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Results 551 - 600 of 1745
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Liu Xiaobing - - 2013
Preclinical research in animal models of peripheral arterial disease plays a vital role in testing the efficacy of therapeutic agents designed to stimulate microcirculation. The choice of delivery method for these agents is important because the route of administration profoundly affects the bioactivity and efficacy of these agents(1,2). In this ...
Boyd Jack H - - 2013
Chronic ischemic mitral regurgitation (IMR) is still a significant clinical problem. It is present in 10-20% of patients with coronary artery disease and is associated with a worse prognosis after myocardial infarction and subsequent revascularization. Currently, coronary artery bypass grafting combined with restrictive annuloplasty is the most commonly performed surgical ...
Hair Clark D - - 2013
Biliary stenting has evolved dramatically over the past 30 years. Advancements in stent design have led to prolonged patency and improved efficacy. However, biliary stenting is still affected by occlusion, migration, anatomical difficulties, and the need for repeat procedures. Multiple novel plastic biliary stent designs have recently been introduced with ...
Dzieniecka M - - 2013
Adequate pulmonary development at birth is the major determinant of postnatal outcome in the perinatal period. Lung hypoplasia is a poorly defined condition. The aim of this study was to investigate expression of Ki-67 in human fetuses with pulmonary hypoplasia compared to fetuses without pulmonary pathology and malformations of other ...
El-Mawardy Mohamed - - 2013
The optimal treatment approach for coronary intramural hematomas has not been well defined, and discussion is limited to scarce data. In addition, the impact of prior thrombolytic therapy in the setting of coronary artery dissections with possible development and/or extension of an intramural hematoma is not well understood. We describe ...
Bank William O - - 2013
Endovascular embolization of brain arteriovenous malformations (AVMs) has improved with liquid occlusive agents, but flow-related and anatomic restrictions limit endovascular capabilities. AVM compartments supplied by leptomeningeal networks and feeding arteries too small and/or tortuous for safe catheterization are rarely penetrated by liquid occlusive agents. A case with both impediments prompted ...
Augoustides J G T - - 2013
Deep hypothermic circulatory arrest for adult aortic arch repair is still associated with significant mortality and morbidity. Furthermore, there is still significant variation in the conduct of this complex perioperative technique. This variation in deep hypothermic circulatory arrest practice has not been adequately characterized and may offer multiple opportunities for ...
Honarmand Hamidreza - - 2013
More than a century ago, inflammation and infection were considered to have atherogenic effects. The old idea that coronary heart disease (CHD) possibly has an infectious etiology has only reemerged in recent years. Atherosclerosis is the main pathological process involved in CHD and is, logically, the first place to look ...
Choudhri Omar - - 2013
Cerebral aneurysms are associated with a 50% mortality rate after rupture and patients can suffer significant morbidity during subsequent treatment. Neurosurgical management of both ruptured and unruptured aneurysms has evolved over the years. The historical practice of using microsurgical clipping to treat aneurysms has benefited in the last two decades ...
Smargiassi Andrea - - 2013
Chest ultrasonography can be a useful diagnostic tool for respiratory physicians. It can be used to complete and widen the general objective examination also in emergency situations, at the patient's bedside. The aim of this document is to promote better knowledge and more widespread use of thoracic ultrasound among respiratory ...
de Kerchove Laurent - - 2013
Aortic valve sparing procedures are increasingly being used to treat aortic root pathologies. Reimplantation of the aortic valve, first described by Dr Tirone David, is a technically demanding procedure whose long-term results are critically dependent on perfect intraoperative restoration of valve anatomy and function. There exists significant variation in how ...
Dahya Vishal - - 2013
Pseudoaneurysms of the carotid artery are very uncommon complications following carotid endarterectomy. Pseudoaneurysms are usually caused by any kind of blunt injury or trauma during carotid artery surgery. CEA has become an increasingly more common vascular surgery performed in the United States. The standard of treatment for a carotid PA ...
Sadekova Nataliya - - 2013
Arterial stiffness has been identified as an important risk factor for cognitive decline. However, its effects on the brain's health are unknown, and there is no animal model available to study the precise impact of arterial stiffness on the brain. Therefore, the objective of the study was to develop and ...
Rubin Lewis J - - 2013
Despite major advances in our understanding of the pathobiology of pulmonary vasculopathy and in the treatment of pulmonary vascular disease, pulmonary hypertension remains a severe condition that frequently progresses to right heart failure and death. This chapter will review several novel approaches to treatment, based on recent observations in both ...
Tu Ly - - 2013
The combination of pulmonary vasoconstriction, in situ thrombosis, and pulmonary arterial wall remodeling is largely responsible for the rise in pulmonary vascular resistance (PVR) and pulmonary arterial pressure (PAP) in patients with pulmonary arterial hypertension (PAH). Even though several drugs have been developed over the past decades, at this time ...
