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Bates Aj A a Centre for Dairy Excellence , 20 Wilson Street, Geraldine 7930 , New - - 2014
Abstract AIM: To assess the effect of analgesia at disbudding on weight gain and milk intake of dairy calves. Four disbudding protocols were used on 3- to 6-week-old Friesian-Jersey calves. Farm staff disbudded 101 calves without sedation or local analgesia, of which 51 received 20mg meloxicam S/C. Veterinary staff disbudded ...
Laeger Thomas - - 2014
Enhanced fibroblast growth factor 21 (FGF21) production and circulation has been linked to the metabolic adaptation to starvation. Here, we demonstrated that hepatic FGF21 expression is induced by dietary protein restriction, but not energy restriction. Circulating FGF21 was increased 10-fold in mice and rats fed a low-protein (LP) diet. In ...
Martel Sebastián I SI Departamento de Ecología and Center of Applied Ecology and Sustainability (CAPES), Facultad de Ciencias Biológicas, P. Universidad Católica de Chile, Santiago, 6513677, - - 2014
Defense against natural aggressors, such as bacterial infections, requires both energy and an immune-cellular response. However, the question as to how these two components are interconnected in small endotherms by means of the host diet remains only poorly understood. Here, we tested in laboratory mice whether dietary proteins and carbohydrates ...
Lettieri Barbato Daniele D Dept. of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica 1, 00133 Rome, Italy. Electronic address: - - 2014
Adipose tissue should not be considered a simple fat sink but a specialized system that promptly and dynamically responds to variations of nutrients, to fulfil its major role in whole-body energy homeostasis. Perturbation of energy storage and utilization, as well as the expansion of adipose tissue during ageing, are hallmarks ...
Liu Xiaoxi X University of - - 2014
Fenofibrate is a PPARα ligand that has been widely used as a lipid lowering agent in the treatment of hypertriglyceridemia. ABCD2 (D2) is a peroxisomal long-chain acyl-CoA transporter that is highly induced by fenofibrate in the livers of mice. To determine if D2 is a modifier of fibrate responses, wild-type ...
van de Pas Niek C A NC The Netherlands Organization for Applied Scientific Research (TNO), Utrechtseweg 48, P.O. Box 360, 3700 AJ, Zeist, The - - 2014
We used a previously developed physiologically based kinetic (PBK) model to analyze the effect of individual variations in metabolism and transport of cholesterol on pravastatin response. The PBK model is based on kinetic expressions for 21 reactions that interconnect eight different body cholesterol pools including plasma HDL and non-HDL cholesterol. ...
Kuem Narae N Department of Food and Nutrition, Brain Korea 21 PLUS Project, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-749, South - - 2014
The aim of the present study was to investigate the anti-obesity effect of oleuropein on high-fat diet (HFD)-induced body weight gain and visceral adiposity in mice, and to explore the underlying mechanisms involved. C57BL/6N mice were fed with a normal diet (ND), high-fat diet (HFD; 40% fat of total energy) ...
Olea Elena E University of - - 2014
Abstract Obstructive sleep apnea (OSA) consists of sleep-related repetitive obstructions of upper airways which generate episodes of recurrent or intermittent hypoxia (IH). OSA commonly generates cardiovascular and metabolic pathologies defining the obstructive sleep apnea syndrome (OSAS). Literature usually links OSA-associated pathologies to IH episodes which would cause an oxidative status ...
Andrade João Marcus Oliveira JM Laboratory of Health Science, Postgraduate Program in Health Sciences; Universidade Estadual de Montes Claros (UNIMONTES), Montes Claros, Minas Gerais, Brazil; Nursing Department; Universidade Estadual de Montes Claros (UNIMONTES), Montes Claros, Minas Gerais, - - 2014
Angiotensin-(1-7) has been described as a new potential therapeutic tool for the treatment and prevention of metabolic disorders by regulating several pathways in visceral white adipose tissue (vWAT). The aim of this study was to access the proteins differentially regulated by Ang-(1-7) using proteomic analysis of visceral adipose tissue. Male ...
