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Meuchel Lucas W LW Department of Physiology, Mayo Clinic College of Medicine, 4-184 W. Jos SMH, Rochester, MN 55905, - - 2011
Members of the growth factor family of neurotrophins [NTs; e.g. brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT3)] and their high-affinity receptors (tropomyosin-related kinase; Trk) and low-affinity receptors p75 neurotrophin receptor (p75NTR) have been localized to pulmonary artery (PA) in humans. However, their role is unclear. Based on previous findings of NTs ...
Moustafa Sherif E - - 2011
Real-time three-dimensional transesophageal echocardiography (RT-3D-TEE) represents a unique perioperative cardiovascular imaging tool which, without any need for off-line reconstruction, has been shown to be highly valuable for evaluating mitral valve and other intracardiac structures. It is highly probable that, in the near future, RT-3D-TEE will have a positive effect on ...
Killory Brendan D - - 2011
: Spinal dural arteriovenous fistulae (dAVFs), are lesions involving an aberrant connection between a radicular feeding artery and the venous system of the spinal cord at the dural sleeve of the nerve root. When rare dAVFs are occult on digitally subtracted catheter-based angiography, they present a diagnostic and therapeutic challenge. ...
Zhang Guofei - - 2011
The optimal surgical management of patients presenting with an aortic coarctation together with other cardiovascular disorders is unclear. In this study, we report the case of an adult male with an aortic coarctation associated with a bicuspid aortic valve and an ascending aortic aneurysm. The patient underwent single-stage repair involving ...
Baranowski Jacek - - 2011
Objectives: We have developed a method using transthoracic echocardiography in establishing optimal visualization of the aortic root, to reduce the amount of contrast medium used in each patient. Background: During transcatheter aortic valve implantation, it is necessary to obtain an optimal fluoroscopic projection for deployment of the valve showing the ...
Cagirci Goksel - - 2011
aortic valve stenosis is the most common valvular heart disease in the Western world. The most common cause of aortic valve stenosis in adults is calcification of a normal trileaflet or congenital bicuspid valve. Calcific aortic valve stenosis is an active disease process characterized by mechanical stress, endothelial damage, lipid ...
Ngo Doan Tm - - 2011
Aortic valve stenosis (AVS) is associated with significant cardiovascular morbidity and mortality. To date, no therapeutic modality has been shown to be effective in retarding AVS progression. We evaluated the effect of angiotensin-converting enzyme inhibition with ramipril on disease progression in a recently developed rabbit model of AVS. The effects ...
Caselli Stefano - - 2011
Pseudoaneurysm of the mitral-aortic intervalvular fibrosa is a rare complication of infective endocarditis of the aortic valve eventually resulting in coronary artery compression, stroke or rupture into the left atrium, aorta or pericardial space. A prompt diagnosis by either transthoracic or transesophageal echocardiography is mandatory to address the patient to ...
Cordova Alfredo C - - 2011
Blunt traumatic injury of the innominate artery occurs infrequently but is commonly lethal. Bovine aortic arch anatomy is a predisposition to this injury. Clinical findings, chest X-ray, and computerized tomography may suggest the diagnosis, and it may be confirmed with angiography. Both interposition and bypass grafting are operative repair methods ...
Helgeson Zach L - - 2011
The transport of particles in surrogate and actual arterial geometries has been investigated synergistically by experimentation and numerical simulation. The motivating application for this work is orbital atherectomy which spawns a particle cloud in the process of debulking plaque from arterial walls. Paired simulations and experiments were performed to prove ...
Gruber Andreas - - 2010
BACKGROUND:: Recently, the non-invasive technique of microscope integrated intraoperative near infrared indocyanine green angiography [ICGA] was developed, allowing assessment of the cerebral vasculature in the operative field after intravenous injection of a fluorescent dye. OBJECTIVE:: To prospectively compare the value of ICGA derived information during cerebral aneurysm surgery with data ...
Haldenwang Peter L - - 2010
This case report illustrates our experience with transapical minimally invasive aortic valve implantation in a patient with an extended aneurysm of the thoracoabdominal aorta, who had previously undergone a replacement of the ascending aorta with concomitant aortic valve reconstruction (David procedure). Endovascular stent grafting of the descending aorta was also ...
