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Molino-Lova R - - 2011
Previous studies have shown that increased levels of C-reactive protein (CRP) predict cardiovascular events, including stroke, myocardial infarction and death from cardiovascular causes. Previous studies have also shown that increased levels of CRP are strong predictors of the progression of pre-existing carotid artery plaques. However, whether CRP is involved in ...
Tessitore Elena E Department of Medicine, Columbia University, New York, New York 10032, - - 2010
Large aortic arch plaques are associated with ischemic stroke. Carotid intima-media thickness (CIMT) is a marker of subclinical atherosclerosis and a strong predictor of cardiovascular disease and stroke. The association between CIMT and aortic arch plaques has been studied in patients with strokes, but not in the general population. The ...
Yorgun Hikmet - - 2010
We investigated the association between atherosclerosis of the thoracic aorta and the severity and extent of coronary atherosclerosis detected by multidetector computed tomography (MDCT) coronary angiography. In 122 patients, atherosclerotic plaque was scored from 0 to 4 points by the percentage of the luminal surface at the cross-sectional area of ...
Quercioli Alessandra - - 2010
Coronary artery disease (CAD) represents the most relevant cause of death and morbidity in the adult population of developed and developing countries. During the last decades, a strong research effort has been performed to identify more selective markers and better assess the cardiovascular risk in both primary and secondary prevention. ...
Hermus Linda - - 2010
Treatment of carotid artery stenosis by endarterectomy or stenting can significantly reduce stroke risk, but is also associated with surgery related mortality and morbidity. At present it is neither possible to assess whether a carotid plaque will become symptomatic or not, nor to define the time when symptoms will occur. ...
Stamatelopoulos Kimon S - - 2010
Rheumatoid arthritis (RA) is associated with accelerated atherosclerosis in the carotid arteries, but little is known about the magnitude of this process in peripheral arteries. Assessing preclinical atherosclerosis in both arterial beds in RA might provide additional prognostic value during risk stratification for primary prevention. Therefore in the present structural ...
Thim Troels - - 2010
Intravascular ultrasound-derived virtual histology (VH IVUS) is used increasingly in clinical research to assess composition and vulnerability of coronary atherosclerotic lesions. However, the ability of VH IVUS to quantify individual plaque components, in particular the size of the destabilizing necrotic core, has never been validated. We tested for correlation between ...
Koskinas Konstantinos C KC Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, - - 2010
The natural history of heterogeneous atherosclerotic plaques and the role of local hemodynamic factors throughout their development are unknown. We performed a serial study to assess the role of endothelial shear stress (ESS) and vascular remodeling in the natural history of coronary atherosclerosis. Intravascular ultrasound-based 3-dimensional reconstruction of all major ...
Prati Francesco - - 2010
The development of imaging techniques for the non-invasive detection of atherosclerosis answered the specific need of identifying vulnerable plaque in asymptomatic patients, verify the presence of atherosclerosis in patients at intermediate risk of coronary artery disease and, lastly, evaluate the results of previous coronary interventions. Coronary computed tomography angiography is ...
Cademartiri Filippo - - 2010
AIM: The purpose of this study was to define the in-vitro and in-vivo effects of intracoronary enhancement on the absolute density values of coronary plaques during multislice computed tomography. METHODS: We studied seven ex-vivo left coronary artery specimens surrounded by olive oil and filled with isotonic saline and four solutions ...
Jim Man-Hong - - 2010
Data of virtual histology (VH) acquired by intravascular ultrasound (IVUS) on saphenous vein graft (SVG) lesions is lacking. This study sought to report the VH IVUS findings in degenerative aortocoronary SVG lesions and correlate various types of plaque compositions (fibrous, fibro-fatty, dense calcium, and necrotic core) with different clinical and ...
Harloff Andreas - - 2010
BACKGROUND AND PURPOSE: To investigate the incidence of retrograde flow from complex plaques (> or =4-mm-thick, ulcerated, or superimposed thrombi) of the descending aorta (DAo) and its potential role in embolic stroke. METHODS: Ninety-four consecutive acute stroke patients with aortic plaques > or =3-mm-thick in transesophageal echocardiography were prospectively included. ...
Eesa M - - 2010
Atherosclerotic disease of the carotid artery is an important cause of ischemic stroke. We evaluated carotid plaque morphologic features by using CTA in addition to stenosis in the setting of symptomatic hemispheric TIA/stroke to identify factors that may predict plaque activity. Six hundred seventy-three patients (408 men; ages, 18-91 years; ...
