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Alencar Allan K N AK Programa de Desenvolvimento de Fármacos, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, - - 2014
Pulmonary arterial hypertension (PAH) is a disease that results in right ventricular (RV) dysfunction. While pulmonary vascular disease is the primary pathological focus, RV hypertrophy and RV dysfunction are the major determinants of prognosis in PAH. The aim of this study was to investigate the effects of (E)-N'-(3,4-dimethoxybenzylidene)-4-methoxybenzohydrazide (LASSBio-1386), an ...
Kudryavtseva Olga O Aarhus - - 2014
L-type Ca(2+) channels (LTCCs) are important for vascular smooth muscle cell (VSMC) contraction, as well as VSMC differentiation, as indicated by loss of LTCCs during VSMC dedifferentiation. However it is not clear whether loss of LTCCs is a primary event underlying phenotypic modulation or whether loss of LTCCs has significance ...
Ozturk Can C Department of Plastic Surgery, Cleveland Clinic, Cleveland, - - 2014
Venous grafting has been widely used in microsurgical training. Different types of vascular grafts have been described in experimental models. In this study we describe for the first time the Y- and X-shaped vein grafts (YVG, XVG) with accompanying drain-out branches as a new tool for the microsurgical training and ...
Arnberg Fabian F Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, - - 2014
The purpose of this study was to investigate the radioligand uptake and iodine contrast distribution in the intra- and extracranial circulation of the rat, after intra-arterial injections to the common carotid artery and different parts of the internal carotid artery. All animal experiments were carried out in accordance with Karolinska ...
Ali Ayyaz A - - 2014
We aim to develop a rat model of veno-arterial extracorporeal membrane oxygenation (VA-ECMO). VA-ECMO was established in twelve Male Sprague-Dawley rats (250-350 g) through cannulation of the right jugular vein for venous drainage and the right femoral artery for arterial reinfusion. Arterial blood pressure was measured using a conductance catheter ...
Gomart Samantha - - 2014
Systemic hypertension may be associated with an increased pulmonary vascular resistance, which we hypothesized could be, at least in part, mediated by increased leptin. Vascular reactivity to phenylephrine (1 mumol/L), endothelin-1 (10 nmol/L) and leptin (0.001-100 nmol/L) was evaluated in endothelium-intact and -denuded isolated thoracic aorta and pulmonary arteries from ...
Mortezaiyan Hojjat H Cardiovascular Intervention Research Center, Rajaei Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR - - 2014
Thrombosis is the most common complication during cardiac catheterization via femoral artery access. Alongside heparinization, fibrinolytic therapy is recommended if there are signs of ischemia in the lower extremity. Given the paucity of data in the existing literature on streptokinase (SK) therapy in pediatrics, we designed this study to assess ...
Liu Bin B aDepartment of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha 410078, China. bHunan Provincial Key Laboratory of Cardiovascular Research, School of Pharmaceutical Sciences, Central South University, Changsha 410078, China cDepartment of Cardiology, Xiangya Hospital, Central South University, Changsha 410008, - - 2014
Recent studies show that resveratrol exerts beneficial effects on prevention of pulmonary hypertension. This study is performed to explore the effects of trimethoxystilbene, a novel resveratrol analog, on rat pulmonary vascular remodeling and right ventricular hypertrophy in hypoxia-induced pulmonary arterial hypertension (PAH) and the underlying mechanisms. Sprague-Dawley (SD) rats were ...
Zhang Hongyu H School of Pharmacy, Zhejiang Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, - - 2014
Apelin is highly expressed in the lungs, especially in the pulmonary vasculature, but the functional role of apelin under pathological conditions is still undefined. Hypoxic pulmonary hypertension is the most common cause of acute right heart failure, which may involve the remodeling of artery and regulation of autophagy. In this ...
Sinha Aditi A Department of Bioengineering, Clemson - - 2014
Abdominal aortic aneurysms (AAA) are progressive dilatations of infra-renal aorta causing structural weakening rendering the aorta prone to rupture. AAA can be potentially stabilized by inhibiting inflammatory enzymes such as matrix metalloproteinases (MMP); however, active regression of AAA is not possible without new elastic fiber regeneration. Here we report the ...
