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Kool Heleen H Department of Pediatric Surgery of the Erasmus MC, Sophia Children's Hospital, Rotterdam, the - - 2014
Pulmonary vascular diseases of the newborn comprise a wide range of pathological conditions with developmental abnormalities in the pulmonary vasculature. Clinically, pulmonary arterial hypertension (PH) is characterized by persistent increased resistance of the vasculature and abnormal vascular response. The classification of PH is primarily based on clinical parameters instead of ...
Awasthy Neeraj N Department of Pediatric Cardiology, Fortis Escorts Heart Institute, New Delhi, India - - 2014
A 1-month old baby boy presented with a mass at the root of the neck. On investigation, a saccular aneurysm arising from the internal jugular vein was diagnosed. The aneurysm was excised after ligating the patent internal jugular vein above and below the origin of the aneurysm. Histopathology confirmed the ...
Tang Haiyang H University of - - 2014
Pulmonary vascular remodeling, mainly due to enhanced pulmonary arterial smooth muscle cell (PASMC) proliferation and migration, is a major cause for elevated pulmonary vascular resistance and pulmonary arterial pressure in patients with pulmonary hypertension (PH). The signaling cascade through Akt, comprised of 3 isoforms (Akt1-3) with distinct but overlapping functions, ...
Starke Robert M RM Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia, - - 2014
Advances in the management and endovascular treatment of intracranial aneurysms are progressing at a tremendous rate. Developments in novel imaging technology may improve diagnosis, risk stratification, treatment planning, intraprocedural assessment, and follow-up evaluation. Evolution of devices, including microwires, microcatheters, balloons, stents, and novel scaffolding devices, has greatly expanded the potential ...
Brinster Derek R - - 2014
This manuscript presents a published record of the use and efficacy of the extracellular matrix CorMatrix and why it may be superior to other materials used for aortic root enlargement. The potential benefits of an extracellular matrix are the natural ingrowth and development of native arterial cells and structure.
Schmit Bradley M BM University of Florida College of - - 2014
The prevalence of aortic aneurysm is five times higher in men than women among the general population. Similar sexual dimorphism also exists in syndromic aortic aneurysms triggered by TGF-β signaling disorders. To understand the responsible mechanisms, we developed an animal model where inducible deletion of the type I TGF-β receptor, ...
Evans William N WN Children's Heart Center - Nevada, 3006 S. Maryland Pkwy Ste. 690, Las Vegas, NV, 89109, USA, - - 2014
Fontan patients are at risk for hepatic fibrosis; however, risk factors are unclear. We performed a multivariate analysis in a small cohort of 14 patients (7-24 years old, mean 15) with Fontan circulation, undergoing cardiac catheterization and transvenous liver biopsies, all demonstrating fibrosis. We found by stepwise regression analysis that the history of ...
Cyron C J CJ Department of Biomedical Engineering, Yale University, New Haven, CT, USA - - 2014
Static and dynamic mechanical instabilities were previously suggested, and then rejected, as mediators of aneurysmal development, which leaves open the question of the underlying mechanism. In this paper, we suggest as a new paradigm the interpretation of aneurysms as mechanobiological instabilities. For illustrative purposes, we compare analytical calculations with computational ...
Kinehara Yuhei - - 2014
Autoimmune pulmonary alveolar proteinosis (aPAP) is a rare lung disease caused by the autoantibody against granulocyte-macrophage colony stimulating factor (GM-CSF). The clinical course of aPAP is variable; in severe cases, patients develop lethal respiratory failure due to pulmonary fibrosis. However, the pathogenesis of pulmonary fibrosis in aPAP has never been ...
Gupta Saurabh K SK 1Department of Cardiology,All India Institute of Medical Sciences,New - - 2014
Although usually shown in embryology textbooks, the presence of the fifth pair of pharyngeal arch arteries has long been controversial. To the best of our knowledge, six pairs of bilaterally symmetrical arteries developing within the pharyngeal arches are yet to be found in any mammalian or avian species. Collateral channels ...
Mohamed Sarjun Basha Khadhar K Department of Cardiology, Institute of Cardiovascular Diseases, The Madras Medical Mission, Chennai, India - - 2014
Syphilitic aortic aneurysm is a rare occurrence in the current antibiotic era. Cardiovascular syphilis has nearly disappeared in developed countries, although it remains a factor in differential diagnosis in developing nations. We report a case of syphilitic aortic aneurysm eroding through the sternum in a 52-year-old man who underwent successful ...
