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Zhou Wenting W Department of Pharmacology, Xinjiang Medical University, 830011- Urumqi, Xinjiang, People's Republic of - - 2014
Cydonia Oblonga Miller (COM) is traditionally used in Uyghur medicine for the prevention of cardiovascular disease. The present study is designed to explore the effects of COM extracts on models and markers of thrombosis and related biomarkers. 20, 40, 80mg/kg/day COM aqueous extracts and 5mg/kg/day aspirin, orally for 14 days ...
Farkas Daniela D Virginia Commonwealth University, Internal Medicine, Division of Pulmonary Disease and Critical Care Medicine, Richmond, Virginia, United States ; - - 2014
Nuclear factor-κB (NF-κB) and interleukin-6 (IL-6), a NF-κB downstream mediator, play a central role in the inflammatory response of tissues. We aimed to determine the role of the classical NF-κB pathway in severe pulmonary arterial hypertension (PAH) induced by SU5416 and chronic hypoxia (SuHx) in rats. Tissue samples from patients ...
Xiang Shui S Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, - - 2014
Coronary artery bypass graft (CABG) surgery is one of the most effective treatments for coronary artery disease. However, neointimal hyperplasia and ultimate luminal occlusion that is caused by vascular smooth muscle cell (VSMC) migration, proliferation and inflammatory response impede the long-term prognosis. The SOCS3 protein is involved in modulating various ...
Ping N-N NN Department of Pharmacology, Xi'an Jiaotong University College of Medicine, Xi'an Shaanxi, P.R. China. - - 2014
The aim of the present study was to determine the optimal initial tension, i.e. initial stretch for rat coronary artery when using the multi-wire myograph system. We used the normalization procedure to mimic physiological conditions and to stretch the coronary arterial segments to normalized internal circumference (IC(1)). It is determined ...
Gregoire E E Aix-Marseille University. Department of General surgery and liver transplantation, Hôpital de la Conception Marseille, France. Electronic address: - - 2014
The main hindrance in promoting living donor liver transplantation remains the morbi-mortality risk for the donor. Considering the opposed remodeling influence of portal and hepatic artery flows, our working hypothesis was to identify a lobar portal vein stenosis capable of inducing a contralateral liver mass compensatory enlargement, without the downstream ...
Yokoi Toshihiro T Department of Neurosurgery - - 2014
Object Although cerebral aneurysmal subarachnoid hemorrhage is a devastating disease for humans, effective medical treatments have not yet been established. Recent reports have shown that regression of some inflammatory-related mediators has protective effects in experimental cerebral aneurysm models. This study corroborated the effectiveness of tumor necrosis factor-α (TNF-α) inhibitor for ...
Yamamoto Yuka Y Fetal & Neonatal Cardiology Program, Division of Pediatric Cardiology; Department of Obstetrics & Gynecology, Juntendo University Faculty of Medicine, Tokyo, - - 2014
Congenital diaphragmatic hernia (CDH) is clinically challenging due to associated lung hypoplasia (LH). There have been no validated parameters to evaluate fetal LH severity. Sildenafil has been shown to improve LH mass in Nitrofen-induced CDH models, but the pulmonary vascular tone has not been evaluated in vivo. To identify the ...
Brito Marlon V MV Departamento de Bioquímica, Universidade Federal de São Paulo, Rua três de Maio, 100, 04044-020 São Paulo, - - 2014
The Bauhinia bauhinioides Kallikrein Inhibitor (BbKI) is a Kunitz-type serine peptidase inhibitor of plant origin that has been shown to impair the viability of some tumor cells and to feature a potent inhibitory activity against human and rat plasma kallikrein (Kiapp 2.4nmol/L and 5.2nmol/L, respectively). This inhibitory activity is possibly ...
Minareci Edibe E Department of Pharmacology, School of Medicine, Akdeniz University, Antalya 07070, - - 2014
Vardenafil was reported to relax rat pulmonary artery through endothelium-dependent mechanisms. The aim of this in vitro study was to investigate other related mechanisms for this effect. Endothelium-intact and denuded artery rings were suspended in order to record isometric tension. In the rings with or without endothelium, the concentration-response curves ...
