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Virdis Agostino A aDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa bDepartment of Clinical and Molecular Medicine, Division of Cardiology, Sant'Andrea Hospital, Sapienza University of Rome, Rome cClinica Medica, University of Milano-Bicocca and IRCCS Multimedica, Sesto San Giovanni, Milan dDepartment of Angiocardioneurology, IRCCS Neuromed, Pozzilli (IS) eDepartment of Molecular Medicine, 'Sapienza' University, Rome fDepartment of Medicine and Surgery, University of Salerno, Salerno gIstituto Auxologico Italiano, Ospedale San Luca, Milan hClinica Medica, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, - - 2014
The evaluation of microvascular structure is, in general, not an easy task. Among the methods that may be applied to humans, plethysmographic evaluation of small arteries and wire or pressure micromyography were extensively used in the last decades. The media-to-lumen ratio of small arteries evaluated by micromyography was demonstrated to ...
Thilo Christian C Department of Radiology and Radiological Science, Medical University of South Carolina, 25 Courtenay Drive, MSC 226, Charleston, SC, 29401, - - 2014
To evaluate the effect of a computer-aided detection (CAD) algorithm for coronary CT angiography (cCTA) on the performance of readers with different experience levels. We studied 50 patients (18 women, 58 ± 11 years) who had undergone cCTA and quantitative coronary angiography (QCA). Eight observers with varying experience levels evaluated all studies for ...
Herman J J Department of Surgery II, Vascular and Transplantation Surgery, Palacky University,Cardiovascular Centre, Olomouc, Czech Republic - - - 2014
The aim of the paper is to determine the causes of varicose vein recurrence and, when neovascularisation is suspected, to confirm or exclude its presence and to establish its contribution to the recurrence of varicose veins. A retrospective analysis of a set of 217 legs reoperated in our department over ...
Akai T T Division of Vascular Surgery, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku - - - 2014
There are various angiographic and runoff scoring systems for evaluating stenosis and arterial occlusion in patients with peripheral artery disease (PAD). The report from the BASIL trial revealed that the Bollinger scoring system, originally designed to classify intra-arterial digital subtraction angiography (IADSA), was sensitive to differences in PAD. The purpose ...
Matsumura Yoshiki Y Department of Cardiovascular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan. Electronic address: - - 2014
Objective: Accelerated atherosclerosis occurs with a high frequency in patients with chronic kidney disease (CKD). We evaluated the association between CKD and thoracic aortic plaques using transesophageal echocardiography (TEE). Methods: This study population consisted of 297 patients who underwent TEE. Aortic plaques were evaluated in the proximal thoracic aorta (PTA) ...
Cheng Bochao B Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, PR China Department of Radiology, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, PR - - 2014
Bone subtraction computed tomography angiography (BSCTA) is better able to facilitate the detection of intracranial aneurysms adjacent to bone structures compared to conventional non-subtracted CTA (CNSCTA). However, the comparison of the diagnostic accuracy of three-dimensional (3D) and two-dimensional (2D) BSCTA and conventional CTA in evaluating intracranial aneurysms remains unclear. To ...
Clarençon Frédéric F Department of Interventional Neuroradiology, Pitié-Salpêtrière Hospital, Paris VI University, 47, Bd de l'Hôpital, 75013, Paris, France, - - 2014
The purpose of our study was to distinguish the different components of a brain arteriovenous malformation (bAVM) on 3D rotational angiography (3D-RA) using a semi-automated segmentation algorithm. Data from 3D-RA of 15 patients (8 males, 7 females; 14 supratentorial bAVMs, 1 infratentorial) were used to test the algorithm. Segmentation was ...
Ohtaka Kazuto - - 2014
BackgroundWe previously reported that arterial infarction of vital organs after lobectomy might occur only after left upper lobectomy and be caused by thrombosis in the left superior pulmonary vein stump. We hypothesized that changes in blood flow, such as blood stasis and disturbed stagnant flow, in the left superior pulmonary ...
Heo Ran R Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and the Weill Cornell Medical College, New York, NY - - 2014
Noninvasive cardiac imaging is widely used to evaluate the presence of coronary artery disease. Recently, with improvements in imaging technology, noninvasive imaging has also been used for evaluation of the presence, severity, and prognosis of coronary artery disease. Coronary CT angiography and MRI of coronary arteries provide an anatomical assessment ...
