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Huang Angela H AH Department of Biomedical Engineering, Yale University, New Haven, CT, 06511, USA, - - 2014
This review will focus on two elements that are essential for functional arterial regeneration in vitro: the mechanical environment and the bioreactors used for tissue growth. The importance of the mechanical environment to embryological development, vascular functionality, and vascular graft regeneration will be discussed. Bioreactors generate mechanical stimuli to simulate ...
Pullamsetti Soni Savai SS Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany, Universities of Giessen and Marburg Lung Center, Giessen, Germany ; - - 2014
The development of therapeutic concepts in pulmonary hypertension is intimately linked with the unraveling of pathogenetic sequelae. This perspective highlights advances in our understanding of the regulation of vasomotion and vascular remodeling that have led to "reverse-remodeling" and regenerative strategies as novel treatment concepts. Progress has been made in understanding ...
Lluri Gentian G Ahmanson/UCLA Adult Congenital Heart Disease Center, Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, - - 2014
Coronary artery development is a delicate, complex, and finely tuned process that includes multiple interactions among many pathways, especially in the pericardium and the developing myocardium. There still exists some controversy on the exact origin of certain cellular components. Nevertheless, an understanding of this extremely important developmental process is paramount ...
Saxena Pankaj P Division of Cardiovascular Surgery, Mayo Clinic, Rochester, MN, - - 2014
Described here is a technique of right atrial cannulation to establish cardiopulmonary bypass for repairing descending thoracic/aortic arch aneurysms via left thoracotomy. This technique provides satisfactory venous return and can be used for retrograde cerebral perfusion during aortic surgery. The technique is safe and has been extensively used by the ...
Byrne Anthony L AL Department of Respiratory Medicine, Prince of Wales Hospital, Randwick, NSW, - - 2014
Peripheral venous blood gas (PVBG) analysis is increasingly being used as a substitute for arterial blood sampling; however, comparability has not been clearly established. To determine if the pH, PCO2 and PO2 obtained from PVBG analysis is comparable with arterial blood gas (ABG) analysis. A search was conducted of electronic ...
Spiotta Alejandro M AM Division of Neurosurgery, Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina, - - 2014
While intravenous administration of tissue plasminogen activator (tPA) remains the only FDA-approved treatment modality for acute ischemic stroke, many patients do not meet the criteria for intravenous tPA and are offered intra-arterial therapy. Rapid advances in devices and approaches have marked the evolution of thrombectomy over the past decade from ...
Taal Maarten W MW Department of Renal Medicine, Royal Derby Hospital, Derby, - - 2014
Epidemiological studies have established arterial stiffness as an important risk factor for cardiovascular events and mortality in people with chronic kidney disease (CKD) at all stages. Although much has been learned about the mechanisms that lead to arterial stiffening in CKD, many questions remain unanswered and the optimal interventions for ...
Leyon Joe J - - 2014
Percutaneous vascular embolization is one of the major applications of interventional radiology. A wide variety of embolization agents are currently available for clinical use. The interventional radiologist needs to be up to date with the newer and different types of embolic agents available along with their biopharmaceutical characteristics, strengths, and ...
Izzy Saef S Department of Neurology (Neurocritical Care), University of Massachusetts Medical School, 55 Lake Ave North, S-5, Worcester, MA, 01655, - - 2014
Cerebral vasospasm (cVSP) consists of the vasoconstriction of large and small intracranial vessels which can lead to cerebral hypoperfusion, and in extreme cases, delayed ischemic deficits with stroke. While most commonly observed after aneurysmal subarachnoid hemorrhage (aSAH), cVSP can also occur after traumatic brain injury (TBI) as we have described ...
González J J Servicio de Urología, Hospital Central de la Cruz Roja San José y Santa Adela, Avenida de Reina Victoria 22-26, 28003, Madrid, Madrid, Spain, - - 2014
A renal artery aneurysm is defined as a dilated segment of renal artery that exceeds twice the diameter of a normal renal artery. Although rare, the diagnosis and incidence of this entity have been steadily increasing due to the routine use of cross-sectional imaging. In certain cases, renal artery aneurysms ...
