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Yuki Ichiro I Department of Neurosurgery, Jikei University School of Medicine, Tokyo, Japan Department of Radiology, UCLA Medical Center, Los Angeles, - - 2014
The authors report on the histologic and immunohistochemical analyses of a cerebral aneurysm embolized with platinum coils and with the longest observation period. A 58-year-old woman presenting with subarachnoid hemorrhage due to ruptured basilar top aneurysm was treated with Guglielmi detachable coils (GDC) 22 years ago. She was the 15th case ...
Hirohata Toshio - - 2014
Osteogenesis imperfecta (OI) is a heterogeneous group of inherited disorders that occur owing to the abnormalities in type 1 collagen, and is characterized by increased bone fragility and other extraskeletal manifestations. We report the case of a patient who was diagnosed with OI following subarachnoid hemorrhage (SAH) secondary to a ...
Mancuso L L Dipartimento di Ingegneria Meccanica Chimica e dei Materiali, Università degli Studi di Cagliari, Piazza d'Armi, 09123 Cagliari, Italy. BT (Biomedical Tissues) Srl, Viale Monastir km 7,300, 09028 Sestu (CA), - - 2014
Atherosclerosis and its complications still represent the leading cause of death in the developed countries. While autologous blood vessels may be regarded as the best solution for peripheral and coronary bypass, they are unavailable in most patients. Even though tissue engineering techniques are often applied to the development of small-diameter ...
Lee Soo Jung SJ Departments of aNeurology bMolecular & Integrative Physiology, University of Michigan cNeurology Service, VA Ann Arbor Healthcare System, Ann Arbor, Michigan, - - 2014
Small penetrating brain artery thickening is a major feature of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Although affected fibrotic arteries of CADASIL have been shown to accumulate collagen, other components that compose pathological arterial walls remain incompletely characterized. We investigated the expression of decorin (DCN), the ...
Lin Li-Mei LM http://orcid.org/0000-0002-6963-9799 Department of Neurosurgery, Johns Hopkins University School of Medicine, The Johns Hopkins Hospital, Baltimore, Maryland, - - 2014
Flow diverters are increasingly used for the treatment of intracranial aneurysms. Understanding cavernous internal carotid artery (cICA) tortuosity may help to predict procedural complexities of deploying flow diverters. Pipeline embolization device (PED) neurointerventions for ICA aneurysms proximal to the ICA termination were reviewed. Cavernous ICA tortuosity was measured as a ...
Lee Jiwon J Department of Physiology, University of Alberta, Edmonton, AB, T6G 2S2, - - 2014
An aortic aneurysm is characterized by widening of the aortic lumen diameter with adverse remodelling of the vascular extracellular matrix. A thoracic aortic aneurysm (TAA) is highly prevalent in patients with a bicuspid aortic valve (BAV). We investigated the structural remodelling in the aneurysmal ascending aorta in correlation to molecular ...
Kawajiri Hidetake H Division of Medical Engineering and Materials, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan; Department of Cardiovascular Surgery, Kyoto Prefectural University of Medicine, Kyoto, - - 2014
In this study, we aimed to describe the development of tissue-engineered self-expandable aortic stent grafts (Bio stent graft) using in-body tissue architecture technology in beagles and to determine its mechanical and histological properties. The preparation mold was assembled by insertion of an acryl rod (outer diameter, 8.6 mm; length, 40 ...
Nave Alexander H AH From the Division of Pulmonology, Department of Internal Medicine, University of Giessen and Marburg Lung Center (UGMLC), Giessen, Germany (A.H.N., I.M., G.N., F.R., M.L.T., F.V., S.H., K.M., I.V., N.W., W.S., R.E.M.); Department of Lung Development and Remodelling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany (A.H.N., I.M., G.N., W.S., R.E.M.); and the Department of Dermatology (J.B.) and Institute of Virology and Cell Biology (J.B., H.S.), University of Lübeck, Lübeck, - - 2014
Pulmonary vascular remodeling, the pathological hallmark of pulmonary arterial hypertension, is attributed to proliferation, apoptosis resistance, and migration of vascular cells. A role of dysregulated matrix cross-linking and stability as a pathogenic mechanism has received little attention. We aimed to assess whether matrix cross-linking enzymes played a causal role in ...
