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Claycombe Kate J KJ USDA-ARS, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58203, USA. Electronic address: - - 2014
Malnutrition during the fetal growth period increases risk for later obesity and type 2 diabetes mellitus (T2DM). We have shown that a prenatal low-protein (8% protein; LP) diet followed by postnatal high-fat (45% fat; HF) diet results in offspring propensity for adipose tissue catch-up growth, obesity and T2DM in Sprague-Dawley ...
Fujishita A A Department of Orthodontics and Dentofacial Orthopedics, Graduate school of Biomedical Sciences, Nagasaki University, Nagasaki, - - 2014
It has been suggested that feeding a soft diet could possibly inhibit normal development of the masticatory function. However, the consequences of such changes in the alimentary habits have yet to be fully clarified. Therefore, the aim of this study was to determine whether a soft diet prevents the development ...
Martin-Creuzburg Dominik D Limnological Institute, University of Konstanz, Mainaustrasse 252, 78464, Konstanz, Germany, - - 2014
Arthropods are incapable of synthesizing sterols de novo and thus require a dietary source to cover their physiological demands. The most prominent sterol in animal tissues is cholesterol, which is an indispensable structural component of cell membranes and serves as precursor for steroid hormones. Instead of cholesterol, plants and algae ...
Pahl Christian C Christian-Albrechts-University Kiel, Institute of Agricultural Engineering, 24098 Kiel, - - 2014
Monitoring rumination behavior serves multiple purposes in feeding and herd management of dairy cows. The process of calving is a major event for cows, and a detailed understanding of alterations in behavioral patterns of animals in the time around calving is important in calving detection. The objective of this study ...
Lapmanee Sarawut S Department of Physiology, Faculty of Science, Mahidol University, Rama VI Road, Bangkok, 10400, - - 2014
Type 2 diabetes mellitus (T2DM) often occurs concurrently with high blood cholesterol or dyslipidemia. Although T2DM has been hypothesized to impair bone microstructure, several investigations showed that, when compared to age-matched healthy individuals, T2DM patients had normal or relatively high bone mineral density (BMD). Since cholesterol and lipids profoundly affect ...
Vengiau Gwendalyn G a Department of Human Ecology, Graduate School of Medicine , The University of Tokyo , Tokyo , - - 2014
Urban migrants in Papua New Guinea have undergone a nutritional transition. The present study investigated associations of socioeconomic status with dietary and physical activity patterns among migrant Bougainvilleans from Nassioi territory in the capital city of Port Moresby, Papua New Guinea. All adults Naasioi migrants residing in Port Moresby were ...
Enomoto Akiko A Postgraduate researcher, Department of Orthodontics, School of Dentistry, Showa University, Tokyo, - - 2014
Mandibular growth is believed to be strongly related to mastication. Furthermore, mandibular condylar cartilage is known to be derived from neural crest cells. We examined whether the degree of chewing affects condylar cartilage growth of the mandible. Mice were fed diets with varying hardness. Genes specific to neural crest-derived cells ...
Park Soo Hyun SH Department of Sport Science, University of Seoul, Seoul, South - - 2014
We tested the hypothesis that an active video game following a high-fat meal would partially prevent the unfavorable effect of a high-fat meal on vascular function in overweight adolescents. Twenty-four overweight adolescents were randomized to either a 60-min active video game (AVG) group (n=12) or seated rest (SR) (n=12) as ...
Boudry Gaëlle G INRA UR1341 ADNC, Domaine de la - - 2014
Dietary peptides are absorbed along the intestine through peptide transporter 1 (PepT-1) which is highly responsive to dietary protein level. PepT-1 is also involved in gut homeostasis, both initiating and resolving inflammation. Low-birth-weight (LBW) neonates are routinely fed a high-protein (HP) formula to enhance growth. However, the influence of this ...
Mak Angel C Y AC Cardiovascular Research Institute, University of California, San - - 2014
The identification of a patient with a rare form of severe dysbetalipoproteinemia allowed the study of the consequences of total absence of apolipoprotein E (apoE). To discover the molecular basis of this rare disorder and to determine the effects of complete absence of apoE on neurocognitive and visual function and ...
Gao Wen-Yi WY From the Division of Gastroenterology and Inborn Errors Products, Office of New Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, New Hampshire Avenue, Silver Spring, - - 2014
To clarify and to understand the potential for misinterpretation of change in fecal fat quantitation during pancreatic enzyme replacement therapy (PERT) trials for treatment of exocrine pancreatic insufficiency. Analysis of clinical trials submitted to the U.S. Food and Drug Administration (FDA) for approval of PERT that enrolled 123 cystic fibrosis ...
