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Kaleschke Gerrit - - 2010
Transcatheter aortic valve implantation has been shown to be a feasible alternative to surgical aortic valve replacement in selected high-risk patients. Although, being less invasive, catheter techniques remain associated with the potential of serious complications. Procedural success and avoidance of such complications critically depends on careful patient selection and comprehensive ...
Bande Marta - - 2010
Surgical aortic valve replacement remains the gold standard for the treatment of severe, symptomatic aortic stenosis. However, percutaneous treatments are challenging this paradigm in high-risk surgical patients. Technological developments have been rapid in the field of percutaneous aortic valve intervention. Two devices have been approved for general use in Europe: ...
Estrera Anthony L - - 2010
BACKGROUND: Reports on outcomes of acute type A aortic dissection (ATAAD) repair after previous cardiac surgery (PCS) are few. Some suggest no difference in mortality while others note decreased risk of free rupture due to adhesions. We analyzed our experience of ATAAD after PCS. METHODS: Between January 1992 and March ...
Ussia Gian Paolo - - 2010
Transcatheter aortic valve implantation has been shown to be an effective and reproducible therapy for severe aortic valve stenosis. Device performance and short-term outcomes of well-deployed prostheses have been extensively investigated and discussed; however, these endpoints have not yet been reported in cases characterized by suboptimal expansion. We describe a ...
Lee Sak - - 2010
Combined coronary artery bypass (CAB) and valve surgery is one of the most challenging surgical procedures, but the operative results have improved over the years. From 1989 through 2004, combined CAB and valve operations were performed in 125 patients. Mean age was 63 years, and 86 patients were male. Forty-six ...
Yuan Shi-Min - - 2010
A bicuspid aortic valve (BAV) is a common congenital heart disease, which affects 1-2% of the population. However, the relationship between BAVs and aortic dilation has not been sufficiently elucidated. A total of 241 BAV patients who were referred to this hospital for cardiac surgery over a 4.75-year period were ...
Leal Gabriela N - - 2010
PRINCIPLE: Mucopolysaccharidosis is an inborn error of metabolism causing glucosaminoglycans tissue storage. Cardiovascular involvement is variable but contributes significantly towards the morbidity and mortality of the patients. OBJECTIVE: To characterise the echocardiographic abnormalities in children and adolescents with different types of mucopolysaccharidosis. METHOD: Echocardiograms and medical records of 28 patients ...
Booth Justin H - - 2010
BACKGROUND: A discrete subaortic membrane cannot only cause left ventricular outflow tract obstruction, but can grow onto the aortic valve leaflets. The late finding of this encroachment is aortic valve insufficiency or stenosis. Echocardiography is used to follow the progression of outflow tract obstruction, but its ability to show subaortic ...
Mahle William T - - 2010
OBJECTIVE: To evaluate the outcomes associated with isolated bicuspid aortic valve (BAV) during childhood and adolescence. STUDY DESIGN: Analysis of a large single institutional cohort of children (n=981) with isolated BAV was undertaken to determine the prevalence of significant ascending aortic dilation and risk of cardiac events. Subjects with known ...
Badiu Catalin Constantin - - 2010
To examine the results of root replacement with aortic valve-sparing in patients with bicuspid aortic valve (BAV) or severe aortic regurgitation (AR). Between 2000 and 2009, 102 patients (mean age 47±17.5 years) underwent aortic valve-sparing procedures for ascending aortic aneurysm or dissection. Patients were assigned to three different groups according ...
Ferrari Enrico - - 2010
The transapical transcatheter aortic valve implantation (TA-TAVI) in degenerated aortic bioprosthesis is an emerging therapy for surgically non-amenable patients. However, the presence of different types of aortic bioprostheses (stented and stentless), available in different sizes (19-27 mm), can be at the origin of important mismatches between the malfunctioning, degenerated aortic ...
Ashikhmina Elena - - 2010
OBJECTIVE: We sought to compare the safety and durability of bicuspid aortic valve repair versus replacement with a bioprosthesis. METHODS: We reviewed medical records of patients aged 18 years or older undergoing bicuspid aortic valve repair for aortic regurgitation from 1984 through 2007. We analyzed early outcomes and predictors of ...
