Search Results
Results 1 - 50 of 2195
1 2 3 4 5 6 7 8 9 10 >
Sekiguchi Yuta Y 1] School of Integrated Design Engineering, Keio University, Yokohama, Japan [2] Molecular Imaging Center, National Institute of Radiological Sciences, Inage, Chiba, - - 2014
The pial and penetrating arteries have a crucial role in regulating cerebral blood flow (CBF) to meet neural demand in the cortex. Here, we examined the longitudinal effects of chronic hypoxia on the arterial diameter responses to single whisker stimulation in the awake mouse cortex, where activity-induced responses of CBF ...
Sirachainan Nongnuch N Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand - - 2014
High factor VIII levels and a risk factor of arterial ischemic stroke is controversial. Levels of factor VIII depend on ethnicity, age, and sex. This report included 24 Thai children with cryptogenic arterial ischemic stroke and 41 controls, with a mean (standard deviation) age of 11.5 (6.3) and 9.0 (4.7), ...
Xiao Yangming Y University of Texas at San - - 2014
Tortuous carotid arteries are often seen in aged populations and are associated with atherosclerosis, but the underlying mechanisms to explain this preference are unclear. Artery buckling has been suggested as one potential mechanism for the development of tortuous arteries. The objective of this study, accordingly, was to determine the effect ...
Butera Gianfranco G Department of Pediatric Cardiology and GUCH Unit,Policlinico San Donato - - 2014
Percutaneous treatment of aortic coarctation is a widely used option. Covered stents have increased the profile of efficacy and safety of this procedure. Here we report on a 32-year-old woman with significant aortic recoarctation associated with aortic wall aneurysm and close proximity of both lesions to the origin of both ...
Chen Zhengju Z Peking University Health Science - - 2014
Cyclic guanosine 3', 5'-monophosphate (cGMP) is considered the only mediator synthesized by soluble guanylyl cyclase (sGC) in response to nitric oxide (NO). However, purified sGC can synthesize several other cyclic nucleotides including inosine 3', 5'-cyclic monophosphate (cIMP). The present study was to determine the role of cIMP in hypoxic contractions ...
Wang Wang W Department of Physiology, Capital Medical University, Beijing, P.R. - - 2014
Hypoxia-induced pulmonary hypertension (HPH) is a clinical syndrome associated with high morbidity and mortality. However, the underlying mechanisms remain unclear. Both the mammalian target of rapamycin (mTOR) and the Notch3 signaling pathways have been reported to be involved in HPH; however, it is unknown whether there is a connection between ...
Maron Bradley A BA From the Divisions of Cardiovascular Medicine (B.A.M., S.Y.C., E.A., Y.-Y.Z., J.L., J.A.L.) and Pulmonary and Critical Care Medicine (W.M.O.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Department of Cardiology, Veterans Affairs Boston Healthcare System, Boston, MA (B.A.M.); and Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA (S.O.V.). - - 2014
The molecular mechanism(s) regulating hypoxia-induced vascular fibrosis are unresolved. Hyperaldosteronism correlates positively with vascular remodeling in pulmonary arterial hypertension, suggesting that aldosterone may contribute to the pulmonary vasculopathy of hypoxia. The hypoxia-sensitive transcription factors c-Fos/c-Jun regulate steroidogenic acute regulatory protein (StAR), which facilitates the rate-limiting step of aldosterone steroidogenesis. We ...
Kurotsu Shota S Keio - - 2014
Idiopathic pulmonary fibrosis (IPF) is thought to involve lung injury caused by reactive oxygen species (ROS), which in turn is followed by abnormal fibrosis. A transforming growth factor (TGF)- β1-induced increase in myofibroblast number plays an important role in this abnormal fibrosis. We recently found that mepenzolate bromide (mepenzolate), which ...
Wirrig Elaine E EE From The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, - - 2014
There is increasing evidence for activation of developmental transcriptional regulatory pathways in heart valve disease. Here, we review molecular regulatory mechanisms involved in heart valve progenitor development, leaflet morphogenesis, and extracellular matrix organization that also are active in diseased aortic valves. These include regulators of endothelial-to-mesenchymal transitions, such as the ...