Kritharis Eleftherios P EP Laboratory of Biomechanics, Biomedical Research Foundation of the Academy of Athens, University of Athens, Athens, - - 2014
Aortic root aneurysms are relatively uncommon but their rupture is a detrimental event with acute hemodynamic compromise and high mortality, and there are few available data on their mechanical properties, although aneurysm rupture occurs when hemodynamic stresses exceed wall strength. This study aimed to fill this gap by examining the ...
Ohanian Jacqueline J Institute of Cardiovascular Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, - - 2014
The structure and function of large arteries alters with age leading to increased risk of cardiovascular disease. Age-related large artery remodeling and arteriosclerosis is associated with increased collagen deposition, inflammation, and endothelial dysfunction. Bioactive sphingolipids are known to regulate these processes, and are also involved in aging and cellular senescence. ...
Luo Ji J University of Leeds, Institute of Medical and Biological Engineering, Leeds, United Kingdom ; - - 2014
Currently available replacement heart valves all have limitations. This study aimed to produce and characterize an acellular, biocompatible porcine pulmonary root conduit for reconstruction of the right ventricular outflow tract e.g. during Ross procedure. A process for the decellularization of porcine pulmonary roots was developed incorporating trypsin treatment of the ...
Etminan Nima N From the Department of Neurosurgery (N.E., K.B., H.-J.S., D.H.) and Institute of Forensic Medicine (C.M.), Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany; Institute for Physiological Chemistry and Pathobiochemistry, Westfalian Wilhelms-University, Münster, Germany (R.D., P.B.); Center for Accelerator Mass Spectrometry, Lawrence Livermore National Laboratory, CA (B.A.B.); Department of Epidemiology, University of Iowa (J.C.T.); Department of Neurology, Mayo Clinic, Rochester, MN (R.D.B.); Division of Neurosurgery, St. Michael's Hospital, Keenan Research Centre for Biomedical Science and the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ontario, Canada (R.L.M.); and Department of Surgery, University of Toronto, Toronto, Ontario, Canada - - 2014
The chronological development and natural history of cerebral aneurysms (CAs) remain incompletely understood. We used (14)C birth dating of a main constituent of CAs, that is, collagen type I, as an indicator for biosynthesis and turnover of collagen in CAs in relation to human cerebral arteries to investigate this further. ...
Ploeg M M Utrecht, - - 2014
Aortic rupture in horses is a rare condition. Although it is relatively common in the Friesian breed, only limited histopathologic information is available. Twenty Friesian horses (1-10 years old) were diagnosed with aortic rupture by postmortem examination. Ruptured aortic walls were analyzed with histology and immunohistochemistry. Based on the histologic ...
Sun X-Z XZ Department of Pediatrics, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, P. R. China. - - 2014
The aim of this study was to investigate the effects of Rho kinase inhibitor-Fasudil on hypoxic pulmonary hypertension (HPH) and pulmonary vascular remodeling in rats. A total of 24 Sprague Dawley rats were evenly randomized into control, model and Fasudil intervention groups. Light and transmission electron microscopy were utilized to ...
Savall Frédéric F Service de Médecine Légale, Centre Hospitalier Universitaire Rangueil, Avenue du Professeur Jean Poulhès, 31059, Toulouse Cedex 9, - - 2014
A 58-year-old man died suddenly in Madagascar and poisoning was suspected. The body was embalmed after death and the general state of preservation was good. We found a major aortic dissection with a large false lumen from the aortic root to the common iliac arteries and a hemopericardium with formalinized ...
Shalhub Sherene S Division of Vascular Surgery, Department of General Surgery, University of Washington, Seattle, Wash. Electronic address: - - 2014
The management of arterial pathology in individuals with vascular Ehlers-Danlos syndrome (vEDS) remains a challenge. Here we describe the correlation between COL3A1 gene mutation type and the clinical phenotype in individuals with vEDS. Individuals with confirmed molecular diagnoses of vEDS were enrolled in a multi-institutional natural history study. Data collected ...
Pillai Anil Kumar AK Department of Radiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390, USA, - - 2014
Segmental arterial mediolysis (SAM) is an uncommon, nonatherosclerotic, noninflammatory, large- to medium-sized arteriopathy first described in 1976. It is characterized histologically by vacuolization and lysis of the outer arterial media leading to dissecting aneurysms and vessel rupture presenting clinically with self-limiting abdominal pain or catastrophic hemorrhages in the abdomen. Patients ...