De Cock Liesbeth J - - 2010
Aortic heart valve disease is a growing health problem and a tissue-engineered aortic heart valve could be a promising therapy. In this paper, decellularized porcine aortic heart valve leaflets are used as scaffolds and loaded with growth factor and heparin via layer-by-layer electrostatic deposition (LbL technique) with the final purpose ...
Conti Carlo A - - 2010
OBJECTIVE: Congenital bicuspid aortic valves frequently cause aortic stenosis or regurgitation. Improved understanding of valve and root biomechanics is needed to achieve advancements in surgical repair techniques. By using imaging-derived data, finite element models were developed to quantify aortic valve and root biomechanical alterations associated with bicuspid geometry. METHODS: A ...
Stabile Eugenio - - 2010
Transcatheter aortic valve replacement is an emerging therapeutic alternative for patients with severe aortic valve stenosis and high surgical risk. The inability to reposition the current prosthesis is a limiting feature of these devices. Here we report on a case of a 74-year-old woman, in which a balloon expandable aortic ...
Bauer Fabrice - - 2010
BACKGROUND: The role of transcatheter aortic valve implantation in the treatment of calcific aortic stenosis is evolving. Immediate and long-term echocardiographic findings are poorly reported. METHODS: Eighty-eight patients in whom surgical aortic valve replacement was contraindicated were studied before and 1 and 7 days, 1 month, and 1 and 2 ...
Ben-Dor Itsik - - 2010
Currently percutaneous aortic valve replacement (PAVR) is indicated for patients at high surgical risk or for inoperable patients. Preprocedural evaluation is crucial to select the patients who will benefit the most and have the procedure done safely. This review will focus on risk assessment and the value of the available ...
Raffaelli L - - 2010
Periodontitis may be a risk factor for atherosclerosis and coronary heart disease. The influence of periodontal pathogens in cardiovascular diseases needs further investigation. Therefore, the aims of this clinical study are: to test the presence of periodontal bacteria DNA in aortic valves and to assess the concomitant presence of the ...
Bigdeli Amir K - - 2010
Aortic recoarctation may be difficult to manage, especially in patients with the need for additional surgical interventions. We describe the case of a 45-year-old man with grown-up congenital heart disease, presenting with recoarctation after initial anatomic repair with a prosthetic graft at the age of 16 years. Further examination revealed ...
Polimenakos Anastasios C - - 2010
OBJECTIVE: Aortic cusp extension valvuloplasty is increasingly used in the management of children and adolescents with aortic stenosis or regurgitation. The durability of this approach and the freedom from valve replacement are not well defined. A study was undertaken to investigate outcomes. METHODS: From July 1987 to November 2008, 142 ...
Selleslagh Philippe - - 2010
Chronic thrombosis of the Carpentier-Edwards SAV porcine aortic bioprosthesis is a very rare complication.We present the case of an 80-year-old male patient with dyspnoea NYHA class III 30 months after coronary artery bypass grafting and aortic valve replacement. Echocardiography showed an increased gradient over the bioprosthesis and blockage of the ...
Finkelstein Ariel - - 2010
BACKGROUND: Percutaneous aortic valve implantation (PAVI) is a procedure gaining popularity and becoming more widely used for the treatment of patients with severe aortic stenosis who are at high risk for surgery. Here we show, for the first time, that a successful and complete elimination of both valvular and subvalvular ...
Funder Jonas Amstrup - - 2010
A flexible aortic root is essential for natural leaflet stress distribution. It is suggested that stentless bioprosthetic valves retain the flexibility of native valves. We investigated aortic root distensibility and cross-sectional area (CSA) in stentless (Solo, n=4; Toronto SPV, n=7), stented (Mitroflow, n=8) and in native valves (n=8) in pigs. ...
Koos Ralf - - 2011
This study sought to examine a possible relationship between the severity of aortic valve calcification (AVC), the distribution of AVC and the degree of aortic valve regurgitation (AR) after transcatheter aortic valve implantation (TAVI) for severe aortic stenosis (AS). 57 patients (22 men, 81±5years) with symptomatic AS and with a ...
Speidl Walter S - - 2010
Aortic stenosis (AS) is associated with significant morbidity and mortality. Recombinant apolipoprotein A-I Milano (rApoA-I(M)) induces atherosclerotic plaque regression. The aims of this study were to determine the effects of rApoA-I(M) on experimental aortic valve degeneration and its mechanisms of action. New Zealand White rabbits (n = 20) were fed ...
