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Results 151 - 200 of 1509
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McCullough Peter A - - 2009
Atherosclerosis, once present, in the intimal and medial spaces of the blood vessel wall becomes calcified due to a variety of cellular and metabolic processes. Patients with chronic kidney disease (CKD) appear to have both accelerated and amplified vascular calcification compared with the general population. Calcium deposition within vascular tissue ...
Tsumori Takara - - 2009
BACKGROUND: Volumetric intravascular ultrasound (IVUS) analysis has contributed significantly to the assessment of coronary artery disease. The aim of this study is to validate the novel IVUS analysis software (NICORAS) compared to the previously validated software (EchoPlaque). METHODS: Selected from clinical cases, we used 30 IVUS images that utilized motorized ...
Beneli Cristina T - - 2009
We have used an experimental model of aorta stenosis, with a Plexiglas plug, simulating a stable atheromatous plaque that promotes local turbulence and thrombosis. With animal survival of more than 24 h, we followed the partial fibrinolysis of the thrombus as well as its posterior organization and incorporation to the ...
Mitani Yoshihide - - 2009
BACKGROUND: Coronary artery lesions (CALs) late after Kawasaki disease were characterized by endothelial dysfunction and low-grade inflammation, surrogate markers for atherosclerosis. We tested the hypothesis that CALs in patients long after Kawasaki disease are accompanied by atheroma-like features, as assessed by virtual histology-intravascular ultrasound, a new method to assess coronary ...
Patterson A J - - 2009
OBJECTIVES AND DESIGN: Both carotid plaque morphology and severity of white matter ischaemia (WMI) have been shown to be independent predictors of stroke risk. This study tests the hypothesis that there is an association between carotid plaque morphology as determined by high-resolution carotid MRI and WMI. MATERIALS AND METHODS: Forty ...
Kashiwagi Manabu - - 2009
BACKGROUND: Thin-capped fibroatheroma (TCFA) is a recognized precursor lesion for acute coronary syndrome (ACS). Positive remodeling (PR) is the predominant pattern of arterial remodeling in patients with ACS. The aim of this study was to evaluate the relationship between coronary arterial remodeling, fibrous cap thickness and high-sensitivity C-reactive protein (hs-CRP) ...
Kato Katsuhiko - - 2009
PURPOSE: Inflamed atherosclerotic plaques may rupture and cause acute myocardial infarction, stroke and other thrombotic events. Early detection of these unstable plaques could, in many cases, prevent such potentially fatal events. 11C-choline or 18F-labelled choline derivatives for visualizing the synthesis of phospholipids, are promising markers of plaque inflammation with potential ...
Dabiri Hossein - - 2009
Persistent infection of arteries with organisms such as Chlamydia pneumoniae was previously found to contribute to the development of atherosclerosis. We investigate the presence of C. pneumoniae in atherosclerotic plaque by polymerase chain reaction and direct immunofluorescence assay, and we examine the correlation between clinical status and the presence of ...
Katritsis Demosthenes G DG Department of Cardiology, Athens Euroclinic, Athens, Greece. - - 2009
Analysis of conventional angiograms has suggested that specific anatomic parameters of particular segments of a coronary artery render them prone to vulnerable plaque development, plaque rupture, and consequent thrombosis. This study aimed at performing a three-dimensional analysis of recanalized left anterior descending (LAD) coronary arteries in patients who had suffered ...
Rozie S - - 2009
The purpose of this study was to examine the volume and the composition of atherosclerotic plaque in symptomatic carotid arteries and to investigate the relationship between these plaque features and the severity of stenosis and the presence of cardiovascular risk factors. One hundred patients with cerebrovascular symptoms underwent CT angiography. ...
Tavora Fabio - - 2010
BACKGROUND: The relationship between adventitial inflammation, plaque type, and culprit plaque morphology in the epicardial arterial circulation has not been studied in detail. METHODS: We studied semiserial sections of coronary arteries at autopsy from patients dying with severe coronary disease, 81 men (age 50 + or - 12 years) and ...
Wetzel David L - - 2009
Heart disease is by far the biggest killer in the United States, and type II diabetes, which affects 8% of the U.S. population, is on the rise. In many cases, the acute coronary syndrome and/or sudden cardiac death occurs without warning. Atherosclerosis has known behavioral, genetic and dietary risk factors. ...