Kim Young Il YI Department of Radiology and Institute of Radiation Medicine, Seoul National University College of Medicine, Clinical Research Institute, Seoul 110-744, - - 2014
We evaluated the effect of close contact between the stent and the graft on the induction of endothelial covering on the stent graft placed over an aneurysm. Saccular abdominal aortic aneurysms were made with Dacron patch in eight dogs. The stent graft consisted of an inner stent, a expanded polytetrafluoroethylene ...
Zhi-Wei Wang W Department of Radiology,PUMC Hospital,CAMS and PUMC,Beijing - - 2014
Objective To assess the role of computed tomography angiography (CTA) using dual-source computed tomography in the preoperative evaluation of old patients scheduled for noncardiac surgery. Methods A retrospective review of the clinical data of patients who underwent CTA in our hospital between May 2011 and May 2013 was performed,and totally ...
Veeram Reddy Surendranath R SR Departments of Pediatrics, University of Texas Southwestern Medical Center, Dallas, - - 2014
This study evaluates the feasibility of delivery and deployment of low and medium molecular weight (LMW and MMW respectively) double-opposing helical (DH) poly-L-lactic acid biodegradable stent (BDS) in rabbit descending aorta (DAO). Secondary objectives were to assess patency and inflammation of stented vessels at 9 months and to investigate safety ...
Saito Kozue K From the Departments of Neurology (K.S., K.N., A.W., H.K.), Pathology (H.I.-U.), Neurosurgery (K.I.), National Cerebral and Cardiovascular Center, Osaka, Japan. - - 2014
Neovascularization associated with plaque vulnerability, particularly in the plaque shoulder, is susceptible to rupture, causing ischemic events. We aimed to use contrast-enhanced ultrasound to evaluate neovessels in carotid plaques quantitatively, focusing on plaque shoulders. Using contrast-enhanced ultrasound with perflubutane, we analyzed 50 consecutive patients who underwent carotid endarterectomy. We measured ...
Valenti Valentina V Carnegie Hill Radiology, New York, NY, USA; Department of Radiology, University "La Sapienza," Sant'Andrea Hospital, Rome, Italy. Electronic address: - - 2014
Cardiovascular magnetic resonance (CMR) has been increasingly used as an alternative method to evaluate the severity of aortic stenosis. The aim of our study was to evaluate whether the indirect measurement of the aortic gradient (Calc-PG), derived from Gorlin's formula, is a reproducible parameter for gradient assessment. Then, we evaluated ...
Nessvi Otterhag Sofia S Vascular Center, Malmö - Lund, Skåne University Hospital, Malmö SE-205 02, Sweden. Electronic address: - - 2014
To evaluate patterns of inflammatory mediators before and after elective endovascular aortic aneurysm repair (EVAR) for abdominal aortic aneurysm (AAA). Inflammatory mediators including soluble urokinase plasminogen activator (suPAR), endothelin (ET)-1, tumour necrosis factor (TNF)-α, interleukin (IL)-6, CD40 ligand (CD40L) and IgM antibodies against phosphorylcholine (IgM anti-PC), were evaluated before and ...
Su Danyan D Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Autonomous Region, PR - - 2014
Objective: To compare the safety and efficacy of warfarin plus aspirin versus aspirin alone for the treatment of children with giant coronary artery aneurysm (CAA) secondary to Kawasaki disease (KD). Methods: We searched the PubMed, EMBASE, Cochrane Library, CNKI, WANFAN and VIP databases. We selected case-controlled trials of warfarin plus ...
Yosibash Zohar Z Department of Mechanical Engineering, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel. Electronic address: - - 2014
A definitive answer to the question whether artery walls are incompressible is to our opinion not yet categorically provided. Experimental-based evidence on the level of compressibility in artery walls is not easily achieved because of the difficulties associated with the measurement of very small differences in volumes under physiological pressure ...
Ashor Ammar W AW Human Nutrition Research Centre, Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle on Tyne, UK; and College of Medicine, University of Al-Mustansiriyah, Baghdad, - - 2014
Several studies tested the effects of supplementation with antioxidant vitamins on arterial stiffness, but the results were contradictory. The aim of our study was to conduct a systematic review and meta-analysis investigating the effect of antioxidant vitamins on arterial stiffness and to determine whether the effects on arterial stiffness vary ...
Fu Chih-Yuan CY Department of Trauma and Emergency Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan. Electronic address: - - 2014
Computed tomography angiography (CTA) has been applied in imaging studies for the assessment of most abdominal and pelvic injuries in some trauma centers. However, in most institutions, CTA is not routinely performed as part of the computed tomography scan protocol. In this study, we aimed to assess the efficiency of ...