Alencar Allan K N AK Programa de Desenvolvimento de Fármacos, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, - - 2014
Pulmonary arterial hypertension (PAH) is a disease that results in right ventricular (RV) dysfunction. While pulmonary vascular disease is the primary pathological focus, RV hypertrophy and RV dysfunction are the major determinants of prognosis in PAH. The aim of this study was to investigate the effects of (E)-N'-(3,4-dimethoxybenzylidene)-4-methoxybenzohydrazide (LASSBio-1386), an ...
Kudryavtseva Olga O Aarhus - - 2014
L-type Ca(2+) channels (LTCCs) are important for vascular smooth muscle cell (VSMC) contraction, as well as VSMC differentiation, as indicated by loss of LTCCs during VSMC dedifferentiation. However it is not clear whether loss of LTCCs is a primary event underlying phenotypic modulation or whether loss of LTCCs has significance ...
Ozturk Can C Department of Plastic Surgery, Cleveland Clinic, Cleveland, - - 2014
Venous grafting has been widely used in microsurgical training. Different types of vascular grafts have been described in experimental models. In this study we describe for the first time the Y- and X-shaped vein grafts (YVG, XVG) with accompanying drain-out branches as a new tool for the microsurgical training and ...
Arnberg Fabian F Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, - - 2014
The purpose of this study was to investigate the radioligand uptake and iodine contrast distribution in the intra- and extracranial circulation of the rat, after intra-arterial injections to the common carotid artery and different parts of the internal carotid artery. All animal experiments were carried out in accordance with Karolinska ...
Ali Ayyaz A - - 2014
We aim to develop a rat model of veno-arterial extracorporeal membrane oxygenation (VA-ECMO). VA-ECMO was established in twelve Male Sprague-Dawley rats (250-350 g) through cannulation of the right jugular vein for venous drainage and the right femoral artery for arterial reinfusion. Arterial blood pressure was measured using a conductance catheter ...
Gomart Samantha - - 2014
Systemic hypertension may be associated with an increased pulmonary vascular resistance, which we hypothesized could be, at least in part, mediated by increased leptin. Vascular reactivity to phenylephrine (1 mumol/L), endothelin-1 (10 nmol/L) and leptin (0.001-100 nmol/L) was evaluated in endothelium-intact and -denuded isolated thoracic aorta and pulmonary arteries from ...
Liu Bin B aDepartment of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha 410078, China. bHunan Provincial Key Laboratory of Cardiovascular Research, School of Pharmaceutical Sciences, Central South University, Changsha 410078, China cDepartment of Cardiology, Xiangya Hospital, Central South University, Changsha 410008, - - 2014
Recent studies show that resveratrol exerts beneficial effects on prevention of pulmonary hypertension. This study is performed to explore the effects of trimethoxystilbene, a novel resveratrol analog, on rat pulmonary vascular remodeling and right ventricular hypertrophy in hypoxia-induced pulmonary arterial hypertension (PAH) and the underlying mechanisms. Sprague-Dawley (SD) rats were ...
Zhang Hongyu H School of Pharmacy, Zhejiang Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, - - 2014
Apelin is highly expressed in the lungs, especially in the pulmonary vasculature, but the functional role of apelin under pathological conditions is still undefined. Hypoxic pulmonary hypertension is the most common cause of acute right heart failure, which may involve the remodeling of artery and regulation of autophagy. In this ...
Sinha Aditi A Department of Bioengineering, Clemson - - 2014
Abdominal aortic aneurysms (AAA) are progressive dilatations of infra-renal aorta causing structural weakening rendering the aorta prone to rupture. AAA can be potentially stabilized by inhibiting inflammatory enzymes such as matrix metalloproteinases (MMP); however, active regression of AAA is not possible without new elastic fiber regeneration. Here we report the ...
Zhang Bo B Department of Pathology and Pathophysiology, Fourth Military Medical University, Xi`an, 710032, PR China. Electronic address: - - 2014
Pulmonary hypertension is a progressive disease characterized by marked pulmonary arterial remodeling and increased vascular resistance. Inflammation and oxidative stress promote the development of pulmonary hypertension. Oxymatrine, one of the main active components of Chinese herb Sophora flavescens Ait (Kushen), plays anti-inflammatory and antioxidant protective roles, which effects on pulmonary ...
