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Fang Hui H Department of Cardiology, Institute of War Surgery, The Third Affiliated Hospital of Third Military Medical University, Chongqing 400042, P.R. - - 2014
This study aimed to analyze the correlation between single nucleotide polymorphisms (SNPs) of the actin, aortic smooth muscle (ACTA2) gene and coronary artery stenosis in patients with type 2 diabetes mellitus (T2DM). Eight SNPs from the promoter region of the ACTA2 gene were screened. Patients with T2DM (n=251) were divided ...
Najafi Mohammad M Biochemistry Department, Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran, - - 2014
Although the role of matrix Gla protein (MGP) is not completely known but, its expression within subendothelial macrophages and vascular smooth muscle cells is suggested to be involved in vascular calcification. In this study, we investigated the associations between the serum MGP levels and the MGP promoter high minor allele ...
Lim Kyung-Seob KS Korea Cardiovascular Stent Research Institute, Gwangju, Korea. ; Heart Research Center Nominated by Korea Ministry of Health and Welfare, Chonnam National University Hospital, Gwangju, Korea. ; Cardiovascular Research Center, Chonnam National University Hospital, Gwangju, - - 2013
Single coronary artery is a rare coronary artery anomaly. Very few previous reports of this anatomical malformation in swine have been found. A 22 kg Yorkshire X Landrace F1 crossbred castrated male swine was presented for enrollment in a coronary stent implantion study. Coronary angiography revealed a single coronary artery ...
Folsom Aaron R - - 2013
How 9p21 variation affects risk of cardiovascular disease is unclear, so we assessed whether 9p21 variants are associated with arterial elasticity or retinal microvascular findings. In the prospective Multi-Ethnic Study of Atherosclerosis (MESA) we assessed 378 SNPs in the 9p21 locus. Within four ethnic groups, we used an additive genetic ...
Aristotle Sharmila - - 2013
Background: Each kidney is supplied by a single renal artery and a single renal vein, which accounts for about 20% of the cardiac output. However, variations in the form of level of origin and arrangement of renal arteries are so frequent. Aim: The present study aimed to note the vascular ...
Maeda Seiji - - 2013
Increased arterial stiffness is an independent risk factor for cardiovascular disease. Arterial stiffness is higher in obese individuals than in nonobese individuals. Lifestyle modifications (i.e. exercise and dietary modification) decrease arterial stiffness in obese individuals. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase, an enzyme responsible for ...
Chawla Kunal - - 2013
During routine dissection of 82-year-old female cadaver with no known unfavorable medical history, we observed bilateral bifid ureter and variation in arterial supply of left kidney only. Careful examination revealed that there were bifid ureters on both sides enclosed in single facial sheath. It was also observed that both the ...
Miyaki Asako - - 2013
BACKGROUND: Obesity and increased arterial stiffness are independent risk factors for cardiovascular disease. The degree of arterial stiffness in obese individuals is greater than that in normal-weight subjects. Pentraxin 3 (PTX3) is mainly produced by vascular tissues and exerts a cardioprotective effect. However, the relationship between PTX3 and arterial stiffness ...
Dash J R - - 2013
The aim of the present work was to study the mechanism of action of curcumin in vasomotion of a physiologically important artery of ruminant i.e. ruminal artery. ACh and SNP were used to study the role of endothelium in relaxation of this artery. Vasorelaxatation by curcumin was studied in a ...
Jarrett Catherine - - 2013
For mammals, acetylcholine (ACh) promotes endothelium-dependent vasodilation primarily through nitric oxide (NO) and prostaglandin-mediated pathways, with varying reliance on endothelial-derived hyperpolarizing factors. Currently, no studies have been conducted on small systemic arteries from wild birds. We hypothesized that ACh-mediated vasodilation of isolated small arteries from mourning doves (Zenaida macroura) would ...
Wong Yuen Y E - - 2013
OBJECTIVE: This study was conducted to determine whether plasma total homocysteine (tHcy) and the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism are associated with abdominal aortic aneurysm (AAA) and aortic diameter. METHODS: This was a cross-sectional study set in Western Australia of 4248 community-dwelling men aged 70 to 88 years. Infrarenal aortic ...
van Setten Jessica J Department of Medical Genetics, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The - - 2013
Arterial calcification is a well-known risk factor for coronary artery disease (CAD) and myocardial infarction (MI). We performed a genome-wide association study on coronary artery calcification and aortic calcification as intermediate traits for CAD/MI. We tested ∼2.5 million SNPs for association with coronary artery calcification and aortic calcification in 2620 ...
