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Yao Longbiao L Cardiovascular Biology Program and Free Radical Biology and Aging Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, - - 2014
The chemokine receptor CXCR4 is expressed on adipocytes and macrophages in adipose tissue, but its role in this tissue remains unknown. We evaluated whether deficiency in either adipocyte or myeloid leukocyte CXCR4 affects body weight (BW) and adiposity in a mouse model of high-fat-diet (HFD)-induced obesity. We found that ablation ...
Homayounfar Reza R National Nutrition and Food Technology Research Institute, Faculty of Nutrition Science and Food Technology, Department of Basic Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, - - 2014
This paper aimed to explore the role of p53 in adipose and some other peripheral tissues of a diet-induced obese model and targeted it using pharmacological approach to ameliorate diet-induced insulin resistance. Five week old male Wistar rats were randomly divided into three groups and fed on low-fat diet (13% ...
Burger Joanna J Division of Life Sciences, Rutgers University, 604 Allison Road, Piscataway, NJ, USA; Environmental and Occupational Health Sciences Institute (EOHSI), Piscataway, NJ, USA. Electronic address: - - 2014
There is an abundance of field data on levels of metals for feathers in a variety of birds, but relatively few data for tissues, especially for migrant species from one location. In this paper we examine the levels of arsenic, cadmium, chromium, lead, manganese, mercury and selenium in muscle, liver, ...
Benoit Bérengère B Lyon University, Univ - - 2014
Dairy products derived from the milk of cows fed in pastures are characterised by higher amounts of conjugated linoleic acid and α-linolenic acid (ALA), and several studies have shown their ability to reduce cardiovascular risk. However, their specific metabolic effects compared with standard dairy in a high-fat diet (HFD) context ...
Wernstedt Asterholm Ingrid I Department of Internal Medicine, Touchstone Diabetes Center, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8549, - - 2014
Chronic inflammation constitutes an important link between obesity and its pathophysiological sequelae. In contrast to the belief that inflammatory signals exert a fundamentally negative impact on metabolism, we show that proinflammatory signaling in the adipocyte is in fact required for proper adipose tissue remodeling and expansion. Three mouse models with an ...
Oliva M E ME Department of Biochemistry, School of Biochemistry, University of Litoral, Ciudad Universitaria El Pozo cc 242, 3000, Santa Fe, - - 2014
The present study analyzes the effect of the replacement of dietary casein by soy protein on the mechanisms underlying dyslipidemia, liver steatosis and altered glucose and lipid metabolism in the skeletal muscle which developed in rats fed long-term a sucrose-rich diet (SRD). Wistar rats were fed a SRD for 4 months. ...
Romao J M JM Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada, T6G - - 2014
Fat deposition influences both meat quality and animal productivity. However, it is not clear how fat development is regulated in growing and fattening beef cattle. This study characterized proteomic changes in subcutaneous adipose tissue from steers fed a high grain diet in an effort to understand the molecular mechanisms of ...
Meale S J SJ Faculty of Veterinary Science, University of Sydney, Sydney, NSW 2006, Australia Lethbridge Research Centre, Agriculture and Agri-Food Canada, Lethbridge, Alberta T1J 4B1, - - 2014
Knowledge of the molecular mechanisms which regulate ovine adipogenesis is very limited. MicroRNAs (miRNAs) have been reported as one of the regulatory mechanisms of adipogenesis. This study aimed to compare the expression of miRNAs related to ovine adipogenesis in different adipose depots and to investigate whether their expression is affected ...
Giordano E E Laboratory of Functional Foods, Madrid Institute for Advanced Studies (IMDEA) - Food, CEI UAM+CSIC, Madrid, - - 2014
Hydroxytyrosol (HT) is the most prominent phenolic component of olives, olive oil, and their by-products, e.g. olive mill waste water. As the link between HT consumption (via extra virgin olive oil intake) and better cardiovascular prognosis is being scientifically validated, HT is entering the market as a potentially useful supplement ...
Sun Xiaowei X Department of Nutrition and Food Hygiene,Public Health College, Harbin Medical University,157 Baojian Road, Nangang District,Harbin, Heilongjiang Province150081,People's Republic of - - 2014
Obesity is considered to be accompanied by a chronic low-grade inflammatory state that contributes to the occurrence of many chronic diseases. Our previous study has demonstrated that histidine supplementation significantly ameliorates inflammation and oxidative stress in obese women. However, the in vivo potential mechanisms are not known. The present study ...
