Search Results
Results 201 - 250 of 1509
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Kunita Eiji - - 2009
A 61-year-old woman with hypercholesterolemia, hypertension and diabetes mellitus was referred to hospital for the evaluation of chest pain at rest. Eccentric 50% stenosis in the proximal right coronary artery was detected by 64-slice multidetector row computed tomography (MDCT). The plaque morphology was considered as soft by Color Code Plaque ...
Gisondi Paolo - - 2009
BACKGROUND: Patients with moderate to severe chronic plaque psoriasis have a higher prevalence of cardiovascular risk factors and atherosclerosis. Arterial stiffness is a measure of endothelial dysfunction and an independent predictor of cardiovascular events. OBJECTIVES: To investigate whether chronic plaque psoriasis is associated with an increased arterial stiffness. METHODS: A ...
Schiro B J - - 2008
Complications of carotid artery stenting (CAS), including stroke, remain relatively high when compared with carotid endarterectomy (CEA). Current selection criteria for patients undergoing CAS are based predominately on surgical risk related to other comorbidities. Little attention is given to the morphology of the atherosclerotic plaque, although studies have shown that ...
Zhang Shaoxiong - - 2008
OBJECTIVE: Because of beam-hardening and blooming artifacts, it is difficult to determine the degree of stenosis caused by calcified coronary artery plaques at coronary CT angiography (CTA). Our goal was to determine how accurate coronary CTA is in evaluating these lesions. MATERIALS AND METHODS: Thirty-one patients who had one or ...
Tanimoto Takashi - - 2009
A 58-year-old man underwent cardiac catheterization for unstable angina. The coronary angiogram revealed severe stenosis of the right coronary artery. Although 20-MHz, phased-array intravascular ultrasound (IVUS) only visualized eccentric, low echoic plaque at the culprit site, optical coherence tomography (OCT) clearly revealed ruptured plaque and an intraluminal thrombus. OCT also ...
Nakajima Makoto - - 2008
An 86-year-old man with a history of brain infarction was admitted because of recurrent stroke with symptoms of left hemiparesis. Ultrasonography revealed a mobile thrombus in the brachiocephalic artery. Although anticoagulant therapy was commenced, neurologic symptoms deteriorated suddenly and he died on the third day. Autopsy indicated that the thrombus ...
Shah Prediman K - - 2009
Development of a thrombus at the site of an atherosclerotic plaque initiates abrupt arterial occlusion and is the proximate event responsible for the vast majority of acute ischemic syndromes. In nearly 75% of cases thrombus overlies a disrupted or ruptured plaque whereas the remainder of the thrombi overly an intact ...
Meyers Philip M - - 2009
Intracranial artery stenosis is assumed to represent atherosclerotic plaque. Catheter cerebral arteriography shows that intracranial stenosis may progress, regress, or remain unchanged. It is counterintuitive that atherosclerotic plaque should spontaneously regress, raising questions about the composition of intracranial stenoses. Little is known about this disease entity in vivo. We provide ...
Sharma Vijay K - - 2009
BACKGROUND: The morphological characteristics of atherosclerotic plaques are considered to determine their cerebral 'embolic potential'. However, these are seldom considered during therapeutic decision-making. METHODS: Assessment and quantification of embolic potential by employing power-M-mode (PMD) transcranial Doppler (TCD) to strengthen risk scoring has been discussed. RESULTS: PMD-TCD is a reliable technique ...
McRobb L - - 2009
Arterial calcification has prognostic significance for cardiovascular outcomes, but its pathogenesis remains unclear. Calcification increases with age, but its prevalence in men suggests hormonal influence. In this study we analyzed the effect of exogenous androgens on calcification of advanced atherosclerotic lesions in the arterial tree of gonadally intact 34-wk-old male ...
Jaffer Farouc A - - 2008
To enable intravascular detection of inflammation in atherosclerosis, we developed a near-infrared fluorescence (NIRF) catheter-based strategy to sense cysteine protease activity during vascular catheterization. The NIRF catheter design was based on a clinical coronary artery guidewire. In phantom studies of NIRF plaques, blood produced only a mild (<30%) attenuation of ...
Fishbein Michael C - - 2010
The lesion responsible for the overwhelming majority of acute coronary events is plaque disruption or erosion with superimposed thrombosis. The term "vulnerable plaque" has been used to describe those atherosclerotic plaques that are particularly susceptible to disruption. Vulnerable plaques are generally characterized as those having a thin inflamed fibrous cap ...
