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Zeng Da-Xiong - - 2013
Our previous study has demonstrated that a plasmid-based short hairpin RNA (shRNA) against cyclin D1 could attenuate the pulmonary artery smooth muscle cell (PASMC) proliferation and pulmonary vascular remodeling in smoking rats. In this report, we examined the efficiency of this shRNA plasmid in monocrotaline-induced pulmonary vascular remodeling. A single ...
Bechler Shane L SL Department of Chemical and Biological Engineering, University of Wisconsin - Madison, Madison, WI 53706, - - 2013
New therapeutic approaches that eliminate or reduce the occurrence of intimal hyperplasia following balloon angioplasty could improve the efficacy of vascular interventions and improve the quality of life of patients suffering from vascular diseases. Here, we report that treatment of arteries using catheter balloons coated with thin polyelectrolyte-based films ('polyelectrolyte ...
Eberlová Lada - - 2012
Objective: Abdominal aortic aneurysm (AAA) is a serious disease due to its covert nature, relatively high prevalence and fatal prognosis in the case of rupture. To obtain new insights into AAA pathogenesis, we examined the relationships between histopathology, multiplex in vitro immunoassay data, diameter and symptomatology. Methods: In a prospective, ...
Doenst Torsten - - 2011
Heated debates revolve around the hemodynamic performance of stented aortic tissue valves. Because the opening area strongly influences the generation of a pressure gradient over the prosthesis, and the outer diameter determines which valve actually fits into the aortic root, it would seem logical that the valve with the greatest ...
Shah Pravin M - - 2010
Although mitral valve prolapse as a disease entity has been recognized for over 50 years, its precise definition has been elusive. Initial reports based the diagnosis on auscultatory findings (late systolic click - murmur), with left ventricular angiography as a confirmative test. Echocardiography, first the M-mode, and subsequently the two-dimensional, ...
Suri Rakesh M - - 2010
Triangular leaflet resection to treat posterior mitral valve prolapse is expedient, sufficient, and durable in eliminating redundant myxomatous tissue and restoring normal leaflet coaptation. After triangular resection and suture reconstruction, mitral scallop height is decreased to a degree commensurate with the area of tissue resected. There are instances however, when ...
Biaggi Patric - - 2010
Echocardiographic assessment of a 72-year-old woman revealed a posterior mitral valve prolapse with an unusual central regurgitation jet. The use of three-dimensional (3D) transesophageal echocardiography elucidated the mismatch between morphologic and color Doppler echocardiographic findings: There was a cleft in the posterior mitral valve in addition to the posterior mitral ...
Lawrie Gerald M - - 2011
A nonresectional technique has been developed for repair of mitral leaflet prolapse causing mitral regurgitation. Polytetrafluoroethylene chordae are used for correction of edge misalignment of the prolapsed mitral leaflet. New chordal length is adjusted during progressive left ventricular inflation to systolic pressure. Annular sizing is determined dynamically after leaflet edge ...
Aubert Stéphane - - 2010
Quadrangular resection is the gold standard in the treatment of posterior leaflet prolapse. Anterior leaflet prolapse has been considered a more challenging problem; several techniques are available to treat it, all with the same goal - mitral valve competency. Nowadays, good long-term results are reported, similar to those for posterior ...
Davlouros Periklis A - - 2011
A 35 years old second gravida was admitted to our department with acute pulmonary oedema after labor. Echocardiography disclosed an intra-atrial membrane prolapsing through the mitral valve in diastole, with two small orifices creating a mean pressure gradient of 7.9mmHg. However the membrane clearly originated away from the mitral valve ...
Gregorini Renato - - 2009
Quadrangular resection of the posterior leaflet of the mitral valve is a well-established technique for the treatment of mitral regurgitation from prolapse of P2. Recently, Suri described triangular resection of the prolapsing scallop, a technique that, avoiding the plication of the annulus corresponding to the resected leaflet, maintains the geometry ...
Terzo Eloisa - - 2009
In this work we investigated which mitral valve leaflet was most often involved in mitral valve prolapse with degenerative mitral valve disease and whether there was an association with breed, age, gender, or weight. Five hundred and thirty-seven dogs with mitral valve prolapse-degenerative mitral valve disease were assessed; the cross-breed ...
Erek Ersin - - 2009
BACKGROUND AND AIM OF THE STUDY: A new mitral valve repair concept to treat mitral regurgitation (MR) due to valve prolapse was recently proposed. In this study, an improved design of this concept is presented, and the results of preliminary hemodynamic studies conducted in an in-vitro prolapse model are reported. ...
