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Qu Shun-Lin SL 1 Key Lab for Arteriosclerology of Hunan Province, Post-Doctoral Mobile Stations for Basic Medicine, Institute of Cardiovascular Disease, University of South China , Hengyang City, Hunan Province, People's Republic of China - - 2014
Mipu1 (myocardial ischemic preconditioning upregulated protein 1) is a novel N-terminal Kruppel-associated box (KRAB)/C2H2 zinc finger superfamily protein, that displays a powerful effect in protecting H9c2 cells from oxidative stress-induced cell apoptosis. The present study aims to investigate the effect of Mipu1 overexpression on oxidized low-density lipoprotein (oxLDL)-induced foam cell ...
Klu Yaa Asantewaa Kafui YA Department of Food Science and Technology, The University of Georgia, 1109 Experiment Street, Griffin, GA 30223-1797, - - 2014
A well-documented health benefit of probiotics is their ability to reduce the incidence of diarrhea in young, malnourished children in the developing countries. This study was undertaken to determine whether peanut butter, a nutritious, low-moisture food could be a carrier for probiotics by observing the survivability of selected probiotic mixtures ...
Lin Ching-Wen CW Academia Sinica, - - 2014
Cholesterol catabolism by actinobacteria has been extensively studied. In contrast, the uptake and catabolism of cholesterol by Gram-negative species is poorly understood. Here we investigated microbial cholesterol catabolism at the subcellular level. (13)C-metabolomic analysis revealed that anaerobically grown Sterolibacterium denitrificans, a betaproteobacterium, adopts an oxygenase-independent pathway to degrade cholesterol. S. ...
Kiriyama Keisuke K Department of Anatomy, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, - - 2014
Parkinson's disease (PD) is an obstinate progressive neurodegenerative disease and characterized by locomotor impairment and dopaminergic neuronal degeneration in the substantia nigra pars compacta (SNc). We examined in here the dietary effect of nucleoprotein (NP) extracted from salmon soft roe on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-injected PD-like mice model to prevent the symptom ...
Zheng Wenchao W Case Western Reserve University, United - - 2014
Effects of serum cholesterol on cholesterol content in the retina is currently unknown. It is also unclear how cholesterol levels are controlled in the retina. High cholesterol diet and oral administrations of simvastatin were used to modulate serum cholesterol in mice. These treatments only modestly affected cholesterol content in the ...
Brenes-Soto Andrea A Animal Science Department, University of Costa Rica, San Jose, Costa - - 2014
Several species in captivity develop nutritional diseases including vitamin A deficiency; cases of this disease have been documented in amphibians, which may be linked to an insectivorous diet lacking in vitamin A or carotenoids. Adults and young of Dyscophus guineti were fed three diets over 9 weeks to evaluate effects ...
Du H H School of Environmental and Biological Engineering, Department of Food Science. Rutgers, The State University of New Jersey, 65 Dudley Rd., New Brunswick, NJ 08901, USA. - - 2014
Molecular rotors may be utilized as non-invasive, non-disruptive and highly sensitive alternatives to conventional measures of bulk viscosity when the oil is entrained in a colloidal fat crystal network. Oil viscosity changes based on the molecular confinement of the oil, which is dependent on its molecular volume. Changes in micro-viscosity ...
de Almeida Torres Rogil José RJ Department of Opthalmology,Pontificia Universidade Catolica do Parana,Rua Emiliano Perneta 390, Conj 1407,CEP - - 2014
The aim of the present study was to evaluate the effect of flaxseed on choroid-sclera complex thickness and on LDL oxidation in the sclera, choroid and retina of diet-induced hypercholesterolaemic rabbits. New Zealand male albino rabbits (n 21) were divided into two groups: group 1 (G1; n 11), fed a ...
