Search Results
Results 251 - 300 of 1509
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Rudd James H F - - 2008
Atherosclerosis imaging with 18F-FDG PET is useful for tracking inflammation within plaque and monitoring the response to drug therapy. Short-term reproducibility of this technique in peripheral artery disease has not been assessed, and the optimal method of 18F-FDG quantification is still debated. We imaged 20 patients with vascular disease using ...
Nair Deepu - - 2008
Framingham risk score is an office-based tool used for long-term coronary heart disease risk stratification. Most acute coronary events occur in association with proximal nonobstructive atherosclerotic plaque. Multislice computed tomography detects both obstructive coronary artery disease (CAD) and proximal atherosclerotic plaque with high accuracy. The association of Framingham risk score ...
Chiu Bernard - - 2008
Quantitative measurements of the progression (or regression) of carotid plaque burden are important in monitoring patients and evaluating new treatment options. 3D ultrasound (US) has been used to monitor the progression of carotid artery plaques in symptomatic and asymptomatic patients, and different methods of measuring various ultrasound phenotypes of atherosclerosis ...
Otsuka Masato - - 2008
BACKGROUND: Noninvasive assessment of coronary atherosclerotic plaque may be useful for risk stratification and treatment of atherosclerosis. MATERIALS AND METHODS: We studied 47 patients to investigate the accuracy of coronary plaque volume measurement acquired with 64-slice multislice computed tomography (MSCT), using newly developed quantification software, when compared with quantitative intracoronary ...
Lee Min Y - - 2008
BACKGROUND: Carotid intima-media thickness (IMT) and plaque burden evaluated by B-mode ultrasound have been used as relevant indicators for carotid atherosclerosis. This study was aimed to investigate the relationship between hemodynamic parameters in the common carotid artery (CCA) and the severity of carotid atherosclerosis in untreated hypertensive patients. METHODS: Carotid ...
Maurice Roch Listz - - 2008
Plaque rupture is correlated with the plaque morphology, composition, mechanical properties, and with the blood pressure. Whereas the geometry can accurately be assessed with intravascular ultrasound (IVUS) imaging, intravascular elastography (IVE) is capable of extracting information on the plaque local mechanical properties and composition. This paper reports additional IVE validation ...
Heuser Richard R - - 2008
Atherosclerotic disease affecting the arteries of the lower extremities becomes symptomatic with the onset of pain either at rest or with ambulation. The disease, commonly referred to as peripheral arterial disease (PAD), affects nearly 30 million individuals in Europe and North America alone. The predominant factor responsible for the impaired ...
Thim T - - 2008
Plaque rupture precipitates approximately 75% of all fatal coronary thrombi. Therefore, the plaque prone to rupture is the primary focus of this review. The lipid-rich core and fibrous cap are pivotal in the understanding of plaque rupture. Plaque rupture is a localized process within the plaque caused by degradation of ...
Van Der Steen Ton - - 2008
The composition and morphology of an atherosclerotic lesion are currently considered more important determinants of acute coronary ischemic syndromes that the degree of stenosis. When a lesion is unstable, it can rupture and cause an acute thrombotic reaction. An unstable plaque can be characterized by a lipid core that is ...
Jeanpierre Emmanuelle - - 2009
BACKGROUND: Fibrates are peroxisome proliferator-activated receptor alpha (PPARalpha) agonists which modulate many aspects of lipoprotein metabolism and inflammation. They have been recently demonstrated to inhibit in vitro expression of tissue factor (TF), the main initiator of blood coagulation, which probably plays a pivotal role in thrombotic complications after plaque rupture. ...
Redgrave Jessica N - - 2008
BACKGROUND AND PURPOSE: Advances in carotid plaque imaging could allow quantification of fibrous cap thickness in vivo. While a cap thickness <65 microm is the accepted definition of rupture-prone plaque in the coronary circulation, the threshold value for carotid plaques is unknown. METHODS: We made detailed histological assessments of 526 ...
Akabame Satoshi - - 2008
BACKGROUND: Multislice computed tomography (MSCT) permits direct visualization of not only coronary artery stenosis but also the characteristics of plaques in patients with coronary artery disease (CAD). Also, because of its potential to be a novel risk factor for cardiovascular disease, interest in non-alcoholic fatty liver disease (NAFLD) is increasing. ...