Bestetti Reinaldo Bulgarelli - - 2014
Our knowledge regarding the anatomophysiology of the cardiovascular system (CVS) has progressed since the fourth millennium BC. In Egypt (3500 BC), it was believed that a set of channels are interconnected to the heart, transporting air, urine, air, blood, and the soul. One thousand years later, the heart was established ...
Eichmann Anne A Yale Cardiovascular Research Center, School of Medicine, Yale University, New Haven, CT 06510-3221, USA. Department of Cellular and Molecular Physiology, School of Medicine, Yale University, New Haven, CT 06510-3221, USA. Center for Interdisciplinary Research in Biology (CIRB), Collège de France, Inserm U1050, CNRS UMR 7241, 75005 Paris, France. - - 2014
Innervation of arteries by sympathetic nerves is well known to control blood supply to organs. Recent studies have elucidated the mechanisms that regulate the development of arterial innervation and show that in addition to vascular tone, sympathetic nerves may also influence arterial maturation and growth. Understanding sympathetic arterial innervation may ...
Lazarov M M University Hospital Ghent/Sint-Augustinus Wilrjk, Sint-Augustinus Ziekenhuis, Oosterveldlaan 24, 2610 Wilrijk Antwerpen, Belgium. Electronic address: - - 2014
This case report presents a 38-year-old male patient who developed a false aneurysm of the superficial femoral artery after minimally invasive plate internal fixation of a comminuted articular distal femoral fracture sustained in a motor vehicle accident. Two days after surgery, the patient developed pain, non-pulsatile swelling on the medial ...
Hasan Ashfaq A Professor and Head, Department of Pulmonary Medicine, Deccan College of Medical Sciences/Owaisi Hospital, Hyderabad, India; Consultant Pulmonologist, Care Institute of Medical Sciences (Banjara), Hyderabad, India. Electronic address: - - 2014
Idiopathic Pulmonary Hypertension (IPAH) is characterized by elevated pulmonary arterial pressure in the absence of an identifiable underlying cause. The condition is usually relentlessly progressive with a short survival in the absence of treatment.(1) We describe a patient of IPAH in whom the pulmonary artery pressures significantly abated with complete ...
Qi Xing-Shun XS Xing-Shun Qi, Ming Bai, Dai-Ming Fan, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an 710032, Shaanxi Province, - - 2014
Currently, nonselective β-blockers (NSBBs) are commonly used for the prevention of variceal bleeding in liver cirrhosis. The beneficial effects of NSBBs are primarily attributed to the reduction in cardiac output by blockade of β1 receptors and vasoconstriction of the splanchnic circulation by the blockade of β2 receptors. The prognostic value ...
Yoshikane Yukako Y Department of Pediatrics, Faculty of Medicine, Fukuoka University, Fukuoka, 814-0180, Japan. Electronic address: - - 2014
Kawasaki disease (KD) is the most common systemic vasculitis of unknown etiology in children, and can cause the life-threatening complication of coronary artery aneurysm. Although a novel treatment strategy for patients with KD-caused vascular lesions is eagerly awaited, their molecular pathogenesis remains largely unknown. c-Jun N-terminal kinase (JNK) is a ...
Köklü Erkan E Clinic of Cardiology, Antalya Education and Research Hospital, Yenigün Mahallesi 1067 Sokak no: 6B/13, Antalya, Turkey, - - 2014
Carotid artery stenting (CAS) is a revascularization modality that is an alternative to carotid endarterectomy. The efficacy of CAS in primary and secondary prevention from ischemic stroke has been demonstrated in various trials. Acute thrombosis of CAS is a rare complication that can lead to dramatic and catastrophic consequences. We ...
Pancholy Samir B SB Program Director, Fellowship in Cardiovascular Diseases, The Wright Center for Graduate Medical Education, Associate Professor of Medicine, The Commonwealth Medical College, Scranton, - - 2014
Radial artery access for performance of coronary and peripheral diagnostic as well as interventional procedures is on the rise. With increasing adoption comes the expected increase in procedural complications. We describe a novel, simple, and effective non-pharmacologic solution for sheath entrapment related to pharmaco-resistant radial artery spasm. © 2014 Wiley ...