Jiang X Y - - 2014
The aim of this study was to evaluate protein expression patterns of liver in response to subacute ruminal acidosis (SARA) induced by high-concentrate diet. Sixteen healthy mid-lactating goats were randomly divided into 2 groups and fed either a high-forage (HF) diet or a high-concentrate (HC) diet. The HC diet was ...
Schauren B C BC 1Post Graduate Program in Health Sciences: Cardiology,Instituto de Cardiologia/Fundação Universitária de Cardiologia,Porto - - 2014
Lifestyle changes have an impact on lipid metabolism. The overload of circulating lipids may lead to endothelial dysfunction, oxidative stress and exaggerated inflammatory response, which may be further aggravated in the presence of overweight. This study aims to describe the postprandial metabolism and inflammatory response in overweight and normal-weight adolescents. ...
Kunisawa Jun J Laboratory of Vaccine Materials, National Institute of Biomedical Innovation, Osaka 567-0085, Japan; Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan; International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan; Department of Microbiology and Immunology, Kobe University School of Medicine, Kobe 650-0017, Japan; Graduate School of Pharmaceutical Sciences and Graduate School of Dentistry, Osaka University, Osaka 565-0871, Japan; - - 2014
Enhancement of intestinal IgA responses is a primary strategy in the development of oral vaccine. Dietary fatty acids are known to regulate host immune responses. In this study, we show that dietary palmitic acid (PA) and its metabolites enhance intestinal IgA responses. Intestinal IgA production was increased in mice maintained ...
Brake D W DW Department of Animal Sciences and - - 2014
Six duodenally and ileally cannulated steers were used in 3 sequential studies to measure 1) basal nutrient flows from a soybean hull-based diet, 2) small intestinal digestibility of raw cornstarch continuously infused into the duodenum, and 3) responses of small intestinal starch digestion to duodenal infusion of 200 or 400 ...
Desaldeleer Cécile C Département de Médecine de l'Enfant et de l'Adolescent, CHU Rennes, Rennes, France; INRA UR1341 ADNC, Saint Gilles, - - 2014
We recently observed that maternal 18:3n-3 increases piglet jejunal permeability. We hypothesized that this would favor intestinal lipopolysaccharide (LPS) passage and alter gut immune system education toward this bacterial ligand. Sows were fed 18:3n-3 or 18:2n-6 diets throughout gestation and lactation. In each litter, two piglets were given oral Gram-negative ...
Sobesky Julia L JL Department of Psychology and Neuroscience, Center for Neuroscience, University of Colorado Boulder, Boulder, CO 80309, USA. Electronic address: - - 2014
High-fat diet (HFD)-induced obesity is reaching worldwide proportions. In addition to causing obesity, HFDs also induce a variety of health disorders, which includes cognitive decline. Hippocampal function may be particularly vulnerable to the negative consequences of HFD, and it is suspected that 'primed' neuroinflammatory processes may mediate this response. To ...
Rotermund Carola C German Center of Neurodegenerative - - 2014
Parkinson's disease (PD) and diabetes belong to the most common neurodegenerative and metabolic syndromes, respectively. Epidemiological links between these two frequent disorders are controversial. The neuropathological hallmarks of PD are protein aggregates composed of amyloid-like fibrillar and serine-129 phosphorylated (pS129) α-synuclein (AS). To study if diet-induced obesity could be an ...
Wahlang Banrida B Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40202, - - 2014
Polychlorinated biphenyls (PCBs) are persistent organic pollutants associated with non-alcoholic fatty liver disease (NAFLD) in epidemiologic studies. The purpose of this study was to evaluate the hepatic effects of a PCB mixture, Aroclor 1260, whose composition mimics human bioaccumulation patterns, in a mouse model of diet-induced obesity (DIO). Male C57Bl/6J ...
