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Jia Guanghong G From the Division of Endocrinology and Metabolism, Department of Medicine (G.J., J.H., B.P.B., V.G.D., A.R.A., M.R.H., A.T.W.-C., J.R.S.), Division of Nephrology and Hypertension, Department of Medicine (A.T.W.-C.), Department of Medical Pharmacology and Physiology (V.G.D., J.R.S.), Diabetes and Cardiovascular Center (G.J., J.H., B.P.B., V.G.D., A.R.A., M.R.H., A.T.W.-C., J.R.S.), and Department of Radiology (L.M.), University of Missouri School of Medicine, Columbia; and Research Service, Harry S. Truman Memorial Veterans Hospital, Columbia, MO (G.J., J.H., B.P.B., L.M., V.G.D., A.R.A., M.R.H., A.T.W.-C., - - 2014
The rising obesity rates parallel increased consumption of a Western diet, high in fat and fructose, which is associated with increased uric acid. Population-based data support that elevated serum uric acids are associated with left ventricular hypertrophy and diastolic dysfunction. However, the mechanism by which excess uric acid promotes these ...
Wang Hsueh-Fang HF Institute of Biomedical Nutrition, Hungkuang University, Taichung 43302, Taiwan, - - 2014
Through a high-fat diet, obesity leads to cardiomyocyte dysfunction and apoptosis. In addition, there is no evidence that probiotics have potential health effects associated with cardiac apoptosis in obese rats. The present study aimed to explore the effects of probiotics on obesity and cardiac apoptosis in rats fed a high-fat ...
Petta Salvatore S Sezione di Gastroenterologia, DiBiMIS, University of Palermo, Italy. Electronic address: - - 2014
Nonalcoholic fatty liver disease (NAFLD) has been associated with increased cardiovascular risk, including coronary artery disease and cardiac dysfunction. In addition, recent evidence highlighted the possible role of epicardial fat as a new cardiometabolic risk factor. We tested the correlation between epicardial fat, alterations in cardiac geometry and function and ...
Boudrahem-Addour Nassima N Laboratory of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Sciences and Technology , Houari Boumediene, Algiers , Algeria - - 2014
Abstract β-Thalassemia (β-thal) is a genetic disorder, representing a major health problem in Algeria. It is associated with altered lipid levels and a state of oxidative stress that can lead to cardiac complications and premature death. We examined the plasma lipid profile and redox status of 46 patients with β-thal ...
Melchior Rw R Department of Perfusion Services, The Children's Hospital of Philadelphia, Philadelphia, PA, USA - - 2014
There is a population of children with epilepsy that is refractory to antiepileptic drugs. The ketogenic diet, a high-fat, low-carbohydrate regimen, is one alternative treatment to decrease seizure activity. Special considerations are required for patients on the ketogenic diet undergoing cardiopulmonary bypass (CPB) to prevent exposure to glucose substrates that ...
Lang Hongmei H Center for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing Institute of Hypertension , Chongqing 400042, - - 2014
High salt diet induces cardiac remodelling and leads to heart failure, which is closely related to cardiac mitochondrial dysfunction. Transient receptor potential channels are implicated in the pathogenesis of cardiac dysfunction. We investigated whether activation of transient receptor potential vanilloid (subtype 1) (TRPV1) by dietary capsaicin can prevent high salt ...
Andersson Charlotte C The Framingham Heart Study, Framingham, MA, - - 2014
Diet soda consumption increases cardiometabolic risk. The aim of this investigation was to assess the relations between self-reported soda consumption and subclinical cardiac remodeling. We assessed the relations between self-reported soda consumption and left ventricular mass (LVM) and left atrial dimension (LAD) (both standardized within sex) in a sample of ...
Hu Ming Chang MC Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, Departments of Internal Medicine, ming-chang.hu@utsouthwestern.edu - - 2014
Cardiac dysfunction in CKD is characterized by aberrant cardiac remodeling with hypertrophy and fibrosis. CKD is a state of severe systemic Klotho deficiency, and restoration of Klotho attenuates vascular calcification associated with CKD. We examined the role of Klotho in cardiac remodeling in models of Klotho deficiency-genetic Klotho hypomorphism, high ...