Prunotto Marco - - 2010
Mitral valve prolapse (MVP) is the most frequent cause of chronic, pure, and isolated mitral regurgitation, and is estimated to affect more than 144 million individuals worldwide. This short review focuses in particular on the structural and cellular aspects of MVP in humans. The key microscopic change in MVP appears ...
Molloi Sabee - - 2009
Breast arterial calcification (BAC) detected on mammography is frequently not included in final reports. However, previous studies have indicated that BAC may be evidence of general atherosclerotic vascular disease, and it can potentially be a useful marker of coronary artery disease. In addition, there are currently no available techniques for ...
Gonen Can - - 2009
BACKGROUND: It has been shown that standard endoscopic features often labeled as gastritis has a poor correlation with histopathology. Recently, high resolution magnifying endoscopy has been reported to be an effective method to diagnose gastritis. The aim of the present study was to compare standard endoscopy with magnifying endoscopy for ...
Manda Jayaprakash - - 2008
We compared live/real time three-dimensional transesophageal echocardiography (3D TEE) with real time two-dimensional transesophageal echocardiography (2D TEE) in the assessment of individual mitral valve (MV) segment/scallop prolapse and associated chordae rupture in 18 adult patients with a flail MV undergoing surgery for mitral regurgitation. 2D TEE was able to diagnose ...
Kelly Robert E RE - - 2008
Pectus excavatum is a depression of the sternum and costal cartilages which may present at birth, or more commonly during the teenage growth spurt. Symptoms of lack of endurance, shortness of breath with exercise, or chest pain are frequent. Although pectus excavatum may be a component of some uncommon syndromes, ...
Kawamura Satoru - - 2008
In this study, 114 Japanese observers (56 men and 58 women) rated the distinctiveness of 48 neutral faces and 48 smiling faces. Analysis showed smiling faces were rated as significantly more distinctive than neutral ones. Greater perceived distinctiveness provides an explanation for previous results that smiling faces are better remembered ...
de Kerchove Laurent - - 2008
OBJECTIVE: Leaflet plication (PL), triangular resection (TR), resuspension with running suture of Gore-Tex (GTx) and extension with autologous pericardial patch (PP) are different techniques to repair aortic leaflet prolapse (LP) for aortic insufficiency (AI). In this study, we report and compare the early and mid-term results of these techniques for ...
Smith Shawn - - 2008
Rats were used to examine the effects of inescapable swim stress on latent inhibition using a conditioned taste aversion procedure. Subjects were subjected to inescapable swim after each of three saccharin taste preexposures and saccharin was later paired with LiCl. The ability of swim to influence latent inhibition was assessed ...
Al-khayer Ahmad - - 2008
STUDY DESIGN: Prospective observational pilot study. OBJECTIVE.: To investigate the effect of right and left radiculopathy on driver reaction time (DRT), and the effect of selective nerve root block (SNRB) on DRT. SUMMARY OF BACKGROUND DATA: The effect of many orthopedic procedures on DRT has already been assessed. To date ...
Robert-Moreno Alex A Centre Oncologia Molecular, IDIBELL, Gran Via km 2.7 Hospitalet, Barcelona, - - 2008
Specific deletion of Notch1 and RBPjkappa in the mouse results in abrogation of definitive haematopoiesis concomitant with the loss of arterial identity at embryonic stage. As prior arterial determination is likely to be required for the generation of embryonic haematopoiesis, it is difficult to establish the specific haematopoietic role of ...
Lapenna Elisabetta - - 2008
BACKGROUND AND AIM OF THE STUDY: Mitral regurgitation (MR) due to commissural prolapse/flail represents a challenging surgical problem for which a variety of reconstructive approaches have been proposed. The study aim was to report the authors' experience with commissural closure within such a difficult setting. METHODS: Between 1998 and July ...
Jakob Stephan M - - 2008
Mucosal pH (pHi) is influenced by local perfusion and metabolism (mucosal-arterial pCO2 gradient, DeltapCO2), systemic metabolic acidosis (arterial bicarbonate), and respiration (arterial pCO2). We determined these components of pHi and their relation to outcome during the first 24 h of intensive care. We studied 103 patients with acute respiratory or ...
