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Chai Qiang Q Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN, 55905, USA, - - 2014
Hydrogen sulfide has emerged as an important endothelium-dependent vasodilator, but its role in shear stress-mediated dilation of coronary arteries is unclear. We examined the role of H2S on shear stress-mediated dilation of isolated mouse coronary arteries. In these vessels, Na2S produced concentration-dependent dilation, which was significantly inhibited by iberiotoxin and ...
Smeets Christophe J P - - 2014
The case is reported of a 38-year-old male patient with pulmonary homograft acute infective endocarditis and aortic root dilation that occurred 13 years after a Ross procedure for bicuspid aortic valve regurgitation. Aortic and pulmonary root replacements were performed, using a Freestyle stentless aortic root bioprosthesis in both cases, with ...
Liang Shi S Department of Histology and Embryology, Shanxi Medical University, 56 Xin Jian Nan Road, Taiyuan, 030001, Shanxi, - - 2014
The second heart field (SHF), foregut endoderm and sonic hedgehog (SHH) signaling pathway are all reported to associate with normal morphogenesis and septation of outflow tract (OFT). However, the morphological relationships of the development of foregut endoderm and expression of SHH signaling pathway members with the development of surrounding SHF ...
Brennan Ian M IM Section of Interventional Radiology, Department of Radiology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, - - 2014
Splenic injury is a rare complication following colonoscopy with fewer than 100 reported cases worldwide to date. We describe a case of splenic laceration presenting 5 days following diagnostic colonoscopy. Although hemodynamically stable, active contrast extravasation on contrast-enhanced multidetector computed tomography predicted likely failure of conservative management. Splenic artery angiography ...
Mishra Arvind - - 2014
We report here a case of a 35 year old male with protein C deficiency who presented with acute right sided hemiparesis with right sided facial palsy due to cerebral arterial thrombosis. He was treated with anticoagulation therapy and improved. This case is interesting as arterial thrombosis is rarely observed ...
Lin Cheng-Hung CH Baltimore, Md.; Pittsburgh, Pa.; and Taipei, Taiwan From the Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine; the Division of Plastic and Reconstructive Surgery, University of Pittsburgh Medical Center; the Center for Vascularized Composite Allotransplantation, Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Chang Gung Medical College and Chang Gung University; and the Division of Plastic Surgery, Department of Surgery, Taipei Veterans General Hospital and National Yang-Ming - - 2014
The mouse is still considered the premier model in basic immunologic and transplant-related research. However, because of its much smaller size, the mouse has proven to be a technically difficult and physiologically fragile model from a surgical standpoint. That is why only a few studies currently use mouse models in ...
Geddings Julia E JE Department of Pathology and Laboratory - - 2014
Deep vein thrombosis (DVT) is a significant cause of morbidity and mortality throughout the world [1]. Risk factors for DVT include major surgery, immobilization, trauma, and cancer among others [1]. Many mouse models of thrombosis have been used to study mechanisms of thrombosis, including those involving small and large veins. ...
Riou Laurent M LM INSERM, UMR_S 1039, Radiopharmaceutiques Biocliniques, Faculté de Médecine de Grenoble, Grenoble, - - 2014
Mouse models of atherosclerosis are extensively being used to study the mechanisms of atherosclerotic plaque development and the results are frequently extrapolated to humans. However, major differences have been described between murine and human atherosclerotic lesions and the determination of similarities and differences between these species has been largely addressed ...
Yap Choon Hwai CH Department of Biomedical Engineering, National University of Singapore, Singapore, - - 2014
Abnormal fluid mechanical environment in the pre-natal cardiovascular system is hypothesized to play a significant role in causing structural heart malformations. It is thus important to improve our understanding of the prenatal cardiovascular fluid mechanical environment at multiple developmental time-points and vascular morphologies. We present such a study on fetal ...
Arun O O Department of Anesthesiology and Reanimation, Faculty of Medicine, Selcuk University, Konya, Turkey. - - 2014
Peri-operative management of infants with trisomy 18 syndrome is challenging due to various congenital cardiac and facial anomalies. We report the anaesthetic management of a 13-day-old neonate with 1 540 g body weight, undergoing closure of patent ductus arteriosus and pulmonary artery banding. Anaesthesia was induced with sevoflurane, fentanyl and ...
