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Stefanutti Claudia C Extracorporeal Therapeutic Techniques Unit, Lipid Clinic and Atherosclerosis Prevention Centre, Immunohematology and Transfusion Medicine, 'Umberto I' Hospital, Rome, Italy, - - 2015
At present, lipoprotein apheresis, combined with high-dose statin and ezetimibe therapy, is the best available means of treating patients with homozygous and statin-refractory heterozygous familial hypercholesterolaemia (FH). However, the extent of cholesterol-lowering achieved is often insufficient to meet the targets set by current guidelines. The recent advent of three new ...
Raju Jayadev J Regulatory Toxicology Research Division, Bureau of Chemical Safety, Food Directorate, Health Products and Food Branch Health Canada, Ottawa, Ontario, Canada. Electronic address: - - 2014
We recently reported that acrylamide, a known rodent and probable human carcinogen, does not increase the risk of azoxymethane (AOM)-induced rat colon precancerous lesions when administered through the diet. Here, we present toxicological data from non-AOM-injected rats. Briefly, male F344 rats were randomized into four dietary groups and received experimental ...
van Rijssel Jacco C JC Institute of Biology Leiden, Leiden University, PO Box 9505, 2300, RA Leiden, The Netherlands; Naturalis Biodiversity Center, PO Box 9517, 2300, RA Leiden, The Netherlands; Present address: EAWAG Center of Ecology, Evolution and Biogeochemistry, 6047, Kastanienbaum, Switzerland; Present address: Institute of Ecology and Evolution, University of Bern, CH-3012, Bern, Switzerland; Tanzania Fisheries Research Institute (TAFIRI), P.O. Box 9750, Dar Es Salaam, Tanzania. - - 2014
Rapid morphological changes in response to fluctuating natural environments are a common phenomenon in species that undergo adaptive radiation. The dramatic ecological changes in Lake Victoria provide a unique opportunity to study environmental effects on cichlid morphology. This study shows how four haplochromine cichlids adapted their premaxilla to a changed ...
Rira M M INRA, UMR 1213 Herbivores, 63122 Saint-Genès Champanelle, - - 2014
The objective of this work was to study nutritional strategies for decreasing methane production by ruminants fed tropical diets, combining in vitro and in vivo methods. The in vitro approach was used to evaluate the dose effect of condensed tannins (CT) contained in leaves of Glyricidia sepium, Leucaena leucocephala, and ...
Gadi Ramprasad R aEinstein Institute for Heart and Vascular Health, Einstein Medical Center bJefferson Medical College, Philadelphia, Pennsylvania, - - 2014
Elevated low-density lipoprotein cholesterol (LDL-C) levels are associated with an increased risk for cardiovascular disease (CVD). Statins have been the cornerstone of lipid therapy to lower LDL-C for the past two decades, but despite significant clinical efficacy in a majority of patients, a large residual risk remains for the development ...
Kühn Julia J Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle-Wittenberg, Von-Danckelmann-Platz 2, Halle (Saale) 06120, Germany. Electronic address: - - 2014
Vitamin D fortified food can help to reduce the prevalence for vitamin D deficiency. Previous data provided evidence that eggs from hens exposed to ultraviolet (UV) light contain large quantities of vitamin D. In the current study, we assessed the efficacy of vitamin D enrichment in eggs upon increasing daily ...
Poulose Shibu M SM Human Nutrition Research Center on Aging, USDA-ARS, Boston, MA 02111, - - 2014
Particles of high energy and charge (HZE particles), which are abundant outside the magnetic field of the Earth, have been shown to disrupt the functioning of neuronal communication in critical regions of the brain. Previous studies with HZE particles, have shown that irradiation produces enhanced indices of oxidative stress and ...
Martins Marcela A MA Department of Pharmacology and Psychobiology, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Av 28 de Setembro 87, Rio de Janeiro, RJ 20551-030, Brazil. - - 2014
The consumption of n-3 polyunsaturated fatty acids (PUFAs) derived from fish oil concomitant with a reduced intake of saturated fats is associated with cardiovascular benefits, which may result from the participation of nitric oxide (NO). In contrast, PUFAs are vulnerable to peroxidation, which could affect the oxidative stability of the ...