Wang Ruoya R George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA, - - 2014
Unique anatomic locations and physiologic functions predispose different arteries to varying mechanical responses and pathologies. However, the underlying causes of these mechanical differences are not well understood. The objective of this study was to first identify structural differences in the arterial matrix that would account for the mechanical differences between ...
Pang Lulu L Department of Pediatrics, Peking University First Hospital, Beijing 100034, China. Electronic address: - - 2014
Collagen accumulation is one of the important pathologic changes in the development of pulmonary hypertension. Previous research showed that adrenomedullin (ADM) mitigates the development of pulmonary hypertension. The present study explored the role of ADM in the development of pulmonary artery collagen accumulation induced by high pulmonary blood flow, by ...
Boronyak Steven M SM Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, - - 2014
Percutaneous approaches to mitral valve repair are an attractive alternative to surgical repair or replacement. Radiofrequency ablation has the potential to approximate surgical leaflet resection by using resistive heating to reduce leaflet size, and cryogenic temperatures on a percutaneous catheter can potentially be used to reversibly adhere to moving mitral ...
Banerjee Tanima T Department of Cell Biology and Physiology, CSIR-Indian Institute of Chemical Biology, Kolkata, WB, - - 2014
Rheumatic Heart Disease (RHD), a chronic acquired heart disorder results from Acute Rheumatic Fever. It is a major public health concern in developing countries. In RHD, mostly the valves get affected. The present study investigated whether extracellular matrix remodelling in rheumatic valve leads to altered levels of collagen metabolism markers ...
Tan Hongmei H Department of Pathophysiology, Zhongshan School of Medicine, Sun Yat-sen University, #74 Zhonshan Road 2, Guangzhou, China - - 2014
This study investigated the role and mechanism of Hyperhomocysteinemia (HHcy) on vascular remodeling in mice. We assessed the effect of HHcy on vascular remodeling using a carotid arterial vein patch model in mice with the gene deletion of cystathionine-beta-synthase (Cbs). Vein grafts were harvested 4 weeks after surgery. Cross sections ...
Yuki Ichiro I Department of Neurosurgery, Jikei University School of Medicine, Tokyo, Japan Department of Radiology, UCLA Medical Center, Los Angeles, - - 2014
The authors report on the histologic and immunohistochemical analyses of a cerebral aneurysm embolized with platinum coils and with the longest observation period. A 58-year-old woman presenting with subarachnoid hemorrhage due to ruptured basilar top aneurysm was treated with Guglielmi detachable coils (GDC) 22 years ago. She was the 15th case ...
Rowinska Zuzanna Z Department of Vascular and Endovascular Surgery, Düsseldorf University Hospital, Düsseldorf, Germany; Institute of Molecular Cardiovascular Research, University Hospital, RWTH Aachen University Department of Medicine, Aachen, - - 2014
The aim of our study was to develop a reproducible murine model of elastase-induced aneurysm formation combined with aortic transplantation. Adult male mice (n = 6-9 per group) underwent infrarenal, orthotopic transplantation of the aorta treated with elastase or left untreated. Subsequently, both groups of mice were monitored by ultrasound until 7 ...
Fleenor Bradley S BS Department of Integrative Physiology, University of Colorado, Boulder, CO; Kinesiology and Health Promotion, and Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, - - 2013
We tested the hypothesis that superoxide signaling within aortic perivascular adipose tissue (PVAT) contributes to large elastic artery stiffening in old mice. Young (4-6 mo), old (26-28 mo), and old treated with TEMPOL, a superoxide scavenger (1mM in drinking water for 3 weeks), male C57BL6/N mice were studied. Compared with ...
Hams Emily E Trinity Biomedical Sciences Institute, School of Medicine, Trinity College Dublin, Dublin 2, - - 2014
Disease conditions associated with pulmonary fibrosis are progressive and have a poor long-term prognosis with irreversible changes in airway architecture leading to marked morbidity and mortalities. Using murine models we demonstrate a role for interleukin (IL)-25 in the generation of pulmonary fibrosis. Mechanistically, we identify IL-13 release from type 2 ...
Bartoli Carlo R CR Division of Cardiovascular Surgery, University of Pennsylvania, Philadelphia, Pa; MD/PhD Program, University of Louisville School of Medicine, Louisville, Ky. Electronic address: - - 2013
Less invasive circulatory support devices have been developed that require anastomosis to a peripheral artery. The Symphony Heart Assist System (Abiomed, Inc, Danvers, Mass) is a volume-displacement pump sewn to the subclavian artery to provide partial circulatory support. The surgical configuration produces nonphysiologic blood pressure and bidirectional flow in the ...
