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Siemelink Marten Antoon MA Laboratory of Experimental Cardiology, University Medical Center Utrecht, Heidelberglaanes 100 Room G02.523, PO Box 85500, 3508 GA, Utrecht, The Netherlands, - - 2014
The last years have witnessed tremendous technical advances in the field of transcriptomics that enable the simultaneous assessment of nearly all transcripts expressed in a tissue at a given time. These advances harbor the potential to gain a better understanding of the complex biological systems and for the identification and ...
Yamawaki-Ogata Aika A Aika Yamawaki-Ogata, Xian-Ming Fu, Akihiko Usui, Yuji Narita, Department of Cardiac Surgery, Nagoya University Graduate School of Medicine, Nagoya 466-8550, - - 2014
An aortic aneurysm (AA) is a silent but life-threatening disease that involves rupture. It occurs mainly in aging and severe atherosclerotic damage of the aortic wall. Even though surgical intervention is effective to prevent rupture, surgery for the thoracic and thoraco-abdominal aorta is an invasive procedure with high mortality and ...
Davis Frank M FM Saha Cardiovascular Research Center, University of Kentucky, Lexington, Kentucky, - - 2014
Aneurysms are common in the abdominal and thoracic regions of the aorta. While generally asymptomatic, progression of aneurysms is associated with the devastating consequences of aortic rupture. Current therapeutic options to prevent rupture are restricted to surgical repair, as there remains a lack of validated pharmaceutical approaches. Absence of proven ...
Lin Albert A aDepartment of Medicine bDepartment of Medicine, Division of Cardiology, Alpert Medical School of Brown University, Rhode Island Hospital, Providence, Rhode Island, - - 2014
A pseudoaneurysm of the mitral-aortic intervalvular fibrosa is a rare but potentially fatal complication seen primarily in the context of infective endocarditis. In this study, we discuss a case of infective endocarditis that was complicated by the rupture of a pseudoaneurysm of the mitral-aortic intervalvular fibrosa. We review the salient ...
Dou Ning-Ning - - 2014
Although neurovascular confliction was believed to be the cause of hemifacial spasm (HFS), the mechanism of the disorder remains unclear to date. Current theories, merely focusing on the facial nerve, have failed to explain the clinical phenomenon of immediate relief following a successful microvascular decompression surgery (MVD). With the experience ...
Wang Yutang Y The Vascular Biology Unit, Queensland Research Centre for Peripheral Vascular Disease, School of Medicine and Dentistry, James Cook University, Townsville, Queensland 4811, - - 2014
Subarachnoid hemorrhage secondary to rupture of an intracranial aneurysm is a highly lethal medical condition. Current management strategies for unruptured intracranial aneurysms involve radiological surveillance and neurosurgical or endovascular interventions. There is no pharmacological treatment available to decrease the risk of aneurysm rupture and subsequent subarachnoid haemorrhage. There is growing ...
Tullius Thomas G TG Jr Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX, - - 2014
Arteriovenous malformations (AVM) of the uterus can cause life-threatening hemorrhage. Unexplained, heavy vaginal bleeding in a reproductive age woman should raise suspicion for an AVM. Here a 37-year-old woman had increasingly severe vaginal bleeding for 15 days. Serum β-hCG was elevated. Two-dimensional transvaginal ultrasound suggested retained products of conception. Before ...
Spentzouris Georgios G Department of Anatomical Sciences, School of Medicine, St. George's University, St. George's, Grenada, West - - 2014
Anomalies in the course and drainage of the Inferior Vena Cava (IVC) may complicate normal functioning, correct diagnosis, and therapeutic interventions within the abdomen. Development of the IVC occurs during the 4th to 8th week of gestation, and due to its developmental complexity, there are many opportunities for malformations to ...
Nakamura Yuichi Y Department of Cardiology and Hematology, Fukushima Medical - - 2014
An 82 years-old man with intermittent claudication was admitted to our hospital. Computed tomography angiography showed his right superficial femoral artery (SFA) was chronic total occlusion (CTO), and we performed endovascular treatment (EVT). We advanced a guide-wire by contralateral transfemoral approach, but guide-wires could not penetrate the occluded SFA lesion ...
Zhao Junjie - - 2014
Stroke or cerebral vascular accidents is among the leading causes of death in the world. With the availability of Digital Subtraction Angiography, transluminal angioplasty has become feasible in many situations and the role of intracranial stents is becoming ever more important in the management of cerebral vascular diseases. In current ...