Sekiguchi Yuta Y 1] School of Integrated Design Engineering, Keio University, Yokohama, Japan [2] Molecular Imaging Center, National Institute of Radiological Sciences, Inage, Chiba, - - 2014
The pial and penetrating arteries have a crucial role in regulating cerebral blood flow (CBF) to meet neural demand in the cortex. Here, we examined the longitudinal effects of chronic hypoxia on the arterial diameter responses to single whisker stimulation in the awake mouse cortex, where activity-induced responses of CBF ...
El-Kurdi Mohammed S MS Neograft Technologies, Inc, Taunton, Massachusetts. Electronic address: - - 2014
Saphenous vein grafts (SVGs) are frequently used for multi-vessel coronary artery bypass grafting and peripheral arterial bypasses; however, the estimated 40% failure rate within the first 5 y due to intimal hyperplasia (IH) and the subsequent failure rate of 2%-4% per year pose a significant clinical problem. Here, we report a ...
Tessier Williams W Inserm UMR 837, Lille University Medical School, UDSL, University Lille Nord de France, Lille, France; Department of Digestive and Oncological Surgery, Lille University Teaching Hospital, CHULille, Lille, - - 2014
Segmental replacement of the esophagus (SRE) is challenging. Allogenic aorta (AA) has shown promising remodeling abilities when used as an esophageal substitute. The aim of this study was to evaluate the feasibility and results of esophageal replacement with fascial flap-wrapped AA segments in a novel rabbit model. Seven Geant des ...
Sirachainan Nongnuch N Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand - - 2014
High factor VIII levels and a risk factor of arterial ischemic stroke is controversial. Levels of factor VIII depend on ethnicity, age, and sex. This report included 24 Thai children with cryptogenic arterial ischemic stroke and 41 controls, with a mean (standard deviation) age of 11.5 (6.3) and 9.0 (4.7), ...
Xiao Yangming Y University of Texas at San - - 2014
Tortuous carotid arteries are often seen in aged populations and are associated with atherosclerosis, but the underlying mechanisms to explain this preference are unclear. Artery buckling has been suggested as one potential mechanism for the development of tortuous arteries. The objective of this study, accordingly, was to determine the effect ...
Butera Gianfranco G Department of Pediatric Cardiology and GUCH Unit,Policlinico San Donato - - 2014
Percutaneous treatment of aortic coarctation is a widely used option. Covered stents have increased the profile of efficacy and safety of this procedure. Here we report on a 32-year-old woman with significant aortic recoarctation associated with aortic wall aneurysm and close proximity of both lesions to the origin of both ...
Andreini Daniele D Centro Cardiologico Monzino, IRCCS Milan, Italy; Department of Clinical Sciences and Community Health, Cardiovascular Section, University of Milan, Milan, Italy. Electronic address: - - 2014
Multidetector computed tomography (MDCT) provides detailed assessment of valve annulus and iliofemoral vessels in transcatheter aortic valve replacement (TAVR) patients. However, data on diagnostic performance of MDCT coronary angiography (MDCT-CA) are scarce. The aim of the study is to assess diagnostic performance of MDCT for coronary artery evaluation before TAVR. ...
Chen Zhengju Z Peking University Health Science - - 2014
Cyclic guanosine 3', 5'-monophosphate (cGMP) is considered the only mediator synthesized by soluble guanylyl cyclase (sGC) in response to nitric oxide (NO). However, purified sGC can synthesize several other cyclic nucleotides including inosine 3', 5'-cyclic monophosphate (cIMP). The present study was to determine the role of cIMP in hypoxic contractions ...
Wang Wang W Department of Physiology, Capital Medical University, Beijing, P.R. - - 2014
Hypoxia-induced pulmonary hypertension (HPH) is a clinical syndrome associated with high morbidity and mortality. However, the underlying mechanisms remain unclear. Both the mammalian target of rapamycin (mTOR) and the Notch3 signaling pathways have been reported to be involved in HPH; however, it is unknown whether there is a connection between ...