Maron Bradley A - - 2013
Pulmonary hypertension (PH) is characterized by pathological changes to cell signaling pathways within the alveolar-pulmonary arteriole-right ventricular axis that results in increases in pulmonary vascular resistance and, ultimately, the development of right ventricular (RV) dysfunction. Cornerstone histopathological features of the PH vasculopathy include intimal thickening, concentric hypertrophy, and perivascular fibrosis ...
Olschewski Horst - - 2013
Prostacyclins have a favourable pharmacological profile for treatment of pulmonary hypertension as they possess vasodilative, antiproliferative, antiaggregatory, and anti-inflammatory properties that may compensate the main pathologic changes in the small pulmonary arteries. In severe pulmonary hypertension these vessels show a deficit in the endogenous prostacyclin secretion. The therapeutic potential of ...
Arrivi A - - 2013
Spontaneous coronary artery dissection (SCAD) is a rare, complex disease, nowadays poorly understood yet. The lack of firm recommendations about this issue is a great limitation which makes any therapeutic decision controversial. The case described is that of a young, otherwise healthy woman, who presented with an ostial dissection of ...
Yılmaz Murat - - 2013
This report describes a rare case of a distal middle cerebral artery (dMCA) aneurysm. That developed a right intracerebral haematoma and subarachnoid haemorrhage. It was treated by surgical exploration and clipping via pterional approach. Clinical findings and surgical approaches of dMCA aneurysm are different from proximal middle cerebral artery (MCA) ...
Brittain Evan - - 2013
Transgenic and toxic models of pulmonary arterial hypertension (PAH) are widely used to study the pathophysiology of PAH and to investigate potential therapies. Given the expense and time involved in creating animal models of disease, it is critical that researchers have tools to accurately assess phenotypic expression of disease. Right ...
Lattouf Omar M OM Department of Surgery/Cardiothoracic, Emory University School of Medicine, Atlanta, Georgia. Electronic address: - - 2013
Historically, the use of cardiopulmonary bypass (CPB) in performing coronary artery bypass grafting (CABG) has been the "gold standard" in coronary revascularization. However, with greater understanding of the inflammatory effects of CPB and the increased risks of strokes in atherosclerotic or calcified aortas, there has been a growing interest in ...
Mosalli Rafat R Department of Pediatrics, Umm Al Qura University, P.O. Box 7607, Mecca 21955, Saudi Arabia ; Department of Pediatrics, International Medical Center, Hael Street, P.O. Box 2172, Jeddah 21451, Saudi - - 2013
Arterial cannulation in neonates is usually performed for frequent blood pressure monitoring and blood sampling. The procedure, while easily executed by skilled neonatal staff, can be associated with serious complications such as vasospasm, thrombosis, embolism, hematoma, infection, peripheral nerve damage, ischemia, and tissue necrosis. Several treatment options are available to ...
Rylski B B Heart Centre Freiburg University, Freiburg, - - 2013
Minimally invasive mitral valve repair is based on several procedural concepts. Recently, three of them have been intensively discussed: aortic occlusion strategy, use of Goretex-Neo-Chordae to repair mitral valve regurgitation and feasibility and efficacy of the minithoracotomy approach in mitral valve treatment of patients after previous cardiac surgery. Twenty years ...
Lutter G G Department of Cardiovascular Surgery, Christian-Albrechts-University of Kiel, School of Medicine, Kiel, - - 2013
  The development of transcatheter techniques for treatment of severe mitral valve regurgitation in the beating heart is focus of recent research. An off-pump treatment technique poses great benefits, particularly for multimorbid patients, often being non-compliant to the gold standard treatment, being open heart surgery with use of a cardiopulmonary ...
Cordova Alfredo C AC Department of Surgery, Memorial Hospital of Rhode Island, The Warren Alpert Medical School of Brown University, Pawtucket, Rhode Island, USA ; Department of Vascular Surgery, Yale University School of Medicine, New Haven, Connecticut, - - 2013
Visceral artery aneurysms (VAA) and pseudoaneurysms (VAPA) can be life-threatening conditions with high incidence of rupture and hemorrhage. Greater availability and increased use of advanced imaging technology has led to the increased incidental detection of asymptomatic visceral aneurysms. In addition, increased percutaneous endovascular interventions have raised the incidence of iatrogenic ...
Zanaty Mario M Department of Neurosurgery, Thomas Jefferson University, Jefferson Hospital for Neuroscience, Philadelphia, PA, - - 2013
The management of mycotic aneurysm has always been subject to controversy. The aim of this paper is to review the literature on the intracranial infected aneurysm from pathogenesis till management while focusing mainly on the endovascular interventions. This novel solution seems to provide additional benefits and long-term favorable outcomes.
