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Results 301 - 350 of 1933
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Chester Adrian H - - 2014
The aortic valve lies in a unique hemodynamic environment, one characterized by a range of stresses (shear stress, bending forces, loading forces and strain) that vary in intensity and direction throughout the cardiac cycle. Yet, despite its changing environment, the aortic valve opens and closes over 100,000 times a day ...
Rama-Merchan Juan Carlos JC Cardiovascular Biomedical Research Unit, Royal Brompton Hospital and Harefield Trust, London, United - - 2014
Fully bioresorbable vascular scaffolds (BVS) are a new approach to the percutaneous treatment of coronary artery disease. The BVS have not yet been fully tested in complex lesions, including chronic total occlusion (CTO). We report a CTO case successfully treated with a second-generation bioabsorbable drug-eluting scaffold.
Kiuchi Ryuta R Department of General and Cardiothoracic Surgery, Kanazawa University, Kanazawa, Japan. Electronic address: - - 2013
It is important for coronary active perfusion systems to avoid myocardial ischemia during off-pump coronary artery bypass grafting. We have developed a new concept for a perfusion system to pump blood based on changes in helium gas volume. This system uses a conventional intra-aortic balloon pump to activate the perfusion ...
Odobescu Andrei A Department of Surgery, University of Montreal, Montreal, QC, - - 2013
To assess the utility of the Thiel arterial model in microsurgical research, we compared interrupted horizontal mattress (HM) sutures to simple interrupted (SI) sutures in human vessels. A microsurgical set-up using an operating microscope and Thiel-embalmed arteries was used to practice ten SI and HM anastomoses. Vessel patency, leak and ...
Penumatsa Krishna C KC 1Tufts Medical - - 2013
The monoamine, serotonin (5-HT), has been previously implicated in pulmonary arterial remodeling and is considered a therapeutic target for the disease pulmonary arterial hypertension. More recently, it has been recognized that the enzyme tissue transglutaminase (TG2) mediates cross linking of proteins with 5-HT, a posttranslational process of monoaminylation known as ...
Sun Zhonghua Z Zhonghua Sun, Discipline of Medical Imaging, Department of Imaging and Applied Physics, Curtin University, Perth, Western Australia 6845, - - 2013
Rapid technological developments in computed tomography (CT) imaging technique have made coronary CT angiography an attractive imaging tool in the detection of coronary artery disease. Despite visualization of excellent anatomical details of the coronary lumen changes, coronary CT angiography does not provide hemodynamic changes caused by presence of plaques. Computational ...
Vandecasteele T T Department of Morphology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820, Merelbeke, - - 2013
The layout of the porcine atriopulmonary junction and immediately adjacent structures was investigated by gross anatomical and vascular corrosion casting studies to meet the need for more in-depth anatomical insights when using the pig as an animal model in the development of innovative approaches for surgical cardiac ablation in man. ...
Bujak Renata - - 2013
Pulmonary embolism (PE) is a common cardiovascular emergency which can lead to pulmonary hypertension (PH) and right ventricular failure as a consequence of pulmonary arterial bed occlusion. The diagnosis of PE is challenging due to non-specific clinical presentation what results in relatively high mortality. Moreover, the pathological factors associated with ...
Romo Aaron A Center for Biomedical and Healthcare Engineering, Ecole Nationale Supérieure des Mines de Saint-Etienne, CIS-EMSE, CNRS:UMR5146, LCG, 158 Cours Fauriel, 42023 Saint Etienne, France. Electronic address: - - 2013
In this study, bulge inflation tests were used to characterize the failure response of 15 layers of human ascending thoracic aortic aneurysms (ATAA). Full field displacement data were collected during each of the mechanical tests using a digital image stereo-correlation (DIS-C) system. Using the collected displacement data, the local stress ...
Tuder Rubin M RM Program in Translational Lung Research, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado. Electronic address: - - 2013
Knowledge of the pathobiology of pulmonary hypertension (PH) continues to accelerate. However, fundamental gaps remain in our understanding of the underlying pathological changes in pulmonary arteries and veins in the different forms of this syndrome. Although PH primarily affects the arteries, venous disease is increasingly recognized as an important entity. ...