Salmasi Shima - - 2014
Intracranial aneurysms are present in 1-5% of population and can be described as "ticking time bombs" that can go off at any time and cause serious harms including permanent disability and death. There are two routinely practiced treatment options for this disease; endovascular coiling and surgical clipping. In recent years ...
Jardim Carlos C Pulmonary Circulation Unit, Pulmonary Division, Heart Institute, University of Sao Paulo Medical School, Sao Paulo, - - 2014
To understand the rational of establishing a goal-oriented therapy for pulmonary arterial hypertension management. During the last decades, the development of targeted therapies and the recognition of prognostic markers represented a major step for improving pulmonary arterial hypertension survival. Now, changing the strategy on using these compounds therapies might represent ...
Dickinson Michael G MG Center for Congenital Heart Diseases, Department of Pediatric Cardiology, Beatrix Children's Hospital and Laboratory CardioVascular Center, GUIDE, University Medical Center Groningen, University of Groningen, the - - 2014
Pulmonary arterial hypertension (PAH) is characterized by development of unique neointimal lesions in small pulmonary arteries, leading to increased right ventricular (RV) afterload and -failure. Novel therapeutic strategies are needed that target these neointimal lesions. Recently, the transcription factor Egr-1 was demonstrated to be upregulated early in experimental neointimal PAH. ...
Birns Jonathan J Department of Ageing & Health, St Thomas' Hospital, London, United Kingdom; Department of Stroke Medicine, King's College Hospital, London, United Kingdom. Electronic address: - - 2014
Following the development of intravenous thrombolysis as a successful treatment for ischaemic stroke, advances in neurointerventional radiology have facilitated endovascular approaches to treatment. This article reviews the available endovascular therapeutic options and their evidence-base. Initial studies demonstrated that endovascular treatment of ischaemic stroke with intra-arterial thrombolysis and/or the use of ...
Dias N V NV Vascular Center, Skånes University Hospital, Malmö, Sweden - - - 2014
This article reviews the solutions for the revascularization of the left subclavian artery during TEVAR. Open surgical revascularization has been the predominant technique used but recent developments may lead to an increasing role of the endovascular revascularization. The different open and endovascular technical options are discussed and the results summarized.
LeFevre Michael L - - 2014
Update of the 2007 U.S. Preventive Services Task Force (USPSTF) recommendation on screening for carotid artery stenosis. The USPSTF commissioned a systematic review to synthesize the evidence on the accuracy of screening tests, externally validated risk stratification tools, the benefits of treatment of asymptomatic carotid artery stenosis with carotid endarterectomy ...
Pérez-Riera Andres Ricardo AR Cardiology Discipline, ABC Medical Faculty, ABC Foundation, Santo André, São Paulo, - - 2014
A 44-year-old man with aortic valve insufficiency and stenosis underwent aortic valve replacement depicting interesting ECG changes. This unique case is discussed, contributing to the understanding of a trifascicular left intraventricular conduction system.
Buell Thomas J TJ University of Virginia, Department of Neurosurgery, P.O. Box 800212, Charlottesville, VA 22908, USA. Electronic address: - - 2014
Endovascular occlusion of cerebral arteriovenous malformations (AVM) is often utilized as adjunctive therapy in combination with radiosurgery or microsurgery. Evidence supports that partial occlusion of AVM via endovascular embolization leads to increased angiogenesis. This phenomenon may be a contributing factor to the decreased efficacy of AVM radiosurgery following embolization. We ...
Fineschi Massimo M Department of Cardiovascular Diseases, University Hospital Santa Maria alle Scotte, Siena, Italy *Massimo Fineschi and Flavio D'Ascenzi contributed equally to the writing of this - - 2014
Angiographic diagnosis and treatment of spontaneous coronary artery dissection is challenging. Complementary use of intracoronary imaging can provide information to guide percutaneous treatments, particularly in these challenging settings. Here we report a case of a 52-year-old woman presenting with an anterior ST-segment elevation myocardial infarction caused by a spontaneous, long, ...
Sizarov Aleksander A Center for Congenital Heart Defects, UMC Groningen, Netherlands - - 2014
To provide comprehensive illustrations of anatomy of the relevant vessels in large experimental animals in an interactive format as preparation for developing an effective and safe transcatheter technique of aortopulmonary and bidirectional cavopulmonary intervascular anastomoses. Computed tomographic angiographic studies in two calves and two sheep were used to prepare 3D ...