Balakhovsky K K Faculty of Civil and Environmental Engineering, Technion - I.I.T., - - 2013
Growth and rupture of aneurysms are driven by micro-structural alterations of the arterial wall yet precise mechanisms underlying the process remain to be uncovered. In the present work we examine a scenario when the aneurysm evolution is dominated by turnover of collagen fibers. In the latter case it is natural ...
Borges Luciano Figueiredo LF Department of Morphology, Federal University of Minas Gerais, Belo Horizonte, - - 2013
In ascending aorta aneurysms (AscAA) the whole vessel wall dilates, while in aortic dissections (AD) the wall cleaves into two sheets. Both may present fine elastic fragmentation and a decrease in collagen. We analyzed whether alterations in the three-dimensional structure of these fibers could be involved in the pathogenesis of ...
Asanome Akira - - 2013
An immature vasa vasorum in the adventitia of arteries has been implicated in induction of the formation of unstable atherosclerotic plaques. Normalization/maturation of the vasa vasorum may be an attractive therapeutic approach for arteriosclerotic diseases. Nerve growth factor (NGF) is a pleotropic molecule with angiogenic activity in addition to neural ...
Biasin Valentina - - 2013
Vascular remodeling is a hallmark of pulmonary hypertension (PH) and is characterized by enhanced proliferation of pulmonary artery smooth muscle cells (PASMC). Accumulating evidence indicates a crucial role of transcription factors in vascular remodeling processes. Here, we characterize the involvement of meprin β, a novel activator protein-1 (AP-1) effector molecule, in PH. Fra-2 ...
Gundiah Namrata - - 2013
We use enzymatic manipulation methods to investigate the individual and combined roles of elastin and collagen on arterial mechanics. Porcine aortic tissues were treated for differing amounts of time using enzymes elastase and collagenase to cause degradation in substrate proteins elastin and collagen and obtain variable tissue architecture. We use ...
Takeuchi Mikinobu - - 2013
The clinical morphology of a filum terminale arteriovenous fistula (f-AVF) is well known; however, pathological details of the fistulized portion are unknown. Herein, we report the pathological findings of the f-AVF. Case report and literature review. To present a detailed pathological examination of the fistulized portion of the f-AVF. A ...
de Brot Simone - - 2013
Pulmonary alveolar microlithiasis (PAM) is a rare pulmonary disorder characterized by the accumulation of calcium phosphate microliths within the alveoli, with only a few cases described in animals. A 10-year-old female Bulldog was euthanized due to history of dyspnea and recurrent pleural and pericardial effusions. At necropsy, numerous multifocal to ...
Wisler James W - - 2013
A traditional perspective of arterial thrombosis begins with vessel wall injury and exposure of subendothelial proteins, including collagen and tissue factor, to circulating cellular and non-cellular components. Adhesion and activation of platelets, mediated by their interaction with von Willebrand protein and collagen, respectively, coupled with tissue factor-mediated activation of coagulation ...
Tsamis Alkiviadis - - 2013
It was recently demonstrated by our group that the delamination strength of ascending thoracic aortic aneurysms (ATAA) was lower than that of control (CTRL, non-aneurysmal) ascending thoracic aorta (ATA), and the reduced strength was more pronounced among bicuspid (BAV) vs. tricuspid aortic valve (TAV) patients, suggesting a different risk of ...
Eckhouse Shaina R SR Division of Cardiothoracic Surgery, Department of Surgery (S.R.E., C.B.L., J.M.O., R.K.P., A.D.R., R.E.S., R.M., J.S.I., J.A.J.) and Division of Cardiology, Department of Medicine (W.B.W.), Medical University of South Carolina, Charleston, SC; Research Service, Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC (J.A.J.); and Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC, and Wm. Jennings Bryan Dorn Veterans Affairs Medical Center, Columbia, SC - - 2013
Thoracic aortic aneurysms (TAAs) develop secondary to abnormal aortic extracellular matrix remodeling, resulting in a weakened and dilated aortic wall that progressed to rupture if left unattended. Currently, no diagnostic/prognostic tests are available for the detection of TAA disease. This is largely driven by the lack of a large animal ...
Polzer Stanislav - - 2013
Arterial physiology relies on a delicate three-dimensional (3D) organization of cells and extracellular matrix, which is remarkably altered by vascular diseases like abdominal aortic aneurysms (AAA). The ability to explore the micro-histology of the aorta wall is important in the study of vascular pathologies and in the development of vascular ...