Pislaru Cristina - - 2008
Vibroacoustography allows imaging of objects on the basis of their acoustic signal emitted during low-frequency (kHz) vibrations produced by 2 intersecting ultrasound beams at slightly different frequencies. This study tested the feasibility of using vibroacoustography to distinguish between normal and calcified femoral arteries in a pig model. Thirteen normal porcine ...
Ohara T - - 2008
BACKGROUND AND PURPOSE: Eccentric stenosis of the coronary artery is associated with plaque disruption and acute coronary syndrome. The purpose of the present study was to determine whether eccentric stenosis of the carotid artery contributes to cerebrovascular events. MATERIALS AND METHODS: Of 6859 patients with vascular diseases who underwent duplex ...
Sugioka Kenichi - - 2008
BACKGROUND AND PURPOSE: The atherosclerotic process is associated with both morphological and functional changes in the carotid artery. We evaluated the relationship between these parameters of the carotid artery and the extent of coronary artery disease (CAD) in patients with preserved left ventricular function. METHODS: The study population consisted of ...
Saam Tobias - - 2008
OBJECTIVES: Via magnetic resonance imaging (MRI), we sought to determine the prevalence of atherosclerotic American Heart Association type VI lesions (AHA-LT6) (lesions with luminal surface defect, hemorrhage/thrombus, or calcified nodule) in carotid arteries that represented all categories of stenosis as measured by duplex ultrasound. BACKGROUND: Arterial stenosis alone has been ...
Kerwin W S - - 2008
Vasa vasorum in the adventitia of atherosclerotic arteries may play a role in plaque progression. In this investigation, a method for characterizing vasa vasorum in the carotid artery is proposed, in which the perfusion properties of the adventitia are probed via dynamic contrast-enhanced (DCE) MRI. A parametric "vasa vasorum image" ...
Kunte Hagen - - 2008
Macrophage infiltration and expression of matrix metalloproteinase-9 (MMP-9) are markers of high-risk atherosclerotic carotid plaques and strong indicators of plaque instability. Use of statins is associated with a decreased risk of stroke and reportedly improves stability of atherosclerotic plaques, but available data addressing the mechanism of this effect are conflicting. ...
Reimann Anja J - - 2008
The present case report describes a 37-year-old man who presented to the emergency room with symptoms of a myocardial infarction but no high-grade stenosis on conventional catheter angiography. Consecutive multidetector row computed tomography of the coronary arteries showed an intimal flap along a fibrous plaque formation in the left anterior ...
Sarzyńska-Długosz Iwona - - 2008
BACKGROUND AND PURPOSE: Atherosclerotic changes in carotid arteries are responsible for 10-20% of strokes. The aim of our study was to examine how the ultrasonic morphology of carotid arteries influences the occurrence of ischaemic stroke (IS). MATERIAL AND METHODS: Ultrasonography of the carotid arteries was performed with a 7-MHz duplex-type ...
With Notø Ann-Trude - - 2008
Echolucent carotid plaques are associated with higher risk for future ischemic cerebrovascular events (CVE) than echogenic plaques independent of the degree of stenosis. Elevated markers of thrombin generation are associated with atherosclerotic plaques and are increased in the acute and chronic phases of CVE. The present study was conducted to ...
Rosenfeld Michael E - - 2008
The innominate artery is a predilection site for atherosclerotic lesion formation in hyperlipidemic mice. The lesions at this site in chow-fed apo E-/- mice progress from fatty streaks through stages that include atheroma with large necrotic areas, fibro-fatty nodules containing chondrocyte-like cells and highly calcified, acellular plaques. The advanced lesions ...
König Andreas - - 2008
Acute coronary syndromes or sudden coronary death are often the first manifestations of coronary artery disease. In the majority of patients, acute coronary syndrome events are caused by plaque rupture in flow-limiting and non-flow-limiting angiographically intermediate stenoses. Histopathologic analyses have shown that plaque composition is related to the occurrence of ...
VanEpps J Scott - - 2009
Cyclic flexure of the coronary arteries can lead to spatially varying fluid and solid stress patterns. These patterns may explain the heterogenous distribution of atherosclerotic lesions. Here we describe the design and validation of an experimental system to simulate coronary-like flexure dynamics on intact arterial segments ex vivo. Our previously ...
Raman Raghav - - 2008
Institutional review board approval was obtained for this HIPAA-compliant study. Informed consent was obtained for prospective evaluation in 21 asymptomatic volunteers (10 women, 11 men; mean age, 60 years) but waived for retrospective (10 patients with and five patients without disease) evaluation. Prospective validation was in phantoms. Quantification of mass ...