Tavori Hagai H Knight Cardiovascular Institute, Center for Preventive Cardiology, Oregon Health and Science University, Portland, OR, - - 2014
The proof of concept that proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition affects cholesterol levels was first established after the demonstration that PCSK9 loss-of-function mutations result in a significant drop in circulating LDL cholesterol levels. Subsequent studies revealed that PCSK9 binds the epidermal growth factor precursor homology domain-A on the ...
Janić Miodrag M Department of Vascular Diseases, University of Ljubljana Medical Centre, Zaloška 7, SI-1000 Ljubljana, Slovenia. Electronic address: - - 2014
New preventive strategies for atherosclerosis are needed. In this study, we tested whether a new therapeutic approach consisting of low dose treatment with a statin and sartan combination could prevent atherogenic diet-induced impairment of the arterial wall in guinea pigs. Twenty-five Dunkin-Hartley guinea pigs were randomly assigned to five experimental ...
Hamid Penny H PH Institute of Parasitology, Biomedical Research Centre Seltersberg, Justus Liebig University Giessen, Schubertstr 81, 35392, Giessen, Germany, - - 2014
Eimeria bovis macromeront formation in bovine endothelial host cells is an energy- and nutrient-demanding process. Obligate intracellular replicating coccidians are generally considered as auxotrophic for cholesterol synthesis and scavenge cholesterol from the host cell by either enhancing the uptake of extracellular cholesterol sources or by upregulating the host cellular de ...
Kim Kyoung Ok KO Division of Food and Nutritional Science & Life Systems, Sookmyung Women's University, Seoul 140-742, - - 2014
We investigated the effects of a high-protein diet and resveratrol supplementation on immune cells changes induced by abdominal irradiation in rats. Female Wistar rats were divided into 5 groups: 1) control diet, 2) control diet with irradiation 3) 30% high-protein diet with irradiation, 4) normal diet with resveratrol supplementation and ...
Guo Tai L TL Department of Biosciences and Diagnostic Imaging, College of Veterinary Medicine, University of Georgia, Athens, GA 30602-7382, USA. Electronic address: - - 2014
Diet and phytoestrogens affect the development and progression of diabetes. The objective of the present study was to determine if oral exposure to phytoestrogen genistein (GE) by gavage changed blood glucose levels (BGL) through immunomodulation in streptozotocin (STZ)-induced diabetic male B6C3F1 mice fed with three different diets. These three diets ...
Schweizer Manuel M Naturhistorisches Museum der Burgergemeinde Bern Bernastrasse 15, CH 3005, Bern, - - 2014
Specialization to nectarivory is associated with radiations within different bird groups, including parrots. One of them, the Australasian lories, were shown to be unexpectedly species rich. Their shift to nectarivory may have created an ecological opportunity promoting species proliferation. Several morphological specializations of the feeding tract to nectarivory have been ...
Wirth Michael D MD From the Cancer Prevention and Control Program (Drs Wirth, Burch, Shivappa, Steck, and Hébert and Mr Hurley), University of South Carolina, Columbia, SC; Department of Epidemiology and Biostatistics (Drs Burch, Shivappa, Steck, and Hébert), University of South Carolina, Columbia, SC; WJB Dorn VA Medical Center (Dr Burch), Columbia, SC; and Department of Epidemiology and Biostatistics (Dr Vena), College of Public Health, University of Georgia, Athens, - - 2014
Shift workers are affected by diet- and inflammation-related diseases, including cardiovascular disease, diabetes, and cancer. We examined a dietary inflammatory index (DII) in relation to shift work from the National Health and Nutrition Examination Survey data (2005 to 2010). The DII was calculated using data from a 24-hour dietary recall. ...
Liu Yi-Qun YQ National Institute for Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, 27 Nanwei Road, Xicheng District, Beijing 100050, - - 2014
Betaine is an important natural component of rich food sources, especially spinach. Rats were fed diets with betaine or spinach powder at the same level of betaine for 10 days to investigate the dose-dependent effects of spinach powder supplementation on hyperhomocysteinemia induced by guanidinoacetic acid (GAA) addition and choline deprivation. ...
