Search Results
Results 251 - 300 of 977
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Waseda Katsuhisa - - 2008
BACKGROUND: Flow dynamics and shear stress may influence downstream vessel segments. The aim of this study was to investigate the potential impact of lumen narrowing within sirolimus-eluting stents (SES) on vessel response at adjacent reference sites. METHODS AND RESULTS: In 135 patients after SES implantation, minimal lumen area (MLA) within ...
Fanggiday James C - - 2008
OBJECTIVES: To evaluate outcomes after percutaneous coronary intervention (PCI) with a drug-eluting balloon catheter (paclitaxel-coated) in patients with coronary artery bifurcation lesions. BACKGROUND: The current practice of provisional stenting of the main branch (MB) is reasonable; however, long-term results of side-branch (SB) treatment are suboptimal. The use of drug-eluting stents ...
Herdeg Christian - - 2008
There is currently no promising interventional solution for in-stent stenosis in previously stented bifurcation lesions, even with drug-eluting stents. Rather than being restricted to stent struts, catheter-based local antiproliferative therapy offers the advantage of homogenous drug transfer to the whole vessel wall, and thereby allows for intracoronary pharmacotherapy without adding ...
Gao Zhan - - 2008
BACKGROUND: With the advent of drug-eluting stents (DES) and much lower rates of target vessel revascularization (TVR), whether adjunctive balloon postdilatation can further optimize outcome is still unknown. The present study was to compare the outcomes of postdilatation with un-postdilatation following deployment of DES. METHODS: From April 2004 to September ...
Kanemitsu Shinji - - 2008
Two cases of drug-eluting stent restenosis after percutaneous coronary intervention in the left main coronary artery and its bifurcation are presented. An off-pump coronary artery bypass grafting following in-stent restenosis was performed. Drug-eluting stents have shown a reduced frequency of in-stent restenosis and a good safety profile compared with bare ...
Hsueh Shu-Kai - - 2008
BACKGROUND: The effectiveness of a transradial approach for percutaneous coronary intervention (PCI) is comparable to that of a transfemoral approach. However, few studies have systematically compared the clinical effectiveness of a transradial approach with that of a transfemoral approach for unprotected left main coronary artery (ULMCA) stenoses. We compared success ...
Hecht Harvey S - - 2008
By providing data previously available only by intravascular ultrasound, 64-slice multidetector computed tomographic angiography (CTA) will impact percutaneous coronary intervention (PCI) in multiple areas: (1) pre-PCI patient selection; (2) identification of significant lesions; (3) in-stent restenosis; (4) procedure planning: stent sizing, choice of intervention, and equipment, chronic total occlusions, 3D-CTA ...
Ramaiah Venkatesh - - 2008
The superficial femoral artery (SFA) is the interventionalist's most frequent adversary in infrainguinal revascularization, and we have yet to conquer it. Despite having numerous devices and techniques in our arsenal, we have, in large part, been unable to devise a treatment that yields not only excellent, safe, and reproducible acute ...
Khattab Ahmed A AA Herz-Kreislauf-Zentrum Segeberger Kliniken GmbH (Academic Teaching Hospital of the University of Kiel), Bad Segeberg, - - 2008
Restenosis is higher among certain subpopulations when subjected to percutaneous coronary interventions even when using drug-eluting stents. The randomised SPIRIT II trial demonstrated the superiority of the XIENCE V Everolimus Eluting Coronary Stent System over the TAXUS Paclitaxel-Eluting Stent System in terms of in-stent late loss at six months among ...
Koo Bon-Kwon - - 2008
AIMS: This study was performed to evaluate the functional outcomes of fractional flow reserve (FFR)-guided jailed side-branch (SB) intervention strategy. METHODS AND RESULTS: One hundred and ten patients treated by provisional strategy were consecutively enrolled and SB FFR was measured in 91 patients. SB intervention was allowed when FFR was ...
Tepe Gunnar - - 2008
BACKGROUND: Drug-eluting stents reduce restenosis in coronary arteries, but clinical trials have failed to prove their efficacy in peripheral arteries. We investigated the use of paclitaxel-coated angioplasty balloons and paclitaxel dissolved in the angiographic contrast medium during angioplasty of the leg. METHODS: In a small, multicenter trial, we randomly assigned ...
Prieto Lourdes R - - 2008
INTRODUCTION: Pulmonary vein stenosis (PVS) is a rare but significant complication of pulmonary vein isolation (PVI). Dilation and stent angioplasty have been described but not compared. METHODS AND RESULTS: All percutaneous interventions for PVS complicating PVI between December 2000 and March 2007 were reviewed. Acute success, defined as post-intervention stenosis ...