Zhang Bo B Department of Pathology and Pathophysiology, Fourth Military Medical University, Xi`an, 710032, PR China. Electronic address: - - 2014
Pulmonary hypertension is a progressive disease characterized by marked pulmonary arterial remodeling and increased vascular resistance. Inflammation and oxidative stress promote the development of pulmonary hypertension. Oxymatrine, one of the main active components of Chinese herb Sophora flavescens Ait (Kushen), plays anti-inflammatory and antioxidant protective roles, which effects on pulmonary ...
Madigan Michael M Department of Veterans Affairs Medical Center, Pittsburgh, Pa; Division of Vascular Surgery, University of Pittsburgh, Pittsburgh, - - 2014
Intimal hyperplasia (IH) contributes to the failure of vascular interventions. While many investigational therapies inhibit the development of IH in animal models, few of these potential therapies can reverse established lesions. Inhaled carbon monoxide (CO) dramatically inhibits IH in both rats and pigs when given perioperatively. It also prevented the ...
Zhang Dexin D Department of Respiratory Medicine, The Second Affiliated Hospital of Medical College, Xi'an Jiaotong University, - - 2014
Our previous study has indicated that activation of PPAR-γ inhibits the proliferation of rat pulmonary artery smooth muscle cells (PASMCs) in vitro through inducing the expression of heme oxygenase-1 (HO-1), which in turn up-regulates the p21(WAF1) expression. In the present study, we intended to determine whether similar mechanisms have been ...
Liu Jianfeng J Department of Postgraduate, Shantou University Medical College, Shantou, Guangdong 515041, - - 2014
The operating microscopes have been applied to modern surgery for nearly a century. However, generations of microsurgeons have to flex their necks and fix their eyes on the eyepieces of a microscope continually that leads to physical and mental fatigue during a long operation. Stereoscopic three-dimensional (3D) media provides more ...
Zhang Song S Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, - - 2014
Aneurysm embolization with coil is now widely used clinically. However, the recurrence of aneurysms after embolization has always plagued neurosurgeons because the endothelial layer of the aneurysm neck loses its integrity after being embolized by coil. Bone marrow-derived endothelial progenitor cells (BM-EPCs) could be incorporated into injured endothelium and differentiate ...
Li Yinghua Y Department of Pathology, Chemon Co. Ltd., Republic of - - 2014
Spontaneous multiple granulomas were present in the animal under the SPF condition and without chemical treatment, in a 19-week-old male Sprague-Dawley control-group rat. Here we describe multiple granulomas and prominent diffuse infiltration by eosinophils in the cecal submucosa, and arteritis in the mesenteric arteries. The multiple granulomas were characterized by ...
Nagaoka Yuki Y Medical and Dental Device Technology Incubation Center, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental - - 2014
Although artificial vessels are available for large diameter arteries, there are no artificial vessels for small diameter arteries of < 4 mm. We created a decellularized vascular scaffold (length, 10 mm; outer diameter, 1.5 mm; inner diameter, 1.3 mm) from rat abdominal arteries. We measured the biomechanical characteristics of the ...
Ibrahim Yasmine F YF Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, 20057, - - 2014
Pulmonary arterial hypertension remains a devastating disease without a cure. The major complication of this disease is the abnormal growth of vascular cells, resulting in pulmonary vascular remodeling. Thus, agents, which affect the remodeled vessels by killing unwanted cells, should improve treatment strategies. The present study reports that antitumor drugs ...
Sasajima Tadahiro T Asahikawa Medical University, 064-0821, Sapporo, N-1W-25 Hokkaido, - - 2014
Vascular surgery for distal vein arterialization (DVA) has been adopted clinically as a strategy for saving arteriosclerotic lower limbs from amputation. To gain more detailed information on DVA, the present study investigated the procedure in hind limbs of rats under isoflurane anesthesia. Since successful DVA requires destruction of venous valves, ...
Liu Yahan Y 0000-0002-5948-4615 Institute of Cardiovascular Science, Peking University Health Science Center, Beijing 100191, - - 2014
Pulmonary arterial hypertension (PAH) is a fatal disease characterized by a progressive increase in pulmonary arterial pressure leading to right ventricular failure and death. Activation of the endothelin (ET)-1 system has been demonstrated in plasma and lung tissue of PAH patients as well as in animal models of PAH. Recently, ...
Ng Keith K Australian School of Advanced Medicine, Macquarie University, Sydney, NSW, - - 2014
Haemodynamic changes in cerebral circulation are associated with the natural ageing process and associated pathology, leading to the development of incapacitating neurological and neurovascular diseases. Due to inherent biological limitations, current literatures mostly aimed at studying the correlation descriptively or quantifying the relationship in vitro or using computational models. In ...
