This study reports the concentration levels of PCB, DDT, HCB and beta-HCH in the human milk of women living in northern Germany over a period of 12 years and determines factors that may influence these levels. From 1986 to 1997 more than 3500 milk samples were analyzed for organochlorine compounds. ...

To further characterize the toxicological risk associated with chemical contaminants in Great Lakes fish, a multigeneration rat reproduction study was designed. Mature chinook salmon (Oncorhynchus tsawytscha), collected during the Fall 1991 spawning runs from Sydenham River, Lake Huron, and Credit River, Lake Ontario, were filleted, lyophilized, and incorporated into standard ...

Polychlorinated biphenyls (PCBs) are fat-soluble environmental pollutants which can be stored in the fatty tissue of breast and secreted in milk. Previous studies have shown that PCBs can influence liver carcinogenesis in animal models but no such studies have been reported in breast. These experiments aimed to determine whether a ...

Fish from the Great Lakes can be contaminated with a plethora of industrial, agricultural, and environmental chemicals. These chemicals have been associated with reproductive and other toxicological effects in fish and fish-eating birds found in the Great Lakes basin. To obtain more insight into this association, several laboratory studies have ...

The Health Canada Multigeneration Study was initiated to determine the consequences in rodents consuming diets containing Lake Ontario (LO) or Lake Huron (LH) chinook salmon over successive generations. Following lyophilization, the contaminant levels in the salmon used in the formulation of the diets for this study exceeded a number of ...

Several authors have suggested that contamination by polychlorinated biphenyls (PCBs) constitutes one of the major causes of the decline of the Eurasian otter (Lutra lutra) in large parts of Europe. This chapter provides an overview of available information regarding PCBs in European otters. Data on PCB concentrations in European otter ...

The mean concentration of the chlorinated biphenyl 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) in plasma from 192 fishermen's wives from the Swedish east coast was on a fresh weight basis 960 (range 80-4300) pg/g and lipid adjusted 160 (range 20-780) ng/g lipid. The concentration of CB-153 in plasma was significantly influenced by age, total ...

Deltamethrin (CAS registry No. 52918-63-5), a synthetic dibromo-pyrethroid insecticide is highly effective against a broad spectrum of insects, and is widely used on crops and in public health programs. Data on the genotoxicity and carcinogenicity of deltamethrin are rather controversial, depending on the genetic system or the assay used. The ...

This study evaluates effects of feeding mercury (Hg) contaminated fish collected from streams on the Oak Ridge Reservation (ORR) on mink. Diets composed of 25, 50, or 75% fish collected from streams on the ORR were fed to mink beginning 3 months prior to breeding and ending 6 weeks following ...

Environmental contamination by pesticides, including the presence of chemical residues in aquatic wildlife, is a widespread ecological problem. Methyl parathion (MP), a widely used organophosphorate insecticide, is a potent neurotoxic in both vertebrates and invertebrates. The effect of a subchronic exposure to MP in aquatic organisms was evaluated in a ...

Mink are carnivores of agroforestry fringe habitats and are exposed to pesticides that biomagnify within the food chain. Some pesticides are thought to disrupt reproductive and endocrine functions. In Expt 1, four groups of mink (n = 10) were fed either a control diet, or diets treated with lindane (1 ...

The subchronic toxicity of 2,2',3,3',4,4'-hexachlorobiphenyl (PCB 128) was investigated in rats following dietary exposure at 0, 0.05, 0.5, 5, or 50 ppm for 13 wk. The growth rate was not affected by treatment and no apparent clinical signs of toxicity were observed. There was a significant increase in liver weight ...

Curcumin and genistein are two natural products of plants obtained from Curcuma longa Linn (turmeric) and soybeans, respectively. Both compounds when present at micromolar concentrations are able to inhibit the growth of estrogen-positive human breast MCF-7 cells induced individually or by a mixture of the pesticides endosulfane, DDT and chlordane ...