Squitti Rosanna R Fatebenefratelli Foundation for Health Research and Education, AFaR Division, "San Giovanni Calibita" Fatebenefratelli Hospital, Rome, Italy; Laboratorio di Neurodegenerazione, IRCCS San Raffaele Pisana, Rome, Italy. Electronic address: - - 2014
Copper is an essential element, and either a copper deficiency or excess can be life threatening. Recent studies have indicated that alteration of copper metabolism is one of the pathogenetic mechanisms of Alzheimer's disease (AD). In light of these findings, many researchers have proposed preventive strategies to reduce AD risk. ...
Chee Yen Wong W Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor Darul Ehsan, - - 2014
Understanding individual's intention, action and maintenance to increase fruit and vegetable intake is an initial step in designing nutrition or health promotion programs. This study aimed to determine stages of change to increase fruit and vegetable intake and its relationships with fruit and vegetable intake, self-efficacy, perceived benefits and perceived ...
Fratter Andrea A 1 Innovation Technology, Labomar Research , Istrana, Treviso, Italy - - 2014
Abstract Chitosan (CH) is a polymer of glucosamine that is extracted from the shells of several sea fruits. It is well recognized as a nutritional supplement that is used to reduce body weight and blood lipid levels, but its clinical efficacy has not been clearly demonstrated. The true mechanism of ...
Sadananthan Suresh Anand SA Singapore Institute for Clinical Sciences, Agency for Science, Technology & Research (A*STAR), Singapore; Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, - - 2014
To develop an automatic segmentation algorithm to classify abdominal adipose tissues into visceral fat (VAT), deep (DSAT), and superficial (SSAT) subcutaneous fat compartments and evaluate its performance against manual segmentation. Data were acquired from 44 normal (BMI 18.0-22.9 kg/m(2) ) and 38 overweight (BMI 23.0-29.9 kg/m(2) ) subjects at 3T ...
Kamel Kamel S KS Renal Division, St Michael's Hospital and University of Toronto, Toronto, ON, - - 2014
Our purpose is to integrate new insights in potassium (K(+)) physiology to understand K(+) homeostasis and illustrate some of their clinical implications. Since control mechanisms that are essential for survival were likely developed in Paleolithic times, we think the physiology of K(+) homeostasis can be better revealed when viewed from ...
Rodrigues Pedro O PO CEDOC, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Campo dos Mártires da Pátria 130, 1169-056 Lisbon, - - 2014
Canned sardines are a ready-to-use fish product with excellent nutritional properties owing to its high n-3 long-chain PUFA content, mainly EPA (20 : 5n-3) and DHA (22 : 6n-3). The present study aimed to assess the effect of two dosages of canned sardines, recommended for the primary and secondary prevention of human CVD, on ...
Gurzell Eric A EA Department of Food Science and Human Nutrition, Michigan State University, MI, United - - 2014
Despite numerous studies investigating n-3 long chain polyunsaturated fatty acid (LCPUFA) supplementation and inflammatory bowel diseases (IBD), the extent to which dietary n-3 LCPUFAs incorporate in gastrointestinal (GI) tissues and correlate with red blood cell (RBC) n-3 LCPUFA content is unknown. In this study, mice were fed three diets with ...
Valente Angelica A FAME Laboratory, Centre for Research and Technology Hellas, Karies, Trikala, 42100, Greece; School of Physical Education and Exercise Sciences, University of Thessaly, Trikala, 42100, - - 2014
An increase in energy intake and/or a decrease in energy expenditure lead to fat storage, causing overweight and obesity phenotypes. The objective of this review was to analyse, for the first time using a systematic approach, all published evidence from the past 8 years regarding the molecular pathways linking non-shivering thermogenesis ...
Lillefosse Haldis H - - 2014
Whey protein intake is associated with modulation of energy metabolism and altered body composition both in human subjects and in animals, but the underlying mechanisms is yet not elucidated. We fed obesity prone C57BL/6J mice high-fat diets with either casein (HF Casein) or whey (HF whey) for six weeks. At ...