Holick Michael F - - 2014
Vitamin D is the sunshine vitamin for good reason. During exposure to sunlight, the UV B photons enter the skin and photolyze 7-dehydrocholesterol to previtamin D3 which in turn is isomerized by the body's temperature to vitamin D3. Most humans have depended on sun for their vitamin D requirement. Skin ...
Vares Guillaume G Research Center for Radiation Protection, National Institute of Radiological Sciences, Inage-ku, Chiba, - - 2014
Both exposure to ionizing radiation and obesity have been associated with various pathologies including cancer. There is a crucial need in better understanding the interactions between ionizing radiation effects (especially at low doses) and other risk factors, such as obesity. In order to evaluate radiation responses in obese animals, C3H ...
Quintelier Kim - - 2013
Stable isotope ratios (δ(13) C and δ(15) N) were measured in human burials from the post-medieval (16th-18th c. AD) Carmelite friary burial grounds at Aalst, a town in Flanders, Belgium. Dietary patterns of 39 adult individuals were analyzed, from a mixed monastic and lay population buried in three different locations, ...
de Luis Daniel Antonio - - 2012
BACKGROUND: Common polymorphisms of the fat mass and obesity associated gene (FTO) have been linked to obesity in some populations. One of these genetic variants (rs9939609) has been related to an increased risk of obesity. OBJECTIVE: Our aim was to evaluate weight loss and adipocytokines levels after two hypocaloric diets ...
Parolini Cinzia - - 2012
BACKGROUND/AIMS: Apolipoprotein (apo)A-I(M) (ilano) , is a molecular variant of apoA-I(wild-type) , associated with dramatically low HDL-cholesterol levels, but no increased risk for cardiovascular disease. In view of the present uncertainties on the role of apoA-I in liver cholesterol removal by way of bile acids and neutral sterols, and of ...
Wu Jun J Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02215, - - 2012
Brown fat generates heat via the mitochondrial uncoupling protein UCP1, defending against hypothermia and obesity. Recent data suggest that there are two distinct types of brown fat: classical brown fat derived from a myf-5 cellular lineage and UCP1-positive cells that emerge in white fat from a non-myf-5 lineage. Here, we ...
Tingbø M G - - 2012
Aquaculture requires feed that ensures rapid growth and healthy fish. Higher inclusion of plant ingredients is desirable, as marine resources are limited. In this study we investigated the effects of higher starch inclusion in feed on muscular extracellular matrix and interleukin expression in farmed cod. Starch was replaced by complex ...
Zhang Gui-Yun - - 2012
Vitamin E comprises a group of eight lipid soluble antioxidant compounds that are an essential part of the human diet. The α-isomers of both tocopherol and tocotrienol are generally considered to have the highest antioxidant activities. γ-tocopherol methyltransferase (γ-TMT) catalyzes the final step in vitamin E biosynthesis, the methylation of ...
Ueta Cintia Bagne - - 2012
Brown adipose tissue (BAT) is predominantly regulated by the sympathetic nervous system and the adrenergic receptor signaling pathway. Knowing that a mouse with triple β-receptor knockout is cold intolerant and obese, we evaluated the independent role played by the β1 isoform in energy homeostasis. First, the 30-minute intravenous infusion of ...
Wang Bin - - 2012
There are scant data on serum lipid profile in the Yi people in China. The Yi farmers and migrants provide an unusual opportunity to estimate effects of environmental factors on serum lipid levels. We conducted a cross-sectional study in the Yi people to estimate prevalence of dyslipidemia and associated factors. ...
Kögel Susanne - - 2012
Food type can affect all functional aspects of an insect's life. We investigated the effects of different diet regimes on life history parameters of the ladybird beetle Harmonia axyridis. Furthermore, we tested the importance of elytral color, sex, and diet on chemical and immune defense in this species. We also ...