Chang Yuhua Y Department of Food Science, University of Massachusetts, Amherst, MA 01003, USA; College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an, Shaanxi 710062, PR - - 2015
The influence of a cationic surfactant (lauric arginate, LAE) on the physical properties and antimicrobial efficacy of thyme oil nanoemulsions was investigated. Nanoemulsions prepared from pure thyme oil were highly unstable due to Ostwald ripening, but they could be stabilized by adding a ripening inhibitor (corn oil) to the oil ...
Fokina N N NN Institute of Biology, Karelian Research Centre, Russian Academy of Sciences, Puskinskaja St. 11, Petrozavodsk 185910, Russia. Electronic address: - - 2014
A study on the effect oil pollution under normal and reduced salinity had on blue mussels Mytilus edulis L. from the White Sea in an aquarium-based experiment and in the natural habitat revealed a change in gill total lipids as a compensatory response. The cholesterol concentration and the cholesterol/phospholipids ratio ...
Zimetti F F Department of Pharmacy, University of Parma, Parma, - - 2014
We investigated the effect of berberine (BBR), an alkaloid showing antiatherogenic properties beyond the cholesterol lowering capacity, on macrophage cholesterol handling upon exposure to human serum and on macrophage responses to excess free cholesterol (FC) loading. Mouse and human macrophages were utilized as cellular models. Cholesterol content was measured by ...
Grimberg Asa A Department of Plant Breeding, Swedish University of Agricultural Sciences, Växtskyddsvägen 1, P.O. Box 101, SE-230 53 Alnarp, Sweden. Electronic address: - - 2014
Oat (Avena sativa L.) is unusual among the cereal grains in storing high amounts of oil in the endosperm; up to 90% of total grain oil. By using oat as a model species for oil metabolism in the cereal endosperm, we can learn how to develop strategies to redirect carbon ...
Wada Eiji E Graduate School of Arts and Sciences, University of Tokyo, Tokyo, - - 2014
Duchenne muscular dystrophy is a lethal X-linked disease with no effective treatment. Progressive muscle degeneration, increased macrophage infiltration, and ectopic calcification are characteristic features of the mdx mouse, a murine model of Duchenne muscular dystrophy. Because dietary phosphorus/phosphate consumption is increasing and adverse effects of phosphate overloading have been reported ...
Saeedi Ramesh R Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, Canada. Electronic address: - - 2014
Lecithin cholesterol acyl transferase (LCAT) is a plasma enzyme which esterifies cholesterol, and plays a key role in the metabolism of high-density lipoprotein cholesterol (HDL-C). Genetic disorders of LCAT are associated with lipoprotein abnormalities including low levels of HDL-C and presence of lipoprotein X, and clinical features mainly corneal opacities, ...
Liu Zheng Z Department of Chemistry and Biochemistry, Queens College of The City University of New York, Flushing, NY 11367 - - 2014
We report a synthetic route to BODIPY-cholesterol conjugates in which the key steps were Suzuki or Liebeskind-Srogl cross-coupling of cholesterol phenyl moieties with structurally diverse BODIPY scaffolds. All conjugates feature single-bonded and hydrophobic linkages between the fluorophore and sterol that are devoid of heteroatoms. Using HeLa cells, we show that ...
Saїdi Saber Abdelkader SA Laboratory of Animal Ecophysiology/Department of Life Sciences , Sfax , Tunisia - - 2014
Abstract The influence of tuna by-product meal (TBM) diets on the activities of antioxidant enzymes in the muscles, gill and kidney of tilapia was evaluated. The control diet (A0) used fish meal (FM) as the sole source of animal protein and the other three diets (A10-A30), 33%-100% of FM was ...