Nash Walter L WL Vision Care Research, Alcon Laboratories, Johns Creek, - - 2014
Lipid deposition on silicone hydrogel (SiHy) lenses, which are believed to be caused by their hydrophobic surface, can lead to discomfort, reduced vision, and inflammatory reactions. This study used a highly specific and sensitive fluorometric enzymatic assay for ex vivo cholesterol analysis of seven types of SiHy lenses: balafilcon A, ...
Utsugi Chizuru C Department of Oral and Maxillofacial Surgery, Asahikawa Medical University, Asahikawa 078-8510, Japan; Department of Sensory Physiology, Asahikawa Medical University, Asahikawa 078-8510, - - 2014
A large number of neurons are generated at the subventricular zone (SVZ) even during adulthood. In a previous study, we have shown that a reduced mastication impairs both neurogenesis in the SVZ and olfactory functions. Pheromonal signals, which are received by the vomeronasal organ, provide information about reproductive and social ...
Majdalawieh Amin F AF Department of Biology, Chemistry and Environmental Sciences, College of Arts and Sciences, American University of Sharjah, P.O. Box 26666, Sharjah, United Arab Emirates, - - 2014
Cholesterol clearance by macrophages is a vital process to eliminate excess cholesterol from the body. Internalization of modified cholesterol by macrophages triggers overexpression of peroxisome proliferator-activated receptor γ1 (PPARγ1) and liver X receptor α (LXRα), two transcription factors that are critically involved in macrophage cholesterol efflux. Recent studies demonstrate that ...
Huang Weihuan - - 2014
Capsaicinoids exist in chili peppers while capsinoids are present in sweet pepper. The present study investigated the effects of capsaicinoids and capsinoids on plasma lipids, relaxation of aorta, atherosclerotic plaque development and fecal sterol excretion in hamsters. Five groups of male hamsters were fed the control diet or one of ...
Schurmann Brittney L BL University of - - 2014
The objectives were to determine the effect of an increase in diet fermentability on 1) rate and extent to which short-chain fatty acid (SCFA) absorption pathways adapt relative to changes in Na(+) transport, 2) epithelial surface area (SA), and 3) barrier function of the bovine ruminal epithelium. Twenty-five Holstein steer ...
Joshi Sangeeta S Cell Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur, 302055, Rajasthan, - - 2014
Zinc deficiency has become a global problem affecting the developed and developing countries due to inhibitors in the diet which prevents its absorption or due to a very low concentration of bioavailable zinc in the diet. Being present in high concentration in the prostate and having diverse biological function, we ...
Agnihotri Nidhi N Chemical Sciences Division, Saha Institute of Nuclear Physics, 1/AF, Bidhannagar, Kolkata, West Bengal 700064, - - 2014
A non-enzymatic approach towards cholesterol detection is presented here, exploiting the electrochemical non-enzymatic route of sensing which has a distinct advantage over other conventional enzymatic processes. Chemically converted Graphene modified with β-CD, being hydrophilic, electroactive and high surface area material, provides a platform for the electrochemical detection of cholesterol using ...
Zhang H B HB Animal Nutrition Institute, Sichuan Agricultural University, Ya'an, 625014, - - 2014
This study was conducted to estimate dietary zinc (Zn) levels on growth performance, carcass traits, and intramuscular fat (IMF) deposition in weaned piglets. Sixty piglets were randomly divided into five groups, as follows: control (basal diet), Zn250, Zn380, Zn570, and Zn760 with supplementation of 250, 380, 570, and 760 mg Zn/kg ...
Lim Soo S From the Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seoul, Korea (S.L.); and General Medicine Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston - - 2014
The average of overweight individual can have differential fat depots in target organs or specific compartments of the body. This ectopic fat distribution may be more of a predictive factor for cardiovascular risk than obesity. Abdominal visceral obesity, a representative ectopic fat, is robustly associated with insulin resistance and cardiovascular ...