Mahendra Jaideep - - 2010
BACKGROUND: Atherosclerosis develops as a response of the vessel wall to injury. Chronic bacterial infections have been associated with an increased risk for atherosclerosis and coronary artery disease. The ability of oral pathogens to colonize in coronary atheromatous plaque is well known. AIM: The aim of this study was to ...
Min James K - - 2010
To assess the prognostic value of coronary artery stenosis identification by coronary computed tomographic angiography (CCTA) for the prediction of major adverse cardiac events (MACE) in a multicenter prospective cohort study. We performed a prospective multicenter observational cohort study of symptomatic patients with suspected or known coronary artery disease (CAD) ...
Saba Luca - - 2010
In the last two decades, a substantial number of articles have been published to provide diagnostic solutions for patients with carotid atherosclerotic disease. These articles have resulted in a shift of opinion regarding the identification of stroke risk in patients with carotid atherosclerotic disease. In the recent past, the degree ...
Knight Joseph - - 2010
Average wall shear-stress (AWSS), average wall shear-stress gradient (AWSSG), oscillatory shear index (OSI) and relative residence time (RRT) are believed to predict areas vulnerable to plaque formation in the coronary arteries. Our aim was to analyze the correlation of these parameters in patients' vessels before the onset of atherosclerosis to ...
Zachrisson H - - 2010
Dual Energy Computed Tomography (DECT) may provide additional information about the chemical composition of tissues compared to examination with a single X-ray energy. The aim of this in vitro study was to test whether combining two energies may significantly improve the detection of soft tissue components commonly present in arterial ...
Thrys?e Samuel A - - 2010
BACKGROUND AND PURPOSE: Mechanical stress may contribute to plaque rupture in patients with carotid atherosclerosis. We determined longitudinal mechanical stresses in carotid atherosclerotic plaques and compared them with known markers of plaque vulnerability. METHODS: Nineteen symptomatic patients scheduled for carotid endarterectomy underwent carotid MRI with a multicontrast protocol to characterize ...
Hirano Mitsumasa - - 2010
This study examined whether combined ultrasound assessment of plaque size and echolucency in the carotid artery had an additive effect for predicting coronary events in patients with coronary artery disease (CAD). Ultrasound assessment of either plaque size or echolucency of carotid artery provides prognostic information on coronary events. Combined assessment ...
Kunte Hagen - - 2010
Cerebral ischemia in patients with carotid artery atherosclerosis is most often caused by thromboembolism, while hemodynamic stroke mechanism is rare. Differences in plaque inflammation according to stroke mechanism are an understudied issue. The purpose of this pilot study was to compare carotid plaque inflammation in patients with thromboembolic and hemodynamic ...
Creane Arthur - - 2010
It has been hypothesised that the stress distribution within the arterial wall may provide an indicator of atherosclerotic plaque rupture. This study presents an automated method for the generation of finite element models of the carotid bifurcation from in vivo computerised tomographic angiography. Models generated using this method have been ...
Oviedo Carlos - - 2010
BACKGROUND: Angiographic classifications of the location and severity of disease in the main vessel and side branch of coronary artery bifurcations have been proposed and applied to distal left main coronary artery (LMCA) bifurcation. METHODS AND RESULTS: We reviewed 140 angiograms of distal LMCA and ostial left anterior descending (LAD) ...
Spence J David - - 2010
A brief review is presented, discussing the relationships between lipoprotein(a) (Lp[a]) and carotid plaque, stenosis and occlusion. Because of compensatory enlargement, stenosis probably results not from plaque growth, but from plaque rupture and thrombosis. Lp(a) is a complex molecule that links thrombosis, thrombolysis and atherosclerosis. The study of Lp(a) as ...
Schwarzw?lder Uwe - - 2010
During the past decade, the endovascular treatment of peripheral arterial disease has become more widespread due to the impressive extension of the endovascular toolbox to include different atherectomy technologies. The promise of atherectomy is to avoid the "barotraumas" defined as complications of traditional angioplasty such as dissection, elastic recoil, and ...
Doyley M M - - 2010
Acute coronary syndromes may occur when life-threatening atherosclerotic plaques rupture in the later stages of advance cardiovascular disease. Coronary angiography is currently the gold standard for assessing the severity of coronary disease; however, its efficacy is questionable. We have developed a prototype intravascular ultrasound (IVUS) system to assess the functional ...