Lu Kun - - 2014
To describe the preparation of nano emodin transfersome (NET) and investigate its effect on mRNA expression of adipose triglyceride lipase (ATGL) and G0/G1 switch gene 2 (G0S2) in adipose tissue of diet-induced obese rats. NET was prepared by film-ultrasonic dispersion method. The effects of emodin components at different ratios on ...
Toedebusch Ryan G RG University of - - 2014
To better understand the impact of childhood obesity on intra-abdominal adipose tissue phenotype, a complete transcriptomic analysis using deep RNA-sequencing (RNA-seq) was performed on omental adipose tissue (OMAT) obtained from lean and western diet induced obese juvenile Ossabaw swine. Obese animals had 88% greater body mass, 49% greater body fat ...
Cichello S A SA School of Life Sciences, La Trobe University, Bundoora, VIC, 3086, Australia, - - 2014
There are a myriad of proteins responsible for modulation of expenditure of energy. Angiotensin II (Ang II) is a vital component of renin-angiotensin system that affects blood pressure and also linked to both cachexia and obesity via fat and muscle metabolism. Previous research suggests that the direct action of Ang ...
Nieminen Petteri P University of Eastern Finland, Faculty of Health Sciences, School of Medicine, Institute of Biomedicine/Anatomy, P.O. Box 1627, FI-70211 Kuopio, Finland; University of Eastern Finland, Faculty of Science and Forestry, Department of Biology, P.O. Box 111, FI-80101 Joensuu, Finland. Electronic address: - - 2014
The fatty acid (FA) compositions of the diet and diverse tissues of the farmed Siberian sturgeon (Acipenser baerii) were analyzed in detail to assess their nutritional quality. Twelve male fish were sampled for muscle, fat, liver, brain, gill, kidney and gonad and the tissue FA measured by gas-liquid chromatography. The ...
Nicod Nathalie - - 2014
While polyphenols are often merely perceived as antioxidants, their biological activities are manifold and include anti-inflammatory actions. A new area of research on polyphenols and health concerns their putative role on cholesterol metabolism, in particular their high density lipoprotein-cholesterol (HDL-c)-raising potential. Indeed, some human studies showed that administration of polyphenol-rich ...
Miranda Diego A DA Duke-NUS Graduate Medical School, - - 2014
Triglycerides within the cytosol of cells are stored in a phylogenetically conserved organelle called the lipid droplet (LD). LDs can be formed at the endoplasmic reticulum, but mechanisms that regulate the formation of LDs are incompletely understood. Adipose tissue has a high capacity to form lipid droplets and store triglycerides. ...
Ovilo C C Departamento de Mejora Genética Animal, INIA, 28040 Madrid, - - 2014
A trial was carried out to compare the effects of different dietary sources of monounsaturated fatty acids (MUFA), on the fatty acid (FA) composition, lipid metabolism and gene transcription in different tissues of Iberian pigs. Twenty-seven Iberian male pigs of 28 kg Live Weight (LW) were divided in two groups ...
Gabriel Gutiérrez-Salmeán GS Sección de Estudios de Posgrado e Investigación. Escuela Superior de Medicina, Instituto Politécnico - - 2014
Overweight and obesity have been associated with increases in cardiometabolic risk. Therapeutics include lifestyle changes and/or pharmacologic agents. However, such interventions are often limited by poor compliance and/or significant side effects. The consumption of certain dietary products, such as cocoa, exerts positive effects on cardiometabolic risk factors. (-)-Epicatechin (EPI), the ...
Andrade João Marcus Oliveira JM Laboratory of Health Science, Postgraduate Program in Health Sciences, Universidade Estadual de Montes Claros (UNIMONTES), Montes Claros, Minas Gerais, - - 2014
Adipose tissue is central to the regulation of energy balance. Two functionally different fat pads are present in mammals: white adipose tissue, the primary site of triglyceride storage, and brown adipose tissue (BAT), which is specialized in heat production. In this context, new strategies capable of modulating the development and ...
Dong Jing J Hefei University of Technology, - - 2014
Adipose tissue macrophage (ATM) plays a central role in obesity-associated inflammation and insulin resistance. Quercetin, a dietary flavonoid, possesses anti-inflammation and anti-insulin resistance properties. However, it is unclear whether quercetin can alleviate high fat diet (HFD)-induced ATM infiltration and inflammation in mice. In this study, five-week-old C57BL/6 mice were fed ...