Cruz-Garcia Lourdes L University of Utah School of Medicine, United - - 2014
Liver X receptors (Lxrs) are master regulators of cholesterol catabolism, driving the elimination of cholesterol from the periphery to the lumen of the intestine. Development of pharmacological agents to activate Lxrs has been hindered by synthetic Lxr agonists induction of massive hepatic de novo lipogenesis and hypertriglyceridemia. Elucidating the function ...
de Sousa Georges G UMR 1331 TOXALIM (Research Centre in Food Toxicology), French National Institute for Agricultural Research (INRA), Laboratory of Xenobiotic's Cellular and Molecular Toxicology, 400 route des Chappes, BP 167, Sophia-Antipolis Cedex, France desousa@sophia.inra.fr - - 2014
French consumers are exposed to mixtures of pesticide residues in part through food consumption. As a xenosensor, the pregnane X receptor (hPXR) is activated by numerous pesticides, the combined effect of which is currently unknown. We examined the activation of hPXR by seven pesticide mixtures most likely found in the ...
Kooijman Sander S Leiden University Medical Center, Netherlands; - - 2014
The melanocortin system is an important regulator of energy balance and MC4R deficiency is the most common monogenic cause of obesity. We investigated whether the relationship between melanocortin system activity and energy expenditure is mediated by brown adipose tissue (BAT) activity. Therefore, female APOE*3-Leiden.CETP transgenic mice were fed a Western-type ...
Bedarida Tatiana T UMR-S 1140 INSERM - Faculty of Pharmacy, Paris Descartes University, Sorbonne Paris Cité, Paris, - - 2014
High protein - low carbohydrate (HP-LC) diets have become widespread. Yet their deleterious consequences, especially on glucose metabolism and arteries, have already been underlined. Our previous study has already shown glucose intolerance with major arterial dysfunction in very old mice subjected to an HP-LC diet. The hypothesis of this work ...
Pérez-Pérez Antonio - - 2014
Abstract Reproductive function is dependent on energy resources. The role of weight, body composition, fat distribution and the effect of diet have been largely investigated in experimental female animals as well as in women. Any alteration in diet and/or weight may induce abnormalities in timing of sexual maturation and fertility. ...
Rama Sowmya S Department of Meat and Marine Sciences, CSIR-Central Food Technological Research Institute, Mysore 570020, - - 2014
This study is aimed at evaluating the protective effect of shrimp carotenoids on ammonia stress in common carp. Crude carotenoid extract from shrimp exoskeleton, astaxanthin and astaxanthin ester fractionated from crude extract was fed to the common carp fingerlings at 100 and 200ppm concentration by incorporating carotenoids into feed. Experimental ...
Seyedmajidi Seyed Ali SA Dental Materials Research Center, School of Dentistry, Babol University of Medical Sciences, Babol, - - 2014
Zinc (Zn) is an essential nutrient that is required in humans and animals for the growth, development, and maintenance of healthy bones. The aim of this study is to investigate the effects of zinc-deficient nutrition on the dental, mandibular, maxillary, and cranial dimensions of rats. This experimental study was carried ...
Vuletic Simona S Northwest Lipid Metabolism and Diabetes Research Laboratories, 401 Queen Anne Ave N, University of Washington, Department of Medicine, Seattle, WA 98109, - - 2014
Apolipoprotein E (apoE), phospholipid transfer protein (PLTP) activity, lipids, total tau and beta amyloid 1-42 (Aβ42) were measured in cerebrospinal fluid (CSF) from controls (n=38) and multiple sclerosis (MS) patients (n=91). ApoE and PLTP activity were significantly reduced in MS compared to non-inflammatory disease controls (NINDC; p<0.05). In NINDC and ...
Loprinzi Paul P Department of Exercise Science, Donna and Allan Lansing School of Nursing and Health Sciences, Bellarmine University, Louisville, Kentucky, - - 2014
No studies have addressed the "fit but fat" paradigm using accelerometry data. The study was to determine if 1) higher levels of accelerometer-determined physical activity are favorably associated with biomarkers in overweight or obese persons (objective 1); and 2) overweight or obese individuals who are sufficiently active have better or ...
Marsche Gunther G Institute of Experimental and Clinical Pharmacology, Medical University of Graz, - - 2014
Epidemiological and clinical studies have shown a consistent association of psoriasis with systemic metabolic disorders including an increased prevalence of diabetes, obesity and cardiovascular disease. Psoriasis is accompanied by systemic inflammation and low levels of high-density lipoprotein (HDL)-cholesterol. Recent studies provided clear evidence that psoriasis affects HDL composition and function. ...
Liang Lei L Department of Cardiology, The People's Hospital of Shaanxi Province, Xi'an, China; Department of Cardiology, The First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, - - 2014
Autophagy, a conservative degradation process for long-lived and damaged proteins, participates in a variety of biological processes including obesity. However, the precise mechanism of action behind obesity-induced changes in autophagy still remains elusive. This study was designed to examine the role of the antioxidant catalase in high fat diet-induced changes ...