La Barbera Gaetano - - 2009
We performed a study on 25 common carotid arteries (CCA) affected by atherosclerotic plaques, comparing them to 25 normal CCA. We researched the presence and localisation of atrial natriuretic factor (ANF) and oxytocin (OX) by immunohistochemistry. We found ANF abundantly expressed in plaques, mainly localising in intima and subintima layers; ...
Hayashi Kentaro - - 2009
BACKGROUND: Carotid artery stenting in patients with high surgical risk is considered as an effective alternative to carotid endarterectomy. Because the occurrence of distal embolization with CAS is still a major concern, an embolus protection device is usually used during the procedure. We developed a technique for observation of embolus ...
Olgac Ufuk - - 2009
We calculate low-density lipoprotein (LDL) transport from blood into arterial walls in a three-dimensional, patient-specific model of a human left coronary artery. The in vivo anatomy data are obtained from computed tomography images of a patient with coronary artery disease. Models of the artery anatomy in its healthy and diseased ...
Oh Pyung Chun - - 2010
Carotid plaque is a marker of subclinical atherosclerosis that predicts the presence of coronary artery disease and cardiovascular events. The patient complained of chest discomfort accompanied by ECG abnormalities. Treadmill test demonstrated horizontal ST segment depression, however, coronary angiography did not show any significant stenosis. Carotid plaque was detected by ...
de Weert Thomas T - - 2009
BACKGROUND AND PURPOSE: Complicated (irregular or ulcerated) carotid plaques have proven to be independent predictors of stroke. We analyzed the frequency and location of plaque irregularities in a large cohort of patients with ischemic cerebrovascular disease and the relation with severity of stenosis, cardiovascular risk factors, and symptomatology. METHODS: Multidetector ...
Kim So Yeon - - 2009
Non-invasive detection and characterization of plaque composition may constitute an important step in risk stratification and monitoring of the progression of coronary atherosclerosis. Multislice computed tomography (MSCT) allows for accurate, non-invasive detection and characterization of atherosclerotic plaques, as well as determination of coronary artery stenosis. The aim of this study ...
Kataoka Tetsuro - - 2009
The current study was designed to investigate the relationship between renal arterial structure and vessel remodeling in patients with atherosclerotic renal artery stenosis (RAS), compared with that seen in coronary artery disease (CAD). The nature and the tissue characterization of atherosclerotic RAS lesions have not been fully explored. Gray scale ...
Nakamura Kae - - 2009
Although it has been demonstrated that statins stabilize atherosclerotic lesions in animal models of advanced atherosclerosis, there is little evidence to suggest that statins have a preventive effect on plaque rupture itself. In the present study, we examined the effect of fluvastatin on plaque disruption using a simple and quick ...
Farooq Muhammad U - - 2009
Optical coherence tomography (OCT) is an emerging imaging modality that provides high-resolution, microstructural information on atherosclerotic plaques in biological systems. Intracoronary OCT can identify thin-cap fibroatheroma and other vulnerable plaques that may be responsible for acute coronary events. These characteristics make OCT helpful in guiding coronary management and interventions, including ...
Nakano K - - 2009
BACKGROUND/AIMS: Oral bacteria, including cariogenic and periodontal pathogens, are thought to be etiological factors in the development of cardiovascular diseases. To define this relationship, we analyzed the distribution of oral bacterial species in cardiovascular specimens. METHOD: Following acceptance into the study, 203 consecutive patients were analyzed, from whom 82 aortic ...
Tani Shigemasa - - 2010
Relationship between angiographic morphology and high-sensitivity C-reactive protein (hs-CRP) levels is not fully understood. The serum levels of hs-CRP levels were higher in focal than in diffuse vasospasm in patients with coronary spastic angina. Intravascular ultrasound showed greater plaque volume at the site of vasospasm in the focal vasospasm, in ...
Harloff Andreas - - 2009
BACKGROUND AND PURPOSE: The purpose of this study was to determine the role of plaques >or=4 mm and thrombi (complex plaques) in the descending aorta (DAo) as an embolic high-risk source for stroke. METHODS: In 63 acute stroke patients scheduled for TEE, territory and embolic pattern of brain ischemia were ...
Romero Javier M - - 2009
BACKGROUND AND PURPOSE: The degree of internal carotid artery (ICA) stenosis is an established primary risk factor for embolic stroke. Recent publications suggest that inflammatory features may also play an important role. Our purpose was to correlate acute neurological symptoms with either carotid artery wall enhancement or plaque calcification, on ...
