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Phababpha Suphawadee S Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, - - 2013
Increased arterial stiffness is a cardiovascular outcome of metabolic syndrome (MetS). The chromosome 9p21 locus has been identified as a major locus for risk of coronary artery disease (CAD). The single nucleotide polymorphism (SNP), rs1333049 on chromosome 9p21.3 has been strongly associated with CAD and myocardial infarction. Increased arterial stiffness ...
Hassanain Hamdy H HH Molecular, Cellular and Developmental Biology Program, the Ohio State University Wexner Medical Center, 1645 Neil Avenue, Columbus, OH 43210, USA. - - 2013
Hypertension represents a major risk factor for cardiovascular events, associating with vascular hypertrophy and dysfunction in resistance vessels. Clevidipine is a novel antihypertensive drug working as a selective calcium channel antagonist with an ultra-short half-life that lowers arterial blood pressure by reducing systemic arterial resistance. The aim was to assess ...
Majumdar Sudeshna - - 2013
Variations in the branching pattern of the axillary artery have paramount importance among anatomists, surgeons and radiologists. A study was conducted on this topic in Kolkata, among the people of West Bengal, a state of India. The upper limbs of 70 cadavers were dissected bilaterally at the Department of Anatomy, ...
Schmidt Augusto Frederico - - 2012
PURPOSE: Congenital diaphragmatic hernia (CDH) is associated with pulmonary hypertension which is often difficult to manage and a significant cause of morbidity and mortality. Our aim was to study the pulmonary artery reactivity in an animal model of CDH. METHODS: To investigate the reactivity of the aorta and left pulmonary ...
Christensen A L - - 2012
We read with interest the recent letter in the Journal about seasonal variation of venous thrombosis by Ribeiro et al [1]. Based on three case-control or case-cohort studies they concluded that there is a small seasonal variation with a trough during spring but since the differences between the four seasons ...
Bos Daniel - - 2012
BACKGROUND: -Atherosclerosis in different vessel beds shares lifestyle and environmental risk factors. We investigated whether this also holds for genetic risk factors. Hence, we used genetic loci for coronary artery calcification (CAC) and serum lipid levels -one of the strongest risk factors for atherosclerosis- to assess their relationship with atherosclerosis ...
Harrison Seamus C SC Centre for Cardiovascular Genetics, UCL, UK. - - 2013
Expansive remodelling is the process of compensatory arterial enlargement in response to atherosclerotic stimuli. The genetic determinants of this process are poorly characterized. Genetic association analyses of inter-adventitial common carotid artery diameter (ICCAD) in the IMPROVE study (n = 3427) using the Illumina 200k Metabochip was performed. Single nucleotide polymorphisms (SNPs) that ...
Ercakmak B - - 2012
During the routine gross anatomical dissection of the right inguinal region of a 45-year-old male cadaver, a variation was observed both in the inferior epigastric artery and the inferior epigastric vein. In this case, the right inferior epigastric artery originated from the femoral artery 13 mm inferior to the inguinal ...
Shukla Praveen P Department of Pharmaceutical Sciences, North Dakota State University, Fargo, 58108-6050, - - 2012
Melatonin inhibits nitric oxide (NO)-induced relaxation of coronary arteries. We tested the hypothesis that melatonin increases the phosphorylation of phosphodiesterase 5 (PDE5), which increases the activity of the enzyme and thereby decreases intracellular cGMP accumulation in response to NO and inhibits NO-induced relaxation. Sodium nitroprusside (SNP) and 8-Br-cGMP caused concentration-dependent ...
Panaich Sidakpal S - - 2012
Objectives: Reduced arterial elasticity is a risk factor for coronary artery disease. Our main objective was to evaluate the association between large arterial elasticity (LAE) and small arterial elasticity (SAE) with subclinical atherosclerosis as reflected by the coronary artery calcium score (CACS). Methods: The Multi-Ethnic Study of Atherosclerosis (MESA) includes ...
Bertolini G - - 2012
In this retrospective study, the appearances of extrahepatic and intrahepatic portal vein aneurysms (PVAs) in dogs were evaluated using multidetector computed tomography (CT). Data from 3060 dogs that underwent abdominal CT were reviewed for focal portal vein dilatation. PVAs were detected in 15/3060 (0.49%) dogs. The bodyweights of dogs with ...
Rai Rajalakshmi - - 2012
Knowledge of variations in the formation of superficial palmar arch is beneficial for successful vascular surgery in the hand as well as for plastic surgeons. The authors describe an unusual completion of superficial palmar arch by first dorsal metacarpal branch of radial artery at the first interdigital cleft which was ...