Densupsoontorn Narumon N Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, - - 2014
Post-operative chylothorax can be cured by a medium-chain triglyceride (MCT)-rich diet. However, there is concern that an MCT-rich diet results in clinical and biochemical deficiencies in fat-soluble vitamins and fatty acids. We compared fat-soluble vitamins status and fatty acids status before and after administration of an MCT-rich diet. Nine children ...
Rönn Monika M Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala University, Uppsala, - - 2014
Since bisphenol A (BPA) has been shown to induce obesity in experimental studies, we explored the associations between BPA and fat mass, fat distribution and circulating levels of adiponectin, leptin and ghrelin in humans. In the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS), fat mass and fat distribution ...
Mull Aaron J AJ Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL 60612, - - 2014
Due to their previously identified naturally and chronically increased levels of skeletal muscle pAMPK we hypothesized and now investigated whether the MRL/MpJ (MRL) mice would be resistant to high fat diet (HFD)-induced metabolic changes. Three-week old male MRL and control C57Bl/6 (B6) mice were randomly assigned to 12weeks of high ...
Eisenach John H JH Departments of Anaesthesiology, Physiology and Biomedical Engineering, Mayo Clinic, 200 First St. SW, Rochester, MN, 55905, USA - - 2014
Dietary sodium affects function of the beta-2 adrenoceptor (ADRB2). We tested the hypothesis that haplotype variation in the ADRB2 gene would influence the cardiovascular and regional vasodilator responses to sympathoexcitatory manoeuvres following low, normal, and high sodium diets, and ADRB2-mediated forearm vasodilation in the high sodium condition. Seventy-one healthy young ...
Yamaguchi Takehiro T Department of Cardiovascular Medicine, Osaka City University Medical School, - - 2014
Metabolic syndrome (MetS) induces serious complications; therefore, we developed a noninvasive MetS model using an extremely small minipig, the Microminipig. For 8 weeks, Microminipigs were administrated a high-fat and high-cholesterol diet (HFCD) for atherosclerosis and N(G)-nitro-l-arginine methyl ester (l-NAME) for inhibiting nitric oxide synthase. HFCD significantly increased serum low-density lipoprotein ...
Chen On O Department of Cardiology, Maimonides Medical Center, Brooklyn, NY, - - 2014
To investigate the association of pericardial, mediastinal, and intrathoracic fat volumes with the presence and severity of coronary artery disease (CAD), metabolic syndrome (MS), and cardiac risk factors (CRFs). Two hundred and sixteen consecutive patients who underwent cardiac magnetic resonance (CMR) imaging and had a coronary angiogram within 12 months ...
Littlejohns Ben B Bristol Heart Institute, School of Clinical Sciences, Faculty of Medicine and Dentistry, University of Bristol, Bristol, - - 2014
Background: We have recently shown that hearts of mice fed high-fat diet exhibit increased vulnerability to ischaemia and reperfusion (I/R) in parallel to changes in catalase protein expression, mitochondrial morphology and intracellular diastolic Ca(2+). Aims: To determine whether switching from high-fat back to normal diet alters vulnerability to I/R and ...
Diwan Vishal V The University of - - 2014
Gender contributes to differences in incidence and progression of chronic kidney disease (CKD) and associated cardiovascular disease. 0.25% adenine diet for 16 weeks was used to induce kidney damage in male and female Wistar rats (n=12/group). Kidney function (blood urea nitrogen/BUN, plasma creatinine/PCr, proteinuria) and structure (glomerular damage, tubulointerstitial atrophy, ...
Catar R A RA Department of Medicine III, Division of Vascular Endothelium and Microcirculation, University Hospital Carl Gustav Carus, TU Dresden, Dresden, - - 2014
Obesity is a well-known risk factor of atherosclerosis and heart failure. In the human heart, a local endothelin system containing prepro-endothelin-1, endothelin-converting enzyme-1, and endothelin receptors A and B has been described. The endothelin system is activated in heart failure; however, the impact of obesity on the cardiac endothelin system ...