Iqbal Javaid J Thorax Centre, Erasmus Medical Centre, Rotterdam, the - - 2013
Current generation of drug-eluting stents has significantly improved the outcomes of percutaneous coronary intervention by substantially reducing in-stent restenosis and stent thrombosis. However, a potential limitation of these stents is the permanent presence of a metallic foreign body within the artery, which may cause vascular inflammation, restenosis, thrombosis, and neoatherosclerosis. ...
Ricci Stefano S All the authors are affiliated with Area di Geriatria, Centro per la Salute dell'Anziano, Universita Campus Bio-Medico di Roma, Roma, - - 2013
This review aims to summarize present knowledge of foot venous return, with a special interest in clinical and research implications. It is based on the latest available publications on foot anatomy and hemodynamics. Five systems are described: the superficial veins of the sole, the deep veins of the sole (with ...
Sexton Travis T Division of Cardiovascular Medicine, The Gill Heart Institute, University of Kentucky, 255 BBRSB, 741 S. Limestone Street, Lexington, KY, 40536-0200, - - 2013
Spurred by advances in understanding the molecular basis of thrombosis, this issue of the Journal of Thrombosis and Thrombolysis is devoted to exploring aspects of novel paradigms and their potential impact on diagnosis and treatment. Complex interplay between blood and vascular cells, inflammation, and pro- and anti-coagulant pathways determines the ...
Mallios Alexandros A Department of Vascular Surgery, Institut Mutualiste Montsouris, Paris, France; Department of Surgery, University of Oklahoma, Tulsa, OK. Electronic address: - - 2013
Preservation of native arteriovenous fistulas (AVFs) in the long term can be technically challenging. Various anatomic or functional problems can occur and multiple open and/or endovascular interventions may be required for extended preservation of native accesses. In this report, we review vascular access maintenance in a 72-year-old woman during a ...
Scott Daniel J - - 2013
Sources of lower extremity and visceral arterial thromboembolism most commonly include the heart and proximal aneurysmal disease. Infrequently, further workup of "cryptogenic" emboli will reveal a mural atheroma or thrombus of the descending thoracic aorta. Without prospective data, anticoagulation and open surgical thrombectomy with or without aortic replacement have been ...
Hetts Steven W SW Department of Radiology and Biomedical Imaging; University of California; San Francisco, CA, USA - - - 2013
We describe a unique case of bilateral cervical spinal dural arteriovenous fistulas mimicking an intracranial dural arteriovenous fistula near the foramen magnum. We review its detection via MRI and digital subtraction angiography and subsequent management through surgical intervention. Pitfalls in diagnostic angiography are discussed with reference to accurate location of ...
Kutty Shelby S Division of Pediatric Cardiology, University of Nebraska College of Medicine, Children's Hospital and Medical Center, Omaha, - - 2013
Congenital mitral valve abnormalities are rare and cause mitral stenosis, regurgitation, or a combination of the two. Three-dimensional echocardiography has provided new insight into the structure and function of both normal and abnormal mitral valves. Three-dimensional imaging permits accurate anatomic diagnosis and enhances two-dimensional echocardiographic data. Moreover, it enables echocardiographers ...
Chen Michael - - 2013
Ruptured and thrombosed cerebral aneurysms pose a risk for rebleeding that may go undetected because they are angiographically occult. The presence of multiple aneurysms may further complicate efforts in accurately identifying the true source because their treatment may circumvent further necessary investigations. This case series and literature review illustrates the ...
Baragetti A A Center for the Study of Atherosclerosis, Bassini Hospital, Cinisello Balsamo, Milan, Italy; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, - - 2013
Pentraxin 3 (PTX3) is an essential component of the humoral arm of innate immunity and, like C-reactive protein, is independently associated with the risk of developing vascular events. Aim of this study was to investigate, in two large population-based surveys, the Bruneck Study and the PLIC Study, whether PTX3 plasma ...