Madigan Michael M Department of Veterans Affairs Medical Center, Pittsburgh, Pa; Division of Vascular Surgery, University of Pittsburgh, Pittsburgh, - - 2014
Intimal hyperplasia (IH) contributes to the failure of vascular interventions. While many investigational therapies inhibit the development of IH in animal models, few of these potential therapies can reverse established lesions. Inhaled carbon monoxide (CO) dramatically inhibits IH in both rats and pigs when given perioperatively. It also prevented the ...
Zhang Dexin D Department of Respiratory Medicine, The Second Affiliated Hospital of Medical College, Xi'an Jiaotong University, - - 2014
Our previous study has indicated that activation of PPAR-γ inhibits the proliferation of rat pulmonary artery smooth muscle cells (PASMCs) in vitro through inducing the expression of heme oxygenase-1 (HO-1), which in turn up-regulates the p21(WAF1) expression. In the present study, we intended to determine whether similar mechanisms have been ...
Liu Jianfeng J Department of Postgraduate, Shantou University Medical College, Shantou, Guangdong 515041, - - 2014
The operating microscopes have been applied to modern surgery for nearly a century. However, generations of microsurgeons have to flex their necks and fix their eyes on the eyepieces of a microscope continually that leads to physical and mental fatigue during a long operation. Stereoscopic three-dimensional (3D) media provides more ...
Zhang Song S Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, - - 2014
Aneurysm embolization with coil is now widely used clinically. However, the recurrence of aneurysms after embolization has always plagued neurosurgeons because the endothelial layer of the aneurysm neck loses its integrity after being embolized by coil. Bone marrow-derived endothelial progenitor cells (BM-EPCs) could be incorporated into injured endothelium and differentiate ...
Li Yinghua Y Department of Pathology, Chemon Co. Ltd., Republic of - - 2014
Spontaneous multiple granulomas were present in the animal under the SPF condition and without chemical treatment, in a 19-week-old male Sprague-Dawley control-group rat. Here we describe multiple granulomas and prominent diffuse infiltration by eosinophils in the cecal submucosa, and arteritis in the mesenteric arteries. The multiple granulomas were characterized by ...
Nagaoka Yuki Y Medical and Dental Device Technology Incubation Center, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental - - 2014
Although artificial vessels are available for large diameter arteries, there are no artificial vessels for small diameter arteries of < 4 mm. We created a decellularized vascular scaffold (length, 10 mm; outer diameter, 1.5 mm; inner diameter, 1.3 mm) from rat abdominal arteries. We measured the biomechanical characteristics of the ...
Ibrahim Yasmine F YF Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, 20057, - - 2014
Pulmonary arterial hypertension remains a devastating disease without a cure. The major complication of this disease is the abnormal growth of vascular cells, resulting in pulmonary vascular remodeling. Thus, agents, which affect the remodeled vessels by killing unwanted cells, should improve treatment strategies. The present study reports that antitumor drugs ...
Sasajima Tadahiro T Asahikawa Medical University, 064-0821, Sapporo, N-1W-25 Hokkaido, - - 2014
Vascular surgery for distal vein arterialization (DVA) has been adopted clinically as a strategy for saving arteriosclerotic lower limbs from amputation. To gain more detailed information on DVA, the present study investigated the procedure in hind limbs of rats under isoflurane anesthesia. Since successful DVA requires destruction of venous valves, ...
Liu Yahan Y 0000-0002-5948-4615 Institute of Cardiovascular Science, Peking University Health Science Center, Beijing 100191, - - 2014
Pulmonary arterial hypertension (PAH) is a fatal disease characterized by a progressive increase in pulmonary arterial pressure leading to right ventricular failure and death. Activation of the endothelin (ET)-1 system has been demonstrated in plasma and lung tissue of PAH patients as well as in animal models of PAH. Recently, ...
Ng Keith K Australian School of Advanced Medicine, Macquarie University, Sydney, NSW, - - 2014
Haemodynamic changes in cerebral circulation are associated with the natural ageing process and associated pathology, leading to the development of incapacitating neurological and neurovascular diseases. Due to inherent biological limitations, current literatures mostly aimed at studying the correlation descriptively or quantifying the relationship in vitro or using computational models. In ...