Alurkar Anand A Department of Neurointervention, King Edward Memorial Hospital, Pune, Maharashtra, - - 2014
A2 aneurysms are rare with a reported incidence of <1% of the intracranial aneurysms. These aneurysms are located between the anterior communicating artery and genu of the corpus callosum. Fusiform aneurysms in this location are even rarer and we present one such case of fusiform A2 aneurysm treated with endovascular ...
Palladino Elisa E Department of General and Digestive Surgery, Chalons en Champagne Hospital, Chalons en Champagne, - - 2014
Background Intra-abdominal fibromatosis is a benign rare tumor of fibrous origin with a significant potential for local invasion and no ability to metastasize, but it can recur. The etiology of desmoid tumors is unknown. It is often associated with conditions such as familial adenomatous polyposis and Gardner syndrome. Case Report ...
Almouradi Tarek T Division of Gatsroenterology and Hepatology, Department of Medicine, John H. Stroger Hospital of Cook County, Chciago, - - 2014
Background Isolated hepatic artery thrombosis is an extremely rare condition with only a few cases reported in the literature. Case Report A 62-year-old woman presented with a 5-day history of right upper quadrant abdominal pain associated with nausea and vomiting. Physical examination revealed right upper quadrant tenderness. Her initial laboratory ...
Verikokos Christos C 2nd Department of Surgery, Vascular Surgery Unit, Laiko General Hospital, Medical School of Athens, Agiou Thoma 17, 11527 Athens, - - 2014
Popliteal artery aneurysms (PAAs) are rare in general population but represent the second most common peripheral arterial aneurysms following those located in the aortoiliac segment. They usually affect men over 60 years old with established cardiovascular disease caused by atherosclerosis. Other more unusual conditions such as trauma, congenital popliteal aneurysm, ...
Cai Wu W Second Affiliated Hospital of Soochow University, Department of Radiology, Suzhou, P.R. - - 2014
Intracranial pial arteriovenous fistulas (AVFs) associated with multiple aneurysms of the main feeding arteries are very rare cerebrovascular lesions. We report a unique case of pial AVFs associated with four aneurysms of the feeding anterior cerebral artery (ACA) which presented as intracerebral hemorrhage (ICH), intraventricular hemorrhage (IVH) and spontaneous subarachnoid ...
Catanese Vincenzo V Division of Vascular Surgery, San Carlo Borromeo Hospital, Milan, - - 2014
Subclavian Artery Dissection (SAD) is a rare condition, generally due to arterial catheterization, blunt trauma or connective tissue disease. Spontaneous or minimally traumatic cases have also been reported. Clinical manifestations are usually chest and/or back pain, pulse loss and paresthesia, whereas nausea, dizziness and vomiting are present in case of ...
Kitaoka Tadashi T Department of Vascular Surgery, Saitama Medical Center, Saitama Medical School, Kawagoe, Saitama, - - 2014
Celiac stenosis or occlusion is attributed partly to increase blood flow at pancreatic arcade from the superior mesenteric artery (SMA) system and may play a causal role in true aneurysm of pancreaticoduodenal artery (PDAA) formation. However, despite possible increased blood flow in the pancreatic arcades like celiac stenosis, PDAAs with ...
Nishimura Kengo K Department of Surgery, Tottori Prefectural Kosei Hospital, Kurayoshi, Tottori, - - 2014
Middle colic artery aneurysms are rare and most have been reported with rupture or symptom. We report the successful elective treatment of a middle colic artery aneurysm without symptom, which is very rare. It failed to perform transcatheter arterial embolization for anatomical reasons, and, thus, the patient, a 77-year-old man, ...
