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Milionis Haralampos H University of Ioannina, School of Medicine, Department of Internal Medicine , 451 10 Ioannina , - - 2014
Introduction: Statins reduce low-density lipoprotein cholesterol (LDL-C) and are currently the mainstay in the treatment of hyperlipidaemia and subsequently the prevention of atherosclerotic cardiovascular disease (CVD). Nevertheless, there is a need to further lower LDL-C, especially in subjects with severe forms of hypercholesterolaemia despite maximum doses of conventional drugs and/or ...
Kosmas Constantine E CE 1Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY; and 2Department of Internal Medicine, Division of Cardiology, New York Medical College/Westchester Medical Center, Valhalla, - - 2014
The role of low-density lipoprotein cholesterol (LDL-C) in the pathophysiology of atherosclerosis is well recognized, and the use of LDL-C lowering medications has led to a significant reduction of cardiovascular risk in both primary and secondary prevention. Statins are the standard of care and their use is supported by extensive ...
Santos-Gallego Carlos G CG Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, Box 1030, New York, NY 10029, - - 2014
This article reconciles the classic view of high-density lipoproteins (HDL) associated with low risk for cardiovascular disease (CVD) with recent data (genetics studies and randomized clinical trials) casting doubt over the widely accepted beneficial role of HDL regarding CVD risk. Although HDL cholesterol has been used as a surrogate measure ...
Weiser Michael J MJ DSM Nutritional Products, HNH, United States; - - 2014
Docosahexaenoic acid (DHA) is an important omega-3 polyunsaturated fatty acid (PUFA) that confers neurodevelopmental benefits. Sufficient omega-3 PUFA intake has been associated with improved mood-associated measures in adult humans and rodents, but it is unknown whether DHA specifically influences these benefits. Furthermore, the extent to which development and puberty interact ...
Dash Sarah S aIMPACT Strategic Research Centre, Deakin University, Geelong bDepartment of Psychiatry cAlimentary Pharmabiotic Centre, University College Cork, Cork, Ireland dDepartment of Psychiatry, The University of Melbourne eThe Florey Institute of Neuroscience and Mental Health, At Genetics Lane, Royal, Parade, The University of Melbourne fOrygen Youth Health Research Centre, Parkville, Victoria gCentre for Adolescent Health, Murdoch Children's Research Institute, Melbourne, Victoria hBlack Dog Institute, Sydney, New South Wales, - - 2014
With depressive disorders the leading source of disability globally, the identification of new targets for prevention and management is imperative. A rapidly emerging field of research suggests that the microbiome-gut-brain axis is of substantial relevance to mood and behaviour. Similarly, unhealthy diet has recently emerged as a significant correlate of ...
Santana-Sagredo Francisca F Research Laboratory for Archaeology and the History of Art, University of Oxford, Oxford, OX1 3QY, - - 2014
The decline of the Tiwanaku state saw the emergence of two new cultures-Pica-Tarapacá and Atacama-during the Late Intermediate Period in northern Chile. Archeological evidence suggests that both groups practised maize agriculture and pastoralism, but that their interaction zones differed significantly. Marine resources are common at Pica-Tarapacá sites, even those far ...
Scheibye-Knudsen Morten M Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, - - 2014
Cockayne syndrome (CS) is an accelerated aging disorder characterized by progressive neurodegeneration caused by mutations in genes encoding the DNA repair proteins CS group A or B (CSA or CSB). Since dietary interventions can alter neurodegenerative processes, Csb(m/m) mice were given a high-fat, caloric-restricted, or resveratrol-supplemented diet. High-fat feeding rescued ...
Backes James M JM Professor, Department of Pharmacy Practice , and Assistant Director, Atherosclerosis and LDL Apheresis Center, University of Kansas Medical Center , Mailstop 4047, 3901 Rainbow Boulevard, Kansas City, KS - - 2014
Omega-3 fatty acids play an important role in cardiovascular health. Although it is suggested that individuals obtain these nutrients through diet, many prefer to rely on supplements. Fish oil supplements are widely used, yet large capsule sizes and tolerability make them less than ideal. Recently, krill oil has emerged as ...