Medda E E Istituto Superiore di Sanità, National Centre for Epidemiology, Surveillance and Health Promotion, Genetic Epidemiology Unit, Viale Regina Elena 299, 00161 Rome, - - 2013
Carotid intima-media thickness (IMT) and arterial stiffness parameters, including aortic augmentation index (AIx) and pulse wave velocity (PWV), are independent predictors of stroke and cardiovascular disease. Genetic effects on these traits were never explored in a Mediterranean country. The present study aims to quantify the contribution of genes, environment and ...
Pfannmüller Bettina - - 2013
Repair of anterior mitral leaflet prolapse is one of the most challenging aspects in mitral valve repair surgery. In this review, we discuss the various techniques developed over the past three to four decades for the repair of anterior mitral leaflet prolapse, debate the pros and cons of each and ...
Bleiziffer S - - 2013
TAVI (transcatheter aortic valve implantation) is a less invasive treatment of the stenotic aortic valve while avoiding midline sternotomy and cardiopulmonary bypass. A crimped biological valve on a self-expanding or balloon-expandable stent is inserted antegradely or retrogradely under fluoroscopy, and deployed on the beating heart. Among the worldwide TAVI programs, ...
O'Connell Caroline - - 2013
Available targeted therapies for pulmonary arterial hypertension are capable only of slowing progression of the disease and a cure remains elusive. However with the improved understanding of the pulmonary vascular remodeling that characterizes the disease, there is optimism that the disconnect between preclinical and clinical studies may be bridged with ...
Galiè Nazzareno - - 2013
Pulmonary arterial hypertension (PAH) is a fatal disease associated with vasoconstriction and vascular remodelling. There are three well-known pathways that contribute to the pathogenesis of PAH: endothelin, nitric oxide and prostacyclin. Treatments targeting these pathways are well established in clinical practice, such as endothelin receptor antagonists, phosphodiesterase type-5 inhibitors and ...
Mahmud Shahid - - 2013
Takayasu arteritis is a systemic vasulitis of large vessels that mainly involves the aorta and its branches. It normally presents in third decade of life and has rarely been reported in children under 10 years of age. We report here a case of Takayasu arteritis in a 5 years old ...
Cozijnsen L L Department of Cardiology, Gelre Hospital, Albert Schweitzerlaan 31, 7334 DZ, Apeldoorn, the Netherlands, - - 2013
We report a case of a 64 year old woman with a calcified ring at the level of the sinotubular junction. Echocardiography and Computed Tomography showed a supravalvular aortic stenosis, without known associated lesions, except for the existence of an aberrant right subclavian artery. These combination of abnormalities makes it ...
Chok A Y AY Department of General Surgery, Changi General Hospital, 2 Simei Street 3, Singapore 529889. - - 2013
Herein, we report a case of early in-stent occlusion due to the ingrowth of soft oedematous mucosal tissue through the lattices of an uncovered stent, which was used for palliation of a postoperative gastrojejunal anastomotic stricture. The in-stent occulsion was treated with the deployment of a second stent, which was ...
Jung Lae-Young LY Division of Cardiology, Department of Internal Medicine, Chonbuk National University Hospital, Jeonju, - - 2013
Drug-eluting stent implantation is an effective treatment for coronary artery disease, yet unexpected serious complications during stent implantation are possible. A 70-year-old man with unstable angina presented with a left main bifurcation lesion. Two drug-eluting stents were successfully deployed at the left main bifurcation lesion by the mini-crush technique under ...
Bonadei I I Section of Cardiovascular Diseases, Department of Experimental and Applied Medicine,, University of Study of Brescia, Brescia, Italy - - - 2013
Aortic valve stenosis is the most common native valve disease and its most common cause in the United States and Europe is the calcification of a normal trileaflet. Recently, there is increasing evidence indicating that valve calcification has common underlying mechanisms with atherosclerosis. This connection raises interest in the potential ...