Lannoy M M Inserm U1148, université Paris 7, hôpital Bichat-Claude-Bernard, 46, rue Henri-Huchard, 75877 Paris cedex 18, - - 2014
The main components of elastic fibers, elastin and fibrillin-containing microfibrils play a structural and mechanical role in the arteries and their essential function is to provide elasticity and resilience to the tissues. However, through control of the quiescent contractile phenotype of arterial smooth muscle cells, elastin also acts as an ...
Morini Marco Francesco MF aIFOM, FIRC Institute of Molecular Oncology bDepartment of Biosciences, University of Milan, Milan, - - 2014
The development of a functionally and anatomically correct vascular network is a complex phenomenon that requires the combined activity of different signaling pathways and transcription factors. Notch signaling activation, for instance, is crucial for arterial specification. Here, we discuss the current knowledge on how other signaling pathways cooperate with Notch ...
Liu Juan J Department of Physiology and Pathophysiology, Peking University Health Science Center, 38 Xue Yuan Road, Beijing, 100191, - - 2014
Soluble guanylyl cyclase (sGC), phosphodiesterase type 5 (PDE5), and guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase (PKG) are all dimeric. The present study was to determine the role of their dimeric status in nitric oxide-induced vasodilatation. In isolated porcine coronary arteries, after 20 h incubation with serum-free medium, serum-containing medium, or phosphate-buffered ...
Baretella Oliver O Department of Pharmacology & Pharmacy and State Key Laboratory of Pharmaceutical Biotechnology, University of Zürich, 8057 Zürich, - - 2014
Levels of the endothelium-derived peptide endothelin-1 (ET-1) are elevated in human obesity, and ET-1 mediated vascular tone is increased. Renal arterial smooth muscle is highly responsive to ET-1. Whether or not endothelium-derived ET-1 affects contractions of the renal artery under normal conditions or in obesity is unknown. The present study ...
Sinha Pranava P Department of Cardiovascular Surgery, Children's National Medical Center, Washington, - - 2014
Previous attempts to support single ventricle circulation mechanically have suggested that a custom-built assist device is needed to push, rather than pull, through the pulmonary circulation. We hypothesized that using a conventional ventricular assist device, with or without conversion of a total cavopulmonary connection to a bidirectional Glenn cavopulmonary connection, would ...
Li W W 1Center of Pediatric Cardiac Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, People's Republic of - - 2013
This study aimed to evaluate the effects of pulmonary artery perfusion with a urinary trypsin inhibitor (UTI) as a lung protective strategy in order to provide an experimental basis for immature lung clinical protective strategies on deep hypothermia with low-flow (DHLF) cardiopulmonary bypass (CPB)-induced pulmonary injury in an infant piglet ...
Shimoda Larissa A LA 1Johns Hopkins - - 2013
In the lung, acute reductions in oxygen lead to hypoxic pulmonary vasoconstriction, whereas prolonged exposures to hypoxia result in sustained vasoconstriction, pulmonary vascular remodeling and the development of pulmonary hypertension. Data from both human subjects and animal models implicates a role for hypoxia-inducible factors (HIFs), oxygen-sensitive transcription factors, in pulmonary ...
Gutierrez Jose - - 2013
Background: Circle of Willis (COW) variants might influence arterial caliber in the brain. We hypothesized that these variants would be associated with the prevalence of intracranial dolichoectasia (DE). Methods: We examined COW variants and DE in a sample of stroke-free participants (n = 436) undergoing magnetic resonance angiography (MRA) as ...
Calais Fredrik - - 2013
Percutaneous coronary intervention (PCI) of lesions in the proximal left anterior descending coronary artery (LAD) may confer a worse prognosis compared with the proximal right coronary artery (RCA) and left circumflex coronary artery (LCX). From May 2005, to May 2011 we identified all PCIs for proximal, one-vessel coronary artery disease ...
