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Masugata Hisashi - - 2011
Arterial stiffness, assessed by cardio-ankle vascular index (CAVI), is clinically used to assess arteriosclerosis. Recently, pulmonary age, as determined by pulmonary function test, has been proposed by the Japanese Respiratory Society as a diagnostic measure for chronic obstructive pulmonary disease (COPD). This study aims to examine the association between CAVI ...
Lynch Fiona M - - 2011
OBJECTIVES: Previous studies have demonstrated that hypertension and diabetes induce significant structural remodelling of resistance arteries from various vascular beds. The hypothesis of this study is that structural alterations of small coronary arteries may occur during hypertension and diabetes. This study is the first to compare human coronary small resistance ...
Ho John S - - 2011
Computed tomography (CT) detection of coronary calcium has become a popular technique for assessing coronary atherosclerosis. Whether CT detection of carotid calcium could similarly assess carotid atherosclerosis is unknown. We thus performed a study evaluating the feasibility of carotid calcium scoring by CT. We also looked for an association between ...
Ogawa Eri - - 2011
BACKGROUND: Candidates for orthotopic liver transplantation (OLT) often have porto-pulmonary hypertension (PPHTN) with pulmonary arterial hypertension (PAH). Poor outcomes of PPHTN contraindicate OLT. There are no guidelines for living-donor liver transplantation (LDLT) in PPHTN patients. METHODS: We present our experiences of LDLT in six patients with moderate or severe PPHTN, ...
López-Candales Angel - - 2011
BACKGROUND: It is now well known that timing of right ventricular outflow tract (RVOT) spectral Doppler signals change with increasing pulmonary hypertension severity. We devised a study to determine whether visual assessment of these RVOT Doppler signals can be useful identifying the severity of pulmonary hypertension. METHODS: Visual inspection of ...
Fischer Aryeh - - 2011
Pulmonary arterial hypertension (PAH) affects approximately 10% of all scleroderma patients, is a devastating manifestation of the disease, and is the leading cause of scleroderma-associated mortality. PAH often presents insidiously and vigilant screening to detect PAH at an early stage is indicated in the care of all patients with scleroderma. ...
Tuder Rubin M - - 2012
This perspective highlights advances in the understanding of the role of cellular metabolism in the pathogenesis of pulmonary hypertension. Insights gained in the past 20 years have revealed several similarities between the cellular processes underlying the pulmonary vascular remodeling in pulmonary hypertension and those seen in cancer processes. In line ...
Mercurio Valentina - - 2011
We describe a 76-year-old former smoker with a diagnosis of combined pulmonary fibrosis and emphysema associated with pulmonary hypertension and rapidly progressive right heart failure, in whom combined treatment with sitaxsentan and sildenafil resulted in sustained improvement of his clinical condition and exercise performance, without any relevant adverse events. Combined ...
- - 2011
The article 'Treating pulmonary hypertension post cardiopulmonary bypass in pigs: milrinone vs. sildenafil analog' by F Urdaneta, EB Lobato, T Beaver, JD Muehlschlegel, DS Kirby, C Klodell and A Sidi published in Perfusion 2008 23: 117-125, 10.1177/0267659108094739 has been retracted.
Zufferey Flore - - 2011
Report of a 16q24.1 deletion in a premature newborn, demonstrating the usefulness of array-based comparative genomic hybridization in persistent pulmonary hypertension of the newborn and multiple congenital malformations. Descriptive case report. Genetic department and neonatal intensive care unit of a tertiary care children's hospital. None. We report the case of ...
Mydin Mohammad - - 2011
Untreated severe chronic thromboembolic pulmonary hypertension has a poor prognosis ending with right heart decompensation and multiorgan failure. This case report demonstrates that it is possible to intervene in the terminal stages of chronic thromboembolic pulmonary hypertension and bridge patients to surgery and recovery using various forms of extracorporeal membrane ...
Pan Xiangbin - - 2011
BACKGROUND: The aim of this study was to investigate differences in molecular mechanisms of pulmonary hypertension between patients with complete transposition of the great arteries (TGA) combined with ventricular septal defect (VSD) and those with VSD alone. METHODS: Twenty-four consecutive patients with pulmonary hypertension (mean pulmonary artery pressure > 30 ...
- - 2011
To the Editor: Parent et al. (July 7 issue)(1) report that echocardiographic evaluation alone had a low positive predictive value for the detection of pulmonary hypertension. An alternative explanation is that the use of only one measurement from the complete echocardiographic evaluation may provide misleading estimates of pulmonary arterial pressure. ...