Presbitero P - - 2011
Recently, the feasibility and safety of percutaneous aortic valve replacement (PAVR) have been reported in the treatment of degenerative aortic valve stenosis in patients at high-risk for surgical aortic valve replacement (AVR). However, so far this therapy has been limited to patients with severe stenosis of the native valve. We ...
Ben-Dor Itsik - - 2010
Patients with severe aortic stenosis and considered at high surgical risk or inoperable, and not eligible for a randomized clinical trial evaluating percutaneous aortic valve replacement (PAVR), were studied. Many of the patients referred to the study did not meet the inclusion criteria and/or had conditions listed in the exclusion ...
Orihashi Kazumasa - - 2010
We report on an everted leaflet of a Carpentier-Edwards Perimount (CEP) valve in an aortic position. A 71-year-old female patient with aortic regurgitation underwent valve replacement with a 21-mm CEP valve. After aortic declamping, transesophageal echocardiography (TEE) revealed significant transvalvular regurgitation due to an immobilized non-coronary leaflet. Upon re-aortotomy, we ...
Lansac Emmanuel - - 2010
Multiplicity of aortic valve repair or sparing techniques results in a lack of standardisation, limiting widespread adoption of such procedures. To treat dilated diameters at the aortic annular base and sinotubular junction while maintaining root dynamics, we propose a standardised and physiological repair approach to the surgical management of aortic ...
Rothman Richard B - - 2010
This is the fourth in a series of letters-to-the-editor discussing phentermine and cardiovascular safety. Yosefy et al., in reporting a case of aortic cusp tear in a 28 year-old woman with a bicuspid aortic valve, attributed the tear to previous phentermine therapy. Evidence of mitral and tricuspid valve thickening was ...
Wendler Olaf - - 2010
Trans-catheter aortic valve implantation is an alternative treatment option for patients facing high risk for aortic valve replacement. Currently, the results of trans-apical trans-catheter procedures performed outside controlled trials are unknown. The Edwards SAPIEN Aortic Bioprosthesis European Outcome (SOURCE) Registry collects data of patients treated at European centres during the ...
Coskun Kasim Oguz - - 2010
The optimal treatment of congenital aortic valve lesions is a controversial issue. This study was performed to evaluate the outcome after surgical treatment of aortic valve lesions in congenital aortic valve disease. Between the years of 2000 and 2008, 61 patients (mean age: 12.6 +/- 9.6 years, range: 1 day ...
Love Barry A - - 2010
Hemodynamically significant perivalvular regurgitation affects about 1.5% of all prosthetic valve implants. Reoperation carries increased risk--especially in the setting of concomitant comorbidities of left ventricular dysfunction, prior coronary artery bypass grafts, renal dysfunction, and advanced age. Transcatheter closure of the perivalvular regurgitant channel using a variety of occluders has been ...
Ruel Marc - - 2010
Transcatheter aortic-valve implantation is a promising new treatment modality for patients with aortic-valve disease, where it may revolutionize the treatment of elderly and high-risk patients. The two devices currently available, the Edwards Sapien valve and the Medtronic CoreValve system, are presented. With a focus on the CoreValve, we describe the ...
Gahide G?rald - - 2010
OBJECTIVE: The purpose of this study was to study the feasibility and diagnostic capability of preoperative cardiac CT for depicting aortic valvular pseudoaneurysms and vegetations in patients referred for aortic endocarditis requiring surgical intervention. MATERIALS AND METHODS: Consecutive patients presenting with active aortic endocarditis requiring surgical intervention were included. CT ...
Uçar Ozgül - - 2010
A 45-year-old man presented to the emergency department with acute oppressive chest pain. On physical examination, a loud decrescendo diastolic murmur of grade 2-3/6 was audible on the left sternal edge. The electrocardiogram was within normal limits and there were no signs of myocardial ischemia. Transthoracic echocardiography revealed an acute ...
Bach David S - - 2010
Echocardiography/Doppler is the standard clinical tool for the assessment of hemodynamics after aortic valve replacement. Analysis can include mean and peak transvalvular gradients, dimensionless valve index, effective orifice area from the continuity equation, geometric orifice area from planimetry, and energy loss coefficient. High gradients after aortic valve replacement can be, ...