Zaki M M Western Vascular Institute (WVI), Department of Vascular and Endovascular Surgery, University College Hospital, Galway (UCHG), Newcastle Road, Galway, Ireland; Department of Vascular Surgery (Unit 7), El-Demerdash Hospital, Faculty of Medicine, Ain-Shams University, Cairo, Egypt. Electronic address: - - 2014
Aortoenteric fistula is a rare but very serious complication of both surgical and endovascular abdominal aortic reconstruction. Since the advent of endovascular abdominal aortic aneurysm repair (EVAR), 20 cases of aortoduodenal fistula associated with aortic stent grafts have been reported.(1) However, only a handful has been reported following inflammatory abdominal ...
Suzuki Masanori M Department of Neurosurgery, Nippon Medical School Chiba Hokusoh Hospital, 1715 Kamagari, Inzai, Chiba, - - 2014
No cerebral aneurysms on the feeder associated with hemangioblastomas that ruptured before resection have been reported. We report a patient with a ruptured flow-related aneurysm associated with cerebellar hemangioblastoma and a tumor feeder treated simultaneously by a single procedure of embolization using N-butyl cyanoacrylate before tumor removal. A 36-year-old female ...
Bayrak SavaƟ S Istanbul Training and Research Hospital, General Surgery Clinic, Fatih, 34098 Istanbul, - - 2014
Mesenteric ischemia is one of the most mortal diseases of the gastrointestinal system causing acute abdomen. In most of the patients, the etiological factor is the obstructive embolism or thrombosis of superior mesenteric artery. In the literature, there have been reports regarding also celiac trunk occlusion in rare situations. The ...
Fine Jenna J 0000-0002-8848-2010 Department of Pediatric Surgery, Geisinger Health System, Janet Weis Children's Hospital, 100 N. Academy Avenue, M.C. 21-70, Danville, PA 17822, - - 2014
Pulmonary hernia, also known as lung herniation or intercostal herniation, is best explained as the lung parenchyma protruding beyond the confines of the thoracic wall. This rare finding can be classified as congenital or acquired. Acquired pulmonary herniations are often the complication of blunt or penetrating trauma to the chest ...
Honda Shintaro - - 2013
The response-to-tissue-injury theory is currently the favorite paradigm to investigate valve pathology. To the best of our knowledge, there are currently no in vivo valve injury models. There are few calcific aortic valve stenosis (AVS) models that develop hemodynamically significant stenosis. Here, we investigated the effect of direct mechanical injury ...
Thomsen Axel Bk - - 2013
Intracellular pH (pHi) in the vascular wall modulates agonist-induced vasocontractile and vasorelaxant responses in mesenteric arteries, whereas effects on myogenic tone have been unsettled. We studied the role of Na(+),HCO3(-) cotransporter NBCn1 in mouse isolated middle cerebral arteries and the influence of pHi disturbances on myogenic tone. Na(+),HCO3(-) cotransport was ...
Wada Kosuke - - 2013
We have developed a mouse model of intracranial aneurysm that recapitulates key features of human intracranial aneurysms. In this model, spontaneous aneurysmal rupture occurs with a predictable time course. Aneurysmal rupture in this model can be easily detected by assessing neurological symptoms. Similar to human intracranial aneurysms, intracranial aneurysms in ...
Derrett-Smith Emma C EC University College London Medical School, Royal Free Campus, London, - - 2013
To delineate the constitutive pulmonary vascular phenotype of the TβRIIΔk-fib mouse model of scleroderma, and to selectively induce pulmonary endothelial cell injury using vascular endothelial growth factor (VEGF) inhibition to develop a model with features characteristic of pulmonary arterial hypertension (PAH). The TβRIIΔk-fib mouse strain expresses a kinase-deficient transforming growth ...
Corada Monica - - 2013
The functional diversity of the arterial and venous endothelia is regulated through a complex system of signalling pathways and downstream transcription factors. Here we report that the transcription factor Sox17, which is known as a regulator of endoderm and hemopoietic differentiation, is selectively expressed in arteries, and not in veins, ...
Zhou Shaotang - - 2013
Arterialized orthotopic liver transplantation (OLT) in the mouse mimics human liver transplantation physiologically and clinically. The present method of sutured anastomosis for reconstruction of the hepatic artery is complex and is associated with high incidence of complications and failure. This makes the endpoint assessment of using this complex model difficult ...