Garg Munish M Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, - - 2014
The objective of this study was to evaluate the cardioprotective effect of herbal bioactive compound ammonium glycyrrhizinate against doxorubicin-induced cardiomyopathy, in experimental animals. Ammonium glycyrrhizinate (50, 100, 200 mg/kg, p.o.) was administered for four weeks in albino rats. Cardiomyopathy was induced with a dose of 2.5 mg/kg i.p. of doxorubicin ...
Tada Hayato H Center for Human Genetic Research, Massachusetts General Hospital, Boston & Broad Institute, Program in Medical and Population Genetics, Cambridge, - - 2014
-Plasma lipid levels as well as coronary artery disease (CAD) have been shown to be highly heritable with estimates ranging from 40%-60%. However, top variants detected by large-scale genome-wide association studies (GWAS) explain only a fraction of the total variance in plasma lipid phenotypes and CAD. -We performed a conditional ...
Puri Rishi R Cleveland Clinic Coordinating Center for Clinical Research, Cleveland, Ohio; Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, - - 2014
Guidelines now recommend high-intensity statin therapy in all patients with proven atherosclerotic disease. Yet the impact of baseline lipoprotein and C-reactive protein (CRP) levels on measures of disease regression to this therapy are unknown. The aim of this study was to test the hypothesis that high-intensity statin therapy causes equivalent ...
Sabe Ashraf A AA Division of Cardiothoracic Surgery, Cardiovascular Research Center, Warren Alpert School of Medicine, Brown University, Providence, - - 2014
The perioperative administration of pleomorphic statin drugs has been implicated in improving outcomes after cardiac surgery. Adaptive autophagy is a highly conserved cellular process that allows for the elimination of dysfunctional cell components in response to stress and survival under starving conditions. We sought to investigate the effects of the ...
Ingolfsdottir Gudrun G Department of Psychology, University of Iceland, Reykjavik, Iceland. Electronic address: - - 2014
The aim of the study was to evaluate trends in body image and dieting among 16-19-year-old students in Iceland from 2000 to 2010. Data from four cross-sectional surveys conducted among Icelandic students in 26 junior colleges using four time points were compared to examine changes in body image and dieting. ...
Khamis Ramzi Y RY Vascular Sciences Section, National Hearth and Lung Institute, Imperial College - - 2014
We aimed to study oxidised low density lipoprotein (oxLDL) as a near infrared fluorescence (NIRF) molecular imaging target, using a monoclonal anti-oxLDL autoantibody (LO1) in mouse and rabbit atherosclerosis models. LO1 and an IgG3k control antibody were labelled with a NIRF dye to give LO1-750 and IgG3-750. Targeting to atherosclerosis ...
Mineda Kazuhide K Tokyo and Tokushima, Japan From the Department of Plastic Surgery, University of Tokyo School of Medicine; and the Department of Plastic Surgery, University of Tokushima School of - - 2014
Autologous fat injection into the breast has been performed widely for breast augmentation and reconstruction because of recent technical and scientific advancements. However, it is important to learn what occurs and how problematic it can be if fat grafting is not conducted appropriately. Oil cysts were explanted from three subjects ...
Lee Yunjung Y Department of Radiology, Seoul National University Hospital, Seoul, - - 2014
Given the potential confounding effect of fat on apparent diffusion coefficient (ADC) in the liver, we have assessed diffusion tensor imaging in liver fibrosis with minimal effect of fat on ADC and fractional anisotropy (FA). Thirty-six mice were used, among which 20 mice were CCl4 treated for fibrosis induction. Diffusion ...
Koziolek Mirko - - 2014
The aim of this magnetic resonance imaging (MRI) study was to investigate gastric emptying after intake of a high-caloric and high-fat standard meal as recommended by FDA and EMA for food-effect bioavailability and fed bioequivalence studies. 12 healthy human subjects (7 male, 5 female) received the standard meal after an ...
Narayan Sreenath S Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, - - 2014
To explore the sensitivity of high-field small animal magnetic resonance imaging to dynamic changes in fat content in the liver and to characterize the effect of prandial state on imaging studies of hepatic fat. A total of three timepoints were acquired using asymmetric spin-echo acquisitions for 12 mice with 24-hour ...