Bajona Pietro - - 2010
The surgical management of the bicuspid-aortic valve along with associated aortic disease remains a challenge. On the basis of recent literature as well as on our own experience, we offer several recommendations for the most appropriate surgical management of the patients with bicuspid-aortic valve disease. In 2006, the American College ...
Subramanian Sreekumar - - 2010
Whereas aortic valve replacement (AVR) is an effective treatment for aortic stenosis, aortic valve repair (AVr) is an excellent alternative to AVR for aortic insufficiency (AI). The advantages of AVr include a lower risk of infective endocarditis, plus avoidance of typical complications associated with mechanical valves (i.e., thromboembolic and hemorrhagic ...
Yuan Shi-Min - - 2010
The unicuspid aortic valve is a very rare congenital anomaly, which usually presents as aortic stenosis, incompetence, or a combination of both. Other congenital disorders may accompany this phenomenon and aortic dilatation and left ventricular hypertrophy are frequent complications. We present a case report of a young, symptomatic patient with ...
Dewey Todd M - - 2010
BACKGROUND: Previous coronary artery bypass grafting increases predicted operative risk for conventional valve replacement, according to the Society of Thoracic Surgeons risk algorithm. Additionally, the presence of coronary artery disease (CAD) has been demonstrated to increase procedural risk with conventional aortic valve replacement. Significant coexisting CAD requires preemptive percutaneous coronary ...
Linke Axel - - 2010
Treatment of aortic stenosis remains challenging in older individuals, as their perioperative mortality for open heart surgery is increased due to comorbidities. Transcatheter aortic valve implantation using the CoreValve ReValving System (Medtronic, Minneapolis, USA) and the Edwards SAPIEN transcatheter heart valve (THV; Edwards Lifescience, Irvine, California, USA) represents an alternative ...
Sambu Nalyaka - - 2010
Aortic stenosis is the most commonly acquired valvular heart disease in the Western world. Surgical aortic valve replacement is currently the gold-standard treatment for patients with severe symptomatic aortic stenosis. Without surgery, the prognosis is extremely poor, with a 3-year survival rate of less than 30%. Transcatheter aortic valve implantation ...
Taimur Saleem - - 2010
Infective endocarditis caused by Gemella morbillorum is a very rare occurrence and only a few cases have been reported in the literature so far. We describe a case of G. morbillorum endocarditis in a 31-year-old Pakistani woman who had a congenitally bicuspid aortic valve. She had also undergone repair of ...
Elmariah Sammy S Hospital of the University of Pennsylvania, Philadelphia, 19104, - - 2010
Fibrocalcific aortic stenosis (AS) results from an active process similar to atherosclerosis that involves basement membrane disruption, lipid deposition, inflammatory cell infiltration, and calcification. Consequently, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) have been extensively studied as potential therapeutic agents capable of slowing the progression of AS. However, two randomized ...
Guarracino Fabio - - 2010
Transoesophageal echocardiography (TEE) may require patient sedation, eventually leading to respiratory depression, a risky condition in severe cardiac disease. Non-invasive ventilation (NIV) has been applied during diagnostic manoeuvres, but its use during TEE has not been reported. We describe NIV-aided continuous TEE monitoring under sedation in the supine position in ...
Hashmi Zubair A - - 2010
Cardiac valve injury after blunt chest trauma is rare. We present a case of blunt chest trauma resulting in an isolated aortic valve rupture treated with aortic valve replacement.
Delgado Victoria - - 2010
Aortic regurgitation after transcatheter aortic valve implantation (TAVI) is one of the most frequent complications. However, the underlying mechanisms of this complication remain unclear. The present evaluation studied the anatomic and morphological features of the aortic valve annulus that may predict aortic regurgitation after TAVI. In 53 patients with severe ...
Hamilton Amanda M - - 2011
Aortic valve sclerosis (AVS) is a common inflammatory heart valve disease prevalent in the population over the age of 65 years. Several published clinical and animal studies have examined the ability of statin treatment to modify disease progression. Clinical trials yielded conflicting results, and animal studies examined the effects of ...
Tzemos Nikolaos - - 2010
This study sought to examine the relationship between proximal aortic dilation and systemic vascular function in men with bicuspid aortic valve (BAV). Proximal aortic dilation in subjects with BAV is associated with structural and functional abnormalities in the ascending aorta. We studied 32 men (median age 31 years [range 28 ...
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