Hoffman Julien I E - - 2011
To the Editor: Parent et al. (July 7 issue)(1) report that echocardiographic evaluation alone had a low positive predictive value for the detection of pulmonary hypertension. An alternative explanation is that the use of only one measurement from the complete echocardiographic evaluation may provide misleading estimates of pulmonary arterial pressure. ...
Gladwin Mark T - - 2011
To the Editor: Parent et al. (July 7 issue)(1) report that echocardiographic evaluation alone had a low positive predictive value for the detection of pulmonary hypertension. An alternative explanation is that the use of only one measurement from the complete echocardiographic evaluation may provide misleading estimates of pulmonary arterial pressure. ...
Blum Arnon - - 2011
To the Editor: Parent et al. (July 7 issue)(1) report that echocardiographic evaluation alone had a low positive predictive value for the detection of pulmonary hypertension. An alternative explanation is that the use of only one measurement from the complete echocardiographic evaluation may provide misleading estimates of pulmonary arterial pressure. ...
Castro Oswaldo - - 2011
To the Editor: Parent et al. (July 7 issue)(1) report that echocardiographic evaluation alone had a low positive predictive value for the detection of pulmonary hypertension. An alternative explanation is that the use of only one measurement from the complete echocardiographic evaluation may provide misleading estimates of pulmonary arterial pressure. ...
Ristow Bryan - - 2011
To the Editor: Parent et al. (July 7 issue)(1) report that echocardiographic evaluation alone had a low positive predictive value for the detection of pulmonary hypertension. An alternative explanation is that the use of only one measurement from the complete echocardiographic evaluation may provide misleading estimates of pulmonary arterial pressure. ...
Nakanishi Norifumi - - 2011
Pulmonary hypertension was defined as mean pulmonary artery pressure ≥25mmHg at the 4th World Symposium on Pulmonary Hypertension. In 2009, the European Society of Cardiology and European Respiratory Society jointly created guidelines for practical pulmonary hypertension classifications and treatments based on the discussions at the 4th World Symposium. This classification ...
Shan Ruihui - - 2012
The initial event of hypoxic pulmonary hypertension is acute hypoxic pulmonary vasoconstriction followed by remodeling of pulmonary arteries. Although 15(S)-hydroxyeicosatetraenoic acid [15(S)-HETE] is found to be able to induce hypoxic pulmonary vasoconstriction, role of 15(S)-HETE in pulmonary artery smooth muscle cells (PASMCs) proliferation has been studied less. We sought evidence ...
Kulik Thomas J - - 2011
Objective and Design.  Pulmonary venous hypertension is a well-characterized cause of pulmonary hypertension in adults, but little is known regarding the relationship between left atrial pressure and pulmonary arteriolar resistance in the young. Also, in adults relief of pulmonary venous hypertension results in a marked fall in pulmonary arteriolar resistance, ...
Clerici Angelo Maurizio - - 2011
We report the case of a 56-year-old man with acute onset of de-novo stabbing, pulsating and diffuse headache with subsequent appearance (within few minutes) of posterior fossa symptoms (vomiting, postural instability, anisocoria, incoordination, dysarthria, retropulsion) lasting 9-12 h. Recurrent hypertensive crises were detected during the acute observation in the Emergency Room, ...
Dib Hanadi - - 2012
Anti-endothelial cell antibodies (AECAs) have been identified in patients with systemic sclerosis (SSc) with and without pulmonary arterial hypertension (PAH) and in patients with idiopathic pulmonary arterial hypertension (iPAH). However, their target antigens remain poorly identified. Sera from 24 patients with SSc without PAH, 20 patients with SSc with PAH, ...
Ma Wanli - - 2011
Pulmonary hypertension is a severe and progressive disease, a key feature of which is pulmonary vascular remodeling. Several growth factors, including EGF, PDGF, and TGF-β1, are involved in pulmonary vascular remodeling during pulmonary hypertension. However, increased knowledge of the downstream signaling cascades is needed if effective clinical interventions are to ...
Berdon Walter E - - 2011
Although noted in the 19th century, it was not until 1938 that Scheid published the combination of left pulmonary artery sling and narrowing of the airway due to annular tracheal cartilages. Unaware of these prior descriptions, and without a precise preoperative diagnosis, Willis Potts in Chicago performed the first successful ...
Gomes Sean - - 2011
We report one of the largest descriptions of the right atrium (RA) in an adult, in absence of Ebstein's anomaly, tricuspid stenosis and other common adult associations of RA enlargement, such as pulmonary hypertension secondary to chronic pulmonary disease or severe mitral valvular pathology and pulmonary embolism. The RA volume ...