Jilaihawi Hasan - - 2010
An 80-year old nun with severe calcific aortic stenosis and a bicuspid aortic valve was referred for transcatheter aortic valve implantation. She was declined for conventional surgery on the basis of poor left ventricular function, frailty, and a logistic EuroSCORE of 29.66. A 29-mm Medtronic-Corevalve bioprosthesis was implanted by transfemoral ...
McKellar Stephen H - - 2010
Bicuspid aortic valve (BAV) is associated with ascending aortopathy predisposing to aneurysmal dilatation and dissection, even after successful aortic valve replacement (AVR). There is, however, scant evidence on which to make recommendations for prophylactic replacement of the ascending aorta at the time of AVR. The medical records of patients who ...
Viscardi Francesca - - 2010
In bicuspid aortic valve (BAV) disease, the role of genetic and hemodynamic factors influencing ascending aortic pathology is controversial. To test the effect of BAV geometry on ascending aortic flow, a finite element analysis was undertaken. A surface model of aortic root and ascending aorta was obtained from magnetic resonance ...
Gotzmann Michael - - 2010
The management of patients with degeneration of surgical bioprosthetic valve replacement remains a challenge because of the higher risk of re-do aortic valve replacement. We present a case series of five patients with degenerated aortic bioprostheses treated with transfemoral transcatheter aortic valve implantation (TAVI). From December 2009 to May 2010, ...
Brown David W - - 2010
the aim of this study was to evaluate the long-term results of transcatheter balloon aortic valvuloplasty, the preferred treatment for congenital aortic stenosis (AS). aortic valve function and reintervention late after this procedure are not well characterized. from 1985 to 2008, 563 patients underwent balloon dilation for congenital AS. After ...
Wakabayashi Kana - - 2011
It is almost unknown which demographic factors or medications affect the progression of aortic stenosis (AS) in Japanese patients with mild AS. We identified a total of 194 patients with native tricuspid valvular AS, defined as a continuous-wave Doppler determined peak aortic valve jet velocity of ≥2.0 m/s, in whom echo ...
Natorska Joanna - - 2011
A role of coagulation in the pathogenesis of aortic stenosis (AS) is unknown. The aim of this study was to investigate the fibrin (Fn) presence and its determinants in calcified stenotic aortic valve leaflets. Twenty-one patients with dominant AS and 17 well-matched patients with dominant aortic insufficiency (AI) undergoing aortic ...
Giordano Vincenzo - - 2011
We report an unusual case of a 78-year-old man readmitted to our Cardiac Surgery Division due to a severe regurgitation of the stentless bioprosthesis Freedom Solo implanted, strictly following the manufacturer's recommendations, approximately six months before for aortic stenosis of native valve. Although different possible etiologies may be determined for ...
Rolf Tanina - - 2011
A 56-year-old patient admitted to hospital for the suspicion of an acute coronary syndrome underwent coronary angiography without detection of significant lesions. Seven days later the echocardiography showed acute severe aortic valve insufficiency. Intraoperatively we found a perforated leaflet probably due to lesion during transcatheter procedure.
Khouzam Rami N - - 2010
This is a case of a 65-year-old male with history of double mechanical valve implantation (aortic and mitral) who presented with symptoms of severe volume overload either related to cardiac disease or underlying cirrhosis. The precise etiology could not be determined by clinical examination and noninvasive diagnostic tests. A cardiac ...
Kutty Shelby - - 2010
BACKGROUND: Main pulmonary artery (MPA) dilation is reported to occur in association with pulmonary valve (PV) abnormalities and in genetic diseases of connective tissue. AIM: To determine whether MPA dilation occurs with bicuspid aortic valve (BAV) in the absence of PV abnormality. METHODS: MPA and aortic dimensions were investigated in ...
Kempfert Jörg - - 2010
BACKGROUND: Conventional aortic valve replacement can be technically challenging in patients with porcelain aorta and is associated with a high rate of stroke and mortality. Porcelain aorta is even sometimes seen as contraindication for surgery. Minimally invasive off-pump transapical aortic valve implantation may be an optimal strategy to treat elderly ...
Cheung Anson - - 2010
Transcatheter aortic valve implantation has been shown to be an effective treatment for severe aortic stenosis in high-risk surgical patients. Many of these patients have significant coexisting coronary artery disease. We report the first case of combined off-pump transapical aortic valve implantation and minimally invasive direct coronary artery bypass via ...