Brunet Isabelle - - 2014
Autonomic sympathetic nerves innervate peripheral resistance arteries, thereby regulating vascular tone and controlling blood supply to organs. Despite the fundamental importance of blood flow control, how sympathetic arterial innervation develops remains largely unknown. Here, we identified the axon guidance cue netrin-1 as an essential factor required for development of arterial ...
Augustine J J Exercise Science, Syracuse University, Syracuse, United - - 2014
Consumption of a high-fat meal (HFM) causes postprandial lipemia and vascular dysfunction. Acute resistance exercise (RE) alone may also have a negative effect on vascular function. The purpose of this study was to measure arterial stiffness and postprandial lipemia after a HFM with or without acute RE. 9 recreationally active ...
Linguraru Marius George MG Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Healthcare System, Washington, DC, USA ; Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Maryland, USA ; School of Medicine and Health Sciences, George Washington University, Washington, DC, - - 2014
Our objective was to determine whether computed tomography angiography (CTA) measurements of pulmonary artery size can noninvasively assess hemodynamics and diagnose pulmonary hypertension (PH) secondary to sickle cell disease (SCD). Twenty SCD patients with confirmed PH were compared with 20 matched controls. Diameters of the pulmonary artery trunk and branches ...
Lind Lars L Department of Medical Sciences, University Hospital, Uppsala University, Uppsala, - - 2014
Different techniques to evaluate endothelium-dependent vasodilation (EDV) in resistance and conduit arteries have been described and have been associated with the occurrence of the metabolic syndrome (MetS) in cross-sectional studies. This study aimed to evaluate whether EDV in resistance and conduit arteries could predict future development of the MetS in ...
Ghandour Abed A Abed Ghandour, Prabhakar Rajiah, Cardiothoracic Imaging Section, Department of Radiology, University Hospitals of Cleveland, Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, United - - 2014
A fistula is an abnormal vascular connection leading to diversion of blood from a high resistance arterial circuit to low resistance venous circuit. Coronary artery fistulas are abnormal communications of the coronary artery with a chamber of the heart, or with any segment of systemic or pulmonary circulation, bypassing the ...
Sánchez María M Nephrology Section, Hospital General Universitario de Elche , Spain - - 2014
Abstract Several vascular abnormalities have been reported in autosomal dominant polycystic kidney disease (ADPKD). Occlusion of the renal artery is uncommon in ADPKD and can be associated with hypertension. We report a 38-year-old woman with ADPKD and severe hypertension, abdominal magnetic resonance angiogram and arteriography revealed left renal artery total ...
Ustunyurt O B OB Department of Obstetrics and Gynecology, Zubeyde Hanım Dogumevi , Bursa , - - 2014
To investigate the effects of antenatal betamethasone on fetal pulmonary blood flow velocity waveforms. The study comprised 28 women with singleton pregnancies at high risk for preterm delivery. They were treated with two doses of 12 mg betamethasone intramuscularly 24 h apart to enhance lung maturity. Flow velocity waveforms were ...
Naumov Alexey Yu AY Chair of Physics of Living Systems, Moscow Institute of Physics and Technology (State University), Moscow, - - 2014
In many studies, the functional state of vessels of different caliber was determined by fitting the lumped parameters of a mathematical model of the bed in order to fit the vascular input impedance (Z in) data. However, reliability of the results obtained in such a way remains uncertain. In this ...
Deuse Tobias T 1] TSI-laboratory, University Heart Center Hamburg, Martinistraße 52, 20246 Hamburg, Germany [2] Cardiovascular Research Center Hamburg (CVRC) and DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Luebeck, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany [3] Cardiovascular Surgery, University Heart Center Hamburg, Martinistraße 52, 20246 Hamburg, - - 2014
Despite the introduction of antiproliferative drug-eluting stents, coronary heart disease remains the leading cause of death in the United States. In-stent restenosis and bypass graft failure are characterized by excessive smooth muscle cell (SMC) proliferation and concomitant myointima formation with luminal obliteration. Here we show that during the development of ...
Elkıran Ozlem O Department of Pediatric Cardiology, Faculty of Medicine, İnönü University; Malatya-Turkey. - - 2014
The evaluation of pulmonary vascular reactivity plays a significant role in the management of patients with pulmonary hypertension. Inhaled nitric oxide in combination with oxygen (O2) has become widely used as an agent for pulmonary vasodilator testing. However, inhaled nitric oxide is not available in many developing countries. Recently, aerosolized ...