Peng Youming - - 2008
AIM: The aim of the present report was to investigate the probable association of circulating levels of PAI-1 and expression of PAI-1 in internal iliac artery walls with atherosclerotic disease in chronic haemodialysis (HD) patients. METHODS: Sixty-eight non-diabetic HD patients and 50 age- and sex-matched healthy normotensive controls participated in ...
Vink Aryan - - 2008
High performance athletes, predominantly professional cyclists, can develop symptomatic arterial flow restriction in one or both legs during exercise. The ischemic symptoms are caused by endofibrosis and/or kinking of the external iliac artery. Because these athletes are young and have no classic risk factors for atherosclerosis, endofibrosis and atherosclerosis are ...
Yoshida Kazumichi - - 2008
Two patients presented with sudden onset of occlusive thrombosis of the atherosclerotic carotid artery. The patients underwent carotid endarterectomy. Histological examination of the specimens clearly showed the presence of pre-existing atherosclerotic plaque with moderate stenosis and occlusive organized thrombus. Blood flow was maintained through a honeycomb pattern of multiple neovascularization ...
Amann Kerstin - - 2008
Calcification of the vascular tree is common in physiologic and pathologic conditions, i.e., aging, diabetes, dyslipidemia, genetic diseases, and diseases with disturbances of calcium metabolism. In chronic kidney disease, vascular calcification is even more common, develops early, and contributes to the markedly increased cardiovascular risk in this particular population. Pathomorphologically, ...
Tsujita Kenichi - - 2008
The purpose of this study was to determine the incidence, location, and clinical features of myocardial bridging (MB) detected by intravascular ultrasound (IVUS) and to compare IVUS-detectable versus angiographically detectable MBs. IVUS images were analyzed in 331 consecutive patients with de novo coronary lesions located in the left anterior descending ...
Rochefort Gaël Y - - 2009
OBJECTIVE AND MOTIVATION: Intravascular ultrasound (IVUS) allows in vivo invasive intra-luminal real-time examination of the arterial wall structure. In this study, we aimed to validate for the first time the in vivo IVUS performing as a diagnostic tool by comparison to the well-established histomorphometry approach, in the largely used rat ...
Grönros J - - 2008
This study investigated the effects of rosuvastatin on plaque progression and in vivo coronary artery function in apolipoprotein E-knockout (ApoE-KO) mice, using noninvasive high-resolution ultrasound techniques. Eight-week-old male ApoE-KO mice (n = 20) were fed a high-fat diet with or without rosuvastatin (10 micromol.kg(-1).day(-1)) for 16 wk. When compared with ...
Gao Hao - - 2008
The rupture of atherosclerotic plaques is known to be associated with the stresses that act on or within the arterial wall. The extreme wall tensile stress is usually recognized as a primary trigger for the rupture of the plaque. The present study used one-way fluid-structure interaction simulation to investigate the ...
Stelagowski M - - 2008
Subtraction angiography is an invasive diagnostic method, which for a long time was a gold standard in carotid artery and intra-cranial vessel imaging. The aim of this research is to evaluate angiographic imaging in predicting atherosclerotic plaque type VI by AHA morphology and to assess its significance in establishing patients' ...
Gardner Craig M - - 2008
OBJECTIVES: This study sought to assess agreement between an intravascular near-infrared spectroscopy (NIRS) system and histology in coronary autopsy specimens. BACKGROUND: Lipid core plaques cannot be detected by conventional tests, yet are suspected to be the cause of most acute coronary syndromes. Near-infrared spectroscopy is widely used to determine the ...
Arroyo L G - - 2008
Calcification of large arteries has been sporadically reported in horses. The pathogenesis is still unknown, but recent studies in humans suggest that this is a regulated biomineralizing process. This study surveyed the prevalence, distribution, and severity of vascular calcification in Thoroughbred and Standardbred racehorses. Histopathologic, ultrastructural imaging, and energy dispersive ...
Okubo Munenori - - 2008
BACKGROUND: Integrated backscatter (IB) intravascular ultrasound (IVUS) and IVUS Virtual Histology (VH) have been developed for tissue characterization, but have never been compared directly. The purpose of this study was to compare the overall agreement between IB-IVUS and IVUS-VH in the tissue characterization of plaques from the same coronary arterial ...
Gewaltig Jan - - 2008
Atherosclerotic lesions develop in the arterial intima. Among the leukocytes that accumulate in advanced atherosclerotic plaques, CD8 T cells play a quantitatively important role. They may be involved in disease progression and plaque destabilization, leading to plaque rupture or erosion. These events finally precipitate cardiovascular events. Therefore, we wished to ...