Astarci Parla - - 2012
We developed a novel resection device to use during transapical transcatheter aortic valve implantation (TAVI) using a circular blade. We assessed the device in 15 human cadavers by transapical approach. After the resection, the aortic annulus was measured using standard probes. A careful examination of the aortic wall, left ventricular ...
Goyal S N - - 2012
Metabolic syndrome (MetS) is defined as a cluster of numerous cardiovascular risk factors, which encompasses obesity, dyslipidaemia, insulin resistance and hypertension. Patients with MetS are more prone to developing cardiovascular events than other patients. To date, several approaches such as physical exercise, dietary control and invasive and non-invasive therapeutic interventions ...
Owida Amal Ahmed - - 2012
Arterial bypass grafts tend to fail after some years due to the development of intimal thickening (restenosis). Non-uniform hemodynamics following a bypass operation contributes to restenosis and bypass failure can occur due to the focal development of anastomotic intimal hyperplasia. Additionally, surgical injury aggravated by compliance mismatch between the graft ...
Guo Jincheng - - 2012
Congenital absence of the left circumflex artery is a rare anomaly of the coronary arteries. A 52-year-old man who developed acute inferior myocardial infarction underwent coronary angiography which revealed the absence of the left circumflex artery and that the surrounding structures were supplied by the infarct-related super-dominant right coronary artery. ...
Chang Ching-Pin - - 2012
Formation of the cardiac outflow tract and great arteries involves complex morphogenetic processes, whose abnormities result in several clinically important diseases. Studies of these developmental processes are therefore important for understanding congenital vascular defects. However, the three-dimensional structure of arteries makes it challenging to analyze the pattern of vasculature using ...
Filipovic Branislav B Institute of Anatomy "Niko Miljanic", University of Belgrade, Faculty of Medicine, 4/2 Dr Subotica, 11000, Belgrade, Serbia. - - 2012
Variations in the number and course of the testicular arteries, often coexisting with variations of the other branches arising from the abdominal aorta, are still reported to be of interest to urology surgeons. During a routine dissection course, an unusual origin of the double left testicular artery was observed in ...
Kapre Madan M Department of ENT, Neeti Clinics, Nagpur, - - 2013
Every surgery is planned on the anatomical arrangement of the structures. Any variation in the arterial arrangement may lead to haemorrhagic episodes during intraoperative procedures. In this study, variations in the branching pattern of external carotid artery were noted. In two of the cases, thyrolingual trunk was observed. In the ...
Chen Shao-Wei - - 2011
We report a previously healthy 21-year-old man who developed disseminated varicella zoster infection complicated with encephalitis, acute renal insufficiency, liver dysfunction, and an apparent pustular skin superinfection with Staphylococcus aureus. He later developed an extensively destructive endocarditis affecting a congenital bicuspid aortic valve, accompanied with leaflet perforation, complete atrio-ventricular (AV) ...
Pereira Barbara Sucupira - - 2011
The objective was to evaluate blood flow in fetal and maternal vessels by Triplex Doppler and its association with development of blood vessels during gestation in the domestic cat. Ten queens were examined weekly from 14 to 63 d after mating. Peak systolic velocity (PSV), end diastolic velocity (EDV), resistance ...
Saueressig Maurício Guidi - - 2011
OBJECTIVE: To experimentally develop tracheal stenosis and malacia to test new models of tracheal stents. METHODS: We resected three cartilaginous rings from the cervical trachea of dogs in group A (n = 5) and six rings in group B (n = 4) to produce malacia. The mucosa of the region ...
Schäfer Ulrich - - 2011
We report a case of a new developed aortic aneurysm 18 month after transcatheter aortic valve implantation in an 80-year-old woman. The abnormality was an incidental finding during routine coronary angiography. © 2011 Wiley-Liss, Inc.
Merk Denis R - - 2011
Rationale:Marfan syndrome (MFS) is a systemic connective tissue disorder notable for the development of aortic root aneurysms and the subsequent life-threatening complications of aortic dissection and rupture. Underlying fibrillin-1 gene mutations cause increased transforming growth factor-β (TGF-β) signaling. Although TGF-β blockade prevents aneurysms in MFS mouse models, the mechanisms through ...
Shreiner Andrew B - - 2012
Pulmonary arterial remodeling is a pathological process seen in a number of clinical disease states, driven by inflammatory cells and mediators in the remodeled artery microenvironment. In murine models, Th2 cell-mediated immune responses to inhaled antigens, such as purified Aspergillus allergen, have been reported to induce remodeling of pulmonary arteries. ...