Meisner Joshua K JK University of Virginia, Department of Biomedical Engineering, Charlottesville, Virginia - - 2013
The mouse ischemic hindlimb model is used widely for studying collateral artery growth (i.e., arteriogenesis) in response to increased shear stress. Nonetheless, precise measurements of regional shear stress changes along individual collateral arteries are lacking. Our goal is to develop and verify trans-illumination laser speckle flowmetry (LSF) for this purpose. ...
Pathak Digant D Department of Minimal Access and Bariatric Surgery, ILS Hospitals, DD-6, Salt Lake City, Sector 1, Kolkata, 700064 - - 2014
Diaphragmatic hernia through the central tendon is a very rare entity. We report on a case that developed to acute intestinal obstruction, secondary to herniation of the small intestine through a small defect in the central tendon of the diaphragm. The patient never had any trauma to his chest or ...
Matoba Tetsuya - - 2013
Atherosclerotic plaque destabilization and rupture is an important pathological condition that may account for approximately 70% of acute myocardial infarction cases. To analyse the mechanisms by which an atherosclerotic plaque destabilizes and ruptures and examine the effects of novel therapeutic approaches, several groups have developed mouse models of plaque rupture. ...
Gordon-Keylock Sabrina S Institute for Stem Cell Research, Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, Scotland, United Kingdom; - - 2013
During mouse development, definitive hematopoietic stem cells (dHSCs) emerge by late E10.5 to E11 in several hematopoietic sites. Of them, the aorta-gonad-mesonephros (AGM) region drew particular attention owing to its capacity to autonomously initiate and expand dHSCs in culture, indicating its key role in HSC development. The dorsal aorta contains ...
Faria Rita R Serviços de Cardiologia e de Cirurgia Cardiotorácica do Centro Hospitalar de Vila Nova de Gaia/ Espinho, - - 2013
Transcatheter valve-in-valve implantation for degenerated bioprostheses is an appealing alternative to reoperation in high-risk patients, and is technically feasible in both aortic and mitral positions. However, concurrent aortic and mitral transcatheter valve-in-valve procedures are seldom described. We aim to report our first case of double transapical valve-in-valve procedure for concomitant ...
Moran Corey S - - 2013
We aimed to determine the effect of mechanistic target of rapamycin inhibitor everolimus on abdominal aortic aneurysm within the angiotensin II (A2)-infused apolipoprotein E-deficient mouse model. Abdominal aortic aneurysm was induced via subcutaneous infusion of A2. Flow cytometry demonstrated increased circulating and aortic C-C chemokine receptor 2 (CCR2) monocytes during ...
Lindberg Karolina - - 2013
Recent studies support a role for FGF23 and its co-receptor Klotho in cardiovascular pathology, yet the underlying mechanisms remain largely elusive. Herein, we analyzed the expression of Klotho in mouse arteries and generated a novel mouse model harboring a vascular smooth muscle cell specific deletion of Klotho (Sm22-KL(-/-) ). Arterial ...
Tian Xueying - - 2013
Avian embryo experiments proved an ingrowth model for the coronary artery connections with the aorta. However, whether a similar mechanism applies to the mammalian heart still remains unclear. Here we analyzed how the main coronary arteries and their orifices form during murine heart development. Apelin (Apln) is expressed in coronary ...
Yamamoto Kota K Department of Surgery and the Interdepartmental Program in Vascular Biology and Therapeutics, Yale University, - - 2013
Technical aspects of creating an arteriovenous fistula in the mouse are discussed. Under general anesthesia, an abdominal incision is made, and the aorta and inferior vena cava (IVC) are exposed. The proximal infrarenal aorta and the distal aorta are dissected for clamp placement and needle puncture, respectively. Special attention is ...
Liu Bin - - 2012
This study aimed to determine whether a cyclooxygenase-2 (COX-2) inhibitor celecoxib influences endothelium-dependent contraction independent of its action on COX-2 and, if so, the underlying mechanism(s). Abdominal aortas and/or carotid arteries from C57BL/6 mice or those with genetic COX-2 deficiency (COX-2(-/-)) were isolated for functional and/or biochemical analyses. Result showed ...