Hernández-Hernández Oswaldo - - 2012
A detailed study was performed to compare the in vivo ileal digestibility and modulatory effects in fecal microbiota of novel galacto-oligosaccharides (GOS) derived from lactulose [GOS-Lu; degree of polymerization (DP) ≥2, 14.0% trisaccharides] and commercial GOS derived from lactose (GOS-La; DP ≥3, 35.1% trisaccharides) in growing rats (5 wk old). ...
van Dijk Susan J - - 2012
The Mediterranean (MED) diet is often considered health-promoting due to its high content of MUFA and polyphenols. These bioactive compounds can affect gene expression and accordingly may regulate pathways and proteins related to cardiovascular disease prevention. This study aimed to identify the effects of a MED-type diet, and the replacement ...
Sogabe Masahiro - - 2012
BACKGROUND AND AIM: Although visceral fat is strongly associated with metabolic syndrome (MS), the association between erosive esophagitis (EE) and visceral and subcutaneous fat types in individuals with MS has remained unclear. In this study, we divided individuals with MS into those with visceral and subcutaneous fat types, and determined ...
Macotela Yazmín - - 2012
Obesity and body fat distribution are important risk factors for the development of type 2 diabetes and metabolic syndrome. Evidence has accumulated that this risk is related to intrinsic differences in behavior of adipocytes in different fat depots. In the current study, we demonstrate that adipocyte precursor cells (APCs) isolated ...
Sun Hua - - 2012
OBJECTIVE: Proprotein convertase subtilisin/kexin type 9 (PCSK9) negatively regulates the low-density lipoprotein (LDL) receptor (LDLR) in hepatocytes, and therefore, plays an important role in controlling circulating levels of LDL-cholesterol. To date, the relationship between PCSK9 and metabolism of apolipoprotein B (apoB), the structural protein of LDL, has been controversial, and ...
Tomé Beatriz - - 2012
Abstract Hepatozoon spp. (Apicomplexa: Haemogregarinidae) are the most commonly reported hemoparasites from snakes. Indeed, of over 300 Hepatozoon species identified, more than 120 were described from snakes. However, recent genetic assessments have found Hepatozoon lineages recovered from both prey and predators, indicating that diet may play an important role in ...
Williams Patricia L - - 2012
This study assessed the affordability of a basic nutritious diet for selected household types relying on income assistance (IA) by comparing potential incomes to the costs of the National Nutritious Food Basket (NNFB) and other essential expenditures in Nova Scotia from 2002 to 2010, and examined the adequacy of IA ...
Wilck Nicola - - 2012
OBJECTIVE: Low and nontoxic proteasome inhibition has anti-inflammatory, antiproliferative, and antioxidative effects on vascular cells in vitro and in vivo. We hypothesized that low-dose inhibition of the proteasome could provide antiatherogenic protection. The present study investigated the effect of low-dose proteasome inhibition on early lesion formation in low-density lipoprotein receptor-deficient ...
Ley Sylvia H - - 2012
Aims: Traditional lipid indices have been associated with type 2 diabetes, but limited data are available regarding non-high-density lipoprotein (non-HDL) cholesterol. In view of recent guidelines for the clinical management of dyslipidemia recommending the monitoring of non-HDL cholesterol as a secondary target after achieving the low-density lipoprotein (LDL) cholesterol goal, ...
Wang Feifei - - 2012
Identification of the protein factors that regulate the adipogenesis and lipid metabolism of adipose tissue is critical for the understanding of the physiology and pathology of obesity and energy homeostasis. In this study, we found that G protein coupled receptor (GPCR) kinase 5 (GRK5) was expressed at a relatively high ...
Marino Dale J - - 2012
Abstract The B6C3F1 mouse is the standard mouse strain used in National Toxicology Program (NTP) carcinogenesis studies. Over time, increased liver tumorigenesis that was correlated with elevated body weights was noted in males and females. NTP therefore replaced the NIH-07 diet with the NTP-2000 diet and returned to group housing ...
Cloete J J E - - 2012
The slaughter and meat quality traits of 20-month-old wool (Merino), dual-purpose (Dohne Merino and South African Mutton Merino [SAMM]) and mutton (Dormer) type sheep were compared. Average live weights of SAMM and Dormer sheep were 23% heavier than those of Dohne Merinos which were 28% heavier than Merinos. Fat depths ...