Melton Phillip E PE Deptartment of Genetics, Texas Biomedical Research Institute, San Antonio, USA. - - 2013
BACKGROUND- Intima-media thickness (IMT) of the common and internal carotid arteries is an established surrogate for atherosclerosis and predicts risk of stroke and myocardial infarction. Often IMT is measured as the average of these 2 arteries; yet, they are believed to result from separate biological mechanisms. The aim of this ...
Wang Wen-Zhu - - 2013
Angiotensinogen (AGT) T174M gene polymorphism has been suggested to be linked to risk of coronary artery disease, however, results from studies of this association have been inconsistent. In this study, we assess the relationship between AGT T174M gene polymorphism and coronary artery disease. We conducted a meta-analysis of 18 case-control ...
Williams-Phillips S S Andrews Memorial Hospital, TAI Wing, 27 Hope Road, Kingston 10, Jamaica, West Indies. - - 2013
Single right coronary artery, so defined because all three coronary arteries arise from the single right aortic sinus of Valsalva, is an extremely rare entity occurring in less than 0.03% of the population. This case identifies a single coronary artery with the left anterior descending coronary artery distally connected to ...
Markus Hugh S - - 2013
BACKGROUND AND PURPOSE: A novel association between a single nucleotide polymorphism on chromosome 7p21.1 and large-vessel ischemic stroke was recently identified. The most likely underlying gene is histone deacetylase 9 (HDAC9). The mechanism by which HDAC9 increases stroke risk is not clear; both vascular and neuronal mechanisms have been proposed. ...
Cesana Francesca - - 2013
Objective. Evidence exists that arterial stiffness, i.e. an independent predictor of cardiovascular and all-causes mortality, has a genetic component. The 9p21 region is associated with a greater susceptibility to coronary disease. Whether this can be ascribed to the fact that genes located on chromosome 9p may also regulate arterial stiffness ...
Thanassoulis George G Department of Medicine and the Research Institute, McGill University Health Centre, - - 2013
Limited information is available regarding genetic contributions to valvular calcification, which is an important precursor of clinical valve disease. We determined genomewide associations with the presence of aortic-valve calcification (among 6942 participants) and mitral annular calcification (among 3795 participants), as detected by computed tomographic (CT) scanning; the study population for ...
Conte Michael S - - 2013
OBJECTIVE: Factors responsible for the variability in outcomes after lower extremity vein bypass grafting (LEVBG) are poorly understood. Recent evidence has suggested that a single nucleotide polymorphism (SNP) in the promoter region of the p27(Kip1) gene, a cell-cycle regulator, is associated with coronary in-stent restenosis. We hypothesized an association with ...
Joh Jin Hyun - - 2013
Purpose: It is important to know the normal diameter of artery throughout the body so that clinicians are able to determine when an artery becomes aneurysmal. However, there are no previous studies on the normal diameter of arteries in the general Korean population. The purpose of this article is to ...
Makita Chiyoko - - 2013
Polymorphous low-grade adenocarcinoma is a rare malignant tumor that mainly occurs in salivary glands, particularly in the hard palate. To date, surgery has been the most commonly used treatment method with the aim of achieving negative margins of resection. Here, we report a case of a 51-year-old woman who presented ...
Kovarnik T - - 2013
The prediction of coronary vessel involvement by means of noninvasive tests is one of the fundamental objectives of preventive cardiology. This review describes the current possibilities of coronary vessel involvement prediction by means of ultrasonographic examination of carotid arteries, analysis of polymorphisms in the genes encoding enzymes responsible for production ...
Phababpha Suphawadee S Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, - - 2013
Increased arterial stiffness is a cardiovascular outcome of metabolic syndrome (MetS). The chromosome 9p21 locus has been identified as a major locus for risk of coronary artery disease (CAD). The single nucleotide polymorphism (SNP), rs1333049 on chromosome 9p21.3 has been strongly associated with CAD and myocardial infarction. Increased arterial stiffness ...
Hassanain Hamdy H HH Molecular, Cellular and Developmental Biology Program, the Ohio State University Wexner Medical Center, 1645 Neil Avenue, Columbus, OH 43210, USA. - - 2013
Hypertension represents a major risk factor for cardiovascular events, associating with vascular hypertrophy and dysfunction in resistance vessels. Clevidipine is a novel antihypertensive drug working as a selective calcium channel antagonist with an ultra-short half-life that lowers arterial blood pressure by reducing systemic arterial resistance. The aim was to assess ...