Hanninen Mikael - - 2013
The junction between the left brachiocephalic vein and the superior vena cava is a high-risk region during lead extraction. Venous laceration with hemodynamic collapse is the most feared complication arising in this region, but arteriovenous fistula formation after excimer laser extraction also has been reported. A case of arteriovenous fistula ...
Higuma Takumi - - 2013
A 90-year-old man was admitted to our hospital with acute ST-segment elevation myocardial infarction. He had a history of post-infarction angina pectoris 79months ago and had a bare-metal stent (BMS) implanted in the proximal left anterior descending artery at our hospital. Emergent coronary angiography demonstrated thrombotic occlusion in the previously ...
Vakhitov Damir - - 2013
Risk factors for early catheter-directed intra-arterial thrombolysis failure in acute lower limb ischemia remain unclear. One hundred forty-nine limbs with acute artery or bypass graft thrombosis underwent catheter-directed thrombolysis (maximum of 48 hours). A retrospective data analysis was carried out to assess possible risk factors for early, 30-day treatment failure. ...
Marinkovic Goran - - 2013
In aortic aneurysms the arterial vessel wall is dilated because of destruction of its integrity, which may lead to lethal vessel rupture. Chronic infiltration of inflammatory cells into the vessel wall is fundamental to aneurysm pathology. We aim to limit aneurysm growth by inhibition of inflammation and reducing endothelial cell ...
Yamashita Atsushi - - 2013
Background: Imaging modalities to assess atherosclerotic plaque thrombogenicity have not been established, so in this study the relationship between [(18)F]-fluorodeoxyglucose ((18)F-FDG) uptake and thrombus formation was investigated in rabbit atherosclerotic arteries. Methods and Results: Atherosclerotic plaque was induced in the iliacofemoral artery by balloon injury and a 0.5% cholesterol diet. At 3 ...
Cho Alexander H - - 2013
This case describes the use of flexible bronchoscopy and cryoadhesion in an 83-year-old man who developed large airway clots following treatment with activated factor VII for a complication of pulmonary hemorrhage during coronary artery bypass graft.
Nie Xiao-Min - - 2013
Stent thrombosis is one of severe complications after sirolimus-eluting stent implantation. Rapamycin (sirolimus) promotes arterial thrombosis in in vivo studies. However, the underlying molecular and transcriptional mechanisms of this adverse effect have not been thoroughly investigated. This study was designed to examine the effects of rapamycin on the expression of ...
Wang Xun - - 2013
Treatment of ring degloving injuries of the finger is one of the most demanding problems in hand surgery. Replantation has been advocated as the best solution if the vessels belonging to the degloved skin are not irreversibly destroyed. We present a case involving a ring finger with circumferentially avulsed skin. ...
Sacilotto Natalia N Ludwig Institute for Cancer Research Ltd, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7DQ, United - - 2013
The mechanisms by which arterial fate is established and maintained are not clearly understood. Although a number of signaling pathways and transcriptional regulators have been implicated in arterio-venous differentiation, none are essential for arterial formation, and the manner in which widely expressed factors may achieve arterial-specific gene regulation is unclear. ...
Sadasivan Chander C Department of Neurological Surgery, Stony Brook University Medical Center, 100 Nicolls Road, HSC T12, Room 080, Stony Brook, NY 11794-8122, - - 2013
Many factors that are either blood-, wall-, or hemodynamics-borne have been associated with the initiation, growth, and rupture of intracranial aneurysms. The distribution of cerebral aneurysms around the bifurcations of the circle of Willis has provided the impetus for numerous studies trying to link hemodynamic factors (flow impingement, pressure, and/or ...
Deng Yong Y Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, - - 2013
Arterial morphogenesis is one of the most critical events during embryonic vascular development. Although arterial fate specification is mainly controlled by the Notch signaling pathway, arterial-venous patterning is modulated by a number of guidance factors. How these pathways are regulated is still largely unknown. Here, we demonstrate that endothelial activation ...
Roccabianca Sara - - 2013
Spontaneous dissection of the human thoracic aorta is responsible for significant morbidity and mortality, yet this devastating biomechanical failure process remains poorly understood. In this paper, we present finite element simulations that support a new hypothesis for the initiation of aortic dissections that is motivated by extensive histopathological observations. Specifically, ...