Bauer Eileen M EM Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America; University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of - - 2014
Pulmonary hypertension (PH) is a progressive and fatal disease with no cure. Vascular remodeling in PH involves intraluminal growth of endothelial and smooth muscle cells, leading to obliterative vascular lesions. Cell growth in these lesions is quasi-neoplastic, with evidence of monoclonality, apoptosis resistance and cancer-like metabolic derangements. Herein we tested ...
Gauthier Kathryn M KM Department of Pharmacology and Toxicology, Medical College of Wisconsin , Milwaukee, WI , - - 2014
Background and Purpose. In rat middle cerebral arteries, endothelium-dependent hyperpolarization (EDH) is mediated by activation of calcium-activated potassium (KCa) channels specifically KCa2.3 and KCa3.1. Lipoxygenase (LOX) products function as endothelium-derived hyperpolarizing factors (EDHFs) in rabbit arteries by stimulating KCa2.3. We investigated if LOX products contribute to EDH in rat cerebral ...
Güzel Aslan A Department of Neurosurgery, Bahcesehir University, MedicalPark Hospital, 27060 Sehit Kamil, Gaziantep, - - 2014
Although there are many experimental studies describing the methodology of the middle cerebral artery occlusion (MCAO) in the literature, only limited data on these distinct anatomical structures and the details of the surgical procedure in a step by step manner. The aim of the present study simply is to examine ...
Gao Wenyan W College of Pharmacy, Harbin Medical University-Daqing, Daqing 163319, Heilongjiang, China. - - 2014
Commiphora opobalsamum is a Traditional Chinese Medicine used to treat traumatic injury, mainly by relaxing blood vessels. In this study, two diterpenes, dehydroabietic acid (DA) and sandaracopimaric acid (SA) were obtained from it by a bioassay-guided approach using isolated rat pulmonary artery rings. The structures of the two compounds were ...
Xu Yixiao Y Department of Pathophysiology, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China , Wenzhou Medical University Renji College, Wenzhou, Zhejiang 325035, - - 2014
Pulmonary arterial hypertension (PAH) is a disease of the small pulmonary arteries characterized by increased vascular resistance. Pulmonary vasoconstriction has been proven to play a pivotal role in PAH. We have previously hypothesized that Panax notoginseng saponins (PNS) might attenuate hypoxia-hypercapnia-induced pulmonary vasoconstriction. The specific objective of the present study ...
Zhao Xin X Department of Anesthesiology, The Second Hospital of Shandong University 247 Beiyuan Road, Jinan 250033, - - 2014
The revascularization therapy of pulmonary embolism is associated with ischemia-reperfusion (IR) injury. However, the effect of IR injury on pulmonary arterial endothelial function has not been elucidated. Male Sprague-Dawley rats were divided into a control, an IR and an IR plus hypoxia-inducible factor 1 alpha (HIF-1α) stabilizer DMOG group. We ...
Efanov Johnny I JI Plastic and Reconstructive Surgery, University of Montreal Hospital Center, Montreal, Quebec, - - 2014
Surgical repair of digital flexion deformities can result in vascular injuries threatening the viability of the affected digit. While uncommon, these injuries are reported to have a rate as high as 0.8% following palmo-digital fasciectomy for Dupuytren's disease. Late presentation of such vascular events pose a challenge, since taking the ...
Sişli E E Department of Cardiovascular Surgery, Acibadem Bakirköy Hospital, Istanbul, Turkey. - - 2014
Pseudo-aneurysm in the plantar region is so rare that there are only sporadic case reports in the literature. The aetiology is usually either iatrogenic or stepping on a piece of glass. In comparison to the medial plantar artery, the lateral plantar artery is the most common arterial structure injured in ...
Sohns Jan M JM Institute for Diagnostic and Interventional Radiology, Center of Radiology, DZHK, Georg-August-University Göttingen, UMG Universitätsmedizin Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany ; German Centre for Cardiovascular Research, DZHK, Göttingen, - - 2014
A 66-years old man suffering from coronary artery disease appeared without symptoms for routine follow-up in our clinic. The echocardiogram revealed a tumorous mass of the right atrium and right ventricle. In the past, coronary revascularization with venous grafts of the right coronary artery and circumflex artery as well as ...