Tran-Dinh Alexy A From the Inserm UMR1148, Paris7 University, Xavier Bichat Hospital, Paris, France (A.T.-D., A.L., L.L., C.J., O.M., P.A.); Paris 7 University, Université Paris Diderot, Paris, France (A.T.-D., P.A.); CHU Bichat Stroke Center, Paris, France (P.A.); CHU de La Réunion, Saint-Pierre, France (O.M.); Paris 13 University, Villetaneuse, France (A.L.); UMR PhAN Laboratory, Nantes, France (G.L.); and University of Nantes Medical School, Nantes, France - - 2014
Low levels of low-density lipoprotein-cholesterol (LDL-C) are suspected to be associated with a risk of hemorrhagic transformation after ischemic stroke. We assessed the risk of hemorrhagic transformation after cerebral ischemia/reperfusion in mice with low levels of LDL-C resulting from proprotein convertase subtilisin kexin 9 (PCSK9) deficiency. PCSK9(-/-) and PCSK9(+/+) mice ...
Sreckovic Ivana I Department of Obstetrics and Gynecology, Medical University of Graz, - - 2014
Gestational diabetes mellitus (GDM) is related to neonatal macrosomia and an increased risk of vascular events. We hypothesized that GDM exerts qualitative effects on neonatal-neonatal high-density lipoprotein (HDL). HDL was isolated from control (n=11) and GDM maternal/neonatal donors (n=9) and subjected to shotgun proteomics. Differences in HDL mobility were assessed ...
Azevedo Jorge F DE JF Departamento de Ciências Biológicas, Faculdades Associadas de Ariquemes/FAAR, Ariquemes, RO, - - 2014
This study sought to morphometrically analyze the jejunal wall of protein-malnourished rats administered a probiotic supplement. The sample consisted of recently weaned Wistar rats (Rattus norvegicus) distributed among four groups: animals given a commercial diet (G1, n = 4); animals given the same ration as G1 plus a probiotic supplement ...
Cheng Andrew M AM University of - - 2014
Among the pleotropic effects of endothelial nitric oxide (NO) is protection against vascular inflammation during high-fat diet (HFD) feeding. The current work investigated the role of the enzyme vasodilatory-stimulated phosphoprotein (VASP) as a downstream mediator of the anti-inflammatory effect of NO signaling in vascular tissue. Methods and Results - Relative ...
Reddy K Vijay Kumar KV Department of Biochemistry and Nutrition, CSIR-Central Food Technological Research Institute, Mysore, 570020, - - 2014
Lipid quantity and quality have been shown to affect serum cholesterol, adipose and serum leptin levels during prenatal and postnatal dietary supplementation of adult rats. Maternal protein deficiency during pregnancy and lactation also affects polyunsaturated fatty acid (PUFA) levels in the offspring. The aim of the present study was to ...
Sabe Ashraf A AA Division of Cardiothoracic Surgery, Cardiovascular Research Center, Warren Alpert School of Medicine, Brown University , Providence, Rhode Island, USA - - 2014
Abstract Resveratrol has been shown to improve cardiac perfusion and ventricular function after chronic ischemic injury. Using proteomic analysis, we sought to objectively investigate potential mechanisms, by which resveratrol exerts its cardioprotective effects in the setting of metabolic syndrome and chronic myocardial ischemia. Yorkshire swine were divided into two groups ...
Sittiya J J a Laboratory of Animal Science, Faculty of Agriculture , Kagawa University , Miki-cho , Kagawa-ken 761-0795 , - - 2014
Abstract 1. To investigate the effect of replacing maize with whole-grain paddy rice (WPR) in broiler chicken diets, with or without enzyme addition, on growth performance and histological structures of the intestinal villi, 14-d-old Marshall Chunky male chicks were divided into 4 groups with 4 replicates of 4 chicks each. ...
Wang Linyuan L Toronto General Research Institute, University health Network, Toronto, Ontario, CanadaFaculty of Medicine, University of Toronto, Toronto, Ontario, - - 2014
An aberrant increase in circulating catabolic hormone, glucagon, contributes to type 2 diabetes pathogenesis. However, mechanisms regulating glucagon secretion and α cell mass are not well understood. In this study, we aim to demonstrate that PI3K signaling is an important regulator of α cell function. Mice with deletion of PTEN, ...
