site of injection. Definitive treatment remains to ...

Selective intra-arterial urokinase (UK) is effective in treating recent arterial thromboembolism. However, usually only partials lysis is achieved and this treatment seems less effective than intravenous streptokinase. At a dose of 37,500 UCTA/hour it does not produce systemic fibrinolysis. This protocol substantially reduces the risk of systemic bleeding and embolism ...

A case of a giant intracavernous carotid aneurysm, surgically treated by combined procedure of trapping and extra- intra-cranial arterial bypass, is reported. The authors reviewed the literature concerning the risks of immediate, early and late ischaemic complications related to carotid surgical occlusion. In agreement with other authors, the usefulness of ...

Mitomycin C (MMC) was microencapsulated with ethylcellulose. The microcapsules contained, on average, 80% of biologically active MMC and had a sustained-release property. The mean particle size was 224 micrometers so that the microcapsules were readily infused into a canine kidney through arterial catheterization. Ex vivo infusion demonstrated that the microcapsules ...

A case is recorded in which intra-arterial injection of thiopentone 2.5 per cent was made into an aberrant branch of the radial artery at the lateral aspect of the wrist. Although the intra-arterial injection of thiopentone is a fairly uncommon accident, especially on the dorsum of the hand, nevertheless, precautions ...

The control of intra-arterial chemotherapy by selective conventional and xero-angiographic exploration of the external carotid artery is reported. With the aid of a catheter inserted into the superior thyroid, facial or super-facial temporal artery, all the main branches of the external carotid artery can be depicted. Xeroangiography in the area ...

The use of the operating room microscope to accomplish microscopic anastomosis is gaining wider application. The technique to accomplish autotransplantation of the intra-abdominal testes involves division of the spermatic artery and vein with reanastomosis to the inferior epigastric vessels under the operating room microscope. The over-all success rate cannot be ...

This study was undertaken to determine if a portion of intravenously administered methylprednisolone sodium succinate (MPSS) might be metabolized by the lung during cardiogenic shock. With plastic microsphere coronary artery embolization, myocardial infarction and shock were produced in mongrel dogs. Animals were assigned to control, intra-arterial MPSS, and intravenous MPSS ...

The orifice of the rat carotid body artery is surrounded by intra-cranial cushions which form a boat-like structure. The cushions are covered by normally looking endothelium, ramified smooth muscle cells are seen in its stroma. The internal elastic lamella remifies where the cushions originate, and delicate elastic fibres extend into ...

In a prospective randomized study, 38 patients with massive upper gastrointestinal tract hemorrhage, mostly due to esophageal varices or erosive gastritis, were treated with either standard medical therapy or standard therapy plus selective intra-arterial vasopressin infusion. Cessation of hemorrhage occurred more frequently in the vasopressin-treated group. The study design did ...

Injection of a crude preparation of cholera enterotoxin into the superior mesenteric artery caused isotonic fluid secretion by the canine small bowel. In dogs previously exposed to cellular antigens of Vibrio cholerae, the time course of the intestinal response to intra-arterial injection of crude enterotoxin was similar to that observed ...

This report describes a case of massive gastric hemorrhage, initially controlled by selective arterial vasopressin infusion. Infusion was followed by extensive necrosis of the gastric wall which necessitated subtotal gastrectomy. Gastric necrosis following arterial infusion is rare and in this case appears to be due to migration of the infusion ...

Computer-aided operator-interactive densitometry has been developed and applied to determine the percent stenosis for obstructive lesions in the coronary arterial tree. Phantom experiments performed to assess system linearity, accuracy of densitometric measurements, nonuniformity in image amplified response, and the interference of structure noise in measuring precision have been described. Three ...

Bronchial angiography and intraarterial infusion of mitomycin-C were successfully performed in 39 of 47 patients with bronchogenic carcinoma. More than one course was given to several patients. No neurologic complications occurred and the side effects were insignificant. The pertinent anatomy of the bronchial and spinal arteries is summarized and a ...

Two cases of inadvertent intra-arterial injection into the anterior turbinates for treatment of allergic rhinitis resulted in retrograde flow of methylprednisolone acetate in the ophthalmic artery. Both patients demonstrated embolization of the retinal circulation, and one of the choroidal circulation as well. Visual outcome was favorable, although one patient showed ...