Heymsfield S B SB Pennington Biomedical Research Center, Baton Rouge, - - 2014
Maximizing fat loss while preserving lean tissue mass and function is a central goal of modern obesity treatments. A widely cited rule guiding expected loss of lean tissue as fat-free mass (FFM) states that approximately one-fourth of weight loss will be FFM (i.e. ΔFFM/ΔWeight = ∼0.25), with the remaining three-fourths being fat ...
Barros Alexandre Guimarães de Almeida AG Instituto Nacional de Ciência e Tecnologia de Medicina Molecular, Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, - - 2014
The regulation of energy balance involves an intricate interplay between neural mechanisms that respond to internal and external cues of energy demand and food availability. Compelling data have implicated the neurotransmitter dopamine as an important part of body weight regulation. However, the precise mechanisms through which dopamine regulates energy homeostasis ...
Moon Hyeongsun H The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, QLD 4102, - - 2014
The role of statin therapy in prostate cancer (PCa) prevention and treatment is plagued by controversy. This critical review of published clinical series reveals several caveats in earlier studies, which reported no benefit. Recent studies that adjust for confounding factors have demonstrated statin therapy to be associated with PCa prevention ...
Holma-Suutari A A Department of Biology, University of Oulu, P.O. Box 3000, 90014 Oulu, Finland. Electronic address: - - 2014
A study concerning persistent organic pollutants in Finnish semi-domesticated reindeer was conducted in northern Finland. The aim of this study was to explore POP presence in different tissues of reindeer. In addition, it was studied how POPs are transported from food concentrates and lichen to reindeer hind tissues and further ...
Brunelli Roberto - - 2014
The long quest for a missing mechanistic rationale accounting for the correlation between plasma cholesterol levels and cardiovascular disease (CVD) has been focused on various possible modifications of low density lipoprotein (LDL), turning this physiological cholesterol carrier into a damaging agent able to trigger atherogenesis and later the onset of ...
Bursać Biljana N BN Department of Biochemistry, Institute for Biological Research "Siniša Stanković", University of Belgrade, 142 Despot Stefan Blvd., 11000 Belgrade, - - 2014
Fructose overconsumption has been involved in the genesis and progression of the metabolic syndrome. Hypothalamus and adipose tissue, major organs for control of food intake and energy metabolism, play crucial roles in metabolic homeostasis. We hypothesized that glucocorticoid signaling mediates the effects of a fructose-enriched diet on visceral adiposity by ...
Miksztowicz V V Laboratory of Lipids and Lipoproteins, Department of Clinical Biochemistry, Faculty of Pharmacy and Biochemistry, INFIBIOC, University of Buenos Aires, Buenos Aires, - - 2014
Adipose tissue produces different metalloproteinases (MMPs), involved in adipogenesis and angiogenesis. Different studies have shown that in obesity the behavior of different MMPs may be altered. However there are scarce data about the effect of insulin-resistance (IR) on MMP-2 and MMP-9 activity in adipose tissue. Our aim was to determine ...
Cortes Victor A VA Departamento de Nutricion, Diabetes y Metabolismo, Escuela de Medicina, Pontificia Universidad Catolica de Chile. Marcoleta # 367, interior, 4to piso. Santiago, - - 2014
Cholesterol has evolved to fulfill sophisticated biophysical, cell signaling and endocrine requirements of animal systems. At a cellular level, cholesterol is found in membranes, where it increases both bilayer stiffness and impermeability to water and ions. Furthermore, cholesterol is integrated into specialized lipid-protein membrane microdomains with critical topographical and signaling ...
Handayani Dian D Nutrition Department, Faculty of Medicine, University of Brawijaya, Jl. Veteran, Malang 65145, Indonesia. - - 2014
Shiitake mushroom have been shown to have health benefits including lowering plasma lipids and preventing body weight gain. However, their underlying mechanisms are largely unknown. The study aim was to assess the potential underlying mechanism of Shiitake mushrooms in lowering plasma triacylglycerol (TAG) in rats fed a high fat diet ...