Lu Hung-Jen HJ Department of Food Science, College of Agriculture, National Pingtung University of Science and Technology, Neipu Township, Pingtung County, Taiwan, - - 2014
The protective effects of ruscogenin on nonalcoholic steatohepatitis in hamsters fed a high-fat diet were investigated. Ruscogenin (0.3, 1.0, or 3.0 mg/kg/day) was orally administered by gavage once daily for eight weeks. A high-fat diet induced increases in plasma levels of total cholesterol, triglycerides, and free fatty acids, while the degree ...
Nishitani Naoko N Department of Nursing, Sugiyama Jogakuen University, - - 2014
Relationships between work-related psychological and physical stress responses and counts of white blood cells (WBCs), neutrophils, and lymphocytes were investigated in 101 daytime workers. Counts of WBCs and neutrophils were positively associated with smoking and inversely correlated with high density lipoprotein (HDL)-cholesterol levels. Additionally, general fatigue score as measured by ...
Meakin Paul J PJ Medical Research Institute, Division of Cardiovascular and Diabetes - - 2014
Mice lacking transcription factor NF-E2 p45-related factor 2 (Nrf2) develop more severe non-alcoholic steatohepatitis (NASH), with cirrhosis, than wild-type (Nrf2(+/+)) mice when fed a high-fat (HF) diet for 24 weeks. Although NASH is usually associated with insulin resistance, HF-fed Nrf2(-/-) mice exhibited better insulin sensitivity than HF-fed Nrf2(+/+) mice. In ...
Deng Jiao J Department of Anesthesiology, University of Virginia, Charlottesville, VA22908, USA Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi'an, People's Republic of - - 2014
About one third of American adults and 20% of teenagers are obese. Obesity and its associated metabolic disturbances including hyperlipidemia are risk factors for cardiovascular diseases including stroke. They can worsen neurological outcome after stroke. We determined whether obesity and hyperlipidemia could induce cerebral vascular remodeling via matrix metalloproteases (MMP) ...
Paek David S DS Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, David Geffen School of Medicine, University of California, Torrance, Los Angeles, CA, - - 2014
Maternal food restriction (MFR) causes intrauterine growth restriction, a known risk factor for developing chronic lung disease. However, it is unknown whether this negative outcome is gender specific or preventable by blocking the MFR-induced hyperglucocorticoidism. Using a well-established rat model, we used metyrapone (MTP), an inhibitor of glucocorticoid synthesis, to ...
Oishi Katsutaka K aBiological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki bDepartment of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa cDepartment of Applied Biological Science, Graduate School of Science and Technology, Tokyo University of Science, Noda, Chiba, - - 2014
We evaluated associations between obesity induced by a high-fat diet (HFD) and the environmental light-dark (LD) cycle that entrains the master circadian clock located in the suprachiasmatic nucleus of mammals. Mice were fed normal diet or HFD for 6 weeks in individual cages with running wheels under a normal 12 h ...
Bussey Charlotte C University of - - 2014
Perivascular adipose tissue (PVAT) exerts an anticontractile effect that is lost in obesity. A recent study reported that bariatric surgery can reverse the damaging effects of obesity on PVAT function with accompanying reduction in systolic blood pressure. However, PVAT function has not previously been characterised following weight loss induced by ...
Neha CNS and CVS Research Laboratory, Pharmacology Division, Department of Pharmaceutical Sciences and Drug Research, Faculty of Medicine, Punjabi University, Patiala, 147002, Punjab, India, - - 2014
A huge body evidences suggest that obesity is the single great risk factor for the development of dementia. Recently, silymarin, a flavonoid, clinically in use as a hepatoprotectant, has been reported to prevent amyloid beta-induced memory impairment by reducing oxidative stress and inflammation in mice brain. However, its potential in ...