Zhang Chao C Department of Neurosurgery, University of Michigan Hospital, Ann Arbor, Michigan, - - 2013
Various aneurysm animal models have been utilized to study the histological reaction post coil embolization. Our aim was to evaluate the imaging findings at day 14 of a rat external carotid artery side wall aneurysm treated with coil embolization using a gradient echo sequence on 7 T MRI and to ...
Wang Jian J Johns Hopkins - - 2013
To clarify the possible mechanism of cigarette smoking-induced pulmonary hypertension, furthermore providing effective targets for prevention and treatment, the effects of chronic cigarette smoking on rat pulmonary arterial smooth muscle in vivo, and nicotine treatment on rat pulmonary arterial smooth muscle cells (PASMCs) in vitro were investigated. In this study, ...
Erling Nilon N Junior Vascular Surgery, Department of Surgery, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto AlegreRS, - - 2013
This study tests the hypothesis that local or remote ischemic preconditioning may protect the intestinal mucosa against ischemia and reperfusion injuries resulting from temporary supraceliac aortic clamping. Twenty-eight Wistar rats were divided into four groups: the sham surgery group, the supraceliac aortic occlusion group, the local ischemic preconditioning prior to ...
Kim In-Gyu IG Department of Surgery, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, - - 2013
Studies of liver anatomy have developed alongside clinical achievements, as these types of research complement each other. The aim of this study is to determine whether or not the portal vein branches (P4d) in 'Nagino's trisectionectomy' exist, and to examine their characteristics using cadaver dissection. From April 2012 to July ...
Enomoto Masahiro - - 2013
Background:Vasopressin is a systemic vasoconstrictor. Its pulmonary vasodilatory effect is controversial and limited data are available on its use in neonates with pulmonary hypertension. Hypothesizing that the vasopressin-induced pulmonary vasodilation is developmentally regulated, we evaluated its pulmonary and systemic arterial response in newborn and adult rats.Methods:Vessels were mounted on a ...
Toba Michie - - 2013
We have investigated the temporal relationship between the hemodynamic and histological/morphological progression in a rat model of pulmonary arterial hypertension that develops pulmonary arterial lesions indistinguishable from those in human pulmonary arterial hypertension. Adult male rats were injected with Sugen5416 and exposed to hypoxia for 3 weeks followed by a ...
Enomoto Masahiro - - 2013
Inhaled nitric oxide (NO) and other cyclic guanosine (cGMP) or adenosine (cAMP) monophosphate-dependent pulmonary vasodilators are often utilized in combination for the treatment of the persistent pulmonary hypertension of the newborn syndrome (PPHN). There is in vitro evidence to indicate that NO downregulate the pulmonary vascular response to cGMP-dependent agonists ...
Marbacher Serge - - 2013
The biological mechanisms predisposing intracranial saccular aneurysms to growth and rupture are not yet fully understood. Mural cell loss is a histological hallmark of ruptured cerebral aneurysms. It remains unclear whether mural cell loss predisposes to aneurysm growth and eventual rupture. Sodium dodecyl sulfate decellularized and nondecellularized saccular aneurysm from ...
Wang Jianzhen - - 2013
Abstract Superior sagittal sinus thrombosis (SSST) is a form of cerebral venous sinus thrombosis (CVST) routinely treated with anticoagulation therapy. Anticoagulation and thrombolysis treatment effects on neurological function, venous recanalization, and brain edema were compared after SSST in rats. Male Sprague-Dawley rats underwent non-fatal SSST induction and were divided into ...
Mendizábal Yolanda - - 2013
We have studied the vasoactive role of prostaglandins derived from perivascular adipose tissue (PVAT) and their effects on endothelial function in healthy rats and rats with metabolic syndrome (SHROB). Mesenteric resistance arteries (MRA) from SHROB and control rats (WKY) were mounted on wire myographs: a) together with a sphere of ...
Pankey Edward A - - 2013
The transient receptor potential (TRPV4) is a nonselective cation channel expressed on many cell types including the vascular endothelium and smooth muscle cells. TRPV4 channels play a role in regulating vasomotor tone and capillary permeability. The present study was undertaken to investigate responses to the TRPV4 agonist GSK101790A on the ...