Gil-Ortega Marta M Departamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad CEU-San Pablo, Madrid, - - 2014
The hypothesis of this study is that long-term high-fat diets (HFD) induce perivascular adipose tissue (PVAT) dysfunction characterized by a redox imbalance, which might contribute to aggravate endothelial dysfunction in obesity. C57BL/6J mice were fed either control or HFD (45% kcal from fat) for 32 weeks. Body weight, lumbar and ...
Long Yang Y Laboratory of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, - - 2014
Increased levels of free fatty acids (FFAs) and hypertriglyceridemia are important risk factors for cardiovascular disease. The effective fraction isolated from radix astragali (RA) has been reported to alleviate hypertriglyceridemia. The mechanism of this triglyceride-lowering effect of RA is unclear. Here, we tested whether activation of the mTORC1-PPAR γ signaling ...
Sanchez-Gurmaches Joan J Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, Massachusetts 01605, - - 2014
Adipose tissue development is poorly understood. Here we use a lineage-tracing strategy optimal for adipocytes to provide evidence that Myf5 precursors are not the exclusive source of brown adipocytes and contribute more to the mature white and brite adipocyte populations than previously thought. Moreover, Myf5-lineage distribution in adipose tissue changes ...
- - 2014
[This corrects the article DOI: 10.1371/journal.pone.0090137.].
Lee Daniel A DA Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine Baltimore, MD, USA ; Division of Biology and Biomedical Engineering, California Institute of Technology Pasadena, CA, - - 2014
The hypothalamus is the central regulator of a broad range of homeostatic and instinctive physiological processes, such as the sleep-wake cycle, food intake, and sexually dimorphic behaviors. These behaviors can be modified by various environmental and physiological cues, although the molecular and cellular mechanisms that mediate these effects remain poorly ...
Gu Yeyi Y Department of Food Science, The Pennsylvania State University, University Park, PA - - 2013
In diet-induced obesity, adipose tissue (AT) is in a chronic state of inflammation predisposing the development of metabolic syndrome. Cocoa (Theobroma cacao) is a polyphenol-rich food with putative anti-inflammatory activities. Here, we examined the impact and underlying mechanisms of action of cocoa on AT inflammation in high fat-fed mice. In ...
Chee Melissa J S MJ Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts - - 2014
Melanin-concentrating hormone (MCH) is an orexigenic neuropeptide that is a ligand for two subtypes of MCH receptors, MCHR1 and MCHR2. MCHR1 is universally expressed in mammals ranging from rodents to humans, but the expression of MCHR2 is substantially restricted. In mammals, MCHR2 has been defined in primates as well as ...
Iacobellis Gianluca - - 2013
Epicardial adipose tissue has recently emerged as new risk factor and active player in metabolic and cardiovascular diseases. Albeit its physiological and pathological roles are not completely understood, a body of evidence indicates that epicardial adipose tissue is a fat depot with peculiar and unique features. Epicardial fat is able ...
Shabalina Irina G - - 2013
The phenomenon of white fat "browning," in which certain white adipose tissue depots significantly increase gene expression for the uncoupling protein UCP1 and thus supposedly acquire thermogenic, fat-burning properties, has attracted considerable attention. Because the mRNA increases are from very low initial levels, the metabolic relevance of the change is ...
Carillon Julie - - 2013
Obesity-related metabolic syndrome is often associated with a decrease of insulin sensitivity, inducing several modifications. However, dietary antioxidants could prevent insulin resistance. We have previously shown the preventive effects of a melon superoxide dismutase (SOD) in obese hamsters. However, its antioxidant effects have never been studied on adipose tissue. We ...
Dib Lea - - 2013
Liver X receptors (LXR) are transcription factors known for their role in hepatic cholesterol and lipid metabolism. Though highly expressed in fat, the role of LXR in this tissue is not well characterized. We generated adipose tissue LXRα knock-out (ATaKO) mice and show that these mice gain more weight and ...
Gaborit B - - 2013
Regional body-fat distribution is one of the key variables that explains the metabolic heterogeneity of obesity and its related cardiovascular risks. According to the ectopy concept, the inability of subcutaneous adipose tissue to store surplus triglycerides may lead to the development of fat in ectopic sites, such as the heart. ...
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