Agarwal Nitin N Departments of Neurological - - 2014
Central retinal artery occlusion, although relatively rare, is an ophthalmological emergency. If left untreated, complete blindness will ensue. Conventional therapies have not significantly improved outcomes compared with the natural history of the disease. Several case series of more recent endovascular approaches, such as intraarterial fibrinolysis, report successful outcomes. Still other ...
Reynolds Matthew R MR Departments of Neurological - - 2014
Extracranial-intracranial (EC-IC) arterial bypass has been used in the treatment of various neurosurgical pathologies including skull base tumors requiring sacrifice of a large intracranial artery; complex intracranial aneurysms requiring trapping; and distal revascularization, moyamoya disease, and symptomatic cerebrovascular stenoocclusive disease. The latter indication has been the subject of intense investigations ...
Demarco J Kevin JK Department of Radiology, Michigan State University, East Lansing, Michigan; - - 2014
In this paper, the authors review the definition of high-risk plaque as developed by experienced researchers in atherosclerosis, including pathologists, clinicians, molecular biologists, and imaging scientists. Current concepts of vulnerable plaque are based on histological studies of coronary and carotid artery plaque as well as natural history studies and include ...
Salem Jean F JF Department of Surgery, American University of Beirut Medical Center, Beirut, - - 2014
Inferior phrenic artery (IPA) pseudoaneurysm is an extremely rare complication of chronic pancreatitis with only three cases reported in the literature so far. It is a serious condition that can be life-threatening if not diagnosed promptly. Recent advances in endovascular interventions made angiography with embolisation the modality of choice for ...
Grunwald Iris Q IQ Director Neuroscience and Medical Affairs, PMI, Anglia Ruskin University, CM1 1SQ Chelmsford, United Kingdom. - - 2014
The purpose of this article is to give an overview of the management of the most common complications encountered during subarachnoid hemorrhage and endovascular treatment of intracranial aneurysms. We reviewed the literature and identified the complications encountered during endovascular treatment of intracranial aneurysms. We report current management strategies of complications ...
Chan Patrick G PG Division of Cardiac Surgery, Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA, - - 2014
Rheumatic mitral valve disease often manifests with leaflet fibrosis, commissural fusion and early calcific degeneration. The thickening and fibrosis of the valvular and subvalvular apparatus has made prosthetic mitral replacement the traditional surgical solution. However, favourable valve morphology in some patients may permit a durable mitral repair rather than replacement. ...
Dai Jian J Department of Cardiology, Yue Yang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, - - 2014
The approach to a chronic total occlusion (CTO) still remains one of the most technical challenges in percutaneous coronary intervention (PCI). CTO lesions with a blunt entry point, calcification, and failure of a previous approach, are the independent predictors of CTO-PCI failure. Here we report a successful antegrade approach for ...
Sanidas Elias E Antwerp Cardiovascular Institute Middelheim, Antwerp, - - 2014
The growing use of the transradial approach for percutaneous coronary interventions has been shown to decrease the risk of major vascular complications. However, in this case report we describe a iatrogenic left main dissection during diagnostic coronary catheterization, which remains a rare, but still life-threatening condition. The adjunctive use of ...
Kallidonis Panagiotis S PS Department of Urology, University of Patras, Patras, - - 2014
Drugeluting metal stents (DESs) have been extensively used in coronary and vascular disease. This type of stents has been proven to provide significantly lower restenosis rates due to the reduction of neo-intimal hyperplasia in comparison to the traditionally used bare metal stents (BMSs). The latter stents have been evaluated for ...
Zhao Yidan Y Latner Thoracic Surgery Research Laboratories and Division of Thoracic Surgery, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, - - 2014
Although multiple gene and protein expression have been extensively profiled in human pulmonary arterial hypertension (PAH), the mechanism for the development and progression of pulmonary hypertension remains elusive. Analysis of the global metabolomic heterogeneity within the pulmonary vascular system leads to a better understanding of disease progression. Using a combination ...
