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Humphrey J D JD Department of Biomedical Engineering, Yale University, and Vascular Biology and Therapeutics Program, Yale School of Medicine, New Haven, CT 06520, USA. - - 2013
Four distinguishing histopathological characteristics of thoracic aortic aneurysms and dissections (TAADs) are the fragmentation or degradation of elastic fibers, loss of smooth muscle, pooling of glycosaminoglycans, and remodeling of fibrillar collagens. Of these, pooling of glycosaminoglycans appears to be unique to these lesions. This review acknowledges the importance of dysregulated ...
Sato Mitsuru - - 2012
Repair of a dissected aorta involves reattaching the media with synthetic glue and/or reinforcement with nonbiodegradable felt. Late complications specific to each aspect of this procedure have been reported. We attempted to regenerate the media by using biodegradable felt. We created a canine model of descending thoracic aortic dissection and ...
Gavish Lilach - - 2012
BACKGROUND AND OBJECTIVES: Recent in vitro studies by our group indicated that low level laser irradiation (LLLI) modifies cellular processes essential to the progression of abdominal aortic aneurysm (AAA). Using high-frequency ultrasonography (HF-u/s) in the angiotensin-II (Ang-II)-infused, apolipoprotein-E-deficient (Apo-E(-/-) ) mouse model of AAA, we found that LLLI markedly inhibited ...
Remus Ebony Washington - - 2012
Abdominal aortic aneurysms (AAAs) are a major cause of morbidity and mortality in the United States today. We employed a model for AAA development using apolipoprotein E knock out mice fed a high-fat diet and treated with ANG II and β-aminopropionitrile (β-APN) for 4 wk. ANG II induces hypertension and ...
Fairman Ronald M - - 2012
We report 30-day and 12-month results of endovascular treatment with the Valiant Thoracic Stent Graft System (Medtronic Vascular, Santa Rosa, Calif) in patients with descending thoracic aortic aneurysms of degenerative etiology. The Valiant stent graft is an evolution of the Talent thoracic stent graft (Medtronic Vascular). The VALOR II (Evaluation ...
Johnston William F WF Division of Vascular and Endovascular Surgery, University of Virginia, Charlottesville, VA 22908, - - 2012
Repair of patients with extent I and II thoracoabdominal aortic aneurysms (TAAAs) is associated with significant morbidity and mortality, whereas repair of more distal extent III and IV TAAAs has a lower risk of paraplegia and death. Therefore, we describe an approach using thoracic endovascular aneurysm repair (TEVAR) as the ...
Fattouch Khalil - - 2012
The aim of this study was to assess the impact of aortic valve morphology and different surgical aortic valve repair techniques on long-term clinical outcomes. Between February 2003 and May 2010, 216 patients with aortic insufficiency underwent aortic valve repair in our institution. Ages ranged between 26 and 82 years ...
Polat Tb - - 2012
The mortality and morbidity of children with pulmonary atresia with intact ventricular septum (PA/IVS) is closely related with right ventricle hypoplasia and its consequent hemodynamics. Prenatal intervention for fetuses with PA/IVS has the potential to improve growth of the RV and the prospect of a biventricular outcome after birth. Successful ...
Bloemsma Gijsbert C - - 2012
BACKGROUND: The purpose of this study was to describe a case of an endovascular exclusion of a ruptured type II renal artery aneurysm in a hemodynamically unstable patient using an endograft. METHODS AND RESULTS: A 73-year-old woman, with an extensive medical history, presented with a sudden onset of abdominal pain ...
Kenny Damien - - 2012
OBJECTIVES: To describe early clinical experience with the Amplatzer Ductal Occluder II Additional Sizes (ADO II AS) for percutaneous arterial duct occlusion in infants and small children. METHODS: Pre-, intra- and post-procedural data analysis of all patients undergoing arterial duct occlusion with the ADO II AS from three tertiary referral ...
Lotan Eyal - - 2012
A 59-year-old female with history of progressive scleroderma and pulmonary fibrosis was referred for biopsy of a pulmonary nodule that was discovered on computed-tomography (CT) chest surveillance, not present on prior CT- scan. Imaging was suspicious for granuloma, malignancy or aneurysm. CT- Angiography (CTA), performed immediately before the procedure, did ...