Dimitrakakis Georgios G Department of Cardiothoracic Surgery, University Hospital of Wales, Heath Park, Cardiff, United - - 2013
Coronary artery perforation is a known complication of percutaneous coronary intervention and potentially life threatening. Normally, these perforations are small and localized. We report the successful surgical management of a coronary artery perforation following stent insertion with extrusion of an 8-cm endarterectomy length of the circumflex coronary artery with a ...
Bothma Pieter A PA Consultant in anaesthesia, London Hyperbaric Unit, James Paget University Hospital, Gorleston, United Kingdom, E-mail: - - 2013
Following our case report on retrograde cerebral venous gas embolism (CVGE),¹ we wish to draw the attention of readers of this journal to a paper in Critical Care Medicine by Weenink et al reporting that severe cerebral arterial gas embolism (CAGE) is a lethal injury in a swine model, not ...
Larche N E NE The Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, New York, - - 2013
Pulmonary hypertension (PH) is a progressive disease that is accompanied by a poor prognosis. Pulmonary vasoconstriction is facilitated through multiple pathways and results in increased pulmonary vascular pressure leading to cell proliferation, vascular remodeling, right ventricular hypertrophy/failure, and ultimately death. Until recently, just six medications were approved -all for one ...
Lee Sang Kook SK Department of Neurosurgery, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, - - 2013
Although surgical techniques for clipping paraclinoid aneurysms have evolved significantly in recent times, direct microsurgical clipping of large and giant paraclinoid aneurysms remains a formidable surgical challenge. We review here our surgical experiences in direct surgical clipping of large and giant paraclinoid aneurysms, especially in dealing with anterior clinoidectomy, distal ...
Stajic Zoran Z Clinic of Cardiology, Military Academy, Belgrade, - - 2013
This article gives contemporary review on the forearm approach for percutaneous diagnostic and interventional coronary procedures. Advantages and disadvantages as well as practical issues and current controversies regarding both radial and ulnar artery approach are discussed throughout the paper. Having in mind advantages of forearm approach in terms of safety ...
Rodrigues Alfredo José - - 2013
The main purpose of the off-pump coronary artery bypass surgery is to reduce morbidity and mortality due cardiopulmonary bypass. However, even though many studies have shown that off-pump coronary artery bypass is feasible and provides hospital morbidity and mortality similar to the on-pump coronary artery bypass graft surgery, probably better ...
Spies James B JB Department of Radiology, Georgetown University Hospital, Washington, District of - - 2013
Strong evidence for both safety and effectiveness of uterine fibroid embolization has been generated since the procedure's introduction. This review will focus on the key articles representing the best evidence to summarize the outcomes from uterine embolization. This review will attempt to answer three important questions associated with uterine embolization. ...
Alias Sherin S Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, - - 2013
Venous thromboembolism comprises deep-vein thrombosis, thrombus in transit, acute pulmonary embolism, and chronic thromboembolic pulmonary hypertension (CTEPH). Pulmonary thromboemboli commonly resolve, with restoration of normal pulmonary hemodynamics. When they fail to resorb, permanent occlusion of the deep veins and/or CTEPH are the consequences. Apart from endogenous fibrinolysis, venous thrombi resolve ...
Hansmann Georg G Department of Pediatric Cardiology and Critical Care, Hannover Medical School, Hannover, - - 2013
The pathobiology of pulmonary arterial hypertension (PAH) is complex and multifactorial. None of the current therapies has been shown to be universally effective or able to reverse advanced pulmonary vascular disease, characterized by plexiform vascular lesions, or to prevent right ventricular failure in advanced PAH. It is thus unlikely that ...
Lanzola Emily E Department of Pathobiology, Cleveland Clinic, Cleveland, Ohio, - - 2013
Hematopoiesis and vascular homeostasis are closely linked to each other via subsets of circulating bone marrow-derived cells with potent activity to repair endothelial injury and promote angiogenesis. As a consequence, abnormalities in hematopoiesis will eventually affect vascular health. Pulmonary arterial hypertension (PAH) is a vascular disease characterized by severe remodeling ...