Wang Jing J Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, - - 2014
Cathepsin G (CatG), a serine protease present in mast cells and neutrophils, can produce angiotensin-II (Ang-II) and degrade elastin. Here we demonstrate increased CatG expression in smooth muscle cells (SMCs), endothelial cells (ECs), macrophages, and T cells from human atherosclerotic lesions. In low-density lipoprotein (LDL) receptor-deficient (Ldlr(-/-)) mice, the absence ...
Zhu Hua-Qing HQ Laboratory of Molecular Biology and Department of Biochemistry, Anhui Medical University, Hefei, Anhui, People's Republic of China; Key Laboratory of Gene Research of Anhui Province, Hefei, Anhui, People's Republic of China. Electronic address: - - 2014
High-fat diet has been reported to be associated with cardiovascular diseases which is implicated in atherosclerosis. However, the underlying mechanisms remain unknown. MicroRNAs (miRNAs) are non-coding small RNAs that control gene expression at the post-transcriptional level. Dysregulated miRNAs have been shown to be involved in atherosclerosis. This study examined whether ...
Mohammed R R Agriculture and Agri-Food Canada, Lethbridge Research Center, Lethbridge, AB, - - 2014
This study characterized the relationship between ruminal temperature ( T: rum) and pH in beef cattle fed growing and finishing diets. In Exp. 1, 16 ruminally-cannulated beef heifers (388.5 ± 34.9 kg BW) were fed 4 growing diets in a replicated 4 × 4 Latin square with four 21-d periods. ...
Van Eck Miranda M Division of Biopharmaceutics, Cluster BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, The - - 2014
ATP-binding cassette transporter A1 (ABCA1) facilitates cellular cholesterol efflux to lipid-poor apolipoprotein AI (apoAI) and plays a key role in the formation and function of HDL. This review summarizes the advances and new insights in the role of ABCA1 in cardiovascular and metabolic diseases from studies in genetically engineered mice. ...
Leclerc Daniel D Departments of Human Genetics and Pediatrics, McGill University, Montreal Children's, Hospital site of the McGill University Health Centre Research Institute, Montreal, - - 2014
Colorectal cancer risk is increased when dietary folate intake is low, with or without a deficiency in methylenetetrahydrofolate reductase (MTHFR). We have observed that intestinal tumors are induced in mice fed low folate diets, and that tumor incidence is increased when these mice also have MTHFR deficiency. This study was ...
Asimakopoulou Anastasia A Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital Aachen, Aachen, - - 2014
Lipocalin-2 (LCN2) belongs to the superfamily of lipocalins and plays critical roles in the control of cellular homeostasis during inflammation and in responses to cellular stress or injury. In the liver, LCN2 triggers protective effects following acute or chronic injury, and its expression is a reliable indicator of liver damage. ...
Voisin Sarah S Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, - - 2014
The type and the amount of dietary fat have a significant influence on the metabolic pathways involved in the development of obesity, metabolic syndrome, diabetes type 2 and cardiovascular diseases. However, it is unknown to what extent this modulation is achieved through DNA methylation. We assessed the effects of cholesterol ...
Phillips Michael C MC The Children's Hospital of Philadelphia, United States - - 2014
Most types of cells in the body do not express the capability of catabolizing cholesterol so cholesterol efflux is essential for homeostasis. For instance, macrophages possess four pathways for exporting free (unesterified) cholesterol (FC) to extracellular high density lipoprotein (HDL). The passive processes include simple diffusion via the aqueous phase ...
Zheng Lan L College of Life Science, Shandong Agricultural University, Taian, Shandong 271018, PR - - 2014
The objective of this study was to set up the mice hyperlipidemic model to observe the pharmacological effects of mycelia zinc polysaccharide (MZPS) of Pholiota nameko SW-02 on lipid metabolism and oxidative stress. IR spectrum of MZPS showed typical structure of fungi polysaccharides. The zinc content, determined by flame atomic ...