The marked species differences in short-term toxicity (30-day LD50) of ca. 10,000 (LD50: guinea pigs ca. 1 microgram/kg body wt and Han/Wistar Kuopio rats more than 9600 micrograms/kg body wt) of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is one of the central issues of the controversies that have developed on the validity of risk ...

PCB 105 (2,3,3',4,4'-pentachlorobiphenyl) congener was fed to weanling Sprague-Dawley rats in a diet combined with 4% corn oil. The animals were distributed randomly into 10 groups, each of which contained 10 males and 10 females, and rats in 8 groups received diets containing PCB at concentrations of 0.05, 0.5, 5, ...

Inuit people residing in the Arctic are unusually exposed to organochlorines through their traditional diet which includes large quantities of sea mammal fat. Recently, 499 Inuit adults from Nunavik (Arctic Quebec) participated in a large health survey and donated a blood sample for organochlorine and heavy metal analysis. Twenty pooled ...

Male Atlantic croaker (Micropogonias undulatus) were exposed to Aroclor 1254 (a PCB mixture) in the diet (0.1 mg/100 g body wt./day) for 30 days during gonadal recrudescence to investigate the effects of the PCB mixture on reproductive neuroendocrine function. The concentrations of biogenic amines (epinephrine [E], norepinephrine [NE], dopamine [DA], ...

Planar PCB congeners are embryotoxic and teratogenic to birds including American kestrels. The developmental toxicity of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) was studied in the posthatching kestrel as a model for the eagle. Nestlings were dosed orally for 10 days with 5 microl/g body weight of corn oil (controls) or the planar ...

The effects of dietary highly hydrogenated soybean oil (HSO) upon the changes caused by dietary polychlorinated biphenyls (PCBs) were examined in rats. Six groups of rats were fed the following diets for 30 d: a 20% soybean oil-containing diet (control diet), a diet in which a half of soybean oil ...

Possible modifying effects of pesticide mixtures on tumorigenesis were investigated with medium-term carcinogenesis protocols for rapid detection of carcinogenic agents using male F344 rats. In the 8-wk liver model, administration of 20 pesticides (19 organophosphorus compounds and one organochlorine), added to the diet each at acceptable daily intake (ADI) levels, ...

Carp from Saginaw Bay, Lake Huron, MI, was fed to White Leghorn chickens for a period of 8 wk. The diets contained 0.3 (control; 0% carp), 0.8 (3.4% carp), and 6.6 (35% carp) mg polychlorinated biphenyls (PCBs)/kg diet, by wet weight (ww). These concentrations corresponded to 3.3, 26, and 59 ...

The present experiment was done to obtain experimental evidence supporting the existence of an optimal initial contamination level of Eimeria acervulina with respect to broiler productivity, as suggested by simulation model outcomes. Three levels of initial (on Day 3) contamination of the litter were applied (low, intermediate and high). The ...

Organochlorine pesticide levels were determined in Neotropical migrant passerines which have populations reported to be declining. Pesticide residues ranging from 0.385 to 27.4 ng/g were found in 19 of 21 birds, including both Hatch Year (HY) and After Hatch Year (AHY) age classes of nine different species. Eighteen of the ...

The estimated intake of PCDD/Fs and co-planar PCBs associated with an average diet consumed in Spain was investigated. The estimated total average intake for PCDDs and PCDFs from an average spanish diet was found to be 142 pg I-TEQ/day (2.4 pg I-TEQ/Kg b.w./day, for a 60 Kg person). PCDDs provided ...

2,4,4'-Trichlorobiphenyl or PCB congener 28 was given to Sprague-Dawley weanling rats and the experimental diets were prepared by mixing the congener in 4% corn oil. The congener was administered to animals placed in four groups, each comprising 10 males or females. The diets contained 0.05, 0.5, 5, or 50 ppm ...

A survey of 21 beers produced in Spain during 1994 was conducted to assess contamination with volatile N-nitrosamines. N-Nitrosodimethylamine (NDMA), the only volatile N-nitrosamine detected, was found in 52% of Spanish beers at or above the detection level (0.05 microgram/kg). The mean NDMA level for all samples was 0.11 microgram/kg, ...

Perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) cause s a permanent change in thermoregulatory control of male offspring of the rat, characterized by a reduced core temperature (Tc over a wide range of ambient temperatures (Ta). To examine the similarities in this effect across species, the thermoregulatory effects of perinatal TCDD were ...

The subchronic toxicity of 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153) was investigated in rats after 13 weeks of dietary exposure. Groups of 10 male and 10 female rats were administered PCB 153 in their diet at levels of 0.05, 0.50, 5.0 or 50 ppm for 13 weeks. The control groups received the diet ...

Polychlorinated organic compounds (POCs) accumulate in tissues with a high fat content. Nursed babies are exposed to POCs through the fat in human milk. Exposure levels are estimated to exceed those considered acceptable as a lifelong daily dose. Nevertheless, mothers are still positively advised as to breast-feeding. In 1988, a ...

The effects of different diets (high carbohydrate, high protein, high fat) and diets contaminated with polychlorinated biphenyls (PCBs) and/or gamma-hexachlorocyclohexane (lindane) on the levels of serum triglycerides, cholesterol and phospholipids were investigated in Wistar rats. Serum triglyceride levels differed significantly among the diets, while those of cholesterol and phospholipids were ...

Three groups of female kittiwakes (Rissa tridactyla) were collected in a North-Norwegian colony: (i) before breeding; (ii) immediately after egg-laying; and (iii) late in the chick-rearing period. Concentrations of 21 selected individual polychlorinated biphenyls (PCBs) were determined in liver, brain and fat tissues by capillary gaschromatography (GC-ECD). This was done ...

PCB 156 (2,3,3',4,4',5-hexachlorobiphenyl) congener was given to weanling Sprague-Dawley rats in diets prepared by mixing it in 4% corn oil. The animals were placed in eight groups, each comprising 10 males or females and received diets that contained 0.01, 0.1, 1, 10 ppm PCB; in addition, two control groups of ...

Carcinogenic effects of pesticide mixtures were examined with our medium-term carcinogenesis protocols using male F344 rats. In the 8-week liver model, combined dietary administration of 20 pesticides (19 organophosphorus compounds and 1 organochlorine), each at acceptable daily intake (ADI) levels, did not enhance rat liver preneoplastic lesion development initiated by ...

The concentration and component types of PCB in adult human liver and fat tissue (64 samples) from forensic autopsy cases of Osaka Prefecture in 1989 were measured for comparison with the data for the same organ and tissue during the period from 1974 to 1984. The mean values of PCB ...

Two groups of C57BL/6J mice received a single oral dose of 1 nmol/kg 2,3,7,8-[3H]tetrachlorodibenzo-p-dioxin (TCDD) alone or in combination with 300 mumol/kg 2,2',4,4',5,5'-hexachlorobiphenyl (HxCB). The disposition of TCDD in liver, fat, skin, spleen, lung and blood was studied at days 3, 7, 13 and 34 after dosage. HxCB cotreatment increased ...

The effects of consumption of environmental contaminants contained in carp (Cyprinus carpio) from Saginaw Bay, Michigan on various hematological parameters and liver integrity of adult female mink (Mustela vision) were determined. Mink were fed diets that contained 0 (control), 10, 20, or 40% carp prior to and throughout the reproductive ...

Humans are exposed to mixtures of polyhalogenated aromatic hydrocarbons, and the potential health effects of these exposures are uncertain. A subset of this class of compounds produce similar spectra of toxicity in experimental animals as does 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), and these chemicals have been classified as "dioxins." In this study, we ...

In the western industrialized world, malnutrition of the lactating mother is not a problem any more. However, new problems, the chemical pollutants in breastmilk, have given rise to concern. Since the seventies, pollution of breastmilk with PCBs and dioxins has taken place. After World War II, more and more PCBs ...

The toxicity of 3,3',4,4'-tetrachlorobiphenyl (PCB 77) and 2,3',4,4',5-pentachlorobiphenyl (PCB 118) was investigated in rats following subchronic dietary exposure. Groups of 10 male and 10 female weanling Sprague-Dawley rats were administered PCB 77 in the diet at 0, 10, 100, 1000, or 10,000 ppb for 13 weeks. PCB 118 was administered ...

