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Wang Zhijie - - 2013
Conduit pulmonary artery (PA) stiffening is characteristic of pulmonary arterial hypertension (PAH) and is an excellent predictor of mortality due to right ventricular (RV) overload. To better understand the impact of conduit PA stiffening on RV afterload, it is critical to examine the arterial viscoelastic properties, which require measurements of ...
Yu Yang - - 2013
Cardiac vein arterialization is seldom applied for treating right coronary artery disease. This study aimed to improve outcomes of cardiac vein arterialization in a porcine model using intramammary artery anastomosis. A chronic, stenotic coronary artery model was established in 12 of 14 Chinese experimental miniature pigs of either sex, which ...
Shen Tingting T Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University (Daqing), Daqing, Heilongjiang Province, - - 2013
Pulmonary hypertension (PH) is characterized with pulmonary vasoconstriction and vascular remodeling mediated by 15-lipoxygenase (15-LO)/15-hydroxyeicosatetraenoic acid (15-HETE) according to our previous studies. Meanwhile, telomerase reverse transcriptase (TERT) activity is highly correlated with vascular injury and remodeling, suggesting that TERT may be an essential determinant in the development of PH. The ...
Byun Hoe-Sup HS Department of Chemistry and Biochemistry, Queens College, The City University of New York, Flushing, NY 11367-1597, USA. Tel: +1 - - 2013
Sphingosine 1-phosphate (S1P) is involved in hyper-proliferative diseases such as cancer and pulmonary arterial hypertension. We have synthesized inhibitors that are selective for the two isoforms of sphingosine kinase (SK1 and SK2) that catalyze the synthesis of S1P. A thiourea adduct of sphinganine (F02) is selective for SK2 whereas the ...
Lemma Massimo M Minimally Invasive Cardiac Surgery Unit, Cardio-Cerebro-Vascular Department, Luigi Sacco University General Hospital, Milan, - - 2013
Coronary artery bypass graft (CABG) is among the most common operations performed in the world. Different surgical strategies can be used with different invasiveness. This paper describes a recent development of the technique that merges the advantages resulting from both the adoption of an 'off-pump no-touch aorta operation' and a ...
Rajakulasingam Ramyah R Department of Cardiology, East and North Hertfordshire NHS Trust, United Kingdom ; Lister Hospital, East and North Hertfordshire NHS Trust, United - - 2013
Anomalous vena cavae can have significant implications for procedures on the right side of the heart. We report a rare anatomical configuration in a 44-year-old female, which to the best of our knowledge, is the first report of such an association. She had a bicuspid aortic valve in conjunction with ...
Fang Jing J The Center for Biomedical Research, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030, China ; Key Laboratory of Organ Transplantation, Ministry of Education, Ministry of Health, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030, China ; Department of Cardiovascular Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030, - - 2013
Although cervical cardiac transplantation is a well recognized useful model in diverse experimental settings, its widespread use, however, has been significantly hampered by the technical challenges relevant to small vessel anastomosis. We herein introduced a simplified two-stitch sleeve technique into arterial anastomosis during the course of cervical cardiac transplantation in ...
Bakaeen Faisal G FG Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas; The Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas; Department of Cardiovascular Surgery, The Texas Heart Institute, Houston, Texas. Electronic address: - - 2013
Modern cardiac practice in the United States is conservative when it comes to using bilateral internal mammary or radial artery grafts in coronary artery bypass surgery. Here, we examine the evidence regarding using other arterial grafts instead of veins as a complement to left internal mammary artery in surgical revascularization. ...
Singh Rajani R Department of Anatomy, AIIMS, Virbhadra Marg, Pashulok, Rishikesh 249201, - - 2013
Anatomical variations in relation to coronary artery and its branches will help cardiac surgeons for refining imaging techniques and coronary artery bypass grafting. A heart was detected with multiple anomalies of coronary arteries in a cadaver. The anomalies of coronary arteries in terms of origin, number of ostia, courses, and ...
Oakley Luke L 0000-0001-9299-7319 Department of Internal Medicine, Naval Medical Center San Diego, Suite 301, 34800 Bob Wilson Drive, San Diego, CA 92101, - - 2013
Aortic insufficiency from iatrogenic valve perforation from nonaortic valve operations is rarely reported despite the prevalence of these procedures. Rapid diagnosis of these defects is essential to prevent deterioration of cardiac function. In this paper, we describe a young man who reported to our institution after two open cardiac surgeries ...