Cequier Enrique E Department of Exposure and Risk Assessment, Norwegian Institute of Public Health, Oslo, Norway; Department of Analytical Chemistry and Organic Chemistry, Universitat Rovira i Virgili, Tarragona, Spain. Electronic address: - - 2015
This study investigates associations between serum concentrations of emerging and legacy halogenated flame retardants (HFRs) in 46 Norwegian women and measured indoor air and dust concentrations of the HFRs as well as detailed information on diet and household factors. Hexabromobenzene (median 0.03ng/g lipid) and Dechlorane 602 (median 0.18ng/g lipid) were ...
Pines A A Sackler Faculty of Medicine, Tel-Aviv University , - - 2014
Clinical guidelines may change with time, as more information from topline studies emerges. Calcium plus vitamin D supplementation became routine decades ago, especially in the older population, based on the assumption that it may promote bone health and prevent fractures, and perhaps induce additional favorable health outcomes. During the past ...
Nigg Joel T JT Department of Psychiatry, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA. Electronic address: - - 2014
Food elimination diets are defined and the history of their investigation in relation to attention-deficit/hyperactivity disorder (ADHD) is reviewed. After noting that a consensus has emerged that an elimination diet produces a small but reliable aggregate effect, the present review provides updated quantitative estimates of effect size and clinical response ...
Chiva-Blanch G G Cardiovascular Research Center (CSIC-ICCC), Barcelona, Spain, - - 2014
The first step in the prevention of cardiovascular disease is healthy lifestyle and diet. Recent systematic reviews of observational studies ranked Mediterranean diet as the most likely dietary model to provide cardiovascular protection. This review updates the knowledge on the effects of Mediterranean diet from observational and randomized trials published ...
Sharpe Laura J LJ School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, NSW 2052, - - 2014
An emerging theme in the regulation of cholesterol homeostasis is the role of the ubiquitin proteasome system (UPS), through which proteins are ubiquitylated and then degraded in response to specific signals. The UPS controls all aspects of cholesterol metabolism including its synthesis, uptake, and efflux. We review here recent work ...
Ferreira Manuela M Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Lisboa, - - 2014
Secondary lymphoid organs form in utero through an inherited and well-established developmental program. However, maternal non-heritable features can have a major impact on the gene expression of the embryo, hence influencing the future health of the offspring. Recently, maternal retinoids were shown to regulate the formation of immune structures, shedding ...
Santos-Gallego Carlos G - - 2014
Low levels of high-density lipoprotein cholesterol (HDL-C) have been associated with an increased risk of coronary heart disease in prospective population studies and clinical trials of high-risk patients treated with a low to moderate intensity statin. As a result, therapeutic targets were developed to increase concentrations of HDL-C. Subsequently, clinical ...
Do Rose Q RQ VA Medical Center, University of Colorado School of Medicine, Denver, CO, - - 2014
The pathogenesis and progression of atherosclerosis are integrally connected to the concentration and function of lipoproteins in various classes. This review examines existing and emerging approaches to modify low-density lipoprotein and lipoprotein (a), triglyceride-rich lipoproteins, and high-density lipoproteins, emphasizing approaches that have progressed to clinical evaluation. Targeting of nuclear receptors ...
Lim Hyunjung H Department of Medical Nutrition, Research Institute of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Yongin, Gyeonggi-do, Republic of - - 2014
Transitions in nutrition patterns tend to emerge through industrialization and economic development. We hypothesized that the dietary patterns among South Korean adults who were 20 years or older have changed significantly from 1998 to 2010. Herein, a repeated cross-sectional analysis of data was followed for 140601 adults. We noted changes ...
Sahebkar Amirhossein A Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran; Metabolic Research Centre, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia; Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, - - 2014
The present study was undertaken to evaluate the anti-dyslipidemic effects of nanoliposomes with different phospholipid compositions. Three sets of liposomal formulations (20Mm; 100nM in size) were prepared with low (SPC), medium (POPC) and high (HSPC) phase transition temperature values with and without cholesterol and anionic phosphatidyl glycerol (HSPC/DSPG; POPC/DMPG; SPC/EPG). ...