Biondi-Zoccai Giuseppe G 1 Dipartimento di Scienze e Biotecnologie Medico-Chirurgiche, Sapienza Università di Roma, Latina, - - 2014
Sham: noun - something that is not what it appears to be and that is meant to trick or deceive people; someone who deceives people by pretending to be a particular kind of person, to have a particular skill, etc.; words or actions that are not sincere or honest. (1) ...
Reis Miranda D D Intensive Care, Erasmus Medical Centre, Rotterdam, The Netherlands - - - 2014
Background: To validate commonly used bedside right ventricular impedance parameters, which are used in determining heart-lung interactions during mechanical ventilation. Methods: Fifteen pigs were equally assigned to either an open or a closed pericardium group. In all animals, an inflatable vascular occluder and a flow probe were placed around the ...
Giesen Leonie A LA Department of Congenital Heart Disease and Department of Anaesthesia, Bristol Heart Institute and Bristol Royal Hospital for Children, Bristol, United - - 2014
Background: Children with pulmonary hypertension routinely undergo pulmonary vascular resistance studies to assess the disease severity and vasodilator responsiveness. It is vital that results are accurate and reliable and are not influenced by the choice of anaesthetic agent. However, there are anecdotal data to suggest that propofol and inhalational agents ...
Kudumula Vikram V East Midlands Congenital Heart Centre, Glenfield Hospital, Groby road, Leicester, UnitedKingdom, LE3 - - 2014
Objectives To evaluate the performance of the Bard Valeo stent in pulmonary artery stenoses. Background The premounted Valeo stent requires only 6-7 French access and can be post-dilated to 20mm on bench testing. Although it appears ideal for implantation in pulmonary artery stenoses in children, it has been unclear whether ...
Conte Giulio G Cardiovascular Division, UZ Brussel-VUB, Laarbeeklaan 101, 1090 Brussels (Belgium). - - 2014
A 76-year-old man with history of coronary artery bypass graft surgery was referred to our department for cryoballoon ablation of symptomatic drug-resistant paroxysmal atrial fibrillation. Thick septum can complicate such procedures; we describe a useful maneuver to circumvent this problem.
Zhou Zhichao Z Erasmus University Medical Center - - 2014
Nitric oxide (NO)-induced coronary vasodilation is mediated through production of cyclic guanosine monophosphate (cGMP), and through inhibition of the endothelin-1 (ET) system. We previously demonstrated that phosphodiesterase-5 (PDE5)-mediated cGMP breakdown and ET each exert a vasoconstrictor influence on coronary resistance vessels. However, little is known about the integrated control of ...
Williams Mitchel T MT From the Department of Neurology, Children's Hospital of Michigan, Wayne State University, - - 2014
An 8-year-old girl in septic shock due to necrotizing methicillin-resistant Staphylococcus aureus (MRSA) pneumonia developed signs of end-organ damage, new right hemiplegia, and left gaze preference. Susceptibility-weighted MRI demonstrated extensive multifocal petechial hemorrhage preferentially at the gray-white matter interface due to septic microemboli (figure). Mechanisms of hemorrhage include small-vessel occlusion leading ...
Verlohren Stefan S Department of Obstetrics, Charite University Medicine Berlin, Germany; Fetal Medicine Unit, St. Georges Hospital NHS Healthcare Trust, London, United - - 2014
Uterine artery Doppler is a widely available screening tool for preeclampsia. However, the predictive accuracy for late-onset preeclampsia is low. We aimed to investigate the relationship of uterine artery Doppler and birthweight in women with early, intermediate and late preeclampsia as compared to women with uneventful pregnancy outcome. In a ...
Gottsäter M M Department of Clinical Sciences, Skåne University Hospital, Lund University, Malmö, - - 2014
Arterial stiffness is influenced by advancing age and vascular disease and is an independent risk factor for cardiovascular events and death. Using ultrasound measurements, arterial stiffness in a specific arterial segment can be assessed. The aim of this observational study was to explore the prospective and cross-sectional associations between arterial ...
El Amrani M M Department of Nephrology and Dialysis, First Medical and Surgical Center, Agadir, - - 2014
Diagnosis of chronic inflammatory syndrome is often a challenge. In dialysis patients, this condition leads to resistance to recombinant human erythropoietin (rHuEPO). We here report a case of a 72-year-old male undergoing chronic hemodialysis and developed rHuEPO resistance without any obvious etiology. Investigations showed a partially thromosed aneurysm of the ...