Okubo Munenori - - 2008
Tissue characterization of plaques of coronary arteries is important to clarify the process of acute coronary syndrome and prevent it. The purpose of this study is to develop an online integrated backscatter intravascular ultrasound (IB-IVUS) system and validate the diagnostic accuracy for the characterization of coronary plaques. A personal computer ...
Shiomi Masashi - - 2008
To clarify the mechanism of coronary outward remodeling, we examined atherosclerotic coronary arteries morphologically using WHHLMI rabbits that develop coronary atherosclerosis spontaneously. Perfusion-fixed coronary segments of WHHLMI rabbits were prepared at 500microm intervals. After immunohistochemical staining and histopathological staining, the areas and lengths of the arterial wall and the lesions ...
Takano Masamichi - - 2008
Atherosclerotic yellow plaques identified by coronary angioscopy are considered as vulnerable plaques. However, characteristics of yellow plaques are not well understood. Optical coherence tomography (OCT) provides accurate tissue characterization in vivo and has the capability to measure fibrous cap thickness covering a lipid plaque. Characteristics of yellow plaques identified by ...
Mohler Emile R ER - - 2008
OBJECTIVE: The relationship between specific gene regulation and subsequent development and progression of atherosclerosis is incompletely understood. We hypothesized that genes in the vasculature related to cholesterol metabolism, inflammation, and insulin signaling pathways are differentially regulated in a site-specific and time-dependent manner. METHODS AND RESULTS: Expression of 59 genes obtained ...
Hori Emiko - - 2008
BACKGROUND: It is said atheromatous plaque is located very focally, but there have been few reports regarding this matter. Various aspects of the pathogenesis of the development of atheromatous plaque at the carotid bifurcation have previously been discussed. We have noted the correlation of plaque localization with characteristics of the ...
Chen Yan - - 2008
The clinical application of 16-slice CT coronary angiography (CTCA) and the impact of plaques differently characterized on assessing coronary artery stenosis were evaluated. Thirty-eight patients with coronary artery disease diagnosed by conventional coronary angiography (CAG) underwent 16-slice CTCA (collimation: 16x0.75 mm; rotation time: 420 msec; kernel: 35f; effective current: 500 ...
Gilard M - - 2008
Intravascular ultrasound (IVUS) is a cornerstone tool for the diagnosis of plaque rupture (PR) but is usually used secondary to the suspicion of PR on angiography; the true incidence of PR may therefore be overestimated. We sought to evaluate predictors of angiographic diagnosis of PR using a non-angiographically driven IVUS ...
Dalager Søren - - 2008
Risk factors for atherosclerosis have limited ability to identify persons at high risk of coronary heart disease. Assessment of subclinical atherosclerosis in peripheral arteries might improve this limitation. We studied the relationship between atherosclerotic plaques in peripheral arteries, coronary plaques, and coronary death. Predefined segments from the left anterior descending ...
Pujadas Ramón - - 2008
The aim of this study was to evaluate the presence of dense mitral annular calcification as a marker of complex aortic atherosclerosis in patients with stroke of uncertain etiology. One hundred twenty-one patients with stroke of uncertain etiology were evaluated for complex aortic atherosclerotic plaques; their presence and severity were ...
Galonska Maximilian - - 2008
RATIONALE AND OBJECTIVES: We investigated if 16-slice multidetector row computed tomography (MDCT) allows correct classification of coronary plaques into calcified or noncalcified and further subclassification of noncalcified plaques into either lipid-rich with a necrotic core or fibrous. MATERIALS AND METHODS: Coronary arteries of 30 isolated hearts were filled postmortem with ...
Brevetti Gregorio - - 2008
Previous reports indicate that the prevalence and severity of carotid stenoses is greater in peripheral artery disease (PAD) than in coronary artery disease (CAD). To date, no study has compared these two populations with respect to plaque echogenicity, which is an independent risk factor for cerebrovascular events. In 43 PAD ...
Heliopoulos John - - 2008
BACKGROUND AND PURPOSE: Studies evaluating the association between carotid plaque composition and occurrence of ischemic cerebrovascular disease reveal inconsistent results. This study correlates the carotid echomorphology with the degree of stenosis in symptomatic and asymptomatic patients. METHODS: We included consecutive patients with hemispheric stroke or asymptomatic carotid artery stenosis assessed ...