Rudd James H F - - 2009
Fluorodeoxyglucose positron-emission tomography (FDG PET) imaging of atherosclerosis has been used to quantify plaque inflammation and to measure the effect of plaque-stabilizing drugs. We explored how atherosclerotic plaque inflammation varies across arterial territories and how it relates to arterial calcification. We also tested the hypotheses that the degree of local ...
Kaya Dilaver - - 2009
BACKGROUND: The aim of this study was to investigate aortic atheromas in stroke subgroups. METHODS: Two hundred consecutive subjects had acute ischemic stroke confirmed by diffusion-weighted imaging (DWI) (195 cases) or computerized tomography (5 cases). Multidetector computed tomographic angiography (MDCTA) (16- or 64-slice) was used to detect atherosclerotic plaques in ...
Ferrero Emanuele - - 2009
We report the cases of two patients with mobile floating carotid plaques (MFCP). Two men were referred to us for carotid investigation after trauma. The duplex ultrasonography scan (DUS) showed the presence of a mobile floating plaque into the internal carotid artery associated with a stenosis of 40% and 65%, ...
Pericevic Ian - - 2009
Intracoronary stent implantation is a mechanical procedure, the success of which depends to a large degree on the mechanical properties of each vessel component involved and the pressure applied to the balloon. Little is known about the influence of plaque composition on arterial overstretching and the subsequent injury to the ...
Venkatesh V - - 2009
AIM: The purpose of this study was to evaluate the improved assessment of coronary atherosclerotic plaque burden by measurement of non-calcified plaque in addition to calcified plaque using CT coronary angiography (CTA). MATERIALS AND METHODS: Low to intermediate-risk outpatients with suspected coronary artery disease were prospectively recruited. Patients underwent CTA ...
Lind Lars - - 2009
It has previously been shown that the degree of shear stress (SS) in the carotid artery is related to both plaque occurrence and intima-media thickness (IMT). Since the echogenecity also is an important feature of plaques, we investigated if a reduced shear stress also is related to the echolucency of ...
Hlawaty Hanna - - 2009
BACKGROUND: Small interfering RNA (siRNA) delivery is a promising approach for the treatment of cardiovascular diseases. Matrix metalloproteinase (MMP) 2 over-expression in the arterial wall has been implicated in restenosis after percutaneous coronary intervention, as well as in spontaneous atherosclerotic plaque rupture. We hypothesized that in vivo local delivery of ...
Badimon Juan Jose - - 2009
Atherosclerosis is a diffuse pathological process characterized by the deposition of lipid and other blood-borne material within the arterial wall of almost all vascular territories. Cholesterol accumulation plays a central role in atherogenesis. It is the result of an imbalance between cholesterol influx and efflux. The disease progresses silently with ...
Chalela J A - - 2009
BACKGROUND: Carotid disease is an important cause of ischemic stroke. Traditionally, therapeutic efforts in carotid disease have been aimed at identifying carotid stenosis in symptomatic patients and treating high-grade stenosis. New research suggests that identifying the vulnerable plaque in symptomatic or asymptomatic patients may be a more rational approach for ...
Sepp Dominik - - 2009
BACKGROUND: Circulating progenitor cells (PCs) are considered to contribute to the remodeling of atherosclerotic plaques. Their surface receptor CXCR4 plays an important role in the recruitment of PCs to their target. This study compares the mobilization of PCs and their functional characteristics in asymptomatic subjects with stable and with unstable ...
Tanaka Shigeko - - 2009
PURPOSE: We estimated the coronary artery wall using maximum intensity fusion (MIF) of whole-heart magnetic resonance (MR) angiography (WHCA) and water suppression-spectral presaturation with inversion recovery (WS-SPIR) 3D T(1)-weighted turbo field echo (3DT(1) TFE). METHODS: We created a phantom using a wall of plastic bottles varied with plastic tapes measuring ...
Wald David S - - 2009
BACKGROUND: Carotid artery ultrasound is a possible screening test for future coronary heart disease (CHD) events to select individuals for preventive treatment. OBJECTIVES: To assess the screening performance of carotid artery intima-media thickness (IMT) and carotid plaque in the identification of individuals with CHD. METHODS: Meta-analysis of case-control and cohort ...
Katumba-Lunyenya Jasper - - 2009
We report a family with three generations of an ELN deletion. The grandfather was normal except for two inguinal herniotomies. The first generation identical twins had supravalvular aortic and multiple peripheral pulmonary artery stenoses. The second generation twins died during the neonatal period of myocardial infarcts.