Thielmann M - - 2011
Transcatheter aortic valve implantation (TAVI) has become a viable treatment option in high-risk patients with symptomatic aortic stenosis. The widespread uses of TAVI procedures in recent years and the steadily growing evolution of numerous new catheter-based devices have led to a remarkable shift in the treatment of this patients group ...
Wilshaw Stacy-Paul SP Faculty of Biological Sciences, Institute of Medical and Biological Engineering, The University of Leeds, Leeds, United Kingdom. - - 2012
Surgeons have used cryopreserved vascular allografts successfully for many years to treat arterial occlusive disease and to repair arterial aneurysms. Vascular allografts demonstrate high patency rates but contain viable cells, which may evoke a rejection response following implantation. Removing the cells could prevent such a response and negate the need ...
Rodríguez-Caulo Emiliano A - - 2011
Giant cell arteritis (GCA) is the most common form of large vessel arteritis. GCA typically involves the branches of the external carotid artery, but is the leading cause of inflammatory aortitis. However, involvement of the aorta often goes undetected. We present a case of an 81-year-old man, with headache and ...
Brountzos Elias - - 2011
PURPOSE: To determine, based on preoperative imaging findings, which patients treated with endovascular abdominal aneurysm repair are at high risk for the development of persistent type II endoleaks. MATERIALS AND METHODS: Preoperative computed tomography (CT) angiographies of 136 patients, treated endovascularly, were retrospectively examined for possible anatomic predictors of type ...
Aronson Paul L - - 2011
Infective endocarditis due to Neisseria sicca, a normal inhabitant of the upper respiratory tract, is rarely reported but associated with embolic phenomena and large vegetations often requiring surgical intervention. We report a previously healthy 12-year-old girl who presented with prolonged fever and altered mental status. The patient developed rapidly progressive ...
Theruvath Tom P - - 2011
Abstract  Central to the pathologic changes in developing aortic aneurysms are alterations in the abundance and activity of proteases, of which the most important for aneurysm production comprise the matrix metalloproteinase (MMP) family. In this review, literature demonstrating the role of MMPs in the development of aortic aneurysms is presented, ...
Gessaroli Massimiliano - - 2012
Stenosis is the main cause of hemodialysis vascular graft failure and it is primarily caused by neointimal hyperplasia (NH) development at the vein-graft anastomosis. Even though NH development factors are well known, their activation pathway still remains disputed and the real role of the mismatch compliance between the vein and ...
Song Xiaohua - - 2012
Maintenance of healthy arteries requires a balance between injuries to the arterial wall and processes of intrinsic arterial repair. Such repair requires the availability of progenitor cells that are local to the wall itself. Progenitor cells from distant reservoirs like the bone marrow may also contribute to repair. Arterial repair ...
Mazzei Valerio - - 2011
Abstract  A 71-year-old female developed a painless neck mass three months following an aortic valve replacement, mitral commissurotomy, and coronary artery bypass. A cervical trunk angio revealed a pseudoaneurysm supplied from a branch of the thyrocervical trunk, which was successfully excised. (J CARD SURG 2011;**:1-2).
Linde Torsten - - 2011
During the development of a mechanical heart valve prosthesis, many studies are conducted to guarantee its correct function. Currently, investigations into the thrombogenic potential of a valve after its replacement are conducted with expensive and time-consuming chronic animal trials. Hence, the study aim was to develop and test an alternative ...
Biçer Asuman - - 2011
Abstract Objectives. Thymosin beta 4 (Tβ4) plays an essential role in cardiac vessel development and is currently being developed as a therapeutic agent for the treatment of coronary artery disease (CAD) in some experimental studies. Thus, we aimed to investigate the association of serum Tβ4 levels and collateral formation in ...
Fantin Alessandro - - 2011
Neuropilin 1 (NRP1) is a transmembrane glycoprotein that is essential for blood vessel development in vertebrates. Best known for its ability to bind members of the vascular endothelial growth factor (VEGF) and class 3 semaphorin families through its extracellular domain, it also has a highly conserved cytoplasmic domain, which terminates ...
Fung George S K GS Department of Radiology, Johns Hopkins University, Baltimore, MD, USA. - - 2011
A detailed three-dimensional (3D) model of the coronary artery tree with cardiac motion has great potential for applications in a wide variety of medical imaging research areas. In this work, we first developed a computer-generated 3D model of the coronary arterial tree for the heart in the extended cardiac-torso (XCAT) ...