Aydin Suna S Elazig Research and Education Hospital, Clinic of Cardiovascular Surgery, Elazig, 23119 Turkey ; School of Medicine, Department of Anatomy, Firat University, Elazig, 23119 - - 2013
Blood is pumped into the cardiac muscle through arteries called the coronary arteries. Over time, the accumulation of cholesterol, coagulation factors, and cells on the walls of these arteries causes the walls to thicken and lose their elasticity, resulting in the development of atherosclerosis. When the blood supply of the ...
Lee Keng Jin KJ Department of Pediatrics, Northwestern University Feinberg School of - - 2013
Pulmonary hypertension is a significant cause of morbidity and mortality in infants. Historically, there has been significant study of the signaling pathways involved in vascular smooth muscle contraction in PASMC from fetal sheep. While sheep make an excellent model of term pulmonary hypertension, they are very expensive and lack the ...
Casullo Joseph - - 2013
CT scans in four cases of chronic superior vena cava or left brachiocephalic vein obstruction demonstrate a systemic-to-cardiac collateral venous pathway through anastomoses between the pericardial branches of systemic veins and the presumed adventitial veins of the ascending aorta and pulmonary trunk. These adventitial veins then drain into tributaries of ...
Sousa Pedro Jerónimo - - 2012
We report the case of a 40-year-old man with known Marfan syndrome who presented with severe aortic valve regurgitation secondary to significant aortic root dilatation. To rule out coronary artery disease and to evaluate the rest of the thoracic aorta before surgery, cardiac computed tomography (CT) was performed. A brief ...
Ren Pingping P Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, - - 2013
ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) is a recently identified family of extracellular metalloproteinases that has been shown to participate in tissue destruction. We hypothesized that ADAMTS-1 and ADAMTS-4 expression is increased in aortic tissues from patients with thoracic aortic aneurysms and dissections. We examined ADAMTS-1 and ADAMTS-4 ...
Kettner Mattias - - 2012
Coronary artery anomalies are found in approximately 1.3 % of symptomatic adult patients undergoing coronary arteriography and encompass a wide variety of anatomic patterns. Single coronary arteries are found in 0.024-0.066 % of this group. The particular type of a single coronary artery with an anatomically correct course of either artery (so-called ...
Arima Yuichiro - - 2012
Neural crest cells constitute a multipotent cell population that gives rise to diverse cell lineages. The neural crest arising from the postotic hindbrain is known as the 'cardiac' neural crest, and contributes to the great vessels and outflow tract endocardial cushions, but the neural crest contribution to structures within the ...
Weber Tobias - - 2012
Background: It is mostly agreed that arterial adaptations occur, among others, in response to changes in mechanical stimuli. Models like bed rest, spinal cord injury or limb suspension have been applied to study vascular adaptations to unloading in humans. However, these models cannot distinguish the role of muscle contractions and ...
Tverskaya M S - - 2012
Metabolism of contractile cardiomyocyte in experimental pulmonary stenosis complicated or not complicated by heart failure was studied by histochemical methods. In pulmonary stenosis not complicated by heart failure, intensification of glycolysis, more intense oxidation of free fatty acids and their metabolites, and acceleration of the citric acid cycle were found ...
Mazur Lynnette - - 2012
We report a case of a 13-year old girl with pectus excavatum who had a Nuss procedure and two years later a new cardiac murmur appeared which on investigation was diagnosed as supravalvular pulmonary artery stenosis. Following removal of the Nuss bar the stenosis resolved.
Whiteley Joseph R - - 2012
A case of a 49 year old man with a giant basilar artery aneurysm requiring rapid ventricular pacing is presented. Rapid ventricular pacing decreased aneurysm size and increased operative exposure, which aided surgical decision making. It also provided decreased wall tension in the aneurysm.
Scaglione Frine E - - 2012
A 2-yr-old male Siberian Tiger (Panthera tigris altaica) died during a fight with a conspecific. At necropsy, significant abnormalities included severe cardiomegaly with cardiac malformations consisting of a large atrial septal defect, a membranous ventricular septal defect, overriding aorta, and stenosis of the pulmonary valve with secondary concentric hypertrophy of ...
Le Victoria P - - 2012
Decreased expression of elastin results in smaller, less compliant arteries and high blood pressure. In mice, these differences become more significant with postnatal development. It is known that arterial size and compliance directly affect cardiac function, but the temporal changes in cardiac function have not been investigated in elastin insufficient ...
Jacobs Marshall L - - 2012
Hearts having a common arterial trunk belong to a family of congenital cardiac malformations for which traditional systems of classification and nomenclature are plagued by internal paradoxes, incompatibility between systems due to the lack of potential for identification of synonyms, or irreconcilable inconsistencies with our current knowledge of cardiac development ...