Ishida Keiichi - - 2011
OBJECTIVES: Pulmonary endarterectomy is the treatment of choice for chronic thromboembolic pulmonary hypertension. Although several reports demonstrated excellent medium-term survival after pulmonary endarterectomy, long-term outcomes remain unclear. We reviewed long-term outcomes and determined risk factors for early and late adverse events. METHODS: Seventy-seven patients were studied. Mean pulmonary arterial pressure ...
Zhang Bo - - 2011
BACKGROUND: Hypoxic pulmonary vasoconstriction may lead to pulmonary hypertension, but the underlying mechanisms of persistent vasoconstriction are still unclear. There is evidence that pulmonary inflammation contributes to the abnormalities of function in the pulmonary artery (PA) following chronic hypoxia exposure. Macrophage migration inhibitory factor (MIF) is an important pro-inflammatory cytokine, ...
Uhrikova Zuzana - - 2011
Alveolar capillary dysplasia (ACD) is an uncommon cause of irreversible persistent pulmonary hypertension in full-term newborn. In ACD there is a failure of formation of air - blood barrier in addition to misalignment of pulmonary veins. The etiology of the disease is still not understood. We present a case report ...
Huang Can - - 2011
Abstract  Tricuspid atresia (TA) is a rare and life-threatening cyanotic congenital heart anomaly, which is traditionally treated by the Fontan procedure. However, this procedure may be limited by the development of pulmonary hypertension and lead to long-term complications. The Bjork procedure offers an alternative for biventricular repair and right ventricular ...
Morimatsu Yoshitaka - - 2011
Pulmonary arterial hypertension (PAH) is a serious pathological phenomenon with poor prognosis, which is associated with morphological as well as hemodynamic alteration of the pulmonary circulation. To establish an animal model mimicking severe human PAH, we combined 2 well-described procedures, i.e. exposure to hypobaric chronic hypoxia and administration of monocrotaline ...
Park Jin-Sun - - 2011
Pulse wave analysis and intima-media thickness (IMT) of carotid artery are the non-invasive indicators of subclinical atherosclerosis. Coronary artery calcification (CAC) score measured by multi-detector computed tomography (MDCT) is well known as a predictor of coronary heart disease (CHD). We investigated the association between coronary calcification assessed by MDCT and ...
Springer Jochen - - 2011
SUMMARY: Pulmonary arterial hypertension is an orphan disease and a model for drug developments over recent years. Expert centers have focused basic science on the pulmonary vasculature and the right ventricle, followed by a direct transfer of innovative concepts to clinical research. Successful examples for translational experimentation are the endothelin ...
Hall Helen Chang - - 2011
Venous hypertension after creation of arteriovenous fistula or arteriovenous shunt occurs in approximately 10-15% of patients (Kojecky et al., Biomed Papers, 2002;146:77-79; Criado et al., Ann Vasc Surg 1994;8:530-535). Its etiology is commonly stenosis and/or thrombosis of the central venous system secondary to previous catheterization with subsequent development of venous hypertension after ...
Fernandes Caio Julio Cesar Dos Santos - - 2011
Schistosomiasis is one of the most prevalent chronic infectious diseases in the world. One of its most severe complications, pulmonary hypertension, occurs in up to 5% of patients with hepatosplenic schistosomiasis. The prevalence of schistosomiasis is so overwhelming that schistosomiasis-associated pulmonary hypertension (Sch-PH) may be the most prevalent cause of ...
Akintunde A A - - 2011
Cor triatriatum is a congenital heart malformation that is characterised by the division of the left or right atrium into two separate chambers by a membrane or diaphragm. Reports among adults are scarce, as most cases are diagnosed during childhood. The risk of mortality is increased when cor triatriatum is ...
Kowal-Bielecka Otylia - - 2011
OBJECTIVE: We aimed to assess the current validity status of the Health Assessment Questionnaire-Disability Index (HAQ-DI) and the 36-item Medical Outcomes Study Short Form Health Survey (SF-36). METHODS: Studies using HAQ-DI and/or SF-36 in patients with pulmonary arterial hypertension (PAH) associated with systemic sclerosis (PAH-SSc) were identified through a systematic ...
Gomez-Arroyo Jose G - - 2012
Severe forms of pulmonary arterial hypertension (PAH) are characterized by various degrees of remodeling of the pulmonary arterial vessels, which increases the pulmonary vascular resistance and right ventricular afterload, thus contributing to the development of right ventricle dysfunction and failure. Recent years have seen advances in the understanding of the ...