Kochi Takashi T Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan ; Graduate School of Biomedical Engineering, Tohoku University, Sendai, Miyagi, - - 2013
Appropriate ischemia models are required for successful studies of therapeutic angiogenesis. While collateral routes are known to be present within the innate vasculature, there are no reports describing the detailed vascular anatomy of the murine hindlimb. In addition, differences in the descriptions of anatomical names and locations in the literature ...
Campos Carlos M - - 2013
The introduction of metallic drug-eluting stents has reduced the risk of restenosis and widened the indications of percutaneous coronary intervention in treatment of coronary artery disease. However, this medical device can induce hypersensitive reaction that interferes with the endothelialization and healing process resulting in late persistent or acquired malapposition of ...
Jaffan Abdel Aziz A AA Division of Interventional Radiology and Image-Guided Medicine, Department of Radiology, Emory University School of Medicine, 1364 Clifton Road NE, Atlanta, GA 30322, - - 2013
Endovascular recanalization of chronic total aortoiliac occlusion is technically challenging. Inability to reenter the true aortic lumen, following retrograde iliac recanalization, is one of the most common causes of failure. We describe a case of a total aortoiliac occlusion where balloon occlusion of the right common iliac artery, following its ...
Tabry Imad F IF Holy Cross Hospital, Fort Lauderdale, FL, - - 2013
A previously described but rarely used surgical technique for the repair of complex or recurrent coarctation of the aorta through a right thoracotomy approach is presented in detail. It has the advantages of being simple and avoiding left chest re-entry, median sternotomy and cardiopulmonary bypass altogether.
Amrane Hafid H Department of Cardiothoracic Surgery, Medisch Centrum Leeuwarden, Leeuwarden, - - 2013
Transcatheter implantation of the CoreValve bioprosthesis (Medtronic, Minneapolis, MN, USA) can be performed surgically through a minimally invasive approach: using an upper-J mini-sternotomy to the second or third intercostal space, the ascending aorta is exposed at a convenient location. After placing two purse-string sutures on the ascending aorta at least ...
Taif Sawsan S Department of Radiology, Khoula Hospital, Muscat, - - 2013
Aneurysms of the gluteal arteries are very rare with the majority being post-trauma pseudoaneurysms. Generally, management of these aneurysms could be surgical or through endovascular techniques. We present a case of a superior gluteal artery pseudoaneurysm complicating a pelvic fracture that presented as a gluteal mass. It was successfully treated ...
De Maria Giovanni Luigi GL Oxford Heart Centre, John Radcliffe Hospital, Oxford University Hospitals, Headley Way, Oxford OX39DU, UK ; Cardiovascular Medicine Department, Catholic University of the Sacred Heart, 00168 Rome, - - 2013
The detachment of atherothrombotic material from the atherosclerotic coronary plaque and downstream embolisation is an underrecognized phenomenon and it causes different degrees of impairment of the coronary microcirculation. During treatment of obstructive atherosclerotic plaque by percutaneous coronary intervention (PCI) distal embolisation (DE) is considered to be inevitable and it is ...
Antov S S University Clinic of Cardiology, Medical Faculty, Ss. Cyril and Methodius University, Skopje, R. - - 2013
(Full text is available at http://www.manu.edu.mk/prilozi). The transradial approach (TRA) for treatment of aortoiliac occlusive disease (AIOD) is nowdays a more common approach than several years ago. This is due to less post-procedural bleeding complications and its impact on mortality. The main reason for the growing interest in the TRA ...
Peng Tien T Department of Medicine, Philadelphia, Pennsylvania, USA ; Division of Pulmonary and Critical Care, Philadelphia, Pennsylvania, - - 2013
The pulmonary circulation is a highly specialized vascular bed that physically and functionally connects the heart and the lungs. The interdependence of these two organs is illustrated in embryonic development, when the lung endoderm protrudes into the surrounding mesoderm as the heart tube elongates and folds into structurally distinct chambers. ...
Grieve Andy P AP Aptiv Solutions, Innovation Centre, Stevenage Bioscience Catalyst, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2FX, - - 2013
In pulmonary hypertension, as in many other diseases, there is a need for a smarter approach to evaluating new treatments. The traditional randomized controlled trial has served medical science well, but constrains the development of treatments for rare diseases. A workshop was established to consider alternative clinical trial designs in ...
Hassoun Paul M PM Johns Hopkins University, Baltimore, Maryland, - - 2013
The 6-Minute Walk Distance (6-MWD) has been the most utilized endpoint for judging the efficacy of pulmonary arterial hypertension (PAH) therapy in clinical trials conducted over the past two decades. Despite its simplicity, widespread use in recent trials and overall prognostic value, the 6-MWD has often been criticized over the ...