Yoshida Takayuki T First Department of Medicine, Hokkaido University School of Medicine, - - 2014
Severe pulmonary hypertension (PH) often develops in patients with pulmonary Langerhans cell histiocytosis (PLCH). Supplemental oxygen treatment is often used, whereas pulmonary arterial hypertension-specific vasodilators are generally considered hazardous because of the possible development of pulmonary edema and deterioration of hypoxia. In the present report, we herein describe a PLCH ...
Karagöz Ahmet A Department of Cardiology, Giresun University, Giresun, - - 2014
Ventricular septal aneurysms are rare clinical entities and their certain prevalence and clinical significance are not well known. Most of them are thought to develop during or after the closure process of the accompanying ventricular septal defects. Although a majority of the patients are typically asymptomatic, the potential risks should ...
Rieg Annette D AD Institute of Pharmacology and Toxicology, Medical Faculty of Rhenish-Westphalian Technical University Aachen, Aachen, Germany ; Department of Anesthesiology, Medical Faculty of Rhenish-Westphalian Technical University Aachen, Aachen, - - 2014
The phosphodiesterase-III inhibitor milrinone improves ventricular contractility, relaxes pulmonary arteries and reduces right ventricular afterload. Thus, it is used to treat heart failure and pulmonary hypertension (PH). However, its action on pulmonary veins (PVs) is not defined, although particularly PH due to left heart disease primarily affects the pulmonary venous ...
Martin Jeffrey S JS a Department of Biomedical Sciences, Quinnipiac University, Hamden, CT 06518, - - 2014
Enhanced external counterpulsation (EECP) improves resistance artery function in coronary artery disease patients. However, whether EECP elicits similar effects in persons with abnormal glucose tolerance (AGT) is unknown. Here we provide novel evidence that EECP significantly improves resistance arterial function in the forearm of persons with AGT, whereas the calf ...
Okamoto Yuki - - 2013
We encountered a surgical case of middle aortic syndrome (MAS) in a 56-year-old man who had resistant hypertension. Computed tomography showed severe stenosis of the abdominal aorta from below the superior mesenteric artery to above the inferior mesenteric artery. Although bilateral renal artery stenosis was confirmed, renal function was within ...
Akkus Nuri Ilker - - 2013
Saphenous vein graft (SVG) anastomotic lesions can have significant fibromuscular hyperplasia and may be resistant to balloon angioplasty alone. Stents have been used successfully to treat these lesions. There are no reports of immediate stent recoil following such treatment in the literature. We describe immediate and persistent stent recoil in ...
Bouwmeester James Christopher - - 2013
The conventional determination of pulmonary vascular resistance does not indicate which vascular segments contribute to the total resistance of the pulmonary circulation. Using measurements of pressure and flow, the reservoir-wave model can be used to partition total pulmonary vascular resistance into arterial, microcirculation, and venous components. Changes to these resistance ...
Agha Hala - - 2013
This study aimed to assess pulmonary functions before and after cardiac surgery in infants with congenital heart diseases and pulmonary overflow and to clarify which echocardiographic parameter correlates best with lung mechanics. Between 2008 and 2009, 30 infants with left-to-right shunt congenital acyanotic heart diseases who had indications for reparative ...
Matsushita Kensuke - - 2013
A 67-year-old woman was admitted with an acute coronary syndrome. Angiographic examination revealed diffuse severe stenosis of the left circumflex artery. A Pressure Wire Certus (St. Jude Medical, St. Paul, MN, USA) was passed to the second post-lateral (PL) branch. To prevent side-branch occlusion, a SION wire (Asahi Intecc Co., ...
Eleftheriou D - - 2013
Kawasaki disease (KD) is an acute self-limiting inflammatory disorder, associated with vasculitis, affecting predominantly medium-sized arteries, particularly the coronary arteries. In developed countries KD is the commonest cause of acquired heart disease in childhood. The aetiology of KD remains unknown, and it is currently believed that one or more as ...
Tabib Avisa - - 2013
This study aimed to evaluate the accuracy of Doppler echocardiography-derived indices in children with pulmonary hypertension secondary to congenital heart disease with left-to-right shunting. Doppler-derived indices including the acceleration time corrected (AcTc), deceleration time corrected, deceleration index, peak velocity, heart-rate-corrected inflection time (InTc), and a new index (the acceleration slope ...
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