Seven patients treated for cardiogenic shock were studied with and without intra-aortic balloon pumping (IABP). Calf and forearm blood flows were determined with a Dohn plethysmograph and arterial pressures were registered intra-arterially and in the great toe and thumb with the cuff method. During IABP, an augmented flow was registered ...

Excessive bleeding from the head and neck sometimes presents a therapeutic problem. Ten patients with this type of haemorrhage have been treated with continous vasopressin infusion for 1-3 days. Haemostasis was quickly established in eight cases. No serious side effects were noted. Infusion of vasopressin has a rapid, beneficial effect ...

The benefits and complications of regional chemotherapy in the treatment of head and neck tumours are discussed. Intra-arterial chemotherapy has been employed in 72 cases of preoperative, postoperative and palliative management. Cytostatic treatment consisted of combined Vincristine, bleomycin, methotrexate, and mitolactol administration by a Watkins-USCI or Sharp chronofusor. In cases ...

Four-hour balloon occlusion of the cranial mesenteric artery in 13 dogs produced a spectrum of widespread ischemic injury to the small bowel ranging from superficial mucosal infarction to transmural infarction. Twenty-four hours after the beginning of balloon occlusion, 15 mCl of 99mTc-pyrophosphate was injected into the cranial mesenteric artery in ...

Transcatheter electrocoagulation is an effective method of experimental vessel occlusion even in the presence of thrombocytopenia and heparinization. This technique was used to occlude 13 arteries in 3 patients. In vitro testing suggests that intra-arterial bipolar platinum electrodes may achieve the therapeutic objectives more rapidly and with less risk, but ...

A technique for the catheterization and intra-arterial infusion of the common carotid artery of the rabbit utilized a simple swivel apparatus, an acrylic head mount, and a silicone rubber sleeve. This method was used for continuous intra-arterial infusion in 29 unrestrained rabbits for periods up to 61 days.

Although cerebral arteriography is commonly employed as a diagnostic radiologic procedure its use is not entirely innocuous. Beside the usual complications of an invasive technique the retention of a knotted distal flexible catheter tip may be encountered. This report presents a case in which this occurred with subsequent extraction by ...

Five infants received 10% calcium gluconate via umbilical artery catheters, which resulted in intestinal bleeding and lesions of the buttock, anus, groin, and thigh. The effects of intra-arterial calcium gluconate in two animal models were investigated. Injection of calcium into the aorta in the region of the posterior mesenteric artery ...

Accidental intra-arterial injection of intramuscular antibiotic preparations is described in 3 cases in infants. In 2 benzathine penicillin was injected, and in 1 rolitetracycline. The clinical features are dominated by arteriolar obstruction which produces gangrene of the most severely affected limb. In addition, neuroloigcal involvement occurs when vessels to nerves ...

Seventeen mongrel dogs were subjected to ligation of the circumflex branch of the left coronary artery. At intervals from 10 to 300 minutes after ligation, 10 ml of a sodium fluorescein and colloidal thorium hydroxide solution were injected via an intra-arterial catheter placed distal to the ligature. Up to 20 ...

CT is the most effective examination technique for studying the evolution of ischemic attacks, but if performed within the first 3 weeks it does not allow prognosis of possible evolution towards necrosis. CBF measurement and vasoreactivity tests under Althesin do allow this prognosis. Thirty patients whose evolution was checked clinically ...

Continuous monitoring of intra-arterial PO2 has many advantages in intensive care. However, there are some problems which have prevented the routine use of this method until now. A commercially available polarographic oxygen electrode was tested in vitro. Continuous PO2 monitoring was performed in vivo in 63 adult patients. The electrode ...

Twelve patients with gross vascular occlusions and with infarcts demonstrated in CT were examined with regard to their hemodynamic situation. Angiography and rCBF with intra-arterial and inhalation techniques were performed. Response to increased arterial hypertension and to CO2 inhalation was tested. It is concluded that one technique alone does not ...

Sixty-two patients with arterial disease of the lower limbs were treated with streptokinase by intermittent administration. All patients had experienced recent aggravation of their arterial disease, and 22 had thrombolysis confirmed by arteriography. In 20 cases clinical study showed repermeation--in 8 cases during the first perfusion and in 8 cases ...

Intra-arterial lidocaine has been utilized to decrease pain by administration prior to contrast material injections during aortofemoral arteriography in over 600 patients. Because this observation was uncontrolled, a double-blind study was performed in 15 patients comparing the effectiveness of intra-arterial lidocaine and saline in the control of pain from contrast ...