Srivastava Deepti - - 2008
Though the lifespan extension mechanism is partly understood from C. elegans to mice, a viable pharmacological intervention is not yet feasible. Here, we report that reserpine largely known as an antipsychotic-antihypertensive drug, can extend C. elegans lifespan. Chronic reserpine treatment from embryo stage or young adults extends the C. elegans ...
DelGaudio John M - - 2008
OBJECTIVE: To determine if degree of lingual tonsil hypertrophy (LTH) correlates with pharyngeal reflux. DESIGN: Prospective. METHODS: Patients with flexible laryngoscopic evidence of LTH were included. Degree of LTH was graded mild, moderate, or severe by two otolaryngologists blinded to pH study results. Three-sensor pH study results were correlated to ...
Demir DurmuĊŸ A - - 2008
We demonstrate that Dirac neutrino masses in the experimentally preferred range are generated within supersymmetric gauge extensions of the standard model with a generalized supersymmetry breaking sector. If the superpotential neutrino Yukawa terms are forbidden by the gauge symmetry [such as a U(1)'], sub-eV scale effective Dirac mass terms can ...
Yoshikai Masaru - - 2008
We designed a mitral valve repair and successfully performed this repair for a case of broad, asymmetrical prolapse in the middle scallop of the posterior mitral leaflet. The repair procedure consists of making a fan-shaped leaflet by resecting the prolapsed portion in a trapezoid shape with detachment of the leaflet ...
Gutiérrez-Chico Juan Luis - - 2008
BACKGROUND: Segmental analysis in mitral prolapse is important to decide the chances of valvular repair. Multiplane transesophageal echocardiography (TEE) is the only echocardiographic tool validated for this aim hitherto. The aim of the study was to assess if segmental analysis can be performed with transthoracic real-time 3-dimensional (3D) echocardiography as ...
Canbaz Fevziye - - 2008
PURPOSE: The objective of this trial was to investigate the capacity of gated perfusion SPECT (GPS) to detect left ventricular aneurysm (ANV) by comparing QGS and 4D-MSPECT (4DM) algorithms with radionuclide ventriculography (RVG). Secondarily, the comparison of GPS ejection fraction (EF) measurements with those of contrast left ventriculography (LVG) and ...
Hirata Kumiko - - 2008
BACKGROUND: Noninvasive and accurate assessment of mitral valve anatomy has become integral in the presurgical evaluation of patients with mitral valve prolapse (MVP). Recently developed real time three-dimensional (RT3D) ultrasound allows online acquisition, rendering, and can provide accurate information on cardiac structures. We sought to evaluate the feasibility of RT3D ...
Martin Jack L - - 2008
OBJECTIVE: This prospective randomized trial compared the Angio-Seal VIP with Perclose Proglide and to manual compression with respect to time to hemostasis and ambulation, patient satisfaction, and vascular complications following percutaneous coronary intervention (PCI). BACKGROUND: The use of arterial closure devices for the reduction of vascular complications following PCI remains ...
Gabriel Ruvin S - - 2008
PURPOSE: In mitral valve prolapse, determining whether the valve is suitable for surgical repair depends on the location and mechanism of regurgitation. We assessed whether cardiovascular magnetic resonance (CMR) could accurately identify prolapsing or flail mitral valve leaflets and regurgitant jet direction in patients with known moderate or severe mitral ...
Goodwin Deborah - - 2008
Paedomorphosis is the retention of juvenile morphology at maturity and is important in generating evolutionary change in domestic species and species in the wild. When comparing dogs with the wolf, this preliminary study saw paedomorphosis in their physical and behavioral traits (Goodwin, Bradshaw, & Wickens, 1997). This preliminary study compared ...
Sellgren Anna - - 2007
OBJECTIVE: To investigate the relationship between ASAT, CKMB, troponin-T and mortality after cardiac surgery. DESIGN: ASAT, CKMB and TnT were analysed in 116 patients. Correlation, sensitivity, specificity and predictive values for permanent myocardial injury (defined as TnT > or = 2.0 microg/l postoperative day four) were calculated. In the second ...
Al Quraishy S - - 2008
A new multivalvulid species, Kudoa pagrusi sp. n., was described from the sea bream Pagrus pagrus. The cysts were oval to ellipsoidal and restricted to the cardiac muscles. The mean spore measurements were 7.0 microm in length and 6.4 microm in width as well as in thickness, while the mean ...
McCarthy Melissa L - - 2008
STUDY OBJECTIVE: We examine the validity of the emergency department (ED) occupancy rate as a measure of crowding by comparing it to the Emergency Department Work Index Score (EDWIN), a previously validated scale. METHODS: A multicenter validation study was conducted according to ED visit data from 6 academic EDs for ...