Colvin Kelley L KL Department of Bioengineering, University of Colorado Denver , Aurora, CO , USA ; Department of Pediatrics-Critical Care, University of Colorado Denver , Aurora, CO , USA ; Cardiovascular Pulmonary Research, University of Colorado Denver , Aurora, CO , USA ; Linda Crnic Institute for Down Syndrome, University of Colorado Denver , Aurora, CO , - - 2014
Therapeutic approaches in pediatric pulmonary arterial hypertension (PAH) are based primarily on clinician experience, in contrast to the evidence-based approach in adults with pulmonary hypertension. There is a clear and present need for non-invasive and objective biomarkers to guide the accurate diagnosis, treatment, and prognosis of this disease in children. ...
Lee Chang-Young CY Department of Neurosurgery, Keimyung University School of Medicine, Daegu, Republic of - - 2014
The crossing Y-stent technique is a viable option for coiling of wide-necked bifurcation aneurysms. However, little is known about the long-term impact of this technique. Very late (>1 year) stent thrombosis following the placement of a crossing Y-stent with dual closed-cell stents for the coiling of a wide-necked basilar tip ...
Roy Tanushree T Post Graduate Student, Department of Anatomy, North Bengal Medical College , Darjeeling, India - - 2014
In a female cadaver unilateral variations were found in upper limb arterial system - as (1) high-up origin of ulnar artery at arm, (2) persistent prominent arteria nervii mediana or median artery, (3) common interosseous artery branching out of brachial artery. Literature review revealed these coexistent anomalies as the consequence ...
Vadivel Arul A Ottawa Hospital Research Institute, Sprott Center for Stem Cell Research, Regenerative Medicine Program and Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, - - 2014
Bronchopulmonary dysplasia (BPD), the chronic lung disease of prematurity, remains a major health problem. BPD is characterized by impaired alveolar development and complicated by pulmonary hypertension (PHT). Currently there is no specific treatment for BPD. Hydrogen sulfide (H2S), carbon monoxide and nitric oxide (NO), belong to a class of endogenously ...
Gutierrez Jose J Department of Neurology, College of Physicians and Surgeons, Columbia University Medical Center New York, NY, - - 2014
Mechanisms underlying brain arterial remodeling are uncertain. We tested the hypothesis that arterial size and location are important determinants of arterial characteristics. We collected large and penetrating brain arteries from cadavers with and without HIV. Morphometric characterization was obtained from digital images using color-based thresholding. The association of arterial size ...
Lee Darrin J DJ Department of Neurological Surgery, University of California, Davis, Sacramento, California, - - 2014
Superior sagittal sinus (SSS) thrombosis has high morbidity and mortality, and urgent recanalization is critical for severe cases. Standard endovascular techniques for thrombolysis and thrombectomy use retrograde venous access, an approach that may be unsuccessful in cases with extensive firm clot burden involving the dural sinuses distal to the SSS. ...
Wan Ab Naim Wan Naimah WN Department of Biomedical Engineering, Faculty of Engineering Building, University of Malaya, 50603 Kuala Lumpur, KL, - - 2014
Aortic dissection, characterized by separation of the layers of the aortic wall, poses a significant challenge for clinicians. While type A aortic dissection patients are normally managed using surgical treatment, optimal treatment strategy for type B aortic dissection remains controversial and requires further evaluation. Although aortic diameter measured by CT ...
Tanaka Michihiro M Department of Neurosurgery, Kameda Medical Center, Higashi-cho 929, Kamogawa City, Chiba, 296-8602, Japan, - - 2014
Fusiform intracranial aneurysm is one of the most difficult pathologies to treat. The role and efficacy of recent advanced endovascular technique and conventional bypass surgery are discussed.
Kiuchi Ryuta R Department of General and Cardiothoracic Surgery, Kanazawa University, Kanazawa, Japan. Electronic address: - - 2013
It is important for coronary active perfusion systems to avoid myocardial ischemia during off-pump coronary artery bypass grafting. We have developed a new concept for a perfusion system to pump blood based on changes in helium gas volume. This system uses a conventional intra-aortic balloon pump to activate the perfusion ...
Odobescu Andrei A Department of Surgery, University of Montreal, Montreal, QC, - - 2013
To assess the utility of the Thiel arterial model in microsurgical research, we compared interrupted horizontal mattress (HM) sutures to simple interrupted (SI) sutures in human vessels. A microsurgical set-up using an operating microscope and Thiel-embalmed arteries was used to practice ten SI and HM anastomoses. Vessel patency, leak and ...