Ahn Yong Hwan - - 2012
Carbohydrate antigen 19-9 (CA19-9) is a specific tumor marker of the biliary, pancreatic and gastrointestinal tracts. CA19-9 is occasionally elevated in serum in patiens with benign pulmonary diseases such as bronchiectasis, idiopathic interstitial pneumonia or collagen disease-associated pulmonary fibrosis. Intralobar pulmonary sequestration is an uncommon congenital lung anomaly. It is ...
Midulla Marco - - 2012
Purpose. The purpose of this study is to present an alternative technique for management of a type II endoleak associated with aneurysm sac enlargement. Technique. We report the use of a transseptal needle-sheath system for a transcatheter transcaval embolization (TTE) in a 3-staged treatment of a persistent type II endoleak ...
Patatas Kyriacos - - 2012
A best evidence topic was written according to a structured protocol. The question addressed was whether embolization is superior to surveillance for a type II endoleak associated with a static sac size post-endovascular abdominal aortic aneurysm repair (EVAR). Four hundred and sixty-one papers were identified, of which 10 papers presented ...
Funaki Brian - - 2012
To evaluate angiographic diagnosis and embolotherapy of patients with enlarging abdominal aortic aneurysms and computed tomographic (CT) diagnosis of type II endoleak. A retrospective review was performed of all patients referred to a single vascular and interventional radiology section from January 1, 2003, to June 1, 2011, with a diagnosis ...
Gomez Jorge - - 2012
An 8-year-old male patient was sent to the catheterization laboratory for assessment of a partial anomalous pulmonary venous connection found by echocardiography. During the intervention, cineangiogram revealed left pulmonary veins draining to the right atrium through left innominate and vertical veins. Despite this anatomical feature, these pulmonary veins were also ...
Eryilmaz Ertu─črul - - 2012
Embolization is a rare but serious complication of venous central catheters in pediatric oncology. The reported cases in the literature are due in common to catheter ruptures. The most common cause is constant compression of the costoclavicular arch, known as "pinch-off" syndrome. We report a seven-year-old boy in whom embolization ...
Bielefeld Kyle J - - 2012
An 8 month old female with hypoplastic left heart syndrome had undergone bidirectional cavopulmonary anastomosis at the age of 4 ½ months and presented with a new continuous flow murmur on routine follow up. Diagnostic catheterization demonstrated a fistula between the left atrial appendage and the neo-aortic arch. The fistula ...
Massis Kamal - - 2012
We report our single-center experience in treating 101 type II endoleaks with ethylene-vinyl-alcohol copolymer (EVOH, Onyx). In all, 65 endoleaks were embolized transarterially, and 36 were treated through a translumbar approach. Since the first transarterial embolization, when we began attempts to treat all patients initially via common femoral access, 58 ...
Gunasekaran Senthil - - 2012
Endoleak is the most common complication after endovascular aneurysm repair. The most common type of endoleak, a type II endoleak, typically follows a benign course and is only treated when associated with increasing aneurysm size. In this case report, we describe a ruptured abdominal aortic aneurysm due to a late, ...
Yu Jin-Lu - - 2012
To study the features and approaches of endovascular treatment for intracranial aneurysms with a ruptured bleb. This retrospective study was carried out from June 2007 to June 2009 in Jilin University, Jilin, China. Thirty patients with intracranial aneurysms with ruptured blebs were included. The aneurysms were diagnosed by digital subtraction ...
Gallagher Katherine A - - 2012
To examine the outcomes following interventions for type II endoleaks in patients with aneurysm sac expansion after endovascular aneurysm repair (EVAR). A retrospective review was conducted of all patients who underwent treatment for type II endoleak from July 2001 to September 2010 in a single center. In this time period, ...
Agnoletti Gabriella - - 2012
OBJECTIVE: The objective of this study was to evaluate the technical feasibility, safety, and efficacy of the new device Amplatzer duct occluder II additional sizes (ADO II AS) for closure of patent ductus arteriosus (PDA). Background: Transcatheter device closure is the standard care for PDA. Currently available technology is not ...
Zhang Xue - - 2012
Type II alveolar epithelial (AT-II) cells produce pulmonary surfactant proteins that are essential for alveolar function. AT-II is a major target in lung injury, and ineffective repair of damaged alveolar epithelia has been postulated to cause pulmonary fibrosis. Previous studies have shown that tyrosine phosphatase Shp2 is expressed highly in ...