Debette Stéphanie - - 2008
BACKGROUND AND PURPOSE: The association of carotid atherosclerosis with body composition and fat distribution is poorly understood. We aimed to test the cross-sectional association of carotid plaques and common carotid artery intima-media thickness with calf circumference (CC), representing peripheral fat and lean mass, and with waist circumference and waist-to-hip ratio, ...
Niizuma Kuniyasu - - 2008
Diagnosis of deep subcortical infarcts based on atherosclerosis of the middle cerebral artery (MCA) is important because this type of infarct is usually more aggressive than typical lacunar infarcts. However, current imaging techniques are of limited utility in the diagnosis of MCA plaques. Here, we report the use of 3-Tesla ...
Dekker M J H J - - 2008
BACKGROUND: Dysregulation of the hypothalamic-pituitary-adrenal axis has been suggested as an independent risk factor for ischemic heart disease. The aim of our study was to evaluate whether two markers of the hypothalamic-pituitary-adrenal axis activity, the level of salivary cortisol and the diurnal salivary cortisol pattern, are associated with atherosclerosis of ...
Dodd Jonathan D - - 2008
OBJECTIVE: The purpose of our study was to evaluate the accuracy of cardiac 64-MDCT to quantify the grade of stenosis of nonculprit lesions. SUBJECTS AND METHODS: Twenty-nine consecutive patients (23 men and six women; mean age, 62 +/- 10 years) presenting with acute coronary syndrome (ACS) had nonculprit coronary lesions ...
Tanaka Atsushi - - 2008
BACKGROUND: Plaque rupture and secondary thrombus formation play key roles in the onset of acute coronary syndrome (ACS). Multidetector computed tomography (MDCT) allows the non-invasive assessment of coronary artery stenosis and plaque properties. In this study, we investigated whether 64-slice MDCT could non-invasively detect a plaque rupture in patients with ...
Tanaka Atsushi - - 2008
The aim of this study was to investigate the distribution and frequency of thin-capped fibroatheromas (TCFAs) within the entire length of culprit coronary arteries in patients with acute coronary syndrome. Our population was drawn from 43 consecutive patients with acute coronary syndrome (with or without ST-segment elevation) who underwent optical ...
Choi Eue-Keun - - 2008
OBJECTIVES: The purpose of this study was to evaluate the prevalence of occult coronary artery disease (CAD) with coronary computed tomography angiography (CTA) to characterize plaque composition and to evaluate the potential of this new technology to impact risk stratification in asymptomatic middle-aged subjects. BACKGROUND: There is a paucity of ...
Bishop Paul D - - 2008
The aim of this study was to determine if significant differences in plaque composition exist between the popliteal and tibial vessels in patients with severe peripheral arterial disease (PAD). Forty-four patients with PAD required either above-knee (n = 38), below-knee (n = 5), or through-knee (n = 1) amputation for ...
Frost Michelle L - - 2008
Arterial calcification leading to increased arterial stiffness, a powerful risk factor for cardiovascular disease, may underlie the association of osteoporosis with cardiovascular disease in postmenopausal women. Osteoprotegerin (OPG), an indirect inhibitor of osteoclastogenesis, may be involved in arterial calcification. We examined relationships between calcification of subclinical atherosclerotic plaque and arterial ...
Klein Jonathan H - - 2008
BACKGROUND: Lipoprotein(a) [Lp(a)] is a putative risk factor for myocardial infarction and stroke and is related to thrombosis and impaired fibrinolysis. We studied relationships of Lp(a) with carotid stenosis, occlusion, and total plaque area, distinct phenotypes of atherosclerosis that may be differentially affected by cardiovascular risk factors. METHODS AND RESULTS: ...
Huang Pin-tong - - 2008
PURPOSE: To evaluate neovascularization within carotid atherosclerotic plaques with contrast-enhanced sonography. METHODS: We used contrast-enhanced sonography to examine 63 patients with carotid atherosclerotic plaques. The features of neovascularization within the plaques were analyzed and correlated with plaque size and echogenicity. RESULTS: There were 81 atherosclerotic plaques, 62 of which (43 ...
Ding Shifang - - 2008
BACKGROUND: Increasing evidences show that disruption of carotid plaque followed by arterio-arterial thromboembolism is an important mechanism in the generation of ischemic stroke. Inflammatory mechanisms play a key role in transforming structurally vulnerable plaques into functionally unstable ones. The purpose of the present study is to evaluate the roles of ...