Penumatsa Krishna C KC 1Tufts Medical - - 2013
The monoamine, serotonin (5-HT), has been previously implicated in pulmonary arterial remodeling and is considered a therapeutic target for the disease pulmonary arterial hypertension. More recently, it has been recognized that the enzyme tissue transglutaminase (TG2) mediates cross linking of proteins with 5-HT, a posttranslational process of monoaminylation known as ...
Sun Zhonghua Z Zhonghua Sun, Discipline of Medical Imaging, Department of Imaging and Applied Physics, Curtin University, Perth, Western Australia 6845, - - 2013
Rapid technological developments in computed tomography (CT) imaging technique have made coronary CT angiography an attractive imaging tool in the detection of coronary artery disease. Despite visualization of excellent anatomical details of the coronary lumen changes, coronary CT angiography does not provide hemodynamic changes caused by presence of plaques. Computational ...
Vandecasteele T T Department of Morphology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820, Merelbeke, - - 2013
The layout of the porcine atriopulmonary junction and immediately adjacent structures was investigated by gross anatomical and vascular corrosion casting studies to meet the need for more in-depth anatomical insights when using the pig as an animal model in the development of innovative approaches for surgical cardiac ablation in man. ...
Bujak Renata - - 2013
Pulmonary embolism (PE) is a common cardiovascular emergency which can lead to pulmonary hypertension (PH) and right ventricular failure as a consequence of pulmonary arterial bed occlusion. The diagnosis of PE is challenging due to non-specific clinical presentation what results in relatively high mortality. Moreover, the pathological factors associated with ...
Romo Aaron A Center for Biomedical and Healthcare Engineering, Ecole Nationale Supérieure des Mines de Saint-Etienne, CIS-EMSE, CNRS:UMR5146, LCG, 158 Cours Fauriel, 42023 Saint Etienne, France. Electronic address: - - 2013
In this study, bulge inflation tests were used to characterize the failure response of 15 layers of human ascending thoracic aortic aneurysms (ATAA). Full field displacement data were collected during each of the mechanical tests using a digital image stereo-correlation (DIS-C) system. Using the collected displacement data, the local stress ...
Tuder Rubin M RM Program in Translational Lung Research, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado. Electronic address: - - 2013
Knowledge of the pathobiology of pulmonary hypertension (PH) continues to accelerate. However, fundamental gaps remain in our understanding of the underlying pathological changes in pulmonary arteries and veins in the different forms of this syndrome. Although PH primarily affects the arteries, venous disease is increasingly recognized as an important entity. ...
Iqbal Javaid J Thorax Centre, Erasmus Medical Centre, Rotterdam, the - - 2013
Current generation of drug-eluting stents has significantly improved the outcomes of percutaneous coronary intervention by substantially reducing in-stent restenosis and stent thrombosis. However, a potential limitation of these stents is the permanent presence of a metallic foreign body within the artery, which may cause vascular inflammation, restenosis, thrombosis, and neoatherosclerosis. ...
Ricci Stefano S All the authors are affiliated with Area di Geriatria, Centro per la Salute dell'Anziano, Universita Campus Bio-Medico di Roma, Roma, - - 2013
This review aims to summarize present knowledge of foot venous return, with a special interest in clinical and research implications. It is based on the latest available publications on foot anatomy and hemodynamics. Five systems are described: the superficial veins of the sole, the deep veins of the sole (with ...
Sexton Travis T Division of Cardiovascular Medicine, The Gill Heart Institute, University of Kentucky, 255 BBRSB, 741 S. Limestone Street, Lexington, KY, 40536-0200, - - 2013
Spurred by advances in understanding the molecular basis of thrombosis, this issue of the Journal of Thrombosis and Thrombolysis is devoted to exploring aspects of novel paradigms and their potential impact on diagnosis and treatment. Complex interplay between blood and vascular cells, inflammation, and pro- and anti-coagulant pathways determines the ...
Mallios Alexandros A Department of Vascular Surgery, Institut Mutualiste Montsouris, Paris, France; Department of Surgery, University of Oklahoma, Tulsa, OK. Electronic address: - - 2013
Preservation of native arteriovenous fistulas (AVFs) in the long term can be technically challenging. Various anatomic or functional problems can occur and multiple open and/or endovascular interventions may be required for extended preservation of native accesses. In this report, we review vascular access maintenance in a 72-year-old woman during a ...