Kashiwagi Manabu M Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, United States of - - 2014
The presence of cholesterol crystals is a hallmark of atherosclerosis, but until recently, such crystals have been considered to be passive components of necrotic plaque cores. Recent studies have demonstrated that phagocytosis of cholesterol crystals by macrophages may actively precipitate plaque progression via an inflammatory pathway, emphasizing the need for ...
Nakagomi Akihiro A Department of Internal Medicine and Cardiology, Tama-Nagayama Hospital, Nippon Medical School, - - 2014
Objective Low serum cholesterol is associated with a poor prognosis in patients with chronic heart failure (CHF). However, the relationships between the serum cholesterol level, production of monocyte proinflammatory cytokines and long-term prognosis in CHF patients remain unclear. Methods A total of 95 CHF patients who had not been treated ...
Shin Hyun Joon HJ Baylor University Medical Center, Baylor Heart and Vascular Institute, Baylor Jack and Jane Hamilton Heart and Vascular Hospital, Dallas, Tex., - - 2014
High-density lipoprotein cholesterol (HDL-C) contains dozens of apoproteins that participate in normal cholesterol metabolism with a reliance on renal catabolism for clearance from the body. The plasma pool of HDL-C has been an excellent inverse predictor of cardiovascular events. However, when HDL-C concentrations have been manipulated with the use of ...
Lui Matthew M 0000-0002-4981-8853 Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, 920 E 28th Street, Minneapolis, MN 55407, - - 2014
Lipid apheresis is used to treat patients with severe hyperlipidemia by reducing low-density lipoprotein cholesterol (LDL-C). This study examines the effect of apheresis on the lipid panel and cardiac event rates before and after apheresis. An electronic health record screen of ambulatory patients identified 11 active patients undergoing lipid apheresis ...
Gao Feng F Department of Hypertension and Endocrinology, Center for Hypertension and Metabolic Diseases, Chongqing Institute of Hypertension, Daping Hospital, Third Military Medical University, Chongqing 400042, - - 2014
High-salt diet-induced cardiac hypertrophy and fibrosis are associated with increased reactive oxygen species production. Transient receptor potential vanilloid type 1 (TRPV1), a specific receptor for capsaicin, exerts a protective role in cardiac remodeling that resulted from myocardial infarction, and peroxisome proliferation-activated receptors δ (PPAR-δ) play an important role in metabolic ...
Girolami Antonio - - 2013
The object of the investigation was the Lucanian dry sausage appearance, meant as color and visible fat ratio. The study was carried out on dry sausages produced in 10 different salami factories and seasoned for 18days on average. We studied the effect of the raw material origin (5 producers used ...
Anis K H - - 2013
We describe a 56-year-old man with an intrasellar craniopharyngioma who underwent transphenoidal resection and abdominal fat grafting of the dural opening. Follow-up MRI showed hypertrophy of the sellar fat graft concurrent with the patient's weight gain. To our best of knowledge sellar fat graft hypertrophy has not been reported before.
Chang Hing-Chiu - - 2013
Purpose:To evaluate the effectiveness of three fat measurement methods for parotid glands in healthy subjects, with or without metallic dental implants.Materials and Methods:The institutional review board approved this study, with informed consent obtained from 114 volunteers undergoing magnetic resonance (MR) imaging at 1.5 T. Fat-saturated (FS) and non-fat-saturated (NFS) fast ...
Sussman Dafna D Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Canada. - - 2013
The use of the ketogenic diet (KD) among women of child-bearing age has been increasing, leading to increased interest in identifying the diet's suitability during gestation. To date, no studies have thoroughly investigated the effect of a gestational KD on offspring growth. Since ketones have been reported to play a ...
Uchida Aki - - 2013
The primary function of the small intestine is digesting and absorbing nutrients from consumed food. Because of this, the small intestine is often thought of as a nutrient thoroughfare-enterocytes taking up nutrients on the apical side and then secreting nutrients from the basolateral side. The small intestine is not commonly ...