Aykut Koray - - 2012
A 32-year-old man was urgently referred to our hospital with severe tricuspid insufficiency following a car accident. The completely flail anterior leaflet, due to the rupture of the papillary muscles, was revealed by a two-dimensional transthoracic echocardiography. In the operation, we also detected a tear on the anterior leaflet and ...
Bae Sang Mook - - 2012
We examined a 63-year-old woman with progressive dyspnea. Two years prior to admission to our hospital, she had been diagnosed with rheumatoid arthritis and treated with hydroxychloroquine (HCQ) with a cumulative dose of 164 g. In addition, 2 months earlier, she had been diagnosed with connective tissue disease-related pulmonary artery ...
Munger Stephanie J SJ Department of Physiology, University of Arizona, Tucson, AZ 85724, USA. - - 2013
Venous valves play a crucial role in blood circulation, promoting the one-way movement of blood from superficial and deep veins towards the heart. By preventing retrograde flow, venous valves spare capillaries and venules from being subjected to damaging elevations in pressure, especially during skeletal muscle contraction. Pathologically, valvular incompetence or ...
Yoshino Satoshi - - 2012
A 68-year-old woman was admitted to our hospital because of back pain and syncope. Transthoracic echocardiography revealed pericardial effusion, a collapsed right ventricle, a giant aneurysm connected to the coronary sinus, a dilated left main trunk coronary artery, and a dilated left circumflex artery (LCx). Furthermore, there was a coronary ...
Mikhailidis Dimitri P - - 2012
The lecture covered the role of lipids in the pathogenesis and treatment of non-cardiac vascular disease. The following conditions were considered: abdominal aortic aneurysms (AAAs), peripheral arterial disease (PAD), carotid artery disease and atherosclerotic renal artery stenosis (ARAS).
Kang Xiao-Long - - 2012
The purpose of the present study was to compare the differences between the role of volume-regulated Cl(-) channels (VRCCs) in veins and arteries. We used the whole cell patch clamp and fluorescence imaging techniques to evaluate swelling-induced Cl(-) current (I(Cl,vol)) and changes in the intracellular concentrations of Cl(-) ([Cl(-)](i)) induced ...
Jo Yong Woo - - 2012
ABSTRACT: The aim of this study was to elucidate the precise anatomy of the perforating branch of the superficial temporal artery in relation to subcutaneous forehead lift (SFL).Ten hemifaces of 6 fresh adult Korean cadavers were used in this study. In 4 hemifaces, following injection of red latex, dissection was ...
Chen Gang - - 2012
Conjoined twins are very rare examples of congenital malformations. In 75% of thoracoomphalopagus conjoined twins, the intracardiac anatomy determines outcome and long-term survival. We successfully separated one case of thoraco-omphalopagus conjoined twins, with one having d-transposition of the great arteries. After control of sepsis, the twin underwent an arterial switch ...
Bi Yonghua - - 2012
The objective of this study was to determine the possibility of creating a novel animal model of abdominal aortic aneurysm (AAA) in rabbits by the periarterial application of papain. Twelve New Zealand white rabbits were randomized into two groups: (1) the papain group, which received 2mg of papain (n=8) and ...
Schleger Simone - - 2012
Primary cardiac malignancies are rare, and the majority are benign. Malignant tumors are often found to be sarcomas arising from structural cells such as muscle, connective tissue, and blood vessels. We report a case of a 62-year-old woman who presented with pulmonary embolism secondary to a primary pulmonary artery chondrosarcoma. ...
Kumar Naveen - - 2012
Variations in the venous pattern of the arm are common. In this case report, we are presenting the variations of the brachial vein and the basilic vein.During the routine dissections which were done by medical undergraduate students, we observed some variations in the veins of the upper limb. In the ...
Fouillade Charles C INSERM, U740, Paris, - - 2013
Notch3 is critically important for the structure and myogenic response of distal arteries, particularly of cerebral arteries. However, signaling pathways acting downstream of Notch3 remain largely unknown. Transcriptome analysis using tail arteries of Notch3-null mice identified a core set of 17 novel Notch3-regulated genes confirmed in tail or brain arteries. ...
Moustafa Sherif - - 2012
Aneurysms of sinus of Valsalva are rare congenital or acquired cardiac anomalies. They most commonly involve the right or non-coronary sinuses. Herein we report a very rare case of a ruptured congenital right sinus of Valsalva aneurysm into the right ventricular outflow tract followed conservatively for at least 10 years ...