Nagella Amrutha Bindu AB Department of Anaesthesia and Critical Care, Mahatma Gandhi Medical College & Research Institute, Pondicherry, - - 2014
A 1-year-old child with no pre-existing cardiac or respiratory disease developed frank pulmonary oedema after administration of a neostigmine-glycopyrrolate mixture to reverse neuromuscular blockade during general anaesthesia. Possible cardiac and extra-cardiac factors that could cause pulmonary oedema in this child were ruled out by appropriate investigations. As the pulmonary oedema ...
Thomas Charlotte C Department of Critical Care, St George's Hospital, University of London, London, - - 2014
The synchronous presentation of a patient with pulmonary embolism (PE) and haemorrhagic cardiac tamponade is uncommon and presents a therapeutic dilemma. Both conditions can be life-threatening and require opposing management strategies. The authors report a 50-year-old woman who presented with abdominal symptoms and subsequent rapid development of dyspnoea and cardiogenic ...
Sheikh Abdul Malik AM Department of Paediatric Cardiology, The Children Hospital and The Institute of Child Health, Ferozpur Road, Lahore, Punjab, - - 2014
The objective of study was to determine pulmonary artery variations and other associated cardiac defects in patients with Tetralogy of Fallot. This cross-sectional, descriptive study was carried out at The Children's Hospital and the Institute of Child Health, Lahore, from January 2006 to December 2012. All patients with Tetralogy of ...
Dovern Elisabeth E Department of Intensive Care Medicine, Reinier de Graaf Gasthuis, Delft, The - - 2014
Massive pulmonary embolism has a high mortality rate. Standard treatment includes systemic thrombolysis. If this fails, surgical embolectomy or a percutaneous catheter-guided approach is advised in current guidelines. However, these treatment options might not be available in many non-tertiary care hospitals. We describe a case of a 25-year old woman ...
Sapienza Paolo - - 2014
Blunt trauma of the popliteal fossa is an uncommon cause of lower limb ischemia and it is associated with a high risk for limb loss. The case of a young man with anterior dislocation of the right knee joint causing post-traumatic popliteal artery occlusion and severe lower limb ischemia is ...
Miyazaki Shinsuke S Cardiovascular Center, Tsuchiura Kyodo Hospital, Tsuchiura, Ibaraki, Japan (S.M., H.T., S.K., Y.K., N.I., T.T., J.I., A.K., H.N., H.H., - - 2014
Periesophageal vagal nerve injury is recognized as a rare complication in atrial fibrillation ablation procedures. We investigated the factors associated with the occurrence of symptomatic periesophageal vagal nerve injury after pulmonary vein antrum isolation. Overall, 535 consecutive patients who underwent sole pulmonary vein antrum isolation were included. Point-by-point radiofrequency applications ...
Karaarslan Ahmet A AA Orthopedics and Traumatology Department, Şifa University Faculty of Medicine, 35100 İzmir, Turkey ; Şifa University Bornova Health Application and Research Center, Kazım Dirik Mahallesi, Sanayi Cadde No. 7, Bornova, 35100 İzmir, - - 2014
This paper is about a posttraumatic distal ulnar artery thrombosis case that has occurred after a single blunt trauma. The ulnar artery thrombosis because of chronic trauma is a frequent condition (hypothenar hammer syndrome) but an ulnar artery thrombosis because of a single direct blunt trauma is rare. Our patient ...
Ambekar Sudheer S 0000-0001-5145-7172 Department of Neurosurgery, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71103, - - 2014
Traumatic pseudoaneurysms are uncommon and one of the most difficult lesions to treat. Traditional treatment methods have focused on parent vessel sacrifice with or without revascularization. We report the case of a patient who underwent successful treatment of an iatrogenic extracranial vertebral artery pseudoaneurysm using the Pipeline Embolization Device. A ...
Veen Egbert J D EJ Surgery and Traumatology, Isala Clinics, Zwolle, The Netherlands - - 2014
A male cyclist presented with a swelling on the forehead. Six weeks before, he fell of his bike and smashed his head on the ground while wearing a helmet. A smooth lump of 1 cm had evolved on the temporal side of his forehead in a few weeks. Duplex ultrasonography ...