Maron Bradley A BA From the Divisions of Cardiovascular Medicine (B.A.M., S.Y.C., E.A., Y.-Y.Z., J.L., J.A.L.) and Pulmonary and Critical Care Medicine (W.M.O.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Department of Cardiology, Veterans Affairs Boston Healthcare System, Boston, MA (B.A.M.); and Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA (S.O.V.). - - 2014
The molecular mechanism(s) regulating hypoxia-induced vascular fibrosis are unresolved. Hyperaldosteronism correlates positively with vascular remodeling in pulmonary arterial hypertension, suggesting that aldosterone may contribute to the pulmonary vasculopathy of hypoxia. The hypoxia-sensitive transcription factors c-Fos/c-Jun regulate steroidogenic acute regulatory protein (StAR), which facilitates the rate-limiting step of aldosterone steroidogenesis. We ...
Kurotsu Shota S Keio - - 2014
Idiopathic pulmonary fibrosis (IPF) is thought to involve lung injury caused by reactive oxygen species (ROS), which in turn is followed by abnormal fibrosis. A transforming growth factor (TGF)- β1-induced increase in myofibroblast number plays an important role in this abnormal fibrosis. We recently found that mepenzolate bromide (mepenzolate), which ...
Bonomo Vito V Department of Internal Medicine, Cardiovascular and Nephrologic Diseases, Department of Cardiology, Cardiovascular Diseases School of Specialization, University of - - 2014
The evaluation of coronary lesions in patients with asymptomatic carotid plaque represents a very promising line of research to assess cardiovascular risk and the possible implementation of a more aggressive prevention therapy. In this study we enrolled 102 patients with intermediate to high cardiovascular risk but no history of coronary ...
Wirrig Elaine E EE From The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, - - 2014
There is increasing evidence for activation of developmental transcriptional regulatory pathways in heart valve disease. Here, we review molecular regulatory mechanisms involved in heart valve progenitor development, leaflet morphogenesis, and extracellular matrix organization that also are active in diseased aortic valves. These include regulators of endothelial-to-mesenchymal transitions, such as the ...
Lannoy M M Inserm U1148, université Paris 7, hôpital Bichat-Claude-Bernard, 46, rue Henri-Huchard, 75877 Paris cedex 18, - - 2014
The main components of elastic fibers, elastin and fibrillin-containing microfibrils play a structural and mechanical role in the arteries and their essential function is to provide elasticity and resilience to the tissues. However, through control of the quiescent contractile phenotype of arterial smooth muscle cells, elastin also acts as an ...
Morini Marco Francesco MF aIFOM, FIRC Institute of Molecular Oncology bDepartment of Biosciences, University of Milan, Milan, - - 2014
The development of a functionally and anatomically correct vascular network is a complex phenomenon that requires the combined activity of different signaling pathways and transcription factors. Notch signaling activation, for instance, is crucial for arterial specification. Here, we discuss the current knowledge on how other signaling pathways cooperate with Notch ...
Liu Juan J Department of Physiology and Pathophysiology, Peking University Health Science Center, 38 Xue Yuan Road, Beijing, 100191, - - 2014
Soluble guanylyl cyclase (sGC), phosphodiesterase type 5 (PDE5), and guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase (PKG) are all dimeric. The present study was to determine the role of their dimeric status in nitric oxide-induced vasodilatation. In isolated porcine coronary arteries, after 20 h incubation with serum-free medium, serum-containing medium, or phosphate-buffered ...
Baretella Oliver O Department of Pharmacology & Pharmacy and State Key Laboratory of Pharmaceutical Biotechnology, University of Zürich, 8057 Zürich, - - 2014
Levels of the endothelium-derived peptide endothelin-1 (ET-1) are elevated in human obesity, and ET-1 mediated vascular tone is increased. Renal arterial smooth muscle is highly responsive to ET-1. Whether or not endothelium-derived ET-1 affects contractions of the renal artery under normal conditions or in obesity is unknown. The present study ...
Sinha Pranava P Department of Cardiovascular Surgery, Children's National Medical Center, Washington, - - 2014
Previous attempts to support single ventricle circulation mechanically have suggested that a custom-built assist device is needed to push, rather than pull, through the pulmonary circulation. We hypothesized that using a conventional ventricular assist device, with or without conversion of a total cavopulmonary connection to a bidirectional Glenn cavopulmonary connection, would ...
Yu Chang Ho CH Division of Biomedical Engineering, Chonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeonbuk 561-756, Republic of - - 2014
The effect of stent design parameters such as porosity, pore density, number of strands, and strut angle to the artery were studied in vitro using particle image velocimetry (PIV). Five mesh stents were implanted into a sidewall aneurysm model. The flow features in a sidewall aneurysm silicone phantom model were ...