Shah Svati H - - 2008
Use of drug-eluting stents (DES) has reduced in-stent restenosis after percutaneous coronary intervention (PCI); however, DES are associated with late stent thrombosis. There is no accurate way to predict in-stent restenosis, although risk factors for atherosclerosis overlap those for in-stent restenosis. Therefore, we evaluated atherosclerosis candidate genes for association with ...
Kamura Aoi - - 2008
In this case report, we describe a rare patient who experienced complete fracture of a sirolimus-eluting stent that was implanted for a focally calcified lesion of the right coronary artery ostium. Although the fractured fragment migrated somewhere in the systemic circulation, fortunately there were no complications. Implantation for ostial lesions ...
Misra Sanjay - - 2008
Percutaneous angioplasty with stent placement is effective for the treatment of renal artery stenosis (RAS). RAS involving the bifurcation is technically challenging because of possible occlusion of a renal artery branch after stent implantation. The present report describes experiences in four patients with stenosis involving the renal artery bifurcation treated ...
Rizik David G - - 2008
The treatment of bifurcation coronary artery disease is a common challenge facing the interventional cardiologist. There have been major advances in techniques as well as more widespread use of drug-eluting stents; both appear to have contributed to the realization of single-digit target lesion revascularization rates as well as improvement in ...
Yevzlin Alexander S - - 2008
We describe the use of directional atherectomy (DA) to restore patency of a thrombosed polytetrafluoroethylene arteriovenous graft with an in-stent restenosis at the venous anastomosis. Technically, the procedure described is not an atherectomy per se, but rather the removal of fibrosis and intimal hyperplasia with sharp endoluminal dissection. Certainly, the ...
Balter S - - 2008
This article summarizes the dosimetric results of an International Atomic Energy Agency coordinated research program to investigate the feasibility of adopting guidance levels for invasive coronary artery procedures. The main study collected clinical data from hospitals located in five countries. A total of 2265 coronary angiograms (CA) and 1844 percutaneous ...
Louvard Yves - - 2008
BACKGROUND: Percutaneous coronary intervention (PCI) of coronary bifurcation lesions remains a subject of debate. Many studies have been published in this setting. They are often small scale and display methodological flaws and other shortcomings such as inaccurate designation of lesions, heterogeneity, and inadequate description of techniques implemented. METHODS: The aim ...
Movahed Mohammad Reza - - 2008
Percutaneous coronary intervention for the treatment of bifurcation lesions is associated with a lower success rate and increased risk of subacute stent thrombosis and restenosis. The goal of this manuscript is to review the current classification of coronary bifurcation lesions and techniques. An algorithmic approach for the treatment of bifurcation ...
Biondi-Zoccai G - - 2008
First-generation drug-eluting stents (DES) have brought major improvements in results of percutaneous coronary intervention (PCI). However, there is currently debate on the safety of these first-generation DES, given the potential for late stent thrombosis, especially after discontinuation of dual antiplatelet therapy. Second-generation DES, such as zotarolimus- (Endeavor) and everolimus-eluting stents ...
Okamura Takayuki - - 2008
A 73-year-old female underwent percutaneous coronary intervention (PCI) because of stable angina. An elective PCI for the RCA lesion was first performed with deploying sirolimus eluting stents (SES). Three weeks later, PCI was also provided in the residual LAD lesion. Eight months later, she presented with new angina. CAG revealed ...
Sukhija Rishi - - 2008
Percutaneous coronary intervention (PCI) for bifurcation lesions is technically limited by the risk of side branch occlusion. In comparison with nonbifurcation interventions, bifurcation interventions have a lower rate of procedural success, higher procedural costs and a higher rate of clinical and angiographic restenosis. The recent introduction of drug-eluting stents (DES) ...
Presbitero P - - 2008
Forty percent of patients treated with CABG need further revascularizations after 10 years mainly due to saphenous--more than arterial--graft disease. In this issue, the Authors make a critical review of current available literature on the treatment of saphenous and arterial graft disease, a subset of lesions for which a clear ...
Pendyala L - - 2008
Although recent advances in percutaneous coronary interventions (PCI) have led to dramatic expansions in procedural complexity, bifurcation lesions (BL) remain a serious challenge for the interventionalist. Turbulent flow dynamics and high shear stress likely predispose coronary bifurcations to development of atherosclerotic plaques. These lesions comprise 15% to 20% of the ...
Zargham Ramin - - 2008
Arterial reconstruction procedures, including balloon angioplasty, stenting and coronary artery bypass, are used to restore blood flow in atherosclerotic arteries. Restenosis of these arteries has remained a major limitation of the application of these procedures, especially in the case of balloon angioplasty. Post-angioplasty restenosis results from two major processes: neointimal ...