Black S A - - 2011
Hybrid procedures for the repair of thoracoabdominal aneurysms have become more widely reported in the literature in the past few years. This procedure was developed as an alternative to the traditional method of open thoracoabdominal repair in the absence of a viable total endovascular solution for all cases. The early ...
Barbash Israel M - - 2011
To develop a catheter-based model of large pulmonary embolism (PE) in swine based on in situ venous thrombus formation. Ten Yorkshire swine underwent transjugular implantation of a retrievable inferior vena cava (IVC) filter. A thrombin and collagen mixture was injected into a confined space created by two balloons inflated proximal ...
Samady Habib - - 2011
Background- Experimental studies suggest that low wall shear stress (WSS) promotes plaque development and high WSS is associated with plaque destabilization. We hypothesized that low-WSS segments in patients with coronary artery disease develop plaque progression and high-WSS segments develop necrotic core progression with fibrous tissue regression. Methods and Results- Twenty ...
Orozco Ludwig D - - 2011
RATIONALE: The rat carotid balloon-injury (BI) model is a widely used model of intimal hyperplasia (IH) and vascular remodeling. A variable degree of IH after BI has been previously reported, and we have encountered technical challenges and suboptimal results with the original method. OBJECTIVE: To evaluate the original rat carotid ...
Flynn Rowan R Department of Medicine, University of Washington, Seattle, Washington 98195-7710, - - 2011
Expression of atheroprotective genes in the blood vessel wall is potentially an effective means of preventing or reversing atherosclerosis. Development of this approach has been hampered by lack of a suitable gene-transfer vector. We used a helper-dependent adenoviral (HDAd) vector to test whether expression of apolipoprotein A-I (apoA-I) in the ...
Bazigou Eleni E Lymphatic Development Laboratory, Cancer Research UK London Research Institute, London, - - 2011
Chronic venous disease and venous hypertension are common consequences of valve insufficiency, yet the molecular mechanisms regulating the formation and maintenance of venous valves have not been studied. Here, we provide what we believe to be the first description of venous valve morphogenesis and identify signaling pathways required for the ...
Kline-Fath Beth M - - 2011
Congenital diaphragmatic hernia, despite advances in therapy, remains a complex condition with significant morbidity and mortality. The etiology of the disorder is still incompletely understood, though the pulmonary hypoplasia and pulmonary hypertension that develop secondarily must be overcome to improve survival. Prenatal US and fetal MRI have helped in the ...
Akdemir Ramazan - - 2011
Evaluation of: Nagy E, Andersson DC, Caidahl K et al. Upregulation of the 5-lipoxygenase pathway in human aortic valves correlates with severity of stenosis and leads to leukotriene-induced effects on valvular myofibroblasts. Circulation DOI: 10.1161/CIRCULATIONAHA.110.966846 (2011) (Epub ahead of print). Understanding the exact pathophysiological mechanism of degenerative aortic stenosis is ...
Bacchetta Matthew - - 2011
Extracorporeal circulatory support revolutionized the field of cardiothoracic surgery, initially in the form of cardiopulmonary bypass (CPB) and then in its modified form, extracorporeal membrane oxygenation (ECMO). Although initial cannulation techniques involved open intrathoracic approaches, the increased prevalence of reoperative sternotomies and the emergence of minimally invasive surgery encouraged the ...
Dupuis Loren E LE Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, 29425, - - 2011
In fetal valve maturation the mechanisms by which the relatively homogeneous proteoglycan-rich extracellular matrix (ECM) of endocardial cushions is replaced by a specialized and stratified ECM found in mature valves are not understood. Therefore, we reasoned that uncovering proteases critical for 'remodeling' the proteoglycan rich (extracellular matrix) ECM may elucidate ...
Basten Bethany L - - 2011
Corrosion casting was utilized to examine the development of gill vasculature in embryonic yellow stingrays, Urobatis jamaicensis (formerly Urolophus jamaicensis). The most marked changes in vascular configuration of the gills occur in the earliest castable stages of gestation. These changes included development of afferent external gill filament vessels and progression ...
Amole Adewumi O - - 2011
A woman in her early 60s with hypertension and hyperlipidemia was undergoing investigations for anemia of unknown etiology. She developed a sudden reduction in visual acuity and bilateral visual field impairment. MRI and angiography revealed acute infarcts in the posterior circulation and severe narrowing of the left vertebral artery origin. ...
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