Geng Chen C Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, - - 2014
Computed tomography angiography (CTA) is a major noninvasive technology for imaging coronary artery disease, and effective and accurate vessel tracking method can help radiologists diagnose the disease more accurately. In this paper, a novel 3D vessel tracking method based on CTA data is presented. The method is comprised of preprocessing, ...
Jin Ning N Department of Medicine, MedStar Union Memorial Hospital, Baltimore, MD, - - 2014
A pulmonary nodule is a single, nearly spherical, well-circumscribed pulmonary opacity up to 30 mm in diameter and surrounded by aerated lung tissue. In radiographs, pulmonary nodules may appear as solid, completely obscuring the lung parenchyma, or as subsolid, not completely obscuring adjacent tissues. A subsolid pulmonary nodule may be ...
Li W W 1Center of Pediatric Cardiac Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, People's Republic of - - 2013
This study aimed to evaluate the effects of pulmonary artery perfusion with a urinary trypsin inhibitor (UTI) as a lung protective strategy in order to provide an experimental basis for immature lung clinical protective strategies on deep hypothermia with low-flow (DHLF) cardiopulmonary bypass (CPB)-induced pulmonary injury in an infant piglet ...
Shimoda Larissa A LA 1Johns Hopkins - - 2013
In the lung, acute reductions in oxygen lead to hypoxic pulmonary vasoconstriction, whereas prolonged exposures to hypoxia result in sustained vasoconstriction, pulmonary vascular remodeling and the development of pulmonary hypertension. Data from both human subjects and animal models implicates a role for hypoxia-inducible factors (HIFs), oxygen-sensitive transcription factors, in pulmonary ...
Gutierrez Jose - - 2013
Background: Circle of Willis (COW) variants might influence arterial caliber in the brain. We hypothesized that these variants would be associated with the prevalence of intracranial dolichoectasia (DE). Methods: We examined COW variants and DE in a sample of stroke-free participants (n = 436) undergoing magnetic resonance angiography (MRA) as ...
Calais Fredrik - - 2013
Percutaneous coronary intervention (PCI) of lesions in the proximal left anterior descending coronary artery (LAD) may confer a worse prognosis compared with the proximal right coronary artery (RCA) and left circumflex coronary artery (LCX). From May 2005, to May 2011 we identified all PCIs for proximal, one-vessel coronary artery disease ...
Hanninen Mikael - - 2013
The junction between the left brachiocephalic vein and the superior vena cava is a high-risk region during lead extraction. Venous laceration with hemodynamic collapse is the most feared complication arising in this region, but arteriovenous fistula formation after excimer laser extraction also has been reported. A case of arteriovenous fistula ...
Higuma Takumi - - 2013
A 90-year-old man was admitted to our hospital with acute ST-segment elevation myocardial infarction. He had a history of post-infarction angina pectoris 79months ago and had a bare-metal stent (BMS) implanted in the proximal left anterior descending artery at our hospital. Emergent coronary angiography demonstrated thrombotic occlusion in the previously ...
Guan Jingxia J Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, PR - - 2013
Transcranial Doppler (TCD) ultrasound is a noninvasive, safe and cost-effective bedside test for evaluating cerebrovascular circulation in real time. It has been rapidly evolving from a simple noninvasive diagnostic tool to an imaging model with a broad spectrum of clinical applications. TCD can show the spectral flow waveforms, blood flow ...
Vakhitov Damir - - 2013
Risk factors for early catheter-directed intra-arterial thrombolysis failure in acute lower limb ischemia remain unclear. One hundred forty-nine limbs with acute artery or bypass graft thrombosis underwent catheter-directed thrombolysis (maximum of 48 hours). A retrospective data analysis was carried out to assess possible risk factors for early, 30-day treatment failure. ...
Marinkovic Goran - - 2013
In aortic aneurysms the arterial vessel wall is dilated because of destruction of its integrity, which may lead to lethal vessel rupture. Chronic infiltration of inflammatory cells into the vessel wall is fundamental to aneurysm pathology. We aim to limit aneurysm growth by inhibition of inflammation and reducing endothelial cell ...
Yamashita Atsushi - - 2013
Background: Imaging modalities to assess atherosclerotic plaque thrombogenicity have not been established, so in this study the relationship between [(18)F]-fluorodeoxyglucose ((18)F-FDG) uptake and thrombus formation was investigated in rabbit atherosclerotic arteries. Methods and Results: Atherosclerotic plaque was induced in the iliacofemoral artery by balloon injury and a 0.5% cholesterol diet. At 3 ...
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