Delgado Victoria - - 2010
Transcatheter aortic valve implantation (TAVI) has been an important breakthrough in the treatment of patients with symptomatic, severe aortic stenosis and contraindications for surgical aortic valve replacement. Accurate aortic root measurements and evaluation of spatial relationships with the coronary ostia are crucial in pre-operative TAVI assessment. In addition, characterisation of ...
Johnson Pamela T - - 2010
The purpose of this review is to show the range of abnormality involving the aortic valve and ascending thoracic aorta using 64- and 128-MDCT with 2D and 3D CT angiography. Ascending aorta abnormality can be complicated by secondary involvement or associated disease involving the aortic valve, coronary arteries, and heart. ...
Arnold Martin M Department of Cardiology, University Hospital Erlangen, Erlangen, Germany. - - 2010
This study assessed the rate of periprocedural embolic ischemic brain injury during transapical aortic valve replacement in 25 consecutive patients. Transcatheter aortic valve implantation is rapidly being established as a new therapeutic approach for aortic valve stenosis. Although initial clinical results are promising, it is unknown whether mobilization and embolization ...
Nietlispach Fabian F Department of Cardiology, St. Paul's Hospital, Vancouver, British Columbia, - - 2010
We describe initial human experience with a novel cerebral embolic protection device. Cerebral emboli are the major cause of procedural stroke during percutaneous aortic valve interventions. With right radial artery access, the embolic protection device is advanced into the aortic arch. Once deployed a porous membrane shields the brachiocephalic trunk ...
Park Chan B - - 2011
There is growing consensus that the ascending aorta should be replaced at the time of aortic valve replacement for bicuspid aortic valve even if it is only moderately dilated; the natural history of nonreplaced sinuses of Valsalva is less clear. We identified patients without defined connective tissue disorder undergoing primary ...
Chan K M John - - 2011
The aim of this study was to determine the feasibility and durability of truly stentless aortic valve replacement using autologous pericardium sutured directly onto the aortic wall. Eleven patients (mean age, 55.9 years) requiring aortic valve replacement were recruited. A circular piece of pericardium about 8 cm in diameter was ...
Szlapka Michal - - 2011
Aortic valve endocarditis with perivalvular abscess formation remains a demanding condition and the results of the surgery are not optimal. Abscess localized in the aortic basis area can weaken the aortic wall, leading to further deterioration and rupture. The presented case allows us to recommend a maximal aggressive approach in ...
Delmo Walter Eva Maria - - 2010
We evaluated the long-term outcome of aortic valve after arterial switch operation (ASO). A retrospective review of 324 hospital survivors after ASO was performed. Echocardiographic findings and incidence and progression of aortic regurgitation (AR) were investigated. Endpoints of the study were the first documented occurrence of moderate or severe AR ...
Pflederer Tobias - - 2010
As populations in Western civilizations are aging, the prevalence of degenerative aortic valve stenosis is increasing. CT imaging provides information on aortic valve pathology in many ways: In nonenhanced scans, aortic valve calcification can be quantified accurately, which helps to understand the pathogenesis and progression of aortic sclerosis and stenosis. ...
Bruschi Giuseppe - - 2010
OBJECTIVE: Aortic valve disease is the most common acquired valvular heart disease in adults. With the increasing elderly population, the proportion of patients with symptomatic aortic stenosis who are unsuitable for conventional surgery is increasing. Transcatheter aortic valve implantation has rapidly gained credibility as a valuable alternative to surgery to ...
Naito Yoshiro - - 2010
BACKGROUND: Inflammation is involved in the pathogenesis of nonrheumatic aortic valve stenosis (AS). Pentraxin3 (PTX3) is produced at the inflammatory site; however, tissue and circulating PTX3 levels in patients with AS remain largely unknown. METHODS: We enrolled 84 patients who received aortic replacement surgery due to AS (n = 53) ...
Saia Francesco - - 2010
We sought to assess what proportion of patients with severe symptomatic aortic stenosis who are excluded from cardiac surgery are eligible for transcatheter aortic valve implantation (TAVI). Between July 2007 and December 2008, 98 patients with severe symptomatic aortic stenosis judged inoperable were referred to our institution for percutaneous aortic ...
Suh William M - - 2010
In some patients with aortic stenosis, dynamic intraventricular gradients like those seen in hypertrophic obstructive cardiomyopathy may develop secondary to left ventricular hypertrophy from chronic pressure overload. With the advent of transcatheter aortic valve implantation, many patients with aortic stenosis and advanced age who formerly would be considered "too high ...