Scott Daniel J - - 2013
Sources of lower extremity and visceral arterial thromboembolism most commonly include the heart and proximal aneurysmal disease. Infrequently, further workup of "cryptogenic" emboli will reveal a mural atheroma or thrombus of the descending thoracic aorta. Without prospective data, anticoagulation and open surgical thrombectomy with or without aortic replacement have been ...
Hetts Steven W SW Department of Radiology and Biomedical Imaging; University of California; San Francisco, CA, USA - - - 2013
We describe a unique case of bilateral cervical spinal dural arteriovenous fistulas mimicking an intracranial dural arteriovenous fistula near the foramen magnum. We review its detection via MRI and digital subtraction angiography and subsequent management through surgical intervention. Pitfalls in diagnostic angiography are discussed with reference to accurate location of ...
Kutty Shelby S Division of Pediatric Cardiology, University of Nebraska College of Medicine, Children's Hospital and Medical Center, Omaha, - - 2013
Congenital mitral valve abnormalities are rare and cause mitral stenosis, regurgitation, or a combination of the two. Three-dimensional echocardiography has provided new insight into the structure and function of both normal and abnormal mitral valves. Three-dimensional imaging permits accurate anatomic diagnosis and enhances two-dimensional echocardiographic data. Moreover, it enables echocardiographers ...
Chen Michael - - 2013
Ruptured and thrombosed cerebral aneurysms pose a risk for rebleeding that may go undetected because they are angiographically occult. The presence of multiple aneurysms may further complicate efforts in accurately identifying the true source because their treatment may circumvent further necessary investigations. This case series and literature review illustrates the ...
Baragetti A A Center for the Study of Atherosclerosis, Bassini Hospital, Cinisello Balsamo, Milan, Italy; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, - - 2013
Pentraxin 3 (PTX3) is an essential component of the humoral arm of innate immunity and, like C-reactive protein, is independently associated with the risk of developing vascular events. Aim of this study was to investigate, in two large population-based surveys, the Bruneck Study and the PLIC Study, whether PTX3 plasma ...
Medda E E Istituto Superiore di Sanità, National Centre for Epidemiology, Surveillance and Health Promotion, Genetic Epidemiology Unit, Viale Regina Elena 299, 00161 Rome, - - 2013
Carotid intima-media thickness (IMT) and arterial stiffness parameters, including aortic augmentation index (AIx) and pulse wave velocity (PWV), are independent predictors of stroke and cardiovascular disease. Genetic effects on these traits were never explored in a Mediterranean country. The present study aims to quantify the contribution of genes, environment and ...
Pfannmüller Bettina - - 2013
Repair of anterior mitral leaflet prolapse is one of the most challenging aspects in mitral valve repair surgery. In this review, we discuss the various techniques developed over the past three to four decades for the repair of anterior mitral leaflet prolapse, debate the pros and cons of each and ...
Bleiziffer S - - 2013
TAVI (transcatheter aortic valve implantation) is a less invasive treatment of the stenotic aortic valve while avoiding midline sternotomy and cardiopulmonary bypass. A crimped biological valve on a self-expanding or balloon-expandable stent is inserted antegradely or retrogradely under fluoroscopy, and deployed on the beating heart. Among the worldwide TAVI programs, ...
O'Connell Caroline - - 2013
Available targeted therapies for pulmonary arterial hypertension are capable only of slowing progression of the disease and a cure remains elusive. However with the improved understanding of the pulmonary vascular remodeling that characterizes the disease, there is optimism that the disconnect between preclinical and clinical studies may be bridged with ...
Galiè Nazzareno - - 2013
Pulmonary arterial hypertension (PAH) is a fatal disease associated with vasoconstriction and vascular remodelling. There are three well-known pathways that contribute to the pathogenesis of PAH: endothelin, nitric oxide and prostacyclin. Treatments targeting these pathways are well established in clinical practice, such as endothelin receptor antagonists, phosphodiesterase type-5 inhibitors and ...
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