Matikainen Niina N Department of Medicine, Cardiovascular Research Unit, Diabetes and Obesity Research Program, Heart and Lung Center, University of Helsinki, Finland; Division of Endocrinology, Helsinki University Central Hospital, University of Helsinki, - - 2014
Postprandial hypertriglyceridemia is an important risk factor for cardiovascular disease. The mechanisms are still unclear. Here it was tested if hepatic de novo lipogenesis (DNL) and lipid oxidation influence the postprandial responses of triglyceride-rich lipoproteins (TRL) in humans. The contribution of hepatic DNL to hepatic TRL production was analyzed in ...
Booman Marije M Department of Ocean Sciences, Memorial University of Newfoundland, St. John's, NL A1C 5S7 Canada. Electronic address: - - 2014
To improve sustainability of aquaculture, especially for carnivorous species like Atlantic cod, replacement of fish oil-based diets with vegetable oil-based diets has been studied. The use of vegetable oil in fish feeds can significantly change the fatty acid composition of fish tissues, and given the importance of fatty acids in ...
Jun Hee-Jin HJ Laboratory of Nutrient Sensing and Adipocyte Signaling, Pennington Biomedical Research Center, Baton Rouge, - - 2014
The transcriptional coactivator peroxisome proliferator-activated receptor γ coactivator (PGC)-1α and its splice variant N terminal (NT)-PGC-1α regulate adaptive thermogenesis by transcriptional induction of thermogenic and mitochondrial genes involved in energy metabolism. We previously reported that full-length PGC-1α (FL-PGC-1α) is dispensable for cold-induced nonshivering thermogenesis in FL-PGC-1α(-/-) mice, since a slightly ...
Constantinou Caterina C University of Patras Medical School, - - 2014
Here, we investigated how low density lipoprotein receptor deficiency (Ldlr(-/-)) modulates the effects of testosterone on obesity and related metabolic dysfunctions. Though sham operated Ldlr(-/-) mice fed western-type diet for 12 weeks became obese and showed disturbed plasma glucose metabolism and plasma cholesterol and triglyceride profiles, castrated mice were resistant ...
Zhang Lei L Neuroscience Division, Garvan Institute of Medical Research, St Vincent's Hospital, Sydney 2010, Australia ; St Vincent's Clinical School, UNSW Australia, Sydney 2052, - - 2014
Neuropeptide Y (NPY) and noradrenaline are commonly co-expressed in sympathetic neurons. Both are key regulators of energy homeostasis and critical for stress-coping. However, little is known about the specific function of NPY in the catecholaminergic system in these regulations. Here we show that mice with NPY expression only in the ...
Wang Bin B State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China. binw1984@163.com - - 2014
High-fat diet (HFD)-induced obesity is often associated with immune dysfunction. Resveratrol (trans-3,5,4'-trihydroxystilbene), which has well-founded immunity-related beneficial properties, was used to elucidate the regulatory effect on glucose metabolism and T-lymphocyte subsets in the development of HFD-induced obesity. Resveratrol, being associated with decreases of plasma leptin and plasma lipids and the ...
Wu Chonglong C Institute for Fetology, First Hospital of Soochow University, Suzhou, - - 2014
This study determines the influence of a prenatal high-sucrose (HS) diet on angiotensin II (Ang II)-mediated pressor response and determine the underlying mechanism. Pregnant rats were provided with a 20% sucrose solution diet throughout gestation. Blood pressure and vascular response to Ang II were measured in 5-month-old adult offspring. Currents ...
Armani Andrea A *Laboratory of Cardiovascular Endocrinology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Pisana, Rome, - - 2014
The mineralocorticoid receptor (MR) controls adipocyte function, but its role in the conversion of white adipose tissue (WAT) into thermogenic fat has not been elucidated. We investigated responses to the MR antagonists spironolactone (spiro; 20 mg/kg/d) and drospirenone (DRSP; 6 mg/kg/d) in C57BL/6 mice fed a high-fat (HF) diet for ...