Intra-arterial lidocaine was found to be an effective and safe method for reducing pain associated with peripheral angiography. A convenient method for delivery is to directly mix 2% lidocaine and contrast material in a ratio of 1:10 by volume. In a comparative evaluation, 25 of 29 patients experienced significantly less ...

Severe peripheral vasoconstriction of the legs due to hypersensitivity to small doses of ergotamine tartrate developed in a patient with migraine headaches. The vasospasm was successfully treated with continuous intra-arterial and intravenous infusion of sodium nitroprusside. The contribution of angiography in the diagnosis and treatment of ergotism is stressed.

In this study, lysine-vasopressin, administered either as a continuous, intravenous infusion (1 unit/kh/hour) or as a selective infusion into the superior mesenteric artery (0.2 unit/minute), produced equal (25%), significant (p less than 0.05), and sustained (60 minute) reductions in portal pressure. Compared to intravenous administration, selective intra-arterial infusion of vasopressin ...

Over a four-year period, eight patients with documented gastrointestinal bleeding had angiography as a part of their investigation and treatment at the Department of Radiology, Victoria General Hospital, Halifax, Nova Scotia. A review of these eighty cases has been carried out and angiography has been found to be both safe ...

Since 1963, regional intra-arterial infusion of anti-cancer agents combined with surgery has been used in the treatment of 56 patients with osteosarcomas. The histologic examination of amputated limbs after prolonged intra-arterial infusion therapy showed remarkable degeneration and necrosis throughout wide areas of tumor tissue. The overall estimated 5-year survival rate ...

A patient is presented who presumably had multiple drugs injected intra-arterially in the right hand. Clinical signs and angiographic evidence of severe vascular insufficiency were well demonstrated. Therapy with fibrinolysin, reserpine, and heparin was followed by a return of normal circulation.

By means of perfusion studies, an analysis was made of the arterial supply to the proximal end of the femur in 150 specimens from autopsied fetuses and children, aged from twenty-six weeks of gestation to fourteen years and eight months old. All died of diseases which did not involve the ...

Intimal thickening of the intra-organ arteries of the major organs have been examined in 253 autopsy cases and, the microscopical findings have been analyzed according to smoking habits. It was found that especially that small arteries of the lung present a significantly higher degree of fibrous intimal thickening in cigarette ...

Paralysis of the right third and fourth cranial nerves, lasting for about six weeks, occurred in a patient following the injection of procaine hydrochloride in the area of the right superior alveolar artery. Ocular complications of dental anesthesia are rare and are probably caused by intra-arterial injection of anesthetic that ...

The relation between ionic composition and cardiotoxicity of two dimers, iocarmate and iozomate, was investigated by selective injection into the left and right coronary arteries, Least toxic reactions developed at a sodium concentration of 263 to 315 mmol/l for sodium-meglumine iocarmate and 271 to 379 mmol/l for sodium-meglumine iozomate.

In nine patients, one with bilateral findings, impending gangrene of the hand due to thrombosis of the palmar arch or digital arteries did not respond to current surgical methods or to common nonsurgical measures and was treated by intra-arterial thrombolysin. The author's recommended diagnostic arteriography, direct surgical treatment, if indicated, ...

A total of 133 canine small bowel segments were isolated in 51 dogs according to a previously described technique that permits an in vivo freeze-thaw experiment to be carried out after perfusion with various cryoprotective agents. All control segments (33) survived. One hundred segments were frozen with cold intra-arterial helium ...

Irreversible ischaemic gangrene of the upper limb developed in a one-year-old child after an unintentional intra-arterial injection of procaine penicillin. The hand needed amputation. Arterial embolization phenomenon along with intense vasospasm appears to have been responsible for this rare complication. Unintentional intra-arterial injection of penicillin intended for intra-muscular use may ...

Echocardiography is perhaps the most useful and accurate method of diagnosis of pericardial effusion. Its noninvasive nature and the ease with which it may be repeated make it doubly attractive. In the hands of a skilled echocardiographer, its accuracy is unequaled by other methods such as carbon dioxide injections, radionuclide ...

Dissatisfaction with the high morbidity and mortality of traditional methods of handling massive gastrointestinal hemorrhage has led to the exploration of means other than surgical to attain hemostasis. Some, such as selective arterial infusion of surgical Pituitrin, have quickly won general acceptance in hospitals where facilities and interested personnel are ...