Brenes Robert A - - 2012
Abdominal aortic aneurysm repair by endovascular techniques have gained wide acceptance as a treatment option. A potential well-known complication of endovascular repair includes endoleak. Specifically, type II endoleak, which is described as retrograde flow into the aneurysm sac through collateral vessels, can occur in up to 30% of patients. Certain ...
Koole Dave - - 2012
The main purpose of this study was to evaluate the influence of smoking on perioperative outcomes of endovascular aneurysm repair (EVAR), aneurysm sac behavior, abdominal aortic aneurysm (AAA) neck growth after EVAR, and its effect on stent graft migration during follow-up. Baseline characteristics and follow-up data were collected prospectively by ...
Evans Kimberly - - 2012
Type II endoleak after endovascular repair of an infrarenal aortic aneurysm (EVAR) may be difficult to diagnose and treat in the best of circumstances. Management is more difficult in the patient with significant renal insufficiency. We report an 81-year-old man with stage IV chronic kidney disease and a rapidly expanding, ...
Resch T - - 2012
Endoleaks are one of the most common reasons for reinterventions and failure after endovascular aneurysm repair (EVAR). Current classifications divide endoleaks into type I-V but a more pragmatic definition is of direct and indirect endoleaks. Direct endoleaks (type I and III) transmit direct systemic pressure to the aneurysm sac and ...
Sun Zhen-Kui - - 2012
Background and Purpose: The aim of this study was to evaluate the anatomical changes and investigate the prevalence in intracranial aneurysm with fenestrations using magnetic resonance angiography (MRA). Materials and Methods: Between June 2008 and October 2010, 4652 patients (aged 23-73 years) with suspected intracranial aneurysm or other cerebrovascular diseases ...
Miao Qing - - 2012
Hypoxic pulmonary hypertension is a life-threatening emergency if untreated. Consistent pulmonary hypertension also leads to arteries and ventricular remodeling. The clinical therapeutic strategy for pulmonary hypertension and the corresponding remodeling mainly interacts with NO, angiotensin II (Ang II) and elevated endothelin (ET) targets. In the present study, we evaluated the ...
Kurata Akira - - 2012
The etiology of the vertebral dissecting aneurysms is largely unknown, and they frequently occurs in relatively healthy young men. Objectives and Methods. A series of 57 consecutive cases defined by angiography were evaluated with regard to deviation in the course of the affected and contralateral vertebral arteries. Division was into ...
Vaish Arvind Kumar - - 2012
We here report a case of osteogenesis imperfecta who presented with severe hypertension and left ventricular failure and had right renal artery occlusion. The case is very interesting as renal artery occlusion has not been reported earlier in osteogenesis imperfecta.
Chihara Shingo - - 2012
Although the Angio-Seal arterial closure device is widely used for preventing bleeding and facilitating early ambulation after arterial puncture, it is also associated with unique complications, such as stenosis, occlusion, or peripheral embolism. We report the first case of a foot ulcer that developed 70 days after an Angio-Seal application. ...
Ananthakrishnan Ganapathy - - 2012
Inadvertent line insertion into the subclavian artery is an uncommon complication of subclavian venous catheterisation, and its timely recognition is vital to minimise risk of harm to the patient. We describe the radiographic, computed tomographic (CT), and angiographic findings in two patients and illustrate the subsequent endovascular management using collagen ...
Brown S - - 2012
Two patients with a patent foramen ovale associated with redundant and fenestrated atrial septal aneurysms and a history of multiple transient ischaemic episodes underwent percutaneous device closure using the Atriasept(™) II septal occluders. After release of the devices, the aneurysms were stabilised and no residual shunts were detected. Certain clinical ...
de Vries Margreet R - - 2012
The current study describes the incidence and phenotype of plaque rupture complications in murine vein grafts. Since matrix metalloproteinases (MMPs) are highly involved in atherosclerotic plaque vulnerability and plaque rupture, we hypothesized that this model can be validated by overexpression of the MMP inhibitor TIMP-1. First we studied 47 vein ...
Frech Andreas - - 2012
Abdominal aortic aneurysms represent both an individual risk of mortality and a socioeconomic burden for health care systems worldwide, but screening is not performed in all countries. Here, the authors summarize the pros and cons of screening to reduce abdominal aortic aneurysm-related mortality.