Yamada Shunsuke S 1Kyushu - - 2014
Hyperphosphatemia contributes to increased cardiovascular mortality through vascular calcification (VC) in patients with chronic kidney disease (CKD). Malnutrition and inflammation are also closely linked to increased risk of cardiovascular death in CKD. However, the effects of Pi overload on inflammation and malnutrition remain to be elucidated. The aim of the ...
Jung Yun-A YA Division of Endocrinology and Metabolism, Department of Internal Medicine, Keimyung University School of Medicine, Daegu, South - - 2014
Accumulating evidence suggests that inhibitors of dipeptidyl peptidase-4 (DPP-4), such as sitagliptin, may play an important role in the prevention of non-alcoholic steatohepatitis (NASH). This study was conducted to elucidate whether sitagliptin could prevent steatohepatitis by inhibiting pathways involved in hepatic steatosis, inflammation, and fibrosis. C57BL/6 mice were fed a ...
Salim Chinnu C Academy of Scientific and Innovative Research (AcSIR), Anusandhan Bhawan, New Delhi, India; Food Protectants and Infestation Control Department, CSIR-Central Food Technological Research Institute, Mysore-570020, - - 2014
Several studies have demonstrated that high glucose feeding induced oxidative stress and apoptosis thereby affecting growth, fertility, aging and lifespan in Caenorhabditis elegans. Earlier studies from our laboratory have clearly established the propensity of monocrotophos, an OPI to alter the physiological and behavioural responses of C. elegans. The present study ...
Burns T A TA The Ohio State University College of Veterinary Medicine, Columbus, - - 2014
In EMS-associated laminitis, laminar failure may occur in response to energy failure related to insulin resistance (IR) or to the effect of hyperinsulinemia on laminar tissue. 5'-Adenosine-monophosphate-activated protein kinase (AMPK) is a marker of tissue energy deprivation, which may occur in IR. To characterize tissue AMPK regulation in ponies subjected ...
de Albuquerque Taddei Silvana Rodrigues SR a Immunopharmacology, Department of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte/MG, - - 2014
Objective: To investigate the effect of Lithothamnium sp (LTT) supplement, a calcium-rich alga widely used for mineral reposition, on strain-induced (orthodontic tooth movement [OTM]) and infection-induced bone resorption (periodontal disease [PD]) in mice. Materials and Methods: Mice were divided into two bone resorption models: one with an orthodontic appliance and ...
Charradi Kamel K Laboratoire des Substances Bioactives (LSBA), Centre de Biotechnologie de Borj Cedria, BP-901, 2050, Hammam-Lif, Tunisia, - - 2014
Obesity is a tremendous public health problem, characterized by ectopic deposition of fat into non-adipose tissues as liver generating an oxidative stress that could lead to steato-hepatitis. Grape seed and skin extract (GSSE) is a complex mixture of polyphenolics exhibiting robust antioxidative properties. We hypothesize that GSSE could protect the ...
Sun Kai K Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, - - 2014
We recently reported that local overexpression of VEGF-A in white adipose tissue (WAT) protects against diet-induced obesity and metabolic dysfunction. The observation that VEGF-A induces a "brown adipose tissue (BAT)-like" phenotype in WAT prompted us to further explore the direct function of VEGF-A in BAT. We utilized a doxycycline (Dox)-inducible, ...
Heiker John T JT Leipzig - - 2014
We have recently demonstrated that C57BL/6NTac and C57BL/6JRj substrains are significantly different in their response to high fat diet induced obesity (DIO). The C57BL/6JRj substrain seems to be protected from DIO and genetic differences between C57BL/6J and C57BL/6N substrains at 11 SNP loci have been identified. To define genetic variants ...
Siddiqi Hasan Salman HS 1Natural Product Research Division, Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi-74800, Pakistan 2Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan 3College of Health Sciences, Mekelle University, - - 2014
: This study was aimed to offer possible pharmacological basis regarding the remedial utilization of Wrightia tinctoria in hypertension and dyslipidemia in certain South Asian traditional systems of medicine, using in vivo as well as in vitro assays. The aqueous-methanolic extract of Wrightia tinctoria seeds (Wt.Cr) caused a dose-dependent (1-10 ...