Choi Joon Hyouk JH Deparment of Cardiology, Jeju National University Hospital, Jeju National University School of Medicine, Jeju, - - 2014
Veno-arterial extracorporeal membrane oxygenation (ECMO) through the femoral vein and artery may cause differential hypoxia, i.e., lower PaO2 in the upper body than in the lower body, because of normal cardiac output with severe impairment of pulmonary function. Hereby, we report the diagnosis and the treatment of differential hypoxia caused ...
Robaldo Alessandro A 0000-0001-9247-8818 Division of Vascular and Endovascular Surgery, Imperia Public Hospital, Via Sant'Agata 57, 18100 Imperia, - - 2014
We report the diagnostic and successful therapeutic images of an acute occlusion of the abdominal and suprarenal aorta. This lesion is a rare but catastrophic pathology which can cause severe ischemic manifestations, depending on the site of obstruction, with high rate of mortality even after treatment. In the majority of ...
Shimizu Takeshi T Department of Cardiology and Hematology, Fukushima Medical University, - - 2014
A 13-year-old boy was brought to our hospital after recovering from ventricular fibrillation that occurred after an episode of chest pain during training with his soccer team. Subsequent 64-slice multidetector computed tomography revealed the left coronary artery arising from the right sinus of Valsalva, which coursed between the ascending aorta ...
Lax Siân S Department of Clinical Respiratory Sciences , Centre for Translational Inflammation Research, University of Birmingham Research Laboratories, Queen Elizabeth Hospital , Birmingham , - - 2014
Arterial oxygen saturation has not been assessed sequentially in conscious mice as a direct consequence of an in vivo murine model of acute lung injury. Here, we report daily changes in arterial oxygen saturation and other cardiopulmonary parameters by using infrared pulse oximetry following intratracheal lipopolysaccharide (IT-LPS) for up to ...
Medrano-Gracia Pau - - 2014
Describing the detailed statistical anatomy of the coronary artery tree is important for determining the aetiology of heart disease. A number of studies have investigated geometrical features and have found that these correlate with clinical outcomes, e.g. bifurcation angle with major adverse cardiac events. These methodologies were mainly two-dimensional, manual ...
Zhang Chao C Department of Neurosurgery, University of Michigan Hospital, Ann Arbor, Michigan, - - 2013
Various aneurysm animal models have been utilized to study the histological reaction post coil embolization. Our aim was to evaluate the imaging findings at day 14 of a rat external carotid artery side wall aneurysm treated with coil embolization using a gradient echo sequence on 7 T MRI and to ...
Wang Jian J Johns Hopkins - - 2013
To clarify the possible mechanism of cigarette smoking-induced pulmonary hypertension, furthermore providing effective targets for prevention and treatment, the effects of chronic cigarette smoking on rat pulmonary arterial smooth muscle in vivo, and nicotine treatment on rat pulmonary arterial smooth muscle cells (PASMCs) in vitro were investigated. In this study, ...
Erling Nilon N Junior Vascular Surgery, Department of Surgery, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto AlegreRS, - - 2013
This study tests the hypothesis that local or remote ischemic preconditioning may protect the intestinal mucosa against ischemia and reperfusion injuries resulting from temporary supraceliac aortic clamping. Twenty-eight Wistar rats were divided into four groups: the sham surgery group, the supraceliac aortic occlusion group, the local ischemic preconditioning prior to ...
Grant Jennifer S JS Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United - - 2013
MicroRNAs are small noncoding RNAs involved in the regulation of gene expression and have recently been implicated in the development of pulmonary arterial hypertension (PAH). Previous work has established that miR-451 is upregulated in rodent models of PAH. The role of miR-451 in the pulmonary circulation is unknown. We therefore ...
Kim In-Gyu IG Department of Surgery, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, - - 2013
Studies of liver anatomy have developed alongside clinical achievements, as these types of research complement each other. The aim of this study is to determine whether or not the portal vein branches (P4d) in 'Nagino's trisectionectomy' exist, and to examine their characteristics using cadaver dissection. From April 2012 to July ...
Enomoto Masahiro - - 2013
Background:Vasopressin is a systemic vasoconstrictor. Its pulmonary vasodilatory effect is controversial and limited data are available on its use in neonates with pulmonary hypertension. Hypothesizing that the vasopressin-induced pulmonary vasodilation is developmentally regulated, we evaluated its pulmonary and systemic arterial response in newborn and adult rats.Methods:Vessels were mounted on a ...
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