Nossek Erez E Department of Neurosurgery, Hofstra North Shore-Long Island Jewish School of Medicine, and North Shore-Long Island Jewish Health System, Manhasset, New York, - - 2014
Postoperative drawings of aneurysms serve as visual records and teaching tools for neurosurgeons and reinforce 3D vascular configurations that are specific for different cerebral aneurysms. This report brings this time-honored tradition back into focus in the digital era, and examines our experience with this technique, particularly in respect to the ...
Pancholy Samir B SB The Wright Center for Graduate Medical Education, The Commonwealth Medical College, Scranton, PA, USA, - - 2014
Radial artery occlusion (RAO) is the most common structural consequence of transradial access (TRA) with an estimated incidence ranging from 2-10 %. Its occurrence is free of any major clinical consequences, especially at rest, with most if not all cases of digital ischemia occurring as a result of embolization, rather than ...
Chatterjee Soumya S Department of Rheumatic and Immunologic Diseases, Orthopedic and Rheumatology Institute, Cleveland Clinic, 9500 Euclid Avenue, Desk A50, Cleveland, OH, 44195, USA, - - 2014
Takayasu arteritis (TA) is 1 of the 2 main causes of large vessel vasculitides (LVV), giant cell arteritis being the other. LVV can also develop in various other systemic diseases. In TA, a wide variety of symptoms result from vascular stenoses, occlusions, and dilation. Aneurysms may develop and may occasionally ...
Goubergrits Leonid L Biofluid Mechanics Laboratory, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, - - 2014
Coils and flow diverters or stents are devices successfully used to treat cerebral aneurysms. Treatment aims to reduce intra-aneurysmal flow, thereby separating the aneurysmal sac from the blood circulation. The focus and this manuscript combining literature review and our original research is an analysis of changes in aneurysmal hemodynamics caused ...
Gorla Riccardo R aCardiology Clinic and University of Insubria, Ospedale di Circolo e Fondazione Macchi, Varese bCardiology and Coronary Intensive Care Unit, IRCCS San Raffaele Hospital and Vita-Salute San Raffaele University, Milan, - - 2014
Drug-eluting stents (DESs) are known to reduce in-stent restenosis rate, compared with bare metal stents (BMSs). Stent thrombosis, one of the most dangerous complications of DES, has emerged as a major concern. This issue has limited the use of DES in unstable coronary artery disease till recent years. In fact, ...
Wollersheim Laurens W LW Department of Cardiothoracic Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The - - 2014
In this review, we discuss the current surgical treatment for aortic valve stenosis. Surgical strategy for treatment of aortic valve stenosis is based on the risk profile of the patient. We reviewed the existing literature and present the current state of the art of these various approaches, taking into account ...
George Isaac I Division of Cardiothoracic Surgery, Columbia College of Physicians and Surgeons, New York Presbyterian Hospital, New York, New York. Electronic address: - - 2014
We describe our experience using the Edwards Sapien transfemoral Retroflex 3 catheter delivery system for transcatheter aortic valve replacement through the transapical and transaortic approaches. Transthoracic transcatheter valve replacement by the transapical and transaortic approaches can be safely and effectively performed with the Retroflex 3 delivery catheter, which affords several ...
Mokin Maxim M Department of Neurosurgery, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA; Department of Neurosurgery, Gates Vascular Institute, Kaleida Health, Buffalo, NY, - - 2014
Endovascular intra-arterial therapy is reserved for strokes from large vessel occlusion. This article reviews the critical role of the location of the occlusion, extent and characteristics of the occlusive thrombus on noninvasive imaging, and identification of ischemic core and salvageable tissue on perfusion imaging for proper patient selection. The advantages ...
Baggott Christopher D CD Department of Neurological Surgery, University of Wisconsin Hospital and Clinics, 600 Highland Avenue, Madison, WI 53792, - - 2014
Cerebral vasospasm causes delayed ischemic neurologic deficits after aneurysmal subarachnoid hemorrhage. This is a well-established clinical entity with significant associated morbidity and mortality. The underlying patholphysiology is highly complex and poorly understood. Large-vessel vasospasm, autoregulatory dysfunction, inflammation, genetic predispositions, microcirculatory failure, and spreading cortical depolarization are aspects of delayed neurologic ...
Eller Jorge L JL Department of Neurosurgery, University at Buffalo, State University of New York, Buffalo, NY, USA; Department of Neurosurgery, Gates Vascular Institute, Kaleida Health, Buffalo, NY, USA; Cerebrovascular Neurosurgery, PeaceHealth Sacred Heart Medical Center, 333 Riverbend Drive, Springfield, OR 97477, - - 2014
Carotid artery angioplasty and stenting (CAS) has experienced an astonishing rate of development over the last 2 decades, becoming a viable alternative to carotid endarterectomy (CEA) in the management of carotid stenosis. Many trials have attempted to compare both treatment modalities and establish indications for each, depending on clinical and ...