Rakshe Tejas - - 2008
Accurate arterial centerline extraction is essential for comprehensive visualization in CT Angiography. Time consuming manual tracking is needed when automated methods fail to track centerlines through severely diseased and occluded vessels. A previously described algorithm, Partial Vector Space Projection (PVSP), which uses vessel shape information from a database to bridge ...
Springer Ivonne - - 2009
PURPOSE: Multislice computed tomography (MSCT) is a novel non-invasive test for detection and analysis of coronary artery plaques. A systematic review was conducted of the literature to compare MSCT with IVUS as the reference standard for assessing coronary artery plaques. MATERIALS AND METHODS: We performed a literature search in the ...
Raffel Owen Christopher - - 2008
Positive coronary arterial remodelling has been shown to be associated with unstable coronary syndromes and ex vivo histological characteristics of plaque vulnerability such as a large lipid core and high macrophage content. The aim of this study is to evaluate the in vivo association between coronary artery remodelling and underlying ...
Husmann Lars - - 2008
OBJECTIVE: To determine the impact of plaque composition on accuracy of quantitative 64-slice computed tomography coronary angiography (CTCA). METHODS: The institutional review board approved this study; written informed consent was obtained from all patients. One hundred consecutive patients (42 women, mean age 64.6 +/- 9.4 years, age range 39-87 years) ...
Sullivan Jerome L - - 2009
It has been proposed that iron depletion protects against cardiovascular disease. There is increasing evidence that one mechanism for this protection may involve a reduction in iron levels within atherosclerotic plaque. Large increases in iron concentration are seen in human atherosclerotic lesions in comparison to levels in healthy arterial tissue. ...
Trivedi R A - - 2008
Atherosclerotic disease of the carotid arteries has been identified as a major cause of stroke and thromboembolism from ruptured atheroma plaques within the walls of these vessels, has been proposed as the putative pathophysiological event underlying cerebral ischaemia. Carotid endarterectomy has been shown to be superior to pharmacotherapy in reducing ...
Clouse Melvin E - - 2008
OBJECTIVE: The purpose of our study was to evaluate a new method using voxel analysis for quantifying noncalcified plaque in coronary arteries using MDCT angiography (MDCTA) compared with luminal stenosis by catheter coronary arteriography. MATERIALS AND METHODS: Forty-one normal and eight abnormal arterial cross sections with noncalcified plaque selected from ...
El-Menyar Ayman A - - 2008
Initiation and progression of coronary atherosclerosis has been associated with inflammation and cytokines balance. The objective of this study is to understand the role of cytokines in the pathophysiology and management of coronary artery disease. Coronary artery disease has been revisited with revision of the pertinent published articles in the ...
Turmel Julie - - 2008
OBJECTIVE: Recent data suggested a relationship between carotid artery intima/media thickness and airway hyperresponsiveness (AHR). Our objective was to assess the potential relationship between AHR and coronary atherosclerosis plaque volume as assessed by 3-dimensional intravascular ultrasound (IVUS). METHODS: Thirty-six subjects had a spirometry and methacholine challenge, skin prick tests, blood ...
Mustafa Ibrahim I Department of Chemical Engineering, NED University of Engineering and Technology, Karachi. - - 2008
To study the usefulness of computer simulations in planning effective treatment of stenosed carotid arteries. Computational study of poststenotic areas of carotid arteries. This study was carried out at the Department of Chemical Engineering, NED University of Engineering and Technology, Karachi from 15th April 2006 till date. Geometric model of ...
Langlois Michel R - - 2008
OBJECTIVE: Reported associations of oxidized low-density lipoprotein (oxLDL) with noninvasive measures of atherosclerosis are inconsistent. In the Asklepios Study cohort of asymptomatic subjects aged 35 to 55 years, we evaluated the relationship of circulating oxLDL with subclinical atherosclerosis in the carotid and femoral arteries. METHODS AND RESULTS: Participants (n=2524, 51.5% ...
Tsutsumi M - - 2008
BACKGROUND AND PURPOSE: Our aim was to assess the feasibility of carotid artery stent placement (CAS) for calcified lesions. MATERIALS AND METHODS: Using embolic protection devices (EPDs), we performed 51 CAS procedures in 43 patients with severe carotid artery stenosis accompanied by plaque calcification. Before intervention, all lesions were subjected ...
Denzel C - - 2009
PURPOSE: Previous studies have demonstrated that plaques from the internal carotid artery with lower median grayscale values are associated with higher complication rates in the perinterventional course. A repeatedly cited limitation of ultrasound is that the single plane used to calculate the median grayscale value is only two dimensional. The ...
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