Search Results
Results 351 - 400 of 1509
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Cheruvu Pavan K - - 2007
OBJECTIVES: Our purpose was to quantify the frequency and distribution of suspected vulnerable lesions, defined as thin-capped fibroatheroma (TCFA) and ruptured plaque, in human coronary artery autopsy specimens. BACKGROUND: Most acute coronary events and sudden death are believed to arise from rupture of a TCFA followed by thrombosis. Although there ...
Derdeyn Colin P - - 2007
Atherosclerotic occlusive disease of the cervical and intracranial arteries leads to ischemic stroke through two separate, but interrelated, mechanisms: local thrombosis or embolism from atherosclerotic plaque, and hemodynamic failure (low flow). In this article, the author discusses the evidence linking these two mechanisms with cerebral ischemia, and the evidence for ...
Kato Masaya - - 2007
BACKGROUND: The aim of the present study was to investigate the clinical implication of metabolic syndrome and carotid artery morphologies on coronary plaque vulnerability in Japanese men with acute coronary syndrome (ACS). METHODS AND RESULTS: Consecutive ACS Japanese men (n=225) underwent emergent coronary angiography and B-mode ultrasonography within 1 week ...
Addabbo Francesco - - 2007
BACKGROUND: Evidence linking chronic kidney disease (CKD) with the increased risk of cardiovascular (CV) complications is firm. It is becoming clear that testing functions of the vascular endothelium in conjunction with various biomarkers may better the definition of CV risk profile in CKD patients. METHODS: Using Multiplexed analysis of 16 ...
Gepner Adam D - - 2007
BACKGROUND: Carotid intima-media thickness (CIMT) testing can assist with cardiovascular risk prediction; however, the requirement for rigorous, time-consuming protocols has limited it use in clinical practice. METHODS: Bilateral images of the common carotid artery (CCA), bulb, and internal carotid artery segments were obtained using a comprehensive scanning protocol. Three abbreviated ...
Groen Harald C - - 2007
Cerebrovascular events are related to atherosclerotic disease in the carotid arteries and are frequently caused by rupture of a vulnerable plaque. These ruptures are often observed at the upstream region of the plaque, where the wall shear stress (WSS) is considered to be highest. High WSS is known for its ...
Gössl Mario - - 2007
Because most myocardial infarctions result from the rupture of a plaque that did not significantly compromise the coronary lumen before the event, experts widely accept that the morphology, composition, and degree of inflammation of a coronary atherosclerotic plaque is more important than the degree of luminal stenosis. Two depicting examples ...
Ohayon Jacques - - 2007
In a vulnerable plaque (VP), rupture often occurs at a site of high stress within the cap. It is also known that vessels do not become free of stress when all external loads are removed. Previous studies have shown that such residual stress/strain (RS/S) tends to make the stress distribution ...
Kruk Mariusz - - 2007
Coronary plaque rupture is a phenomenon underlying most acute coronary events. Although gender is an important determinant of the incidence and clinical course of coronary atherosclerosis, its relation to plaque rupture is unknown. Therefore, we assessed gender differences in native artery plaque rupture characteristics and their related clinical presentations. There ...
Saba L - - 2007
BACKGROUND AND PURPOSE: Ulceration is a severe complication of carotid plaque. The purpose of this study was to evaluate the role and the diagnostic efficacy of multidetector row CT angiography (MDCTA) and ultrasound (US) echo color Doppler (US-ECD) in the study of patients with carotid plaque complicated by ulceration through ...
Kalidindi S R - - 2007
Increasing attention has been focused on the appropriate role of surrogate markers in the development of novel anti-atherosclerotic therapies. Technological advances in imaging modalities allow for visualisation of the entire arterial wall. Intravascular ultrasound (IVUS) has been increasingly employed to precisely quantify the extent of coronary atherosclerosis. Use of IVUS ...
Hara Tetsuya - - 2007
BACKGROUND: The ability to evaluate coronary stenosis using multi-detector computed tomography (MDCT) has been well discussed. In contrast, several studies demonstrated that the plaque burden measured by intravascular ultrasound (IVUS) has a relationship to the risk of cardiovascular events. the accuracy of MDCT was studied to determine plaque and vessel ...
Snow M - - 2007
AIM: European and North American studies have confirmed the benefits of carotid endarterectomy for patients with symptomatic carotid artery stenoses >70%. However, the management of asymptomatic patients and those with lesser degrees of stenosis is less certain. Several studies have suggested that, for these subgroups, the targeting of potentially unstable ...