Zhang L L Feed Science Institute, College of Animal Science, Zhejiang University, Hangzhou 310058, Zhejiang Province, - - 2014
The maternal effect of different Se source in offspring of young broiler breeders has been reported, but the lasting maternal effect of different sources of Se on offspring of breeders has received limited attention, so this study was conducted to investigate the effects of different maternal Se sources on Se ...
Kumar Vikram V Centre for Energy, Indian Institute of Technology, Guwahati, Assam 781039, - - 2014
A single-stage mixotrophic cultivation strategy was developed with a novel microalgal isolate Chlorella sorokiniana FC6 IITG for high cell density lipid-rich biomass generation. The strain was evaluated for growth and lipid content under different physico-chemical parameters, nutritional conditions and trophic modes. Finally, a single-stage mixotrophic fed-batch cultivation strategy was demonstrated ...
Dolejš Igor I Institute of Biotechnology and Food Science, Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava, Radlinského 9, 81237 Bratislava, - - 2014
Clostridium acetobutylicum immobilised in polyvinylalcohol, lens-shaped hydrogel capsules (LentiKats(®)) was studied for production of butanol and other products of acetone-butanol-ethanol fermentation. After optimising the immobilisation protocol for anaerobic bacteria, continuous, repeated batch, and fed-batch fermentations in repeated batch mode were performed. Using glucose as a substrate, butanol productivity of 0.41g/L/h ...
Brake D W DW Department of Animal Sciences and - - 2014
Greater postruminal flows of protein increase small intestinal starch digestion in cattle. Our objective was to determine if small intestinal starch digestion is increased by duodenal supplementation of AA. We fed 5 duodenally and ileally cannulated steers a low-starch soybean hull-based diet in 5 × 5 Latin square designs and ...
Kang Ping P Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University, Wuhan, 430023, China, - - 2014
This study was conducted to investigate whether aspartate (Asp) could improve liver energy status in the lipopolysaccharide (LPS)-challenged pigs. Twenty-four weaned pigs were assigned to four treatments: (1) nonchallenged control (control diet and saline-treated); (2) LPS-challenged control (the same control diet and LPS-challenged); (3) LPS + 0.5 % Asp treatment (0.5 % Asp diet ...
Koutelidakis Antonios E AE Unit of Human Nutrition, Laboratory of Food Chemistry and Analysis, Department of Food Science and Human Nutrition, Agricultural University of Athens , Iera Odos, Greece - - 2014
Abstract The hypothesis that iron and fat in the diet may affect green tea extract (GTE) bioactivity, in particular antioxidant capacity and gene expression, was proposed and tested in mice. Thirty mice were randomly assigned to have for 37 days free access to standard or high-fat diets with or without ...
Dallaire M P MP Département des Sciences Animales, Université Laval, Québec, QC, G1V 0A6 Canada; Institute of Nutrition and Functional Foods, Québec, QC, G1V 0A6 - - 2014
The purpose of this study was to determine the effects of conjugated linoleic acid (CLA), Sterculia foetida oil (STO), and fish oil (FO) on milk yield and composition, milk FA profile, Δ(9)-desaturation activity, and mammary expression of 2 isoforms of stearoyl-coenzyme A desaturase (SCD-1 and SCD-5) in lactating dairy cows. ...
Zhou Jie - - 2014
Post-fermented tea has been used for the prevention of metabolic syndrome in Western China. Present study reports the biochemical mechanism of lipid-lowering effects of Jing-wei fu tea (JWFT), a variety of post-fermented tea on high-fat diet-induced hyperglycemia and obesity in rats. Aqueous extract of JWFT was prepared by putting them ...