Csonka C C University of Szeged and Pharmahungary Group, Szeged, - - 2014
It has been previously shown that hyperlipidemia interferes with cardioprotective mechanisms. Here, we investigated the interaction of hyperlipidemia with cardioprotection induced by pharmacological activators of ATP-sensitive K+- (KATP) channels. Hearts isolated from rats fed a 2% cholesterol-enriched diet or normal diet for 8 wk were subjected to 30 min of ...
Traversi I I Department of Earth, Environment and Life Sciences (DiSTAV), University of Genoa, Italy; Interuniversity Consortium INBB, Rome, Italy. Electronic address: - - 2014
A wide range of endocrine disrupter chemicals can mimic steroid hormones causing adverse health effects. Nonylphenol (NP) and t-octhylphenol (t-OP) are man-made alkylphenolic environmental contaminants possessing controversial endocrine disruption properties. This study has investigated the effects of NP and t-OP enriched diets on hepatic tissue and biotransformation activities in the ...
Pashevin D D Bogomoletz Institute of Physiology, Department of general and mollecular patophysiology, Kiev, - - 2014
Proteasomal degradation of proteins contributes significantly to the regulation of the vital functions of cells. Disturbances in proteasomal proteolysis play pivotal role in pathologies of the cardiovascular system, such as atherosclerosis. Here, we report data showing the angioprotective properties of quercetin mediated by its effect on proteasomal proteolysis. Experiments were ...
Nishimura Satoshi S Department of Cardiovascular Medicine,Translational Systems Biology and Medicine Initiative,Reserach Division of Cell and Molecular Medicine, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan, - - 2014
Body weight is tightly regulated by food intake and energy dissipation, and obesity is related to decreased energy expenditure (EE). Herein, we show that nucleotide pyrophosphatase/phosphodieseterase 2 (ENPP2, autotaxin) is an adipose-derived, secreted enzyme that controls adipose expansion, brown adipose tissue (BAT) function, and EE. In mice, Enpp2 was highly ...
Coban Hasan B HB Department of Agricultural and Biological Engineering, The Pennsylvania State University, University Park, Pennsylvania, 16802, USA, - - 2014
Phytase is an important feed and food additive, which is both used in animal and human diets. Phytase has been used to increase the absorption of several divalent ions, amino acids, and proteins in the bodies and to decrease the excessive phosphorus release in the manure to prevent negative effects ...
Monfort-Pires Milena M a Department of Nutrition, School of Public Health , University of São Paulo , - - 2014
Objectives: We investigated whether diet quality was associated with leisure-time physical activity (LTPA) and television viewing and the associations of these variables with traditional cardiovascular risk factors and novel biomarkers in individuals at cardiometabolic risk. Methods: A total of 193 prediabetic adults (63.7% women, mean age 54.1 years), screened for a ...
Schiavon Fabiana P M FP Department of Pharmacology and Therapeutic, State University of Maringá, Maringá, Paraná, PR, 87020-900, - - 2014
Liver glycogen catabolism was evaluated in male Swiss mice fed a high-fat diet rich in saturated fatty acids (HFD) or normal fat diet (NFD) during one week. Liver glycogenolysis (LG) and liver glucose production (LGP) were measured either under basal or stimulated conditions (infusion of glycogenolitic agents). Thus, isolated perfused ...
Razzeto Gabriela S GS Department of Biochemistry and Biological Sciences, Faculty of Chemistry, Biochemistry and Pharmacy, National University of San Luis, IMIBIO- SL. CONICET, San Luis, 5700, - - 2014
Soybeans, due to their antioxidant properties, present beneficial health effects. The objective was to evaluate if replacing casein with soy flour, modifies antioxidant defenses in rat liver, compared to animals that continued being fed with casein based diets (normocaloric and hypercaloric). Four groups of rats were used: CC (control casein), ...
Sim Woo-Cheol WC College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul 151-742, Republic of - - 2014
Collaborative regulation of liver X receptor (LXR) and sterol regulatory element binding protein (SREBP)-1 are main determinants in hepatic steatosis, as shown in both animal models and human patients. Recent studies indicate that selective intervention of overly functional LXRα in the liver shows promise in treatment of fatty liver disease. ...