Vaccarezza María Magdalena MM Servicio de Neurología Infantil, Hospital Italiano de Buenos Aires, CABA, - - 2014
The modified Atkins diet (MAD) is an alternative therapeutic diet for the treatment of drug-resistant epilepsy. It consists of a diet with 60% energy from fat, 30% from protein, and 10% from carbohydrates. The objective of this article is to present a series of nine patients diagnosed with refractory epilepsy ...
King Vicky - - 2014
Maternal overnutrition during pregnancy is associated with an increased risk of obesity and cardiometabolic disease in the offspring; a phenomenon attributed to 'developmental programming'. The post-weaning development of obesity may associate with exacerbation of the programmed metabolic phenotype. In mice, we have previously shown that exposure to maternal overnutrition causes ...
Kim JieHoon - - 2014
Abstract Background. Excess subcutaneous fat causes not only cosmetic issues, but also substantial systemic health problems. Cryolipolysis has been reported to provide non-invasive fat reduction that significantly reduces subcutaneous fat cells with controlled, localized cooling. Objective. This study intended to determine whether a cryolipolysis device can effectively reduce subcutaneous fat ...
Helms Eric R ER Sport Performance Research in New Zealand (SPRINZ) at AUT Millennium Institute, AUT University, Auckland, New - - 2014
Athletes risk performance and muscle loss when dieting. Strategies to prevent losses are unclear. This study examined the effects of two diets on anthropometrics, strength and stress in athletes. This double-blind crossover pilot study began with 14 resistance-trained males (20-43 yr) and incurred one drop-out. Participants followed carbohydrate-matched, high-protein low-fat ...
Russo Matteo A - - 2014
The beneficial effects of the Mediterranean diet (MD) have been first observed about 50 years ago. Consumption of fresh vegetables and fruits, cereals, red wine, nuts, legumes, etc. has been regarded as the primary factor of protection from many human pathologies by the Mediterranean diet. Subsequently, this was attributed to ...
Schoeler Natasha E NE NIHR University College London Hospitals Biomedical Research Centre, Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK; Neurosciences Unit, UCL Institute of Child Health & Great Ormond Street Hospital for Children NHS Foundation Trust, 4/5 Long Yard, London, UK. Electronic address: - - 2014
Ketogenic dietary therapies are an effective treatment for children with drug-resistant epilepsy. There is currently no high-quality evidence regarding ketogenic dietary therapies in adults, and further research has been recommended. This audit aimed to provide further evidence for the feasibility of dietary treatment for adults and to consider factors that ...
Wencelová M M Institute of Animal Physiology, Slovak Academy of Sciences, Košice, Slovak - - 2014
Enrichment of wheat bran (WB), corn meal (CM) and barley flakes (BF) with the oleaginous fungus Cunninghamella echinulata (CE) might lead to effective use of these byproducts in ruminant nutrition. We examined their effects on rumen fermentation and lipid metabolism. WB, CM and BF substrates without or with brewer's grains ...
Ramos-Sanchez Eduardo Milton EM Departamento de Imunologia, Instituto de Ciências Biomédicas, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, São Paulo, SP, - - 2014
Antiretroviral therapy has been associated with side effects, either from the drug itself or in conjunction with the effects of human immunodeficiency virus infection. Here, we evaluated the side effects of the protease inhibitor (PI) indinavir in hamsters consuming a normal or high-fat diet. Indinavir treatment increased the hamster death ...
Tu Yaosheng Y Traditional Chinese Medicine Pharmacological Research Office, Guangdong Provincial Institute of Traditional Chinese Medicine, Guangzhou, Guangdong 510095, P.R. - - 2014
It has previously been demonstrated that curcumin possesses a hypocholesterolemic effect and potentiates numerous pharmacological effects of curcumin, however, the mechanisms underlying this hypocholesterolemic effect and the interaction between curcumin and piperine remain to be elucidated. In the present study, male Sprague-Dawley rats were fed on a high-fat diet (HFD) ...