Spradley Frank T FT Section of Experimental Medicine, Georgia Regents University Augusta, Georgia ; Department of Medicine, Georgia Regents University Augusta, - - 2013
Chronic renal failure (CRF) is associated with hypertension and concomitant endothelial dysfunction, enhanced vasoconstriction, and nitric oxide synthase (NOS) dysfunction. Vascular function in patients is assessed in peripheral extremity arteries like the finger arteries, whereas animal studies often use the centrally located aorta. Therefore, we examined whether peripheral tail artery ...
Porras-González Cristina - - 2013
The effects of human urotensin II (hUII) on the vascular tone of different animal species has been studied extensively. However, little has been reported on the vasoactive effects of rat urotensin (rUII) in murine models. The aim of the present study was to investigate the effects of rUII on vasoreactivity ...
Labruijere Sieneke - - 2013
Endothelin-1 causes long-lasting contraction via endothelin type A receptor (ETAR) in isolated rat mesenteric arteries (RMA) that cannot be readily terminated by removing the agonist, or by adding the ETAR antagonist BQ123 or the NO donor sodium nitroprusside. It could be terminated by adding calcitonin-gene related peptide (CGRP), most likely ...
Senadheera Sevvandi - - 2013
In pregnancy, the vasculature of the uterus undergoes rapid remodelling to increase blood flow and maintain perfusion to the fetus. The present study determines the distribution and density of caveolae, transient receptor potential vanilloid type 4 channels (TRPV4) and myoendothelial gap junctions, and the relative contribution of related endothelium-dependent vasodilator ...
Allen Robert A - - 2013
The objective of this study was to evaluate the long-term performance of cell-free vascular grafts made from a fast-degrading elastic polymer. We fabricated small arterial grafts from microporous tubes of poly(glycerol sebacate) (PGS) reinforced with polycaprolactone (PCL) nanofibers on the outer surface. Grafts were interpositioned in rat abdominal aortas and ...
Alzoubi Abdallah - - 2013
Pulmonary arterial hypertension (PAH) is characterized by elevated pulmonary arterial pressure with lumen-occluding neointimal and plexiform lesions. Activation of store-operated calcium entry channels promotes contraction and proliferation of lung vascular cells. TRPC4 is a ubiquitously expressed store-operated calcium entry channel, but its role in PAH is unknown. We tested the ...
Colvin Kelley L - - 2013
Rationale Autoimmunity has long been associated with pulmonary hypertension. Bronchus associated lymphoid tissue plays important roles in antigen sampling and self-tolerance during infection and inflammation. Objectives We reasoned that activated bronchus associated lymphoid tissue would be evident in rats with pulmonary hypertension, and that loss of self-tolerance would result in ...
Guo Qiang - - 2013
A recent study from our group demonstrated that the Ca(2+)-sensing receptor (CaSR) was upregulated, and the extracellular Ca(2+)-induced increase in cytosolic Ca(2+) concentration ([Ca(2+)]cyt) was enhanced in pulmonary arterial smooth muscle cells from patients with idiopathic pulmonary arterial hypertension and animals with experimental pulmonary hypertension (PH). However, it is unclear ...
Khanamiri Saereh S Department of Biomedical Sciences, Faculty of Health and Medical Sciences, Danish National Research Foundation Centre for Cardiac Arrhythmia, The Panum Institute, University of Copenhagen, 12.5.14, Blegdamsvej 3, 2200 Copenhagen N, Denmark. - - 2013
The goal of the present study was to determine the role of KCNQ-encoded Kv channels (Kv7 channels) in the passive and active regulation of coronary flow in normotensive and hypertensive rats. In left anterior descending coronary arteries from normotensive rats, structurally different Kv7.2 to 7.5 activators produced relaxations, which were ...
Zhang Chao - - 2013
The HydroCoil Endovascular Aneurysm Occlusion and Packing Study clinical trial, comparing HydroCoil with platinum coils, reported an 8.6% reduction in significant recurrence following cerebral aneurysm coil embolization. We sought to better understand the mechanism of aneurysmal healing following HydroCoil implantation using the rat external carotid artery (ECA) sidewall aneurysm model. ...
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