Li Zhi-Yong - - 2010
OBJECTIVES: It remains controversial whether patients with severe disease of the internal carotid artery and a coexisting stenotic lesion downstream would benefit from a carotid endarterectomy (CEA) of the proximal lesion. The aim of this study was to simulate the hemodynamic and wall shear effects of in-tandem internal carotid artery ...
Kurnatowska Ilona - - 2010
AIM: Both vascular calcification and atherosclerosis are highly prevalent in patients with end-stage renal disease (ESRD) and have been associated with increased cardiovascular morbidity. Because those two phenomena might be only coincidentally related in chronic haemodialysis (HD) patients, in this study, coronary artery calcification (CAC), common carotid artery intima media ...
Tanaka Shinichiro - - 2010
BACKGROUND: Tissue characteristics of coronary plaques can be evaluated using integrated backscatter intravascular ultrasound (IB-IVUS), while fractional flow reserve (FFRmyo) is an index of functional coronary stenosis. We assessed the relation between functional stenosis and the characteristics of plaque tissue using FFRmyo and IB-IVUS. METHODS AND RESULTS: A total of ...
Mahabadi Amir A - - 2010
OBJECTIVE: We aimed to determine, whether the amount of local pericoronary fat volume is associated with the presence of plaque burden in the underlying coronary artery segment. METHODS: We assessed 311 coronary segments from ECG-gated contrast-enhanced dual-source computed tomography for presence of plaque as well as segmental pericoronary fat volume. ...
Hatsukami Thomas S - - 2010
Stroke is a leading cause of mortality and long-term morbidity. As a means for stroke prevention, an estimated 99,000 carotid endarterectomy procedures were performed in the USA in 2006. Traditionally, the degree of luminal stenosis has been used as a marker of the stage of atherosclerosis and as an indication ...
Raggi Paolo - - 2010
Coronary artery calcification (CAC) has long been known to occur as a part of the atherosclerotic process; recently it has been shown to be an active process resembling bone formation within the vessel wall. There is good evidence that the extent of CAC reflects the total coronary atherosclerotic burden and ...
Larsen Katarína - - 2010
Plaque rupture and luminal thrombosis is the most common cause of coronary occlusion that leads to acute coronary syndromes. High-risk plaques, or vulnerable plaques, are defined as lesions that are prone to rupture, also known as thin cap fibroatheroma (TCFA), or lesions prone to erosion or with calcified cores. This ...
Fujii Kenichi - - 2010
OBJECTIVES: We evaluated the geographic distribution of thin-cap fibroatheromas (TCFAs) in the coronary arteries using optical coherence tomography (OCT), a high-resolution imaging modality. BACKGROUND: Plaque rupture is the most frequent cause of acute myocardial infarction (AMI). It has been recognized that TCFA is the primary plaque type at the site ...
Okura Hiroyuki - - 2010
BACKGROUND: Plaque rupture may be present in the peripheral arteries of the patients at high risk for cardiovascular events and is possibly associated with vascular vulnerability. METHODS AND RESULTS: One hundred one iliofemoral arteries from 101 patients undergoing angioplasty were studied. Intravascular ultrasound imaging was performed before intervention. Plaque rupture ...
Kobayashi Hitomi - - 2010
OBJECTIVE: Cardiovascular (CV) morbidity and mortality are increased in rheumatoid arthritis (RA). Prior investigations of the association of RA with measures of carotid atherosclerosis have yielded conflicting results. We compared carotid intima-media thickness (IMT) of both the common carotid (CCA) and proximal internal carotid (bulb-ICA) arteries, and plaque prevalence, between ...
Jezovnik Mateja Kaja - - 2010
AIM: There is growing evidence that venous thrombotic and arterial atherosclerotic diseases are interrelated. This presumption is supported by the similar ethiopathogenesis, risk factors and clinical appearance of the two diseases. We investigated whether the prevalence of preclinical indicators of atherosclerosis is higher in patients with spontaneous venous thrombosis than ...
Hamirani Yasmin S - - 2010
OBJECTIVE: Associations between various plaque types in coronary and carotid arteries using multidetector row computed tomography (MDCT) have not yet been reported. We evaluated MDCT correlation of total plaque and various plaque subtypes in carotid and coronary arteries. METHODS: We studied 62 patients who had both carotid and cardiac computed ...