Pershad Ashish - - 2011
The GuideLiner catheter (Vascular Solutions, Inc.) is a monorail guiding catheter extension that serves to facilitate stent delivery and is approved for providing extra support and coaxial guide engagement. The objective of this manuscript is to familiarize interventionalists with this new device, describe its versatile uses, and its limitations with ...
Mardini Joëlle - - 2011
Current practice guidelines recommend that pulmonary blastomycosis be treated with antifungal agents such as amphotericin B and itraconazole. Echinocandins are not recommended because of poor in vitro activity against Blastomyces dermatitidis and lack of supporting clinical data. We report a case of chronic pulmonary blastomycosis treated successfully with caspofungin.
Luna Michael - - 2011
The Guideliner catheter (Vascular Solutions, Minneapolis, Minnesota) is a novel, rapid exchange catheter that allows deep vessel intubation. We describe 21 patients in whom the Guideliner catheter (7 French in 76% and 6 French in 24%) was used to facilitate equipment delivery (n=14) or vessel engagement (n=7). Pressure dampening upon ...
Murphy John Conleth - - 2011
Performing Percutaneous Coronary Intervention (PCI) in arteries with complex anatomy remains a clinical problem. In particular tortuosity within a coronary vessel is frequently encountered and can hamper delivery of balloons or stents to coronary stenoses. This has led to the development of a number of adjuvant devices to assist stent ...
Naylor A Ross - - 2011
Year 2011 sees the publication of US guidelines that recommend expanding indications for carotid artery stenting into "average-risk" patients, whereas guidelines from Australia/New Zealand largely do not. This article reviews the status of invasive treatment of carotid disease and highlights 2 controversial issues that were not really addressed in these ...
Holden Andrew - - 2011
The role of endovascular treatment of atherosclerotic renal artery disease is uncertain, particularly after the publication of the Angioplasty and Stenting for Renal Artery Lesions trial and other randomized trials. These trials have shown that nonselective treatment of patients with renal artery stenosis does not result in a benefit when ...
Piñero González de la Peña P - - 2011
OBJECTIVES: To evaluate the relation between the material retrieved from distal filters after carotid angioplasty and stenting and the development of ischemic brain lesions in diffusion-weighted imaging (DWI). To determine the influence of demographic, clinical, and procedural variables in the pathogenesis of emboli and in ischemia after carotid angioplasty and ...
Iadanza Alessandro - - 2011
We describe an acute coronary syndrome due to thrombosis of an aortic coronary bypass graft, treated with percutaneous coronary intervention, bivalirudin and a combined technique of thrombectomy and distal embolic protection system.
Stehouwer Marco C - - 2011
The use of minimized extracorporeal circuits (MECC) in cardiac surgery is an important measure to increase the biocompatibility of cardiopulmonary bypass during coronary artery bypass grafting (CABG). These circuits eliminate volume storage reservoirs and bubble traps to minimize the circuit. However, the reduction in volume may increase the risk of ...
Antoine Radcliffe A - - 2011
Patients diagnosed with primary or metastatic liver cancer face a daunting future that is complicated by limited treatment options. Percutaneous hepatic perfusion is a novel approach to chemotherapy delivery that offers significant benefits over contemporary modalities. Percutaneous hepatic perfusion is a procedure in which a chemotherapeutic agent is administered at ...
Piecuch J - - 2011
The placement of an inferior vena cava (IVC) filter is a therapeutic method for selected patients with deep venous thrombosis and pulmonary embolism. However, insertion and placement of the filter may be associated with certain complications. For instance, retroperitoneal hematoma resulting from perforation of the wall by the filter is ...
Welle Mary Kay - - 2011
Venous thromboembolism (VTE) is a significant cause of morbidity and mortality in trauma. What is known regarding VTE prophylaxis has been extrapolated from nontrauma data. Optimal methods of VTE prevention for trauma remain controversial and unknown. Trauma patients are unique and heterogeneous rendering many forms of treatment inappropriate. The most ...
Jassar Arminder S - - 2011
  Inferior vena cava (IVC) filter placement is recommended for acute proximal deep venous thrombosis if anticoagulation is contraindicated. A 52-year-old man presented with weakness, dyspnea, syncope, and renal failure 8 months after IVC filter placement. Imaging revealed migration of the IVC filter to the right ventricle. Endovascular retrieval was ...
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