Hartung Dagmar - - 2007
Inflammation plays an important role in vulnerability of atherosclerotic plaques to rupture and hence acute coronary events. The monocyte-macrophage infiltration in plaques leads to upregulation of cytokines and metalloproteinase enzymes. Matrix metalloproteinases result in matrix dissolution and consequently expansive remodeling of the vessel. They also contribute to attenuation of fibrous ...
Guzman Raul J - - 2007
Arterial calcification is a complex and independently regulated process with risk factors similar to those for atherosclerotic occlusive disease. It may develop either within the atherosclerotic intima or in the media. When calcification is found in coronary or lower extremity arteries, it is an independent predictor of cardiovascular events and ...
Ishibashi Fumiyuki - - 2008
Yellow plaques seen during coronary angioscopy are thought to be the surrogates for superficial intimal lipids in coronary plaque. Given diffuse and heterogeneous nature of atherosclerosis, yellow plaques in coronaries may be seen as several yellow spots on diffuse coronary plaque. We examined the topographic association of yellow plaques with ...
Wagenknecht Lynne E - - 2007
The extent of shared risk factors for calcified atherosclerotic plaque (CAP) of the coronary, carotid, and abdominal aortic arteries is unknown. CAP was measured by computed tomography in 1,125 individuals in families affected with diabetes. Statistical methods adjusted for the lack of independence between observations. CAP scores were standardized, and ...
Manfrini Olivia - - 2008
BACKGROUND: Vagal fibres are distributed both in the perivascular connective tissue and in the adventitia around the circumference of arteries, and contribute to coronary artery dilation. The aim of the manuscript is to examine whether morphologic changes of the vessel wall due to the atherosclerotic process might be associated with ...
Dowe David A - - 2007
Coronary computed tomographic angiography is leading a technologic revolution in the field of cardiac imaging. For the first time, it is possible to image the wall of the coronary artery noninvasively to assess plaque burden, characterize plaque, and assess the degree of stenosis. This paper explores the possibility of using ...
Higashikuni Yasutomi - - 2007
BACKGROUND: The relationship between coronary artery remodeling and culprit plaque composition in vivo has not been fully evaluated by spectral analysis of intravascular ultrasound (IVUS) radiofrequency (RF) data. METHODS AND RESULTS: IVUS RF analyses were performed for 56 consecutive de novo culprit lesions of 52 patients undergoing percutaneous coronary intervention. ...
Kume Teruyoshi - - 2007
BACKGROUND: Several studies have shown that rotational atherectomy (RA) is associated with higher rates of the slow-flow phenomenon and that ablated particles may be the possible cause. Intravascular ultrasound (IVUS) has an intrinsic limitation in assessing plaque morphology behind the calcification because of acoustic shadowing. Therefore, the purpose of this ...
Ichikawa Minoru - - 2008
A 62-year-old man was performed stent implantation for right subclavian artery stenosis two years ago. For the evaluation of stent patency, multislice computed tomography (MSCT) was performed. Volume rendering image demonstrated that the stent was patent, but curved multiplanar reformation revealed a relatively low- density area inside the stent, suggesting ...
Kitta Yoshinobu - - 2008
Echolucent carotid plaque is considered to predict coronary events. This study examined whether echolucent carotid plaque may predict in-stent restenosis (ISR) in coronary arteries. This study included 202 patients who had elective and successful percutaneous coronary intervention (PCI) with bare metal stents in de novo lesions of native coronary arteries ...
Lind Lars - - 2007
OBJECTIVE: The echogenecity measured by ultrasound of atherosclerotic plaques is related to future cardiovascular events. The aim of the present study is to relate the grey scale median of the intima-media complex (IM-GSM) of the common carotid artery (CCA) to the echogenecity of carotid plaques. MATERIAL AND RESULTS: In the ...
Kawano Taro - - 2008
BACKGROUND: To identify subclinical high-risk plaques is potentially important because those vulnerable plaques may have a greater likelihood of rupture and subsequent thrombosis. The aim of this study is to reveal the histology of angioscopic yellow plaques known as vulnerable plaques by intravascular ultrasound radiofrequency data analysis. METHODS: Thirty-one coronary ...
Hyafil Fabien F Sinai Translational and Molecular Imaging Institute and Imaging Science Laboratories, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, New York, New York 10029, - - 2007
Sudden fibrous cap disruption of 'high-risk' atherosclerotic plaques can trigger the formation of an occlusive thrombus in coronary arteries, causing acute coronary syndromes. High-risk atherosclerotic plaques are characterized by their specific cellular and biological content (in particular, a high density of macrophages), rather than by their impact on the vessel ...