Serrone Joseph C JC Department of Neurosurgery, UC College of Medicine, Cincinnati, OH, - - 2014
Unlike saccular or berry aneurysms, which present more often with subarachnoid hemorrhage, fusiform aneurysms present more often with ischemic stroke or mass effect. The most time-tested treatment of fusiform vertebrobasilar aneurysms consists of flow reduction or flow reversal. Recently, flow diversion has been attempted with mixed results in the posterior ...
Hadjimiltiades Stavros S Department of Cardiology, AHEPA University Hospital, Thessaloniki, - - 2014
We describe the successful closure of an aortic paravalvular bioprosthetic valve leak with the simultaneous percutaneous deployment of two vascular plugs.
Choudhri O O Neurosurgery, Stanford University, Palo Alto, CA, - - 2014
Placement of external ventricular drains is a common, life-saving neurosurgical procedure indicated across a variety of settings. While advances have made the procedure quite safe, the potential for iatrogenic morbidity and mortality continues. Herein, we document our experience with the endovascular management of three pseudoaneurysms associated with EVD placement. We ...
Tanweer O O New York University, New York, NY, - - 2014
Cerebral aneurysms (CAs) and abdominal aortic aneurysms (AAAs) are both degenerative vascular pathologies that manifest as an abnormal dilation of the arterial wall. They arise with different morphologies in different types of blood vessels under different haemodynamic conditions. Although these aneurysms are treated as very different and separate pathologies, we ...
Rocchiccioli S S Institute of Clinical Physiology of CNR, Pisa, - - 2014
A major drawback in atherogenesis research is the difficulty of investigating early phase of disease in the clinical context. A high-cholesterol diet animal model of coronary artery disease was exploited in order to characterized by histomorphometry early stages of disease and to identify plaque-related markers of accelerated atherogenesis. The comparison ...
Sen Shurjo K SK National Human Genome Research Institute, NIH, Bethesda, MD 20892, - - 2014
Coronary artery calcification (CAC) is a heritable and definitive morphologic marker of atherosclerosis that strongly predicts risk for future cardiovascular events. To search for genes involved in CAC, we used an integrative transcriptomic, genomic, and protein expression strategy by using next-generation DNA sequencing in the discovery phase with follow-up studies ...
Spacek M M Dpt. of Cardiology, University Hospital Motol, - - 2014
Since its introduction in 1982, transcranial Doppler ultrasound (TCD) has become an important diagnostic and monitoring tool and its usefulness has been well established in many clinical applications. In carotid artery stenting (CAS), TCD has mostly been reserved for the optimization of emboli protection devices. Currently, with increasing use of ...
Rojas-Marte Geurys G Department of Medicine, Maimonides Medical Center, Brooklyn, NY, USA - - 2014
A 63-year-old female was diagnosed with severe aortic stenosis, who underwent a diagnostic coronary angiography via transradial approach prior an aortic-valve replacement. After imaging the left coronary system, entrapment of the diagnostic catheter was encountered as a result of spasm of the radial artery. An arteriogram of the arm revealed ...
Rabinovitch Marlene M From the Cardiovascular Institute and Department of Pediatrics (M.R.) and Department of Medicine (M.R.N.), Stanford University School of Medicine, CA; INSERM UMR_S 999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis-Robinson and Université Paris-Sud, School of Medicine, Le Kremlin-Bicêtre (C.G., M.H.); and AP-HP, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, Hôpital de Bicêtre, France (M.H.). - - 2014
This review summarizes an expanding body of knowledge indicating that failure to resolve inflammation and altered immune processes underlie the development of pulmonary arterial hypertension. The chemokines and cytokines implicated in pulmonary arterial hypertension that could form a biomarker platform are discussed. Pre-clinical studies that provide the basis for dysregulated ...
Paulin Roxane R From the Department of Medicine, University of Alberta, Edmonton, Alberta, - - 2014
Numerous molecular abnormalities have been described in pulmonary arterial hypertension (PAH), complicating the translation of candidate therapies to patients because, typically, 1 treatment addresses only 1 abnormality. The realization that in addition to pulmonary artery vascular cells, other tissues and cells are involved in the syndrome of PAH (eg, immune ...