Rosenkranz Michael - - 2009
BACKGROUND: Carotid artery stenting (CAS) is associated with the risk of intraprocedural stroke. A better understanding of specific risk factors could help to improve the procedure and to reduce the overall risk of CAS. We addressed the role of carotid plaque echolucency as potential risk factor for cerebral embolism during ...
Sen Souvik - - 2009
Patients with severe aortic arch plaque are at high risk for stroke. This article addresses the complex nature of the association between aortic arch plaque and stroke. The aortic arch plaque poses a diagnostic and therapeutic challenge to the clinician. The different imaging modalities currently available for evaluating aortic plaque ...
Nyquist Paul A - - 2009
BACKGROUND: Monocyte chemoattractant protein 1 (MCP-1), acting in concert with its receptor chemokine receptor 2 (CCR2), promotes recruitment of macrophages into atherosclerotic plaque. We examined whether single nucleotide polymorphism (SNP) variants in the MCP-1 or CCR2 genes independently or in combination are associated with carotid artery atherosclerosis in an African ...
Wald David S - - 2009
BACKGROUND: Ultrasound-detected carotid artery intima-media thickness (IMT) and carotid plaque are possible screening tests for coronary heart disease (CHD) among asymptomatic individuals. OBJECTIVE: To assess the increase in screening performance of combining carotid IMT and plaque compared with each measurement alone in the identification of individuals with CHD. METHODS: Ultrasound ...
Insull William W - - 2009
Atherosclerosis develops over the course of 50 years, beginning in the early teenage years. The causes of this process appear to be lipid retention, oxidation, and modification, which provoke chronic inflammation at susceptible sites in the walls of all major conduit arteries. Initial fatty streaks evolve into fibrous plaques, some ...
Johnsen Stein Harald - - 2009
Atherosclerosis is the underlying cause of most myocardial infarction (MI) and ischemic strokes. B-mode ultrasound of carotid arteries provides measures of intima-media thickness (IMT) and plaques, both widely used as surrogate measures of cardiovascular disease. Although IMT and plaques are highly intercorrelated, IMT's role as a marker of atherosclerosis has ...
Luque Ana - - 2009
BACKGROUND: Previous studies have demonstrated that expression of CD105 is a sensitive marker and indicator of endothelial cell/microvessel activation and proliferation in aggressive solid tumour growth and atherosclerotic plaque lesions. Since intimal neovascularization contributes significantly to subsequent plaque instability, haemorrhage and rupture. METHODS: We have used immunohistochemical analysis to investigate ...
Wylie Mark P MP Dublin Institute of Technology's School of Manufacturing and Design Engineering, Dublin, Ireland. - - 2009
The use of therapeutic ultrasound delivered via small diameter wire waveguides may represent an emerging minimally invasive approach in the treatment of chronic total occlusions (CTOs), calcified and fibrous plaques. The distal-tip mechanical vibrations (typically 0-210 microm peak-to-peak) have been reported to debulk rigid calcified and fibrous tissues while healthy ...
Isma'eel Hussain - - 2010
Patients with a coronary artery calcification score (CACS) of zero and an intermediate risk of coronary artery disease have been shown to have a low prevalence of non-calcified coronary artery plaque (NCP). 181 consecutive patients with CAC 'zero', undergoing cardiac computed tomography angiography (CCTA) angiography at our center were evaluated. ...
Ingelsson Erik - - 2009
OBJECTIVE: We evaluated associations of serum retinol-binding protein 4 (RBP4) with subclinical cardiovascular disease (CVD). RESEARCH DESIGN AND METHODS: Subclinical CVD was measured with echocardiography, carotid artery ultrasound, brachial artery ultrasound, and invasive forearm endothelial vasoreactivity in 1,008 70-year-old participants (50% women) of the Prospective Investigation of the Vasculature in ...
Nozue Tsuyoshi - - 2009
BACKGROUND: Many clinical trials have shown that 3-hydroxy-3-methylglutaryl-conenzyme A reductase inhibitors (statins) can significantly reduce the incidence of coronary artery disease in both primary and secondary prevention. A recent study showed that aggressive lipid-lowering therapy with statins could achieve regression of coronary artery plaque evaluated with gray-scale intravascular ultrasound (IVUS). ...
Petranovic Milena - - 2009
BACKGROUND: Multidetector computed tomography (MDCT) has recently emerged as a potential noninvasive alternative for high-resolution imaging of coronary arteries. OBJECTIVE: In this study, we evaluated 64-slice MDCT for detection, quantification, and characterization of atherosclerotic plaque burden in nonculprit lesions. METHODS: Data from 11 patients who underwent both MDCT and intravascular ...
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