Li Jing - - 2013
Our laboratory has previously demonstrated that 15-lipoxygenase (15-LO)/15-hydroxyeicosatetraenoic acid (15-HETE) is involved in hypoxic pulmonary arterial hypertension. Chronic hypoxia-induced vascular inflammation has been considered as an important stage in the development of pulmonary arterial hypertension. Here, we determined the contribution of 15-HETE in the hypoxia-induced pulmonary vascular inflammation. Chronic hypoxia-induced ...
Gogas Bill D - - 2013
The concept of edge vascular response (EVR) was first introduced with bare-metal stents and later with radioactive stents of various activity levels. Although radioactive stents reduced intra-stent neointimal hyperplasia and thereby the incidence of in-stent restenosis in a dose-dependent manner, tissue proliferation at the non-irradiated proximal and distal stent edges ...
Lebreton Guillaume - - 2013
Cardiopulmonary bypass (CPB) is responsible for an inflammatory response that can lead to postoperative organ dysfunction. Undernutrition increases the risk of organ failure. We investigated the effect of undernutrition on the inflammatory response and mesenteric vascular reactivity induced by CPB in rats. CPB was performed in Wistar rats given normal ...
Anderson Julia A - - 2013
Hemostasis maintains the blood in a fluid state under physiological conditions, yet enables rapid clot formation at sites of vascular injury to prevent excessive bleeding. Disruption of hemostasis can lead to thrombosis, which can occur in arteries, veins, or in the chambers of the heart. Factors contributing to thrombosis in ...
Logan Jeongok G - - 2013
Arterial stiffness is an important clinical marker of cardiovascular diseases. Although many studies have been conducted on different racial groups, less is known about arterial stiffness in Asian Americans. Korean Americans constitute the fifth largest subgroup in the Asian American population and reportedly have a noticeably high prevalence of hypertension. ...
Meyer Matthias R - - 2013
Obesity and arterial hypertension, important risk factors for atherosclerosis and coronary artery disease, are characterized by an increase in vascular tone. While obesity is known to augment vasoconstrictor prostanoid activity in endothelial cells, less is known about factors released from fat tissue surrounding arteries (perivascular adipose). Using lean controls and ...
Jiang Dong-Mei - - 2013
Endothelial dysfunction is the pathophysiological characteristic of pulmonary arterial hypertension (PAH). Some paracrine factors secreted by bone marrow-derived endothelial progenitor cells (BMEPCs) have the potential to strengthen endothelial integrity and function. This study investigated whether BMEPCs have the therapeutic potential to improve monocrotaline (MCT)-induced PAH via producing vasoprotective substances in ...
Dou Dou - - 2012
ABSTRACT: Sulfhydryl-dependent formation of interprotein disulfide bonds in response to physiological oxidative stimuli is emerging as an important mechanism in the regulation of various biological activities. Soluble guanylyl cyclase (sGC) and cGMP-dependent protein kinase (PKG) are key enzymes for actions caused by cGMP-elevating agents including nitric oxide (NO). Both sGC ...
Chen Di - - 2012
Specification of arteries and veins is a key process for establishing functional vasculature during embryogenesis and involves distinctly different signaling mechanisms. Angiogenic factor VEGFA is required for differentiation of arteries, however, the upstream angiogenic factor for vein specification is unknown. Klippel-Trenaunay syndrome (KTS) is a congenital vascular disease associated with ...
Huk Danielle J DJ Center for Cardiovascular and Pulmonary Research, Columbus, OH, - - 2013
Calcific aortic valve disease (CAVD) is a major public health problem with no effective treatment available other than surgery. We previously showed that mature heart valves calcify in response to retinoic acid (RA) treatment through downregulation of the SRY transcription factor Sox9. In this study, we investigated the effects of ...