Schmidt Augusto Frederico - - 2012
PURPOSE: Congenital diaphragmatic hernia (CDH) is associated with pulmonary hypertension which is often difficult to manage and a significant cause of morbidity and mortality. Our aim was to study the pulmonary artery reactivity in an animal model of CDH. METHODS: To investigate the reactivity of the aorta and left pulmonary ...
Christensen A L - - 2012
We read with interest the recent letter in the Journal about seasonal variation of venous thrombosis by Ribeiro et al [1]. Based on three case-control or case-cohort studies they concluded that there is a small seasonal variation with a trough during spring but since the differences between the four seasons ...
Bos Daniel - - 2012
BACKGROUND: -Atherosclerosis in different vessel beds shares lifestyle and environmental risk factors. We investigated whether this also holds for genetic risk factors. Hence, we used genetic loci for coronary artery calcification (CAC) and serum lipid levels -one of the strongest risk factors for atherosclerosis- to assess their relationship with atherosclerosis ...
Harrison Seamus C SC Centre for Cardiovascular Genetics, UCL, UK. - - 2013
Expansive remodelling is the process of compensatory arterial enlargement in response to atherosclerotic stimuli. The genetic determinants of this process are poorly characterized. Genetic association analyses of inter-adventitial common carotid artery diameter (ICCAD) in the IMPROVE study (n = 3427) using the Illumina 200k Metabochip was performed. Single nucleotide polymorphisms (SNPs) that ...
Ercakmak B - - 2012
During the routine gross anatomical dissection of the right inguinal region of a 45-year-old male cadaver, a variation was observed both in the inferior epigastric artery and the inferior epigastric vein. In this case, the right inferior epigastric artery originated from the femoral artery 13 mm inferior to the inguinal ...
Shukla Praveen P Department of Pharmaceutical Sciences, North Dakota State University, Fargo, 58108-6050, - - 2012
Melatonin inhibits nitric oxide (NO)-induced relaxation of coronary arteries. We tested the hypothesis that melatonin increases the phosphorylation of phosphodiesterase 5 (PDE5), which increases the activity of the enzyme and thereby decreases intracellular cGMP accumulation in response to NO and inhibits NO-induced relaxation. Sodium nitroprusside (SNP) and 8-Br-cGMP caused concentration-dependent ...
Panaich Sidakpal S - - 2012
Objectives: Reduced arterial elasticity is a risk factor for coronary artery disease. Our main objective was to evaluate the association between large arterial elasticity (LAE) and small arterial elasticity (SAE) with subclinical atherosclerosis as reflected by the coronary artery calcium score (CACS). Methods: The Multi-Ethnic Study of Atherosclerosis (MESA) includes ...
Bertolini G - - 2012
In this retrospective study, the appearances of extrahepatic and intrahepatic portal vein aneurysms (PVAs) in dogs were evaluated using multidetector computed tomography (CT). Data from 3060 dogs that underwent abdominal CT were reviewed for focal portal vein dilatation. PVAs were detected in 15/3060 (0.49%) dogs. The bodyweights of dogs with ...
Rai Rajalakshmi - - 2012
Knowledge of variations in the formation of superficial palmar arch is beneficial for successful vascular surgery in the hand as well as for plastic surgeons. The authors describe an unusual completion of superficial palmar arch by first dorsal metacarpal branch of radial artery at the first interdigital cleft which was ...
Astarci Parla - - 2012
We developed a novel resection device to use during transapical transcatheter aortic valve implantation (TAVI) using a circular blade. We assessed the device in 15 human cadavers by transapical approach. After the resection, the aortic annulus was measured using standard probes. A careful examination of the aortic wall, left ventricular ...
Goyal S N - - 2012
Metabolic syndrome (MetS) is defined as a cluster of numerous cardiovascular risk factors, which encompasses obesity, dyslipidaemia, insulin resistance and hypertension. Patients with MetS are more prone to developing cardiovascular events than other patients. To date, several approaches such as physical exercise, dietary control and invasive and non-invasive therapeutic interventions ...
Owida Amal Ahmed - - 2012
Arterial bypass grafts tend to fail after some years due to the development of intimal thickening (restenosis). Non-uniform hemodynamics following a bypass operation contributes to restenosis and bypass failure can occur due to the focal development of anastomotic intimal hyperplasia. Additionally, surgical injury aggravated by compliance mismatch between the graft ...
Guo Jincheng - - 2012
Congenital absence of the left circumflex artery is a rare anomaly of the coronary arteries. A 52-year-old man who developed acute inferior myocardial infarction underwent coronary angiography which revealed the absence of the left circumflex artery and that the surrounding structures were supplied by the infarct-related super-dominant right coronary artery. ...