Rodriguez-Navarro Jose Antonio JA Department of Developmental and Molecular Biology, Institute for Aging Studies, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, - - 2012
Cytosolic proteins can be selectively delivered to lysosomes for degradation through a type of autophagy known as chaperone-mediated autophagy (CMA). CMA contributes to intracellular quality control and to the cellular response to stress. Compromised CMA has been described in aging and in different age-related disorders. CMA substrates cross the lysosomal ...
Alcalay Roy N RN Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA. - - 2012
Recent studies have demonstrated an association between a Mediterranean-type diet and Alzheimer's risk. We assessed the association between Mediterranean-type diet adherence and Parkinson's disease (PD) status. Two hundred and fifty-seven PD participants and 198 controls completed the Willett semiquantitative questionnaire that quantifies diet during the past year. Scores were calculated ...
Mao Gloria E GE Center for Human Nutrition, UCLA School of Public Health, UCLA, Los Angeles, CA, - - 2012
The "New Western-style Diet" (NWD) characterized by high in fat and low in fiber, vitamin D, calcium, and methyl donors--are considered as a risk factor for prostate cancer. Previous studies have shown that premalignant lesions of human prostate have decreased expression of the Retinoid X Receptor alpha (RXRα). This study ...
Deluycker Anneke M - - 2012
Titi monkeys (genus Callicebus) are small-bodied platyrrhines that supplement their predominantly frugivorous diet with variable amounts of leaves, seeds, and/or arthropod prey. Notable interspecific variation in the amount of insect prey in the diet has been observed in Callicebus, ranging from 0% to 20%. In this study, I investigate the ...
de Luis Daniel Antonio - - 2012
BACKGROUND: The high variation in responses to bariatric surgery might be partially explained by genetic effects. Recently, common polymorphisms of the fat mass and obesity-associated gene (FTO) have been linked to obesity in some populations. Only two studies have investigated the effect of FTO variants on weight loss of morbid ...
Schipper Aafke M - - 2012
We assessed dietary exposure of the little owl Athene noctua to trace metal contamination in a Dutch Rhine River floodplain area. Diet composition was calculated per month for three habitat types, based on the population densities of six prey types (earthworms, ground beetles and four small mammal species) combined with ...
de Sousa Ferreira Soares Geórgia - - 2012
With changes in human consumption from animal fats to vegetable oils, the search for seed types, often from unconventional vegetable sources has grown. Research on the chemical composition of both seed and oil for Brazilian Okra in South America is still incipient. In this study, flour and oil from organic ...
Oliveira Carolina P - - 2012
The aim was to investigate new markers for type 2 diabetes (T2DM) dyslipidemia related with LDL and HDL metabolism. Removal from plasma of free and esterified cholesterol transported in LDL and the transfer of lipids to HDL are important aspects of the lipoprotein intravascular metabolism. The plasma kinetics (fractional clearance ...
Dani M A - - 2012
A synergistic effect in the somatotropic axis (GH1-GHR-IGF1) was observed in 736 young Nelore (Bos indicus) bulls under ad libitum grass feeding conditions on irrigated pasture in central Brazil. Stepwise substitution of shorter alleles of the promoter region of the growth hormone gene (GH1) and the P1 promoter of the ...
Lange Yvonne - - 2012
A variety of intercalating amphipaths increase the chemical activity of plasma membrane cholesterol. To test whether intracellular cholesterol can be similarly activated, we examined NPC1 and NPC2 fibroblasts, since they accumulate large amounts of cholesterol in their late endosomes and lysosomes (LE/L). We gauged the mobility of intracellular sterol from ...
James Anthony P AP School of Public Health, Curtin University of Technology, Curtin Health Innovation Research Institute and the Australian Technology Network Universities, Centre for Metabolic Fitness, GPO Box U1987, Perth, WA 6845, Australia ; Curtin Health Innovation Research Institute and the Australian Technology Network Universities, Centre for Metabolic Fitness, Perth, WA 6845, - - 2012
Chylomicron particles are continually synthesised and secreted from the intestine even in the absence of ingested fat. It is possible that following consumption of low doses of fat the basal level of chylomicron secretion and subsequent metabolism are sufficient to metabolise this fat without an increase in postprandial chylomicron concentrations. ...
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