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 3,3',4,4',5-pentachlorobiphenyl (PCB 126), or 2,3,3',4,4',5-hexachlorobiphenyl (PCB 156) on thyroid hormone metabolism were studied in 13-week feeding studies in female Sprague-Dawley rats. The diets were supplemented with the compounds tested at concentrations ranging from 0.2 to 20 micrograms/kg diet for TCDD, 7 to 180 micrograms/kg diet for ...

Effects of chronic dietary exposure to low levels of PCBs (polychlorinated biphenyls) on reproduction, growth and whole body burdens were investigated in three generations of Peromyscus polionotus. Mated pairs were maintained on a diet containing 5 mg/kg PCBs (Aroclor 1254) for 12 months, beginning exposure as young adults; matched controls ...

Aflatoxin (AF) B1 is a main contaminant in diverse agricultural products. In an attempt to reduce this problem and the hazards to human health, an AFB1 inactivating system with ammonia has been developed. In this work we evaluated the efficiency of the system in mice using micronucleus (MN) and sister ...

A clinical trial using the combination of rice bran fiber (RBF) and cholestyramine (CHO) was carried out on Yu-Cheng patients in 1993-1994. By the analysis of blood and stool samples collected from the patients before and after (or during in the case of stool), it was verified that the administration ...

Carp (Cyprinus carpio) collected from Saginaw Bay, Michigan, containing 8.4 mg total polychlorinated biphenyls (PCBs)/kg and 194 ng of 2,3,7,8-tetrachloro-dibenzo-p-dioxin equivalents (TEQs)/kg, were substituted for marine fish at levels of 0, 10, 20, or 40% in the diets of adult ranch mink (Mustela vison). The diets, containing 0.015, 0.72, 1.53, ...

This study was undertaken to compare the tumour promoting effects induced by 3,4,5,3',4'-pentachlorobiphenyl (PCB 126) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In addition, interactive effects in rats treated with combinations of PCB 126 and TCDD were studied. Partially hepatectomized female Sprague-Dawley rats were initiated with nitrosodiethylamin. After 5 weeks of recovery the promotion ...

Analyses of potential dietary exposure to chlorpyrifos residues were conducted by the Department of Pesticide Regulation (DPR). Potential acute dietary ingestion of chlorpyrifos for all labelled uses was based on the 95th percentile of user-day exposures. Margins of safety (MOSs) for potential acute dietary exposure to chlorpyrifos residues were based ...

Organochlorine concentrations were determined in blubber samples from 33 Tursiops truncatus stranded on the Texas and Florida coastlines. All tissues had measurable concentrations of 4,4'-DDE (0.18-70.7 microg/g lipid weight) and SigmaPCB (4.1-149 microg/g lipid weight). Pesticide and PCB concentrations were similar to those reported in Tursiops truncatus from the Atlantic ...

Twenty organochlorine pesticide compounds (OCPs) and 20 polychlorinated biphenyl (PCB) congeners known to be the most abundant or toxicologically significant were determined in samples of a representative Finnish diet and in individual foodstuffs. OCPs were isolated and cleaned-up by solvent extraction and concentrated sulphuric acid treatment according to the methods ...

Direct and indirect measures of growth and energy storage were evaluated as indicators of subchronic 1,1,1-trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane (o,p'-DDT) exposure in juvenile sailfin mollies (Poecilia latipinna). Three-day-old mollies were exposed to 0, 1, 10, 25, 50, 75, and 100 micrograms/liter o,p'-DDT for 21 days. Tissue residues, percentage weight gain, RNA and DNA ...

BACKGROUND: The study was designed to quantitate factors such as preparation time, waste, and contamination associated with three different feeding systems for peptide-based diets and to determine appropriate hang times. METHODS: Intensive care unit patients were randomized to receive a peptide-based diet in 1500-mL prefilled, sterile closed-system containers (CS) infused ...