Chu John W - - 2010
This study aimed to assess the accuracy of two-dimensional echocardiography (echo) in diagnosing unicuspid aortic valve (UAV) and to determine echo features that could improve the diagnosis. We reviewed transthoracic/transesophageal echoes (TTE/TEE) from our hospital database for adult patients who had aortic valve surgery with a preoperative echo diagnosis of ...
Gupta Anubhav - - 2010
Bicuspid aortic valve is a common congenital cardiac anomaly that poses a surgical challenge in young patients. We describe replacement of a bicuspid aortic valve with a stentless glutaraldehyde-treated autologous pericardial prosthesis in a 16-year-old girl.
Alkadhi Hatem H Institute of Diagnostic Radiology, University Hospital, Zurich, - - 2010
The purpose of this study is to evaluate the diagnostic performance of CT, compared with that of echocardiography and surgery, for differentiating between bicuspid and tricuspid aortic valves. Forty-seven patients with bicuspid valve and 47 patients with tricuspid aortic valve underwent retrospectively ECG-gated dual-source CT and echocardiography. Thirty-four (72%) of ...
Zahn Ralf - - 2011
Treatment of elderly symptomatic patients with severe aortic stenosis and co-morbidities is challenging. Transcatheter aortic valve interventions [balloon valvuloplasty and transcatheter aortic valve implantation (TAVI)] are evolving as alternative treatment options to surgical valve replacement. We report the first results of the prospective multi-centre German Transcatheter Aortic Valve Interventions-Registry. Between ...
Miller Jordan D JD Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, - - 2010
To test the hypothesis that valvular calcium deposition, pro-osteogenic signaling, and function can be altered in mice with advanced aortic valve disease. "Reversa" mice were given a Western-type diet for 12 months and screened for the presence of aortic valve stenosis. Mice with advanced valve disease were assigned to 1 ...
Haberthür David - - 2011
Objective: Valvuloplasty of the aortic valve is currently used in selected patients for severe calcified aortic valve disease, but clinical effectiveness is low and complication rate remains high. In this study, the total particle load after valvuloplasty and the embolization risk of calcific debris into the coronary arteries was analyzed ...
Du Xin - - 2011
Aortic stenosis (AS) is the most common valvular disease in adult cardiac surgery and its incidence continues to rise. Increasingly older patients are being referred for coronary artery bypass grafting (CABG) with mild to moderate AS. Concomitant aortic valve replacement (AVR) for patients with moderate or severe AS undergoing CABG ...
Folkmann Sandra - - 2010
The increasing number of interventions for percutaneous aortic valve replacement (AVR) justify a renewed evaluation of one-year survival rates after open AVR with and without coronary artery bypass in octogenarians. Risk factors influencing mortality are compared, and the patients' quality-of-life (QoL) after one year is assessed. One hundred and fifty-four ...
Purvis John - - 2011
Bicuspid aortic valve (BAV) is a common condition but is only rarely associated with embolic complications. We describe a 42-year-old man with recurrent posterior circulatory ischemic strokes that resulted in ataxia and cognitive impairment. Transesophageal echocardiography demonstrated a BAV with mild stenosis, moderate calcification, and a dilated ascending aorta. The ...
Klass Oliver - - 2011
The purpose of this study was to compare planimetric aortic valve area (AVA) measurements from 256-slice CT to those derived from transesophageal echocardiography (TEE) and cardiac catheterization in high-risk subjects with known high-grade calcified aortic stenosis. The study included 26 subjects (10 males, mean age: 79±6; range, 61-88 years). All ...
Takahashi Nobuyuki - - 2010
Aortic valve sclerosis, calcification, and stenosis are common in the elderly. Increased life expectancy has resulted in a growing population of elderly people, with a corresponding increase in the number of patients with these degenerative aortic valve diseases. We report a case of severe aortic stenosis in an 82-year-old woman ...
Majunke Nicolas - - 2010
BACKGROUND: A 70-year-old man diagnosed with hypertension, severe chronic obstructive lung disease and critical aortic stenosis symptomatic by NYHA functional class III heart failure and frequent hospitalisations for volume overload was referred for percutaneous aortic valve implantation. INVESTIGATION: Cardiac catheterisation revealed a severe aortic stenosis with a peak to peak ...
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