Farkas Laszlo L Division of Pulmonary Disease and Critical Care Medicine, Department of Internal Medicine, Victoria Johnson Center for Obstructive Lung Disease, Virginia Commonwealth University, Richmond, VA 23298-0456, USA. lfarkas @ - - 2013
The last decade has seen substantial changes in our understanding of the pathobiology of pulmonary arterial hypertension (PAH), a severe and devastating disease without curative treatment. It is now accepted that injury to the endothelial cells of the pulmonary arteries is central for the subsequent development of lumen-obliterative lung vascular ...
Demerouti Eftychia - - 2012
Pulmonary Arterial Hypertension (PAH) is a disease of small pulmonary arteries, characterized by vascular proliferation and remodeling. Progressive increase in pulmonary vascular resistance ultimately leads to right ventricular heart failure and death. PAH-specific drug therapy led to improvement in clinical outcomes, and survival. While the survival is better, progression of ...
Southerland Kevin W KW Department of Surgery, Division of Surgical Sciences, Duke University Medical Center, Durham, North Carolina, - - 2013
Ischemic cardiovascular disease remains the leading cause of death worldwide. Despite advances in the medical management of atherosclerosis over the past several decades, many patients require arterial revascularization to reduce mortality and alleviate ischemic symptoms. Technological advancements have led to dramatic increases in the use of percutaneous and endovascular approaches, ...
Hamdan Allen - - 2012
Chronic venous disease, reviewed herein, is manifested by a spectrum of signs and symptoms, including cosmetic spider veins, asymptomatic varicosities, large painful varicose veins, edema, hyperpigmentation and lipodermatosclerosis of skin, and ulceration. However, there is no definitive stepwise progression from spider veins to ulcers and, in fact, severe skin complications ...
Parakh Neeraj N Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India. - - 2013
The fibrous body between the mitral and aortic valve, known as mitral-aortic intervalvular fibrosa (MAIVF) is prone to infection and injury resulting in pseudo-aneurysm formation. Because of its relative rarity, we are far from making any conclusion regarding the natural history and appropriate therapeutic strategy for this condition. We report ...
Burnett Bruce - - 2013
This article describes the risk factors, diagnostic tools, and therapeutic approaches for venous thromboembolism (VTE), which includes primarily deep vein thrombosis and pulmonary embolism, as well as VTE occurring at other sites. Outpatient management strategies are emphasized.
Sakamoto Shigeyuki - - 2012
The use of cerebral protection devices in endovascular treatment for innominate artery (IA) stenosis is not well established. We describe a novel technique for cerebral protection during endovascular stenting of symptomatic IA stenosis. An 82-year-old man presented with acutely scattered brain infarction by artery-to-artery embolism due to IA stenosis. Endovascular ...
Hulin Alexia - - 2012
INTRODUCTION: Myxomatous mitral valve is one of the most common heart valves diseases in human and has been well characterized at a functional and morphological level. Diseased valves are thickened as a result of extracellular matrix remodeling and proteoglycans accumulation accompanied by the disruption of the stratified structures of the ...
Roos M W MW Department of Medical Sciences, Clinical Physiology, Uppsala University, UAS ent 35, S-751 85 Uppsala, - - 2013
Intimal hyperplasia at the distal anastomosis is considered to be an important determinant for arterial and arteriovenous graft failure. The connection between unhealthy hemodynamics and intimal hyperplasia motivates the use of computational fluid dynamics modeling to search for improved graft design. However, studies on the fluid mechanical impact on intimal ...
El Khoury Gebrine - - 2012
During the past 15 years, important advances in the field of aortic valve repair have transformed it from an infrequent and anecdotal exercise to a feasible and attractive alternative to valve replacement in selected patients with pure aortic insufficiency. These advances include a deeper understanding of the functional anatomy of ...
Rand T - - 2012
Treatment of infrapopliteal arteries has developed to a standard technique during the past two decades. With the introduction of innovative devices, a variety of techniques has been created and is still under investigation. Treatment options range from plain balloon angioplasty (POBA), all sorts of stent applications, such as bare metal, ...
Hunter Stacy D - - 2013
The aim of this study was to determine the effect of hatha yoga on arterial elasticity and endothelial function. First, a cross-sectional study was performed to determine whether yoga practitioners would demonstrate greater arterial compliance and endothelium-dependent vasodilation than their sedentary peers. Second, an intervention study involving 13 sedentary middle-aged ...
Meier Pascal - - 2012
The field of interventional cardiology continues to progress quickly. The efficacy of percutaneous interventions with newer generation drug-eluting stents has advanced a lot over the last decade. This improvement in stent performance has broadened the level of indication towards more complex interventions such as left main and multi- vessel PCI. ...
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