Troupis Theodore - - 2013
Description of a rare variation is provided alongside with a review of the literature with special references to anatomic, embryologic, and clinical issues it may create. This was a cadaveric dissection conducted during a pregraduate anatomy course that is accompanied by short review of the literature and critical appraisal. During ...
Neragi-Miandoab S - - 2013
The most widely used heart valve worldwide is the Edwards Sapien, which currently has 60% of the worldwide transcatheter aortic valve implantation (TAVI) market. The CoreValve is next in line in popularity, encompassing 35% of the worldwide TAVI market. Although these two valves dominate the TAVI market, a number of ...
Ioakeimidis Nikolaos - - 2013
Phosphodiesterase (PDE) enzymes are widely distributed throughout the body, having numerous effects and functions. The PDE type 5 (PDE5) inhibitors are widely used to treat erectile dysfunction (ED). Recent, intense preclinical and clinical research with PDE5 inhibitors has shed light on new mechanisms and has revealed a number of pleiotropic ...
Simard Trevor - - 2013
Percutaneous coronary intervention is the most prevalent method for coronary artery revascularization. Initial interventions using balloon angioplasty had limited efficacy because coronary dissections, arterial recoil, and neointimal formation led to high rates of abrupt vessel closure and clinical restenosis. With the introduction of coronary stents, vascular dissections were stabilized and ...
May Khan Abigail - - 2013
The objective of this review is to summarize the recent data pertaining to aortic dilatation in congenital heart disease (CHD) and to discuss the current understanding of the pathophysiology and management of this disease. Aortic dilatation is a common finding in CHD. However, acute aortic complications appear to be relatively ...
Scott John P - - 2013
The safety of anesthesia has improved greatly in the past three decades. Standard perioperative monitoring, including pulse oximetry, has practically eliminated unrecognized arterial hypoxia as a cause for perioperative injury. However, most anesthesia-related cardiac arrests in children are now cardiovascular in origin, and standard monitoring is unable to detect many ...
Teixeira-Mendonça Carina - - 2013
Failure of the normal cardiopulmonary transition can lead to persistent pulmonary hypertension of the newborn. Some degree of pulmonary hypertension complicates the course of more than 10% of all neonates with respiratory failure. This review article discusses the vascular abnormalities associated with neonatal pulmonary hypertension. Common therapies including inhaled nitric ...
Allín Jorge G - - 2013
The "accordion effect" is a mechanical remodeling of the arterial wall produced by endoluminal introduction of stiff guidewires, leading to vessel wall shortening and development of multiple eccentric constrictions. This phenomenon is unresponsive to vasodilators and may lead to unnecessary stenting of the pseudo-lesions. It must be suspected with the ...
Eto Masataka M Department of Cardiovascular Surgery, Kyushu University, Fukuoka, Japan Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan - - 2013
during mitral valve surgery, it is important for surgeons to understand the anatomy of the mitral valve annulus to prevent surgical complications. This study aimed to perform morphometry of the mitral annulus to facilitate secure suturing during ring annuloplasty or replacement of the mitral valve. an anatomical study was carried ...
Minami Noriaki - - 2013
A 60-year-old woman was admitted to the hospital due to a sudden loss of consciousness. Computed tomography (CT) revealed a thick subarachnoid hemorrhage in almost all of the parachiasmatic cisterns, including the sylvian cisterns, with mild hydrocephalus. Three dimensional (3D)-CT angiography showed an irregularly shaped aneurysm at the bifurcation of ...
Hogendoorn Wouter - - 2013
Ruptured descending thoracic aortic aneurysm (rDTAA) is a life-threatening disease. In the last decade, thoracic endovascular aortic repair (TEVAR) has evolved as a viable option and is now considered the preferred treatment for rDTAAs. New opportunities as well as new challenges are faced by both the surgeon and the anesthesiologist. ...
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