Hassanat F F Agriculture and Agri-Food Canada, Dairy and Swine Research and Development Centre, 2000 College Street, Sherbrooke, Quebec, Canada J1M - - 2014
The objective of this study was to investigate the effects of changing forage source in dairy cow diets from timothy silage (TS) to alfalfa silage (AS) on enteric CH4 emissions, ruminal fermentation characteristics, digestion, milk production, and N balance. Nine ruminally cannulated lactating cows were used in a replicated 3 ...
Chang Seo-Na SN Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Seoul, - - 2014
Prostate cancer is the most frequently diagnosed cancer in Western men, and more men have been diagnosed at younger ages in recent years. A high-fat Western-style diet is a known risk factor for prostate cancer and increases oxidative stress. We evaluated the association between dietary animal fat and expression of ...
Shi Lei L College of Animal Science and Technology, Shanxi Agricultural University, Taigu 030801, PR China; Lab of Animal Reproductive biotechnology, Shanxi Agricultural University, Taigu 030801, PR China. Electronic address: - - 2014
The objective of this study was to investigate the different levels of dietary Se (from sodium selenite) on the proliferation of SSCs (spermatogonial stem cells) in testis of roosters. Also, the antioxidant status and Se content in blood plasma and testis were evaluated. A total of eighty 12-week-old Hy-Line Variety ...
Paturi Gunaranjan G The New Zealand Inst. for Plant and Food Research Limited, Private Bag 92169, Auckland, 1142, New - - 2014
The effects of kiwifruit on large bowel health were investigated in healthy rats. Four-week old Sprague-Dawley rats were given diets containing 10% homogenized green kiwifruit, gold kiwifruit or 10% glucose solution (control) over 4 or 6 wk. Green kiwifruit increased the fecal output compared to control. Growth of certain bacterial ...
Zhao L L Department of Food Science and Human Nutrition, University of Florida, Gainesville, - - 2014
Background and Objective:We have previously demonstrated that gamma tocotrienol (γT3) potently inhibits adipocyte hyperplasia in human adipose-derived stem cells (hASCs). In this study, our objective was to investigate the γT3 effects on early onset obesity, inflammation, and insulin resistance in vivo.Methods:Young C57BL/6 J mice were fed a high fat (HF) diet ...
Nam Mi Kyung MK Industrial Bioresource Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-606, Republic of - - 2014
The present study was performed to investigate the potential effects of the unripened dried fruit of Rubus coreanus Miq., Rubi Fructus (RF), on hepatic steatosis and lipid metabolism in mice fed with a high‑fat diet (HFD) known to induce obesity and hyperlipidaemia. Rubi Fructus extract (RFex) fed mice demonstrated a reduced body weight ...
Castro H H Molecular Biology, Nutrition and Biotechnology (Nutrigenomics). University of the Balearic Islands (UIB), CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Palma de Mallorca, - - 2014
ObjectiveWe analysed the effects of a short exposure to a cafeteria diet during early infancy in rats on their metabolic response to fed/fasting conditions in key tissues involved in energy homeostasis.Methods10-day-old male pups were fed a control or a cafeteria diet for 12 days and then sacrificed under ad libitum ...
Camargo Antonio A Lipids and Atherosclerosis Unit, IMIBIC/Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, - - 2014
Our aim was to assess the use of peripheral blood mononuclear cells (PBMC) as an in vivo cellular model to evaluate diet-induced changes in the oxidative stress status by analysing the gene expression pattern of NADPH-oxidase subunits and antioxidant genes. A randomized, controlled trial assigned metabolic syndrome (MetS) patients to ...
Marais A David AD Chemical Pathology, University of Cape Town, National Health Laboratory Service and Medical Research Council Cape Heart Group, Cape Town, South Africa. Electronic address: - - 2014
Atherosclerosis is a complex process involving the build-up of arterial plaque incorporating low-density lipoprotein cholesterol (LDL-C) and an inflammatory response. Lowering plasma LDL-C confers cardiovascular benefit for patients with hypercholesterolemia resulting from genetic and/or lifestyle factors. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key regulator of LDL-C metabolism. Secreted ...
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