Astley Henry C - - 2007
Animals moving through arboreal habitats face several functional challenges, including fitting onto and moving on cylindrical branches with variable diameters and inclines. In contrast to lizards and primates, the arboreal locomotion of snakes is poorly understood, despite numerous snake species being arboreal. We quantified the kinematics and performance of corn ...
Berul Charles I - - 2007
BACKGROUND: Transvenous pacemaker leads in children are often placed with redundant lead length to allow for anticipated patient growth. This excess lead may rarely prolapse into the pulmonary artery and potentially interfere with valve function. We sought to determine the response to lead repositioning on pulmonary valve insufficiency. METHODS: Retrospective ...
Butnor Kelly J - - 2007
Visceral pleural invasion (VPI) increases the T category of non-small cell lung carcinomas (NSCLCs) that otherwise only meet T1 criteria to T2. The American Joint Committee on Cancer provides no guidelines on what constitutes VPI. Penetration beyond the visceral pleural elastic layer (VPEL) has been proposed as the minimum criterion ...
Osswald Sandra S - - 2007
INTRODUCTION: Mitral valve prolapse (MVP) is a disqualifying condition for USAF aviators. Trained USAF aviators, and in recent years flying training applicants, may be granted waiver for initial or continued flying duties following extensive, periodic evaluation. This study examines the usefulness of the various tests performed in that evaluation process ...
Balmain Sean - - 2007
Up to 50% of patients with the clinical syndrome of heart failure have preserved left ventricular systolic function (HF-PSF). These patients may have abnormalities of ventriculo-vascular coupling, due to increased vascular and ventricular stiffness. We compared arterial compliance, microvascular vasodilator function and venous capacitance (VC) in 3 groups of patients ...
Yu W-C - - 2008
Carotid-femoral pulse wave velocity (cf-PWV) is a validated marker of arterial stiffening over the central arteries. Brachial-ankle pulse wave velocity (ba-PWV) integrates the mechanical properties from both the central and peripheral arteries and may be more representative than cf-PWV as arterial load for left ventricle (LV). We compared ba-PWV with ...
Nishiuchi Yukiko - - 2007
The distribution of Mycobacterium avium-intracellulare complex (MAC) in residences was examined. MAC was only recovered from bathrooms but not from other sites of residences. The appearance ratio in the bathrooms of patients with pulmonary MAC was significantly higher than that in healthy volunteers' bathrooms (P=.01). For 2 patients, the genotypes ...
Cornell Anna - - 2007
Recent implementation of the International Civil Aviation Organization (ICAO) amendment 167 to Annex 1 allows pilots from ICAO contracting states to fly until 65 yr old. In response to the new ICAO standard, the Federal Aviation Administration (FAA) commissioned an Aviation Rulemaking Committee (ARC) to make recommendations on whether the ...
Metcalfe Kristin - - 2007
Amphibiobeania epiphylla is a new, monotypic taxon of Beaniidae (Cheilostomata) from Darwin, Northern Territory. It is unique among the 6,000 living species of Bryozoa in that it encrusts mainly living tree leaves (chiefly the mangrove Rhizophora stylosa). The consequence of living in such a specialized habitat is that colonies are ...
Lee Jung S - - 2007
OBJECTIVE: The aim of this study was to compare gated blood pool single photon emission computed tomography (SPECT) (GBPS) and multidetector row computed tomography (MDCT) for the determination of right ventricular ejection fraction (RVEF) and right ventricular volumes (RVV) and to compare first-pass radionuclide angiography (FP-RNA) as the gold standard. ...
Telejko Elwira - - 2007
BACKGROUND: The efficacy of the angiotensin-converting enzyme (ACE) inhibitor perindopril in the treatment of hypertension, stable coronary artery disease, and heart failure is well established. The reduced stability of the current salt, perindopril-tert-butylamine, in extreme climatic conditions has prompted research into more stable compounds. This article presents stability and bioequivalence ...
Coutinho Gonçalo F - - 2007
Chordal replacement with expanded polytetrafluoroethylene (ePTFE) sutures has proven to be a simple, versatile, and durable technique for the treatment of prolapsed cusps causing mitral valve regurgitation. ePTFE is known for its strong resistance to tension, and is judged to be unbreakable under physiological conditions. Herein are reported two cases ...
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