Kawahara Ichiro - - 2008
BACKGROUND: Plaque rupture is believed to be a critical event that leads to thromboembolic complications in atherosclerotic carotid artery disease. Intraplaque hemorrhage can also cause fibrous cap disruption and may be related to the progression of atherosclerosis. However, the mechanism that leads to fibrous cap disruption is not well defined, ...
Martin Richard M - - 2008
CONTEXT: Circulating IGF-I is inversely associated with ischemic heart disease incidence. Whether this association relates to alterations in plaque growth or stability, and the role of IGF-II and the major binding proteins [IGF binding protein (IGFBP)-2 and -3], is unclear. OBJECTIVE: Our objective was to test the hypothesis that circulating ...
Chatzizisis Yiannis S - - 2008
Although conventional linear 3-dimensional (3D) reconstruction of coronary arteries by intravascular ultrasound has been widely used for the assessment of plaque volume and progression; the volumetric error (VE) that is produced has not been adequately studied. Linear and geometrically correct 3D reconstruction was applied in 16 coronary arterial segments from ...
Jensen Lisette Okkels - - 2008
During percutaneous coronary intervention, the reference segment is assessed angiographically. This report described the discrepancy between angiographic and intravascular ultrasound (IVUS) assessment of reference segment size in patients with type 2 diabetes mellitus. Preintervention IVUS was used to study 62 de novo lesions in 41 patients with type 2 diabetes ...
Bobryshev Y V - - 2008
Plaque rupture is the most common type of plaque complication and leads to acute ischaemic events such as myocardial infarction and stroke. Calcification has been suggested as a possible indicator of plaque instability. Although the role of matrix vesicles in the initial stages of arterial calcification has been recognized, no ...
Tang T Y - - 2008
INTRODUCTION: Inflammation is a recognized risk factor for the vulnerable atherosclerotic plaque. The aim of this study was to explore whether there is a difference in the degree of Magnetic Resonance (MR) defined inflammation using Ultra Small Super-Paramagnetic Iron Oxide (USPIO) particles, within carotid atheroma in completely asymptomatic individuals and ...
Henriksen Peter A - - 2008
Human neutrophil elastase (HNE) is present within atherosclerotic plaques where it contributes to matrix degradation and weakening of the vessel wall associated with the complications of aneurysm formation and plaque rupture. It is joined by other extracellular proteases in these actions but the broad range of substrates and potency of ...
Haberal I - - 2008
A 36-year-old man presented for treatment of headache, paresthesis, and weakness of his right arm and leg. Examination revealed an atherosclerotic plaque in the left common carotid artery, lying to the left internal carotid artery and resulting in 99% stenosis. The plaque was removed successfully by carotid endarterectomy. Pathological examination ...
Saba Luca - - 2008
PURPOSE: Stroke is a leading cause of severe disability in the western world. A correct diagnostic procedure to stratify risk is necessary in order to rapidly plan the most efficient therapy. The purpose of this work was to evaluate the agreement between ultrasound echo-color Doppler (US-ECD) and multidetector-row CT angiography ...
Brunner G - - 2008
There is growing evidence that calcified arterial deposits play a crucial role in the pathogenesis of cardiovascular disease. This paper investigates the challenging problem of unsupervised calcified lesion classification. We propose an algorithm, US-CALC (UnSupervised Calcified Arterial Lesion Classification), that discriminates arterial lesions from non-arterial lesions. The proposed method first ...
Tong Li-Li - - 2008
Vascular calcification is highly prevalent and often severe in patients with chronic kidney disease. Arterial calcification in patients with chronic kidney disease can result from the deposition of mineral along the intimal layer of arteries in conjunction with atheromatous plaques or from calcium deposition in the medial wall of arteries, ...
Saba Luca - - 2008
OBJECTIVE: Atherosclerotic disease of the carotid arteries is one of the most important causes of stroke. Our objective was to evaluate the interobserver agreement in the measurement of the degree of carotid plaque stenosis by using MDCT angiography (MDCTA) and the effects produced using different window parameters and by the ...
Wu Yen-Wen - - 2008
High tissue matrix metalloproteinase (MMP) activity has been reported to be associated with atherosclerosis and plaque rupture. The aim of this study was to elucidate the diagnostic value of serum MMP-1 in carotid stenosis and its dynamic change after stenting. We measured high-sensitivity C-reactive protein (hs-CRP) and MMP-1 in 37 ...
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