Rahman Awahan - - 2012
Huntington's disease is a neurodegenerative disorder that also gives raise to widespread changes in peripheral organs and tissues. We tested the hypothesis that vascular dysfunction may occur in Huntington's disease by studying R6/1 mice which express exon 1 of the mutant huntingtin gene. We assessed arterial function in R6/1 and ...
Troupis John M - - 2013
After the advent of ECG gated cardiac CT angiography (CCTA) there has been significant improvement in image quality of the ascending aorta. As a result the sinuses of valsalva are readily assessable. Sinuses of valsalva aneurysm can cause significant dysfunction of the aortic root and annulus and can be congenital ...
Boldt Jessica - - 2012
Objective: The aim of tissue engineering is, for instance, to create a new valve or organ which is similar to the native one. This new construct may have the capability of growth, repair and remodelling. One instance were tissue engineering offers an enormous advantage is in the treatment of Tetralogy ...
Agrifoglio Marco - - 2012
Abstract  The widely used peripheral vein site of cannulation (i.e., the femoral vein) cannot always be employed in the setting of re-redo procedures. We propose a safe and simple surgical technique for a femoral vein cannulation using the greater saphenous vein as the inflow tract for the venous drainage in ...
Klimek-Piotrowska Wiesława - - 2012
During a routine dissection at the Department of Anatomy, Collegium Medicum, Jagiellonian University, one cadaver was found to have multiple variations of the arteries of the upper limbs. The variations pertained to the course of the brachial artery as well as to its distribution. An unusual formation of the superficial ...
Rayoo R - - 2012
Partial anomalous pulmonary venous drainage is a rare congenital anomaly which can lead to right heart enlargement. It may present in isolation or more commonly in association with other congenital cardiac anomalies. We present three different cases of partial anomalous pulmonary venous drainage in adults. The importance of identifying partial ...
Gunnal S A - - 2012
The mitral valve is a complex structure that is altered by disease states. The classical image of the mitral valve is a bicuspid valve with two leaflets and two papillary muscles. The reason for the present study is to study the morphology and morphometry of the mitral valve. This study ...
Ishii Yoichiro - - 2012
Objectives: To investigate the 'I-shaped' sign as a novel echocardiographic marker for antenatal diagnosis of d-transposition of the great arteries (dTGA) in routine cardiac examination, and to compare its prevalence in dTGA, other congenital heart diseases (CHDs), and normal structural hearts. Methods: This retrospective evaluation involved 1,134 pregnant women undergoing ...
Stein Andreas - - 2012
This report presents a case of pulmonary air embolism during implantation of a cardiac resynchronisation therapy system. For left ventricular pacing the thinnest available coronary sinus lead was used in association with a standard subclavian vein introducer sheath. It is hypothesised that the difference of size between the small lead ...
Duan Bin - - 2012
Heart valve disease is a serious and growing public health problem for which prosthetic replacement is most commonly indicated. Current prosthetic devices are inadequate for younger adults and growing children. Tissue engineered living aortic valve conduits have potential for remodeling, regeneration, and growth, but fabricating natural anatomical complexity with cellular ...
Papangeli Irinna I UCL-ICH, 30 Guilford St, London WC1N 1EH, - - 2013
Growth and remodeling of the pharyngeal arch arteries are vital for the development of a mature great vessel system. Dysmorphogenesis of the fourth arch arteries can result in interruption of the aortic arch type B, typically found in DiGeorge syndrome. Tbx1 haploinsufficient embryos, which model DiGeorge syndrome, display fourth arch ...
Leclère Franck Marie - - 2012
OBJECTIVES/HYPOTHESIS: The use of the sternocleidomastoid (SCM) flap for reconstructive surgery of the mandible seems to be a practicable although underestimated option. STUDY DESIGN: This study was conducted on 15 cadavers that had been neoprene-latex injected in the middle and inferior pedicles. METHODS: Lengths of the SCM were equally divided ...
Hubbell Margaret C MC Divisions of Physiology, Pharmacology, and Biochemistry, Center for Perinatal Biology, Loma Linda University Schoolof Medicine, Loma Linda, California 92350, - - 2012
Chronic hypoxia increases vascular endothelial growth factor (VEGF) and thereby promotes angiogenesis. The present study explores the hypothesis that hypoxic increases in VEGF also remodel artery wall structure and contractility through phenotypic transformation of smooth muscle. Pregnant and nonpregnant ewes were maintained at sea level (normoxia) or 3,820 m (hypoxia) ...
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