Pichamuthu Joseph E JE Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania; Center for Vascular Remodeling and Regeneration, University of Pittsburgh, Pittsburgh, - - 2013
Ascending thoracic aortic aneurysm (ATAA) predisposes patients to aortic dissection and has been associated with diminished tensile strength and disruption of collagen. Ascending thoracic aortic aneurysms arising in patients with bicuspid aortic valve (BAV) develop earlier than in those with tricuspid aortic valves (TAV) and have a different risk of ...
Luan Yun - - 2013
Our previous studies have shown that bone marrow mesenchymal stem cells (BMSCs) can inhibit the progression of pulmonary artery hypertension (PAH) in the monocrotaline (MCT) model in the short term. The aim of this study was to further investigate the long-term effect of BMSCs on PAH and to explore the ...
Deatrick Kristopher B - - 2013
Post thrombotic syndrome therapy is primarily palliative, and the associated vein wall inflammatory mechanisms are unclear. Vein wall fibrotic injury following deep venous thrombosis (VT) is associated with elevated matrix metalloproteinases (MMPs). Whether and by what mechanism MMP9 directly contributes to vein wall remodeling after VT is unknown. WT and ...
Stephen Elizabeth A - - 2013
Like engineered materials, an artery's biomechanical behavior and function depend on its microstructure. Glycation is associated with both normal aging and diabetes and has been shown to increase arterial stiffness. In this study we examined the direct effect of glycation on the mechanical response of intact arteries and on the ...
Lisy Milan - - 2013
The use of glues to repair disrupted tissue during acute type-A aortic dissection (TAD) surgery may be discontinuous, and cause embolization and cell necrosis. We report a method of fibrin sealant patch (FSP) to reinforce dissected aortic tissue with a collagen double layer coated with fibrinogen/thrombin on either side (TachoSil®; ...
Snorradottir Asbjorg Osk - - 2013
Hereditary Cystatin C Amyloid Angiopathy (HCCAA) is a rare genetic disease in Icelandic families caused by a mutation in the cystatin C gene, CST3. HCCAA is classified as a cerebral amyloid angiopathy and mutant cystatin C forms amyloid deposits in cerebral arteries resulting in fatal haemorrhagic strokes in young adults. ...
Jiu-Sheng Ren - - 2013
Growth, residual stresses and mechanical responses of arterial walls under the inner pressure are investigated within the framework of a finite deformation hyper-elasticity theory. A biomechanical model for a two-layer thick-walled circular cylindrical tube is proposed to address the mechanical effects of finite volumetric growth and residual stresses of arterial ...
Soares A L F - - 2013
Mathematical models can provide valuable information to assess and evaluate the mechanical behavior and remodeling of native tissue. A relevant example when studying collagen remodeling is the Ross procedure because it involves placing the pulmonary autograft in the more demanding aortic valve mechanical environment. The objective of this study was ...
Davidson Laura J - - 2013
Objectives: This study was designed to evaluate the efficacy and safety of the CardioDex arterial closure device, which is a novel femoral artery closure device used following percutaneous cardiac catheterization. Background: Current devices utilized to achieve hemostasis of the femoral artery following percutaneous cardiac catheterization include collagen plug and suture ...
Dutta Debaditya - - 2013
Mechanical strength is a key design factor in tissue engineering of arteries. Most existing techniques assess the mechanical property of arterial constructs destructively, leading to sacrifice of a large number of animals. We propose an ultrasound-based non-invasive technique for the assessment of the mechanical strength of engineered arterial constructs. Tubular ...
Abi Rafeh Nidal - - 2013
Off-label "double-wire" technique for closure of large-bore vascular access has been reported in the setting of percutaneous aortic valvuloplasty. We present 5 cases of high-risk percutaneous coronary intervention (HRPCI) supported by a 2.5 LP Impella assist device with 13 and 14 Fr size femoral access. Following successful HRPCI, vessel closure ...
Kallappa Parameshwarappa Shashidhar - - 2013
A 35-year-old male fisherman was admitted with complaints of increasing back pain and abdominal discomfort of 1-year duration. Physical examination revealed a prominently visible, expansile, pulsatile, well-defined, nontender abdominal mass in the epigastric, umbilical and both lumbar areas. Computed tomographic (CT) angiography revealed a large juxtarenal aortic aneurysm with a ...
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