Geyer Stefan H - - 2012
This study aimed at providing an objective metric characterization of the aortic arch of a mouse fetus featuring a double lumen aortic arch malformation. As a side effect it provides reference data defining the length and the diameters of the aortic arch segments of normally developed mouse fetuses at developmental ...
Wootton David M - - 2012
Systemic delivery of tissue-type plasminogen activator (t-PA) to dissolve a thrombus after a heart attack or stroke is accompanied by the risk of hemorrhage. A recent study shows the use of nanoaggregates to target t-PA to the thrombus in mouse models of mesenteric injury and pulmonary embolism.
Peruzzotti-Jametti Luca - - 2012
Lymphocytic hypophysitis is a rarely recognized disease that is characterized by inflammatory infiltration and destruction of the pituitary gland. The etiology of lymphocytic hypophysitis is still unclear, but an autoimmune pathogenesis has been advocated. In fact, histopathologic specimens reveal a diffuse infiltration of the hypophysis by CD3(+)CD4(+) T cells and ...
Turamanlar Ozan O Department of Anatomy, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, - - 2012
The hepatic and renal veins drain into the inferior vena cava. The upper group of hepatic veins consists of three veins which extend to the posterior face of the liver to join the inferior cava. The left renal vein passes anterior to the aorta just below the origin of the ...
Van Den Berg J - - 2012
This paper will review the literature in order to define lesion characteristics that determine decision for surgical or endovascular therapy in patients with chronic critical limb ischemia (CLI). The typical pattern of disease is multilevel, infrainguinal disease. The great majority of patients with CLI can be treated by endovascular means, ...
Yeung Tsz Wai - - 2012
Object Use of a flow-diverting device has shown promising short-term results in the management of vertebral artery (VA) dissecting aneurysms, but there is still uncertainty regarding its long-term efficacy and safety. The authors report their initial experience with respect to the potential utility and long-term clinical outcomes of using a ...
Vajda Z - - 2012
Procedural safety and high rates of in-stent recurrent stenotic lesions (ISR) remain a concern in the endovascular treatment of intracranial atherosclerotic disease (ICAD). In the present study technical feasibility, safety and efficacy of the paclitaxel eluting balloon-expandable coronary stent Coroflex(®) Please was assessed in the treatment of ICAD. A total ...
Psarros Costas - - 2012
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in developed countries, with an increasing prevalence due to an aging population. The pathology underpinning CVD is atherosclerosis, a chronic inflammatory state involving the arterial wall. Accumulation of low density lipoprotein (LDL) laden macrophages in the arterial wall and ...
Shah Abhidha - - 2012
The authors report an extremely rare cause of cervicomedullary cord compression by anomalous ectatic vertebral arteries. A 50-year-old male patient presented with a 9 month history of progressive quadriparesis. Investigations revealed that the vertebral arteries on both sides had a mirror-like course and caused a deep indentation into the high ...
Balderi A - - 2012
PURPOSE: The aim of this study was to analyse our 8 years of experience with endovascular treatment of visceral aneurysms and pseudoaneurysms. MATERIALS AND METHODS: From January 2002 to September 2009, we used an endovascular approach to treat 30 patients (22 men, eight women) affected by aneurysm (n=18) or pseudoaneurysm ...
Nakiri Guilherme S - - 2012
In the presence of associated subarachnoid hemorrhage, the treatment of arterial dissection can be classified as either deconstructive (involving occlusion or sacrifice of the parent vessel) or reconstructive (preserving blood-flow through the parent vessel). In both treatment strategies, the main goal is to prevent any further risk of rebleeding. However, ...
Egger Jan - - 2012
In this work, we present modeling and visualization techniques for virtual stenting of aneurysms and stenoses. In particular, contributions to support the computer-aided treatment of artery diseases - artery enlargement (aneurysm) and artery contraction (stenosis) - are made. If an intervention takes place, there are two different treatment alternatives for ...
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