Abe Takayuki - - 2013
CHESS pulse can suppress the signal originating from aliphatic fat protons but cannot suppress the signal from olefinic fat protons, which is near the resonance frequency of water protons. Adipose tissue contains various fat species; aliphatic fat comprises about 90 % and olefinic fat about 10 % of adipose tissue. Thus, CHESS ...
Lazar Adina N - - 2012
Although cholesterol has been involved in the pathophysiology of Alzheimer disease (AD), its distribution in the cerebral cortex over the course of AD is unknown. We describe an original method to quantify cholesterol distribution using time-of-flight secondary ion mass spectrometry imaging. Cholesterol was unevenly distributed along the cortical thickness, being ...
Morelli Annamaria - - 2012
In the male, metabolic syndrome (MetS) is associated to an increased risk of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS). A recently established rabbit model of high fat diet (HFD)-induced MetS showed hypogonadism and the presence of prostate gland alterations, including inflammation, hypoxia and fibrosis. The present ...
Van Krimpen M M - - 2011
1. From an experiment with 504 laying hens (ISA Brown strain, 18-40 weeks of age), 90 40-week old hens were used for determining digesta mean retention time (MRT) and gut weight development. This experiment comprised 6 dietary treatments according to a 2 × 3 factorial design. Factors were dietary apparent metabolisable energy ...
Schurr Mark R - - 2011
Interactions with humans impact many aspects of behavior and ecology in nonhuman primates. Because of the complexities of the human-nonhuman primate interface, methods are needed to quantify the effects of anthropogenic interactions, including their intensity and differential impacts between nonhuman primate groups. Stable isotopes can be used to quickly and ...
Knap I - - 2011
Salmonella continues to be a major public health burden worldwide. Poultry are known to be one of the main reservoirs for this zoonotic pathogen. It has previously been shown that a single dose of Bacillus subtilis reduces fecal shedding of Salmonella enterica serovar Enteritidis, whereas no effect on long-term colonization ...
Yan G L - - 2011
The effects of sodium alginate oligosaccharides (sAO) on growth performance, cecal microbiota, Salmonella translocation to internal organs, and mucosal immune responses to challenge with Salmonella enterica serovar Enteritidis in broiler chickens were investigated. We designed an experiment with a 2 × 3 factorial arrangement, in which 3 feed treatments with ...
Callaway Todd R - - 2011
Abstract Salmonella can live undetected in the gut of food animals and be transmitted to humans. Animal diets can impact intestinal populations of foodborne pathogens, including Salmonella spp. Orange juice production results in a waste product, orange peel and orange pulp, which has a high nutritive value and is often ...
Yang Fan - - 2011
The experiment was conducted with the objective of examining the effects of high molybdenum (Mo) on the apoptosis of splenic lymphocytes in broilers by the methods of experimental pathology and flow cytometry (FCM). Three hundred 1-day-old avian broilers were divided into four groups of 75 each and were fed on ...
Jiang R R - - 2011
The effects of dietary supplemental nicotinic acid (NA) on growth performance, carcass characteristics and meat quality were investigated in three genotypes of chicken. Fast-growing AA (Arbor Acres) broilers were compared with two genotypes of a slow-growing local breed, Beijing-You, that had undergone selection for and against intramuscular fat content respectively ...
Pujols Joan - - 2011
The objective of this study was to evaluate if spray dried porcine plasma (SDPP) containing porcine circovirus type 2 (PCV2) genome supplemented in feed could transmit PCV2 to pigs challenged with porcine reproductive and respiratory syndrome virus (PRRSV). Twenty-three PRRSV-free pigs, non-viraemic for PCV2, were housed in bio-safety level 3 ...
Stiner Mary C - - 2011
Franchthi Cave in southern Greece preserves one of the most remarkable records of socioeconomic change of the Late Pleistocene through early Holocene. Located on the southern end of the Argolid Peninsula, the area around the site was greatly affected by climate variation and marine transgression. This study examines the complex ...
Itoh Yasunori - - 2011
We studied the effects of cholesterol load on urinary stone in rats receiving a standard diet or a high fat diet. Sixty male rats were randomized to two groups and were fed either a standard diet (SD group) or a high fat diet (HFD group) for 8 weeks. Then the ...
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