Perez Vinicio de Jesus VD Division of Pulmonary and Critical Care Medicine, Stanford University Medical Center, 300 Pasteur Drive Grant S140B, Stanford, CA 94305, USA. Electronic address: - - 2014
Pulmonary arterial hypertension (PAH) is a life-threatening disorder that is associated with elevated pulmonary pressures and right heart failure resulting from progressive loss and thickening of small pulmonary arteries. Despite their ability to improve symptoms, current therapies fail to prevent disease progression, leaving lung transplantation as the only therapy in ...
Martin David M DM Department of Mechanical Engineering, Dublin Institute of Technology, Bolton Street, Dublin 1, - - 2014
In many computational fluid dynamics (CFD) studies of stented vessel haemodynamics, the geometry of the stented vessel is described using non-deformed (NDF) geometrical models. These NDF models neglect complex physical features, such as stent and vessel deformation, which may have a major impact on the haemodynamic environment in stented coronary ...
Georgakarakos Efstratios E Department of Vascular Surgery, University Hospital of Alexandroupolis, "Democritus" University of Thrace, Alexandroupolis, Greece, - - 2014
Endovascular aneurysm repair (EVAR) is considered to be the treatment of choice for abdominal aortic aneurysms (AAA). Despite the initial technical success, EVAR is amenable to early and late complications, among which the migration of the endograft (EG) with subsequent proximal endoleak (Type Ia) leads to repressurization of the AAA ...
Taichman Darren B - - 2014
Choices of pharmacological therapies for pulmonary arterial hypertension (PAH) are ideally guided by high-level evidence. Provide clinicians advice regarding pharmacologic therapy for adult patients with PAH as informed by available evidence. This guideline was based on systematic reviews of English language evidence published between 1990 and November 2013, identified using ...
Sagar Jayesh - - 2014
Aneurysms infra-patellar region are uncommon. Of them, true aneurysms are very rare and that of posterior tibial artery are extremely rare. The more common, pseudoaneurysms are commonly associated with trauma whereas the true ones are linked with either inflammatory or mycotic origins.Case Presentation: We reported another case of true aneurysm ...
Kamtchum Tatuene J J From the Neurology Division (J.K.T., P.P., A.K.), Department of Clinical Neurosciences; Hyperbaric Medicine Centre (R.P.), Department of Emergency Medicine; and Neuroradiology Division (K.O.L., M.I.V.), Department of Imaging and Medical Information Sciences, Geneva University Hospitals, Geneva, - - 2014
Diving-related decompression illness is classified into 2 main categories: arterial gas embolism and decompression sickness. The latter is further divided into types 1 and 2, depending on the clinical presentation. MR imaging is currently the most accurate neuroimaging technique available for the detection of brain and spinal cord lesions in ...
Yagel Simcha S Division of Obstetrics and Gynecology, Hadassah-Hebrew University Medical Centers, Jerusalem, - - 2014
Scanning of the fetal venous system is a necessary part of complete fetal organ scanning to confirm landmark anatomy such as the ductus venosus, course of the umbilical veins, etc, and whenever cardiovascular anomalies are identified, to exclude associated anomalous development of the fetal veins. We aimed to develop a ...
Bertanha Matheus M Department of Surgery and Orthopedics, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, SP, Brazil; Blood Transfusion Center, Cell Engineering Lab., Botucatu Medical School, São Paulo State University (UNESP), Botucatu, SP, Brazil. Electronic address: - - 2014
Clinical experience for peripheral arterial disease treatment shows poor results when synthetic grafts are used to approach infrapopliteal arterial segments. However, tissue engeneering may be an option to yield surrogate biocompatible neovessels. Thus, biological decellularized scaffolds could provide natural tissue architecture to use in tissue engineering, when the absence of ...
Liu Qin Q Department of Mechanical Engineering, University of Texas at San Antonio, San Antonio, TX 78249, - - 2014
Artery bent buckling has been suggested as a possible mechanism that leads to artery tortuosity, which is associated with aging, hypertension, atherosclerosis, and other pathological conditions. It is necessary to understand the relationship between microscopic wall structural changes and macroscopic artery buckling behavior. To this end, the objectives of this ...
Qi Xing-Shun XS Xing-Shun Qi, Ming Bai, Zhi-Ping Yang, Dai-Ming Fan, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an 710032, Shaanxi Province, - - 2014
Nowadays, transjugular intrahepatic portosystemic shunt (TIPS) has become a mainstay treatment option for the management of portal hypertension-related complications in liver cirrhosis. Accumulated evidence has shown that its indications are being gradually expanded. Notwithstanding, less attention has been paid for the selection of an appropriate stent during a TIPS procedure. ...
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