Irshad Khalid - - 2007
PURPOSE: To report early clinical experience with virtual histology intravascular ultrasound (VH IVUS) in carotid endoluminal repair. TECHNIQUE: A 2.9-F, 20-MHz catheter that utilizes computer software to demonstrate the histological components of arteriosclerotic plaque was evaluated during carotid angioplasty and stenting. VH IVUS images were created following a pullback through ...
Ikeno Fumiaki - - 2007
OBJECTIVES: Using intravascular ultrasound (IVUS) and histology, the purpose of this study was to evaluate the occurrence of arterial wall overstretch and Dotter effect following revascularization with a plaque excision (PE) catheter compared with balloon angioplasty. BACKGROUND: Previous studies have demonstrated the safety and feasibility of plaque excision for the ...
Boivie Patrik - - 2007
OBJECTIVE: Aortic atherosclerosis may cause cerebrovascular accidents in cardiac surgery. Aortic plaque distribution was analyzed in relation to surgical manipulation. DESIGN: In 24 autopsy subjects the thoracic aorta was digitally analyzed by macro-anatomic mapping of plaques. Plaque density was compared in different anatomical segments. Hazards associated with surgical manipulation were ...
Kiani Adnan - - 2007
OBJECTIVE: Soluble CD154 (sCD154) is involved in the pathogenesis of systemic lupus erythematosus (SLE), as well as in the initiation and progression of atherosclerotic lesions. We determined the association of sCD154 with coronary calcium and carotid plaque at the baseline visit of the Lupus Atherosclerosis Prevention Study. METHODS: Serum samples ...
Furuichi Shinichi - - 2007
Slow flow or no-reflow is a serious complication during percutaneous coronary intervention (PCI), but little is known about the risk factors. A 64-year-old man underwent coronary angiography and PCI for stable angina. Pre-interventional intravascular ultrasound demonstrated an ultrasound attenuated coronary plaque, as a long eccentric bulky plaque with a marked ...
Tamiya Eiji - - 2008
BACKGROUND: Intravascular ultrasound (IVUS) has been used for assessment of the coronary arteries. However, few IVUS studies have been reported on the aorta. MATERIALS AND METHODS: To assess the presence of atherosclerotic disease in the aorta by the use of IVUS, 29 patients with heart disease (24 men and 5 ...
Okura Hiroyuki - - 2007
To investigate the impact of arterial remodelling on long-term clinical outcome after stent implantation in patients with acute coronary syndrome (ACS). 134 patients with ACS were enrolled. External elastic membrane (EEM) cross-sectional area (CSA) and lumen CSA were measured. Plaque and media CSA was calculated as EEM minus lumen CSA. ...
Tahara Nobuhiro - - 2007
OBJECTIVES: We investigated factors for carotid artery inflammation by [(18)F]-fluorodeoxyglucose (FDG) positron emission tomography (PET). BACKGROUND: Inflammation is present in some atherosclerotic plaques. The FDG-PET is capable of identifying and quantifying vascular inflammation within atherosclerotic plaques. METHODS: The FDG-PET imaging was performed in 216 consecutive patients (63 +/- 9 years, ...
Gasser T Christian - - 2007
Balloon angioplasty intervention is traumatic to arterial tissue. Fracture mechanisms such as plaque fissuring and/or dissection occur and constitute major contributions to the lumen enlargement. However, these types of mechanically-based traumatization of arterial tissue are also contributing factors to both acute procedural complications and chronic restenosis of the treatment site. ...
Walker Sara E - - 2008
Male cynomolgus macaques (n=91) consumed an isoflavone (IF)-free, atherogenic control diet containing casein/lactalbumin for 5 months, then were randomized to three groups: control (n=30) continued on the control diet; low IF (n=30) received a mixture of unmodified and IF-depleted soy protein isolate (SPI) (0.94 mg IF/g protein, approximating a human ...
Cheng Victor Y - - 2007
How well absence of coronary artery calcium (CAC) predicts the absence of noncalcified coronary artery plaque (NCAP) has not been elucidated. We conducted a cross-sectional study of 554 outpatients to quantify NCAP prevalence as a function of CAC score. All patients underwent CAC scoring followed by 64-slice computed tomographic coronary ...