Chang Ching-Pin - - 2012
Formation of the cardiac outflow tract and great arteries involves complex morphogenetic processes, whose abnormities result in several clinically important diseases. Studies of these developmental processes are therefore important for understanding congenital vascular defects. However, the three-dimensional structure of arteries makes it challenging to analyze the pattern of vasculature using ...
Filipovic Branislav - - 2012
Variations in the number and course of the testicular arteries, often coexisting with variations of the other branches arising from the abdominal aorta, are still reported to be of interest to urology surgeons. During a routine dissection course, an unusual origin of the double left testicular artery was observed in ...
Kapre Madan M Department of ENT, Neeti Clinics, Nagpur, - - 2013
Every surgery is planned on the anatomical arrangement of the structures. Any variation in the arterial arrangement may lead to haemorrhagic episodes during intraoperative procedures. In this study, variations in the branching pattern of external carotid artery were noted. In two of the cases, thyrolingual trunk was observed. In the ...
Chen Shao-Wei - - 2011
We report a previously healthy 21-year-old man who developed disseminated varicella zoster infection complicated with encephalitis, acute renal insufficiency, liver dysfunction, and an apparent pustular skin superinfection with Staphylococcus aureus. He later developed an extensively destructive endocarditis affecting a congenital bicuspid aortic valve, accompanied with leaflet perforation, complete atrio-ventricular (AV) ...
Pereira Barbara Sucupira - - 2011
The objective was to evaluate blood flow in fetal and maternal vessels by Triplex Doppler and its association with development of blood vessels during gestation in the domestic cat. Ten queens were examined weekly from 14 to 63 d after mating. Peak systolic velocity (PSV), end diastolic velocity (EDV), resistance ...
Saueressig Maurício Guidi - - 2011
OBJECTIVE: To experimentally develop tracheal stenosis and malacia to test new models of tracheal stents. METHODS: We resected three cartilaginous rings from the cervical trachea of dogs in group A (n = 5) and six rings in group B (n = 4) to produce malacia. The mucosa of the region ...
Schäfer Ulrich - - 2011
We report a case of a new developed aortic aneurysm 18 month after transcatheter aortic valve implantation in an 80-year-old woman. The abnormality was an incidental finding during routine coronary angiography. © 2011 Wiley-Liss, Inc.
Merk Denis R - - 2011
Rationale:Marfan syndrome (MFS) is a systemic connective tissue disorder notable for the development of aortic root aneurysms and the subsequent life-threatening complications of aortic dissection and rupture. Underlying fibrillin-1 gene mutations cause increased transforming growth factor-β (TGF-β) signaling. Although TGF-β blockade prevents aneurysms in MFS mouse models, the mechanisms through ...
Shreiner Andrew B - - 2012
Pulmonary arterial remodeling is a pathological process seen in a number of clinical disease states, driven by inflammatory cells and mediators in the remodeled artery microenvironment. In murine models, Th2 cell-mediated immune responses to inhaled antigens, such as purified Aspergillus allergen, have been reported to induce remodeling of pulmonary arteries. ...
Thielmann M - - 2011
Transcatheter aortic valve implantation (TAVI) has become a viable treatment option in high-risk patients with symptomatic aortic stenosis. The widespread uses of TAVI procedures in recent years and the steadily growing evolution of numerous new catheter-based devices have led to a remarkable shift in the treatment of this patients group ...
Wilshaw Stacy-Paul SP Faculty of Biological Sciences, Institute of Medical and Biological Engineering, The University of Leeds, Leeds, United Kingdom. - - 2012
Surgeons have used cryopreserved vascular allografts successfully for many years to treat arterial occlusive disease and to repair arterial aneurysms. Vascular allografts demonstrate high patency rates but contain viable cells, which may evoke a rejection response following implantation. Removing the cells could prevent such a response and negate the need ...
Rodríguez-Caulo Emiliano A - - 2011
Giant cell arteritis (GCA) is the most common form of large vessel arteritis. GCA typically involves the branches of the external carotid artery, but is the leading cause of inflammatory aortitis. However, involvement of the aorta often goes undetected. We present a case of an 81-year-old man, with headache and ...
Brountzos Elias - - 2011
PURPOSE: To determine, based on preoperative imaging findings, which patients treated with endovascular abdominal aneurysm repair are at high risk for the development of persistent type II endoleaks. MATERIALS AND METHODS: Preoperative computed tomography (CT) angiographies of 136 patients, treated endovascularly, were retrospectively examined for possible anatomic predictors of type ...
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