Ye Liping - - 2012
The dimeric status of nitric oxide (NO)-sensitive soluble guanylyl cyclase (sGC) is obligatory for its catalyzing activity to synthesis the second messenger cyclic guanosine monophosphate (cGMP), which leads to vasodilatation. The present study was conducted to determine whether or not the dimerization of sGC is modulated by thiol-reducing agents and ...
Xu Jianqiang - - 2012
BACKGROUND: ALTHOUGH CARINA SHIFT AND PLAQUE SHIFT ARE SUGGESTED AS MECHANISMS OF SIDE BRANCH OSTIAL (SBO) COMPROMISE AFTER MAIN VESSEL (MV) STENTING IN BIFURCATION LESIONS, THERE ARE FEW DIRECT EVIDENCE. OUR PURPOSE WAS TO CONFIRM THE MECHANISM OF SBO COMPROMISE AFTER MV STENT IMPLANTATION.METHODS AND RESULTS: INTRAVASCULAR ULTRASOUND IMAGES OF ...
Paulin Roxane R Vascular Biology Research Group; Department of Medicine; University of Alberta; Edmonton, AB - - 2012
Pulmonary artery hypertension (PAH) is a proliferative disorder associated with enhanced pulmonary artery smooth muscle cell proliferation and suppressed apoptosis. The sustainability of this phenotype requires the activation of pro-survival transcription factor like the signal transducers and activators of transcription-3 (STAT3). Using multidisciplinary and translational approaches, we and others have ...
van Schouwenburg Inge M - - 2012
Large population-based studies are needed to establish the magnitude and duration of the recently suggested association between arterial and venous thromboembolism. In 1997-98, all inhabitants of Groningen, the Netherlands, aged 28-75 years (n = 85 421), were invited to participate in a study that followed and monitored responding subjects (n = 40 856) for venous and arterial ...
Pisano Calogera - - 2012
We aimed to identify a phenotype of ascending thoracic aortic aneurysm (TAA), which, more than others, evolves into type A dissection (TAD). Aortic specimens were obtained from patients undergoing surgical repair of TAA and TAD (108 and 26, respectively). Histopathological and immunohistochemical analyses were performed by using adequate tissue specimens, ...
Audet Audrey - - 2012
Audet A, Côté N, Couture C, Bossé Y, Després J-P, Pibarot P & Mathieu P (2012) Histopathology Amyloid substance within stenotic aortic valves promotes mineralization Aims:  Accumulation of apolipoproteins may play an important role in the pathobiology of calcific aortic valve disease (CAVD). We aimed to explore the hypothesis that ...
Howard L S LS National Pulmonary Hypertension Service (London), Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, - - 2012
We have shown previously that hypoxia inhibits the growth of distal human pulmonary artery smooth muscle cells (PASMC) isolated under standard normoxic conditions (PASMC(norm)). By contrast, a subpopulation of PASMC, isolated through survival selection under hypoxia was found to proliferate in response to hypoxia (PASMC(hyp)). We sought to investigate the ...
Min Robert J - - 2012
PurposeTo conduct a pilot study to demonstrate a novel method of using a proprietary cyanoacrylate (CA) for closure of superficial veins. MATERIALS AND METHODS: Right and left superficial epigastric veins from two swine models were utilized due to the vein's similarities with the human great saphenous vein. Under ultrasound guidance, ...
Kudlicka Jaroslav - - 2012
Purpose: Patency of mature vascular access for hemodialysis is mostly limited by the growing stenoses leading to acute access thrombosis. The therapy of choice is usually percutaneous balloon angioplasty (PTA). However, PTA injures the vessel wall and subsequent re-stenosis develops faster than de novo stenosis. Therefore, the key is in ...
Hosokawa Seiki - - 2012
PURPOSE: To explore the optimal contrast material (CM) concentration for distinguishing CM, carotid stent (CS), and neck components in cone-beam computed tomography (CBCT) during carotid angiography (CBCT-CA). MATERIALS AND METHODS: A neck phantom containing CS and contrast-filled imitation vessels of 9 mm diameter was scanned using CBCT. CM (300 mgI/ml) was used ...
1 2 3 4 5 6 7 8 9 10 >