Tamakawa N N Department of Neurosurgery, National Hospital Organization Toyohashi Medical Center; - - 2007
Currently carotid artery stenting (CAS) as well as carotid endoarterectomy (CEA) have become widely accepted forms of treatment for carotid artery stenosis, although complications associated with distal embolism remain problematic. Therefore it is important to have an accurate understanding of the properties of carotid plaque before undertaking CAS in order ...
Kaneda Hideaki - - 2008
BACKGROUND: While only few data exist correlating cardiovascular risk factors with volumetric measurements of coronary atheroma burden in patients with coronary artery disease, a recent report using intravascular ultrasound (IVUS) demonstrated independent predictors of atherosclerotic burden in a native coronary artery with relatively mild narrowing (20-50% diameter stenosis by visual ...
Rdzanek Adam - - 2007
The article presents a case of a 68-year old male admitted to coronary care unit because of acute coronary syndrome without ST segment elevation. In coronary angiography a lesion in the left main coronary artery (LMCA) is found. Intravascular ultrasound (IVUS) examination confirms the diagnosis of the ruptured plaque with ...
Schroeder Stephen - - 2007
Multislice detector spiral computed tomography (MSCT) is a noninvasive modality for visualization and evaluation of atherosclerosis in vivo in different arterial beds. Rapid technical advances led to a significant improvement of the diagnostic accuracy of coronary MSCT angiography. The most popular clinical application with best scientific Medical evidence of MSCT ...
Pico Fernando - - 2007
BACKGROUND AND PURPOSE: Clinical and imaging studies have reported an independent and intriguing association between intracranial arterial dolichoectasia (IADE) and markers of small-vessel disease (SVD) such as lacune(s). We used a large brain-autopsy collection to investigate the relation between IADE and pathologically assessed cerebral SVD. METHODS: The entire arterial tree ...
Wainstein Marco - - 2007
Diagnosing plaque vulnerability may have therapeutic and prognostic implications. We used a heat sensor-tipped thermography guidewire to identify temperature variations in atherosclerotic coronary arteries in patients undergoing stent placement. This study is the first human experience with the ThermoCoil Guidewire (TG). TG consists of a 0.014 inch wire which rotates ...
Nandalur Kiran R - - 2007
Calcification has been associated with carotid plaque stability; however, an acceptable in vivo method to define plaques based on this component remains to be developed. The purpose of our study was to compare calcified and noncalcified volumes of carotid artery culprit symptomatic plaques with asymptomatic plaques using multidetector computed tomography. ...
García-García Héctor M - - 2007
According to pathologic studies, the content of a necrotic core increases in a "linear fashion" as plaque enlarges. In addition, these 2 plaque characteristics have been associated with plaque vulnerability. This study assessed the relation between plaque cross-sectional area (CSA) and content of necrotic core (NC). Twenty-five patients (75 arteries) ...
Roberts William Clifford - - 2007
This study compares the amounts of cross-sectional area narrowing of the right coronary artery (RCA) in patients having endarterectomy of this artery at the time of coronary artery bypass grafting (CABG) to the amounts of narrowing in the same artery at necropsy in patients with fatal coronary artery disease (CAD). ...
Valenti Luca - - 2007
BACKGROUND/AIMS: Hyperferritinemia has been associated with cardiovascular mortality in hemodialysis patients. The aim of this study was to evaluate whether serum ferritin was affected by iron and oxidative status and by genetic factors (HFE mutations and the Ala9Val MnSOD polymorphism), and to assess the association between ferritin and cardiovascular damage ...
Hoefer Imo E - - 2007
Stimulation of neovascularization (angiogenesis, arteriogenesis) has emerged as a promising new strategy to treat patients with coronary disease. These strategies aim to improve cardiac function by ensuring myocardial perfusion and to reduce the risk of myocardial infarction. While angiogenesis describes a de-novo formation of small caliber capillary vessels, arteriogenesis leads ...
Sasaki Takeshi - - 2007
It is widely believed that rupture of a vulnerable atherosclerotic plaque leads to acute coronary events and stroke. However, the exact mechanisms involved in the plaque rupture remain unknown. Pathological animal models are valuable in the research on human disease mechanism, their therapy, and drug development. Recently, we have proposed ...
Baroncini Liz Andréa Villela - - 2007
BACKGROUND: To analyse histological composition and progression of carotid plaque. METHODS: Thirty-one patients (22 males, mean age 68.03 +/- 7.3 years) admitted for carotid endarterectomy for extracranial high-grade internal carotid artery stenosis (>or= 70% luminal narrowing) were enrolled. The patients were divided into 2 groups according to symptomatology (group I, ...
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