Aoki Jiro J Cardiovascular Research Foundation, Columbia University Medical Center, 111 East 59th Street, New York, NY 10022, - - 2008
Drug-eluting stents (DES), which locally elute antiproliferative drugs, can dramatically inhibit neointimal growth. However, several pathological studies have indicated that DES may delay healing after vascular injury, and DES implantation may be theoretically associated with a risk of coronary artery aneurysm formation. Coronary aneurysms have been reported from 3 days ...
Jabara Refat R Saint Joseph's Cardiovascular Research Institute, Saint Joseph's Hospital of Atlanta, 5673 Peachtree Dunwoody Road, Atlanta, GA 30342, USA. - - 2008
We sought to evaluate a new second-generation drug-eluting stent (DES), comprising a slow-release biodegradable polylactide coglycolide (PLGA) polymer and low-dose paclitaxel on a thin-strut cobalt chromium stent platform, in a clinically relevant animal model. Our previous work demonstrated subacute vascular toxicity and necrosis triggering late excess neointima in pig coronaries, ...
Kim Jin Won JW Cardiovascular Center, Korea University, Guro Hospital, 97 Gurodong-Gil, Guro-gu, Seoul, Republic of - - 2008
This study was designed to investigate whether endothelial dysfunction is related to drug-eluting stent (DES) implantation at 6 months after stenting. Current available DES could delay vessel healing and subsequently impair endothelial function. Endothelial function was estimated at 6-month follow-up in 75 patients (31 men, mean age 62.1 years) with ...
Miranda-Malpica Emma - - 2008
Inflammation is the primary response to vessel wall injury caused by stent placement in coronary arteries. Cytokines of the interleukin-1 family are central regulators in immunoinflammatory mechanisms. The objective of this study was to test for association between IL-1 family gene polymorphisms and risk for restenosis after coronary stent placement. ...
Brasselet Camille - - 2008
AIMS: In-stent restenosis is related to neointimal hyperplasia. Heating reduces neointimal hyperplasia but promotes constrictive remodeling after balloon angioplasty. We aimed to assess the ability of local heating in inhibiting restenosis and in-stent neointimal hyperplasia and its potential side effects on arterial thrombosis. METHODS AND RESULTS: Atherosclerotic-like lesions were induced ...
Groenewegen, Hendrik Cornelis
Introduction: In recent years therapeutic advances of percutaneous coronary intervention (PCI) such as the stent and later the drug eluting stent have improved mortality and morbidity for patients with CHD. However PCI is still troubled by two major limitations: in-stent restenosis and late stent thrombosis. Aims: In this thesis the ...
Härle Tobias - - 2008
A 44-year-old female presented with acute inferior myocardial infarction. Emergency coronary angiography showed an aneurysm of the proximal right coronary artery and an occlusion of the vessel downstream due to a huge organized thrombus. Mechanical fragmentation, glycoprotein IIb/IIIa antagonist, and intracoronary thrombolysis were all tested without success. Finally, the aneurysm ...
Lal Brajesh K - - 2008
Ultrasound velocity criteria for the diagnosis of in-stent restenosis in patients undergoing carotid artery stenting (CAS) are not well established. In the present study, we test whether ultrasound velocity measurements correlate with increasing degrees of in-stent restenosis in patients undergoing CAS and develop customized velocity criteria to identify residual stenosis ...
Wang Xiaoyin - - 2008
OBJECTIVE: An economic evaluation was performed, using modelling techniques, to compare 1-year total costs of four revascularisation procedures in patients with multivessel disease: on-pump coronary artery bypass grafting (CABG); off-pump CABG; percutaneous coronary intervention (PCI) with bare-metal stents (BMS); and PCI with drug-eluting stents (DES). METHODS: Clinical data were derived ...
Geraldes Pedro - - 2008
BACKGROUND: Percutaneous transluminal coronary angioplasty (PTCA) and stent implantation are associated with intimal hyperplasia and extracellular matrix (ECM) accumulation, resulting in restenosis. We showed that local delivery of 17-beta-estradiol (17betaE) reduced restenosis following PTCA and stent implantation by 47 and 23%, respectively. Because estrogens decreased type I and type III ...
Foussas S G - - 2008
The choice of optimal revascularization strategy in patients with coronary artery disease (CAD) is becoming more challenging lately, due to recent advances in percutaneous coronary intervention (PCI) and coronary artery bypass grafting surgery (CABG). On one hand, drug-eluting stents (DES) have emerged as a solution to the problem of restenosis ...
Sheiban Imad - - 2008
Percutaneous coronary revascularization has been a mainstay in the management of coronary artery disease since its introduction in the late 1970s. Bare-metal stents and, more recently, first-generation drug-eluting stents (DES), such as sirolimus-eluting (Cypher) and paclitaxel-eluting stents (Taxus), have further improved results of percutaneous coronary intervention (PCI) by improving early ...