Chopard Romain - - 2010
The present study investigated whether IVUS could serve as a reliable reference in validating MDCT characterization of coronary plaque against a histological gold standard. Twenty-one specimens were postmortem human coronary arteries. Coronary cross-sections were imaged by 40 MHz IVUS and by 64-slice MDCT and characterized histologically as presenting calcified, fibrous ...
Coombs Peter R - - 2010
Mobile atheromatous plaque at the origin of the internal carotid artery (ICA) is a rare finding at the carotid ultrasound examination. Acute thrombosis is unusually seen. Either may be secondary to plaque hemmorhage, plaque ulceration, carotid dissection, or proximal embolus. We report an 89-year-old male suffering from an acute neurologic ...
Ishio Naoki - - 2010
Previous intravascular ultrasound (IVUS) studies have shown coronary artery atherosclerosis even in angiographically normal reference segment. However, IVUS has not been performed in all of the three major coronary arteries. A total of 50 patients with single-vessel disease underwent IVUS evaluation in the proximal two-thirds of the three major coronary ...
Grunfeld Carl - - 2010
BACKGROUND: Distal coronary artery disease (CAD) is less amenable to surgery or stenting compared with proximal disease. However, little is known about the epidemiology of distal versus proximal CAD. METHODS: We determined the prevalence and factors associated with proximal, mid, and distally located plaque in the left anterior descending, left ...
Zhou Guangyi - - 2010
OBJECTIVE: The 5-lipoxygenase catalyzed formation of leukotriene lipid mediators is a mediator for inflammatory response in arteries. The present study investigated the relationship between atorvastatin and the 5-lipoxygenase pathway in an atherosclerotic rabbit model. METHODS: Thirty male New Zealand White Rabbits were randomized into negative control, positive control and atorvastatin ...
Mutoh Tatsushi - - 2010
Background. Digital subtraction angiography (DSA) remains an important tool for diagnosis of carotid stenosis but is associated with risk for periprocedural complications. This is the first report of direct intraoperative and histolopathologic visualization of DSA-related carotid plaque disruption. Case. A 64-year-old man diagnosed to have a 60% right carotid stenosis ...
Abe Yuko - - 2010
The purpose of this study is to evaluate whether release of inflammatory markers locally from an atherosclerotic plaque after carotid artery stenting (CAS) is associated with plaque echogenicity and calcification. The study consisted of 36 patients with 42 severely stenotic carotid arteries who underwent CAS with the distal balloon occlusion. ...
Pirodda A - - 2010
OBJECTIVES: We aimed to verify the extent of a previously cited relationship between tympanosclerosis and atherosclerosis by investigating subjects with dysfunction in lipid metabolism but no clinically apparent symptoms of atherosclerotic disease. METHODOLOGY: Forty hypercholesterolemic patients were submitted to Doppler ultrasound examination of carotid and vertebrobasilar arterial regions; results were ...
Matsumoto Shoji - - 2010
OBJECTIVES: This study aimed to evaluate the relationship between the amount of aspirated debris during distal balloon-protected carotid artery stenting (CAS) and the pre-intervention plaque composition, as assessed by Virtual Histology (VH) intravascular ultrasound (IVUS). METHODS: The study subjects were 25 consecutive patients (mean age, 73.0 +/- 5.2 years; 20 ...
Chiu Bernard - - 2010
Quantitative measurements of the progression (or regression) of carotid plaque burden are important in monitoring patients and evaluating new treatment options. We previously developed a quantitative metric to analyze changes in carotid plaque morphology from 3-D ultrasound (US) on a point-by-point basis. This method requires multiple segmentations of the arterial ...
Yoshimoto Tetsuyuki - - 2010
Carotid artery restenosis is a serious complication following carotid endarterectomy (CEA), so preventative management of the risk factors is important. The present study investigated the potential of cilostazol, a mediator of vascular stabilization as well as inhibitor of platelet aggregation, to suppress restenosis on the ipsilateral carotid artery and new ...
Chu Zhi-gang - - 2010
Coronary artery disease (CAD) is a common and severe complication of type 2 diabetes mellitus (DM). The aim of this study is to identify the features of CAD in diabetic patients using coronary CT angiography (CTA). From 1 July 2009 to 20 March 2010, 113 consecutive patients (70 men, 43 ...
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