Barbosa Kiriaque Barra Ferreira - - 2014
The aim of this study was to investigate the potential modulators of erythrocyte glutathione peroxidase (GPx) activity in young and apparently healthy individuals. One hundred one individuals (53 women and 48 men) were evaluated for anthropometric measurements, biochemical markers, clinical, dietary, and endogenous and exogenous components of the antioxidant defense ...
Breevoort Sarah R SR From the Department of Pharmacology, University of Virginia, - - 2014
The ability of high-density lipoprotein (HDL) particles to accept cholesterol from peripheral cells, such as lipid-laden macrophages, and to transport cholesterol to the liver for catabolism and excretion in a process termed reverse cholesterol transport (RCT) is thought to underlie the beneficial cardiovascular effects of elevated HDL. The liver X ...
Abro Rani R Department of Animal Nutrition and Management, Swedish University of Agricultural Sciences, P.O. Box 7024, S-75007 Uppsala, - - 2014
Chitinolytic activity, nutrient uptake and intestinal barrier functions were investigated in gut tissues of Arctic charr (Salvelinus alpinus) fed iso-nitrogenous diets based on fish meal, with or without inclusion of zygomycetes (Rhizopus oryzae). We found that gut tissue of Arctic charr had significant chitinase activity, of both endo- and exo-chitinase ...
Calkin Anna C AC Diabetes and Dyslipidaemia, Baker - - 2014
Rationale: The E3 ubiquitin ligase IDOL triggers lysosomal degradation of the LDL receptor. The tissue-specific effects of the IDOL pathway on plasma cholesterol and atherosclerosis have not been examined. Objective: Given that the liver is the primary determinant of plasma cholesterol levels, we sought to examine the consequence of effect ...
Mehta Kamal D KD Kamal D Mehta, Department of Molecular and Cellular Biochemistry, The Ohio State University College of Medicine, Dorothy M Davis Heart and Lung Center, Columbus, OH 43210, United - - 2014
Protein kinase C-β (PKCβ), a member of the lipid-activated serine/threonine PKC family, has been implicated in a wide range of important cellular processes. Very recently, the novel role of PKCβ in the regulation of triglyceride homeostasis via regulating mitochondrial function has been explored. In this review, I aim to provide ...
Kontush Anatol A National Institute for Health and Medical Research (INSERM), UMR-ICAN 1166; University of Pierre and Marie Curie - Paris 6; Pitié - Salpétrière University Hospital; ICAN; Paris, France - - 2014
Low plasma levels of HDL-cholesterol (HDL-C) represent a strong and independent risk factor for cardiovascular disease. HDL particles display a wide spectrum of atheroprotective activities, which include effluxing cellular cholesterol, diminishing cellular death, decreasing vascular constriction, reducing inflammatory response, protecting from pathological oxidation, combating bacterial infection, lessening platelet activation, regulating ...
Tavernier Annabelle A Institut National de la Santé et de la Recherche Médicale (INSERM) Unité Mixte de Recherche en Santé (UMRS) 1149, Unité de Formation et de Recherche (UFR) de Médecine Paris Diderot, Sorbonne Paris Cite, Paris, - - 2014
The importance of B-isoform of leptin receptor (LEPR-B) signaling in the hypothalamus, pancreas, or liver has been well characterized, but in the intestine, a unique site of entry for dietary nutrition into the body, it has been relatively ignored. To address this question, we characterized a mouse model deficient for ...
Thomsen Karen Louise KL Department of Hepatology and Gastroenterology - - 2014
Background: Non-alcoholic steatohepatitis (NASH) is increasing in prevalence, yet the consequences for liver function are unknown. We studied ureagenesis, an essential metabolic liver function of importance for whole-body nitrogen homeostasis, in a rodent model of diet induced NASH. Methods: Rats were fed a high-fat, high-cholesterol diet for 4 and 16 ...
Martin Seth S SS Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, - - 2014
High-density lipoprotein (HDL) is astonishingly complex, but the de facto standard for its measurement has been remarkably simple: total cholesterol content. It is time to prioritize higher-resolution HDL measurement techniques that capture better the biologically and clinically important characteristics of HDL. Scientific advances have ushered in a new era in ...
Verbeek Jef J Department of Hepatology, University Hospitals KU Leuven, Leuven, - - 2014
No therapy for non-alcoholic steatohepatitis (NASH) has been approved so far. Roux-en-y gastric bypass (RYGB) is emerging as a therapeutic option, although its effect on NASH and related hepatic molecular pathways is unclear from human studies. We studied the effect of RYGB on pre-existent NASH and hepatic mitochondrial dysfunction-a key ...
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