Bosiers Marc - - 2008
Since major meta-analyses of randomized controlled trials in interventional cardiology showed the potential of drug-eluting stents in decreasing restenosis and reintervention rates after coronary artery stenting, one of the next steps in the treatment of arterial occlusive disease is the transfer of the active coating technology towards peripheral arterial interventions. ...
Sun Zhonghua - - 2009
PURPOSE: The aim of this study was to perform a systematic review of the diagnostic accuracy of multi-detector row computed tomography angiography (MDCT) for detection of coronary in-stent restenosis in patients treated with coronary stenting when compared to invasive catheter angiography. MATERIALS AND METHODS: A search of PUBMED and MEDLINE ...
Ponnuthurai Francis A - - 2007
Complications of percutaneous coronary intervention include in-stent restenosis (ISR) and in-stent thrombosis (IST) which have different underlying pathophysiological processes and different treatment strategies. ISR is primarily due to excessive neointimal growth and occurs in 20-30% of bare-metal stents (BMS). Drug-eluting stents (DES) have decreased the rates of ISR (< 10%), ...
Voudoukis Theodore - - 2007
BACKGROUND AND PURPOSE: Recent reports concerning coronary, carotid, and femoral vasculature have proposed the use of drug-eluting metal stents (MS) to improve clinical and angiographic outcomes. Based on these reports, we used paclitaxel-eluting MS within an animal renal artery lumen and compared the results with those using a bare-metal stent. ...
Chen Jack P - - 2007
The marked reduction of in-stent restenosis of drug-eluting stents (DES) has dramatically affected modern interventional therapy for coronary artery disease. The promises of this potential panacea, however, have been recently attenuated by the specter of late stent thrombosis. Stent thrombosis and in-stent restenosis reduction represent the double-edged sword of neointimal ...
El-Jack Seif S - - 2007
OBJECTIVE: We sought to define clinical and angiographic variables that may predict patients and lesions at increased risk for distal embolism during percutaneous intervention (PCI), as assessed by debris retrieval from a distal-protection filter device. BACKGROUND: Distal thrombo- and atheroembolism may contribute to periprocedural myocardial necrosis during PCI, which may ...
Scheinert Dierk - - 2007
OBJECTIVE: To evaluate the AngioSculpt (ASC), a novel scoring balloon catheter designed to treat complex diffuse fibro-calcific atherosclerotic lesions and avoid device slippage during deployment, in patients with infra-popliteal disease. METHODS: The ASC incorporates a flexible nitinol scoring element containing three or more spiral struts which encircle a minimally compliant ...
Otsuka Yoritaka - - 2007
Calcified lesions are a cause of stent underexpansion which significantly increases the subsequent risks of in-stent restenosis and thrombosis, even when drug-eluting stents are used. In this report, we describe a novel balloon catheter (SafeCut) that enabled adequate dilatation of in-stent restenosis in a previously underexpanded sirolimus-eluting stent that was ...
Nakamura Mamoo - - 2007
STUDY OBJECTIVE: Using serial intravascular ultrasound (IVUS), the efficacy of reduced-dose sirolimus-eluting stents (SESs) in the prevention of neointimal hyperplasia (NH) and maintenance of luminal patency in human coronary arteries was evaluated. BACKGROUND: In the animal model, a broad therapeutic window regarding sirolimus doses in suppressing NH has been reported. ...
Braun Peter - - 2007
BACKGROUND: The optimal interventional approach to treat lesions in small coronary arteries is still undetermined and controversial. This randomized, multicenter trial was designed to compare the 6-months restenosis and clinical event rates in two treatment groups: balloon angioplasty as a primary strategy and provisional stenting versus primary implantation of a ...
Oszkinis G G Department of General and Vascular Surgery, Poznań University of Medical Sciences Poznań, Poland - - - 2007
Surgical procedures designed to restore vascular patency for a recurrent stenosis following carotid endarterectomy (CEA) are burdened with technical difficulties as well as with the possibility of serious neurological complications. An endovascular approach employing transluminal percutaneous angioplasty and stenting (PTAS) is a promising solution to these problems. We aimed to ...
Tsuchida Keiichi - - 2008
BACKGROUND: Percutaneous treatment of stenoses involving aorto-ostial lesions is technically demanding and has been associated with lower procedural success and poorer clinical and angiographic outcomes when compared with non-ostial lesions. This study evaluated the immediate and long-term (2-year) outcome of aorto-ostial stenoses treated with paclitaxel-eluting stents (PES). METHODS: From February ...
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