Day Elisabeth - - 2011
An 11-month-old girl presented with a history of failure to thrive, vomiting, polydipsia, polyuria and visual inattention. She was found to have malignant hypertension due to unilateral renal artery stenosis. This was successfully treated with percutaneous transluminal balloon angioplasty. Nearly 10 years following this initial presentation, she remains normotensive on ...
Belik Jaques - - 2011
Tetrahydrobiopterin (BH4) is a regulator of endothelial nitric oxide synthase (eNOS) activity. Deficient levels result in eNOS uncoupling, with a shift from nitric oxide to superoxide generation. The hph-1 mutant mouse has deficient GTP cyclohydrolase I (GTPCH1) activity, resulting in low BH4 tissue content. The adult hph-1 mouse has pulmonary ...
Zeng Wei-Jie - - 2011
It has been reported that short-term sildenafil therapy is safe and effective for patients with pulmonary arterial hypertension. However, data regarding the impact of sildenafil on the survival of patients with idiopathic pulmonary arterial hypertension remain limited. The study was conducted on 77 patients with newly diagnosed idiopathic pulmonary arterial ...
Crary Shelley E - - 2011
Vascular complications, including pulmonary hypertension (PH), have been reported to occur following splenectomy for various disorders,including hereditary spherocytosis (HS). We performed a prospective cross-sectional study of 36 adults with HS (78% with prior splenectomy)utilizing echocardiography to estimate tricuspid regurgitant jet velocity (TRV) as well as measurement of N-terminal pro-B-type natriuretic ...
He Xi-Ju - - 2011
OBJECTIVES: To obtain the biomechanical and morphological remodelling of hepatic arteries in swine with portal hypertension. METHODS: A number of 20 white pigs was used, of which 14 were subjected to liver cirrhosis and portal hypertension (PHT) induced by carbon tetrachloride and pentobarbital; the rest were used as the control ...
Bartelds Beatrijs - - 2011
Abstract BACKGROUND:Pulmonary arterial hypertension (PAH) is a progressive angioproliferative disease with high morbidity and mortality. Although the histopathology is well described, its pathogenesis is largely unknown. We previously identified the increased presence of mast cells and their markers in a rat model of flow-associated PAH. The aim of this study ...
York Michael - - 2011
PURPOSE OF REVIEW: The review provides an update of the epidemiology, pathogenesis, risk factors, screening and treatment of pulmonary arterial hypertension in systemic sclerosis. RECENT FINDINGS: Several recent studies have investigated the utility of several noninvasive screening methods and the propagation of new treatments promise the clinician better outcomes than ...
Leichsenring-Silva F - - 2011
1. This study investigates the time course of pulmonary arterial hypertension (PAH) due to monocrotaline (MCT) and its association with cardiac function and oxidative stress markers in the left ventricle (LV). 2. Male Wistar rats were divided into six groups: 7 days, 21 days, and 31 days for both control and MCT ...
Strasberg Steven M - - 2011
The risks of developing sinistral portal hypertension as a result of occlusion of the splenic vein close to its termination during a Whipple procedure are unclear. Our purpose was to compare the pattern of venous collateral development after splenic vein ligation in an extended Whipple procedure with the pattern of ...
Sanz Javier - - 2011
ObjectiveTo quantify right ventriculo-arterial coupling in pulmonary hypertension by combining standard right heart catheterisation (RHC) and cardiac magnetic resonance (CMR) and to estimate it non-invasively with CMR alone.DesignCross-sectional analysis in a retrospective cohort of consecutive patients.SettingTertiary care centre.Patients139 adults referred for pulmonary hypertension evaluation.InterventionsCMR and RHC within 2 days (n=151 ...
Prada-Delgado Oscar - - 2011
A 62-year-old woman presented with a 2-year history of progressive vocal hoarseness. She had had mitral-valve replacement for rheumatic mitral stenosis 21 years earlier, but her severe pulmonary hypertension had not resolved, and progressive clinical manifestations had developed.
Douwes Johannes M - - 2011
AimsTo assess the occurrence and prognostic value of acute vasodilator response (AVR) in paediatric vs. adult pulmonary arterial hypertension, and idiopathic/hereditary pulmonary arterial hypertension (iPAH/HPAH) vs. pulmonary arterial hypertension associated with congenital heart disease (PAH-CHD) using three different response criteria.Methods and resultsNinety-nine PAH patients underwent AVR testing (37 children, 62 ...
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