Peiffer Daniel S DS 1Medicine, Medical College of - - 2014
Diets containing either freeze-dried black raspberries (BRB) or their polyphenolic anthocyanins (AC) have been shown to inhibit the development of N-nitrosomethylbenzylamine (NMBA)-induced esophageal cancer in rats. The present study was conducted to determine if PCA, a major microbial metabolite of BRB AC, also prevents NMBA-induced esophageal cancer in rats. F344 ...
Fan Eric Wen-Chou EW Division of Urology, Department of Surgery, Chi-Mei Medical Center, Tainan, - - 2014
To study the role of tumor necrosis factor-α in bladder dysfunction associated with obesity. Male 8-week-old C57BL/6J mice were divided into three groups: (i) control mice; (ii) vehicle-treated high-fat diet-fed mice; and (iii) etanercept-treated high-fat diet-fed mice. High-fat diet feeding lasted for 12 weeks, vehicle or etanercept (0.8 mg/kg/day, a tumor ...
Baumgarner Katherine M KM University of North Carolina Wilmington, Department of Psychology, Wilmington, NC, USA. Electronic address: - - 2014
Obesity increases susceptibility for numerous diseases and neurological disorders including cardiovascular disease, metabolic syndrome, and dementia. One factor that may contribute to the increased risk for these conditions is the development of chronic inflammation. The current study evaluated whether diet-induced obesity (DIO) affects cognitive performance by increasing neuroinflammation and prolonging ...
Bouchard-Mercier Annie A Institute of Nutrition and Functional Foods (INAF), Laval University, 2440 Hochelaga Blvd., Quebec, G1V 0A6, - - 2014
A large inter-individual variability in the plasma triglyceride (TG) response to fish oil consumption has been observed. The objective was to investigate the gene-diet interaction effects between single-nucleotide polymorphisms (SNPs) within glucokinase (GCK) gene and dietary carbohydrate intakes (CHO) on the plasma TG response to a fish oil supplementation. Two ...
Jlali Maamer M INRA, UR83 Recherches Avicoles, F-37380 Nouzilly, - - 2014
The enzyme β,β-carotene-15,15'-mono-oxygenase 1 (BCMO1) is responsible for the symmetrical cleavage of β-carotene into retinal. We identified a polymorphism in the promoter of the BCMO1 gene, inducing differences in BCMO1 mRNA levels (high in adenines (AA) and low in guanines (GG)) and colour in chicken breast muscle. The present study ...
Shin Sung Joon SJ 1Department of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk University-Seoul, Republic of - - 2014
Sodium sensitivity (SS) is a phenomenon in which significant changes in blood pressure (BP) are observed based on sodium intake. The renin-angiotensin-aldosterone system plays a critical role in sodium handling and hypertension. We identified the specific responses of renin and aldosterone based on dietary sodium intake and revealed the relationship ...
Qin Zhexue Z Vascular Biology Section, Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA; Department of Cardiovascular Diseases, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, - - 2014
Diet-induced obesity and metabolic syndrome are important contributors to cardiovascular diseases. The decreased nitric oxide (NO) bioactivity in endothelium and the impaired response of smooth muscle cell (SMC) to NO significantly contribute to vascular pathologies, including atherosclerosis and arterial restenosis after angioplasty. Sarco/endoplasmic reticulum Ca(2+) ATPase (SERCA) is an important ...
Anderson Jacqueline M JM School of Pharmaceutical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes, 580, B17, Sao Paulo 05508-000, SP, - - 2014
The proprotein convertase subtilisin/kexin type 9 (PCSK9) has a key role in the regulation of plasma low-density lipoprotein (LDL) cholesterol by enhancing the degradation of LDL receptor. Functional variants in PCSK9 have been associated with differences in plasma lipids and may contribute to the variability of the response to cholesterol-lowering ...
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