Qiong Sun S Tourism Institute of Beijing Union University, No.97, Beisihuan East Road, Chao Yang District, Beijing, PR - - 2014
Pu'er Tea is a kind of traditional historical famous tea which gains its name for native government jurisdiction in Pu'er (now Xishuangbanna in Yunnan, Pu'er city etc), and takes Pu'er (now Ninger county of Pu'er city) city as its collecting and distributing center .It is famous all over the world ...
Valadao Jason M - - 2014
A ketogenic diet (KD) may decrease central nervous system oxygen toxicity symptoms in divers, and in view of this implication a feasibility/ toxicity pilot study was performed to demonstrate tolerance of KD while performing normal diving profiles. The exact mechanism of neuroprotection from the KD remains unknown; however, evidence to ...
Stradling C - - 2014
Dietary recommendations are key to cardiovascular disease (CVD) management. The underpinning evidence is generally based on data generated from single nutrient or food types. However, food is not consumed in such a manner, and components may interact synergistically or antagonistically depending on the dietary composition. Analyses of dietary patterns have ...
Barba I I University Hospital Vall d'Hebron, Barcelona, - - 2014
Dislipemia is a risk factor for cardiovascular diseases through the accumulation of cholesterol esters in coronary atherosclerotic plaques and indirectly because it can induce type-2 diabetes that it is, in turn, another cardiovascular risk factor. The formation of atherosclerotic plaques is a complex and much studied process that usually takes ...
Caraballo Roberto Horacio RH Servicio de Neurología, Hospital de Pediatría "Prof Dr Juan P Garrahan", Buenos Aires, Argentina. Electronic address: - - 2014
The ketogenic diet (KD) has been used as an alternative to antiepileptic drugs (AEDs) for patients with refractory epilepsy. Lennox-Gastaut syndrome (LGS) belongs to the group of epileptic encephalopathies that often prove refractory to AED treatment. In this prospective study we assess the efficacy and tolerability of the KD in ...
Mudryj Adriana N AN a Human Nutritional Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, - - 2014
Pulses (beans, peas, and lentils) have been consumed for at least 10 000 years and are among the most extensively used foods in the world. A wide variety of pulses can be grown globally, making them important both economically as well as nutritionally. Pulses provide protein and fibre, as well as ...
Zhao Yimin Y Department of Food Science and Nutrition, Zhejiang University, Hangzhou, People's Republic of - - 2014
The results of randomized controlled trials in relation to the effect of regular black tea consumption on serum cholesterol concentration were inconsistent. We aimed to investigate and quantify the effect of black tea consumption on serum concentrations of total, LDL and HDL cholesterol. We systematically searched and identified relevant literatures ...
Mason Julie K JK Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, 150 College St., Toronto, ON, M5S 3E2, Canada, - - 2014
Docosahexaenoic acid (DHA) is considered to be important for cardiac and brain function, and 17β-estradiol (E2) appears to increase the conversion of α-linolenic acid (ALA) into DHA. However, the effect of varying ALA intake on the positive effect of E2 on DHA synthesis is not known. Therefore, the objective of ...
Reid Christopher A CA Florey Institute of Neuroscience and Mental Health, the University of Melbourne, Parkville, Australia. Electronic address: - - 2014
Metabolic dysfunction leading to epilepsy is well recognised. Dietary therapy, in particular the ketogenic diet, is now considered an effective option. Recent genetic studies have highlighted the central role metabolism can play in setting seizure susceptibility. Here we discuss various metabolic disorders implicated in epilepsy focusing on energy deficiency due ...
Bougouin A A Animal Nutrition Group, Wageningen University, Wageningen, PO Box 338, 6700 AH, the Netherlands Department of Animal Science, University of California, Davis 95616 - - 2014
Phytase, a widely used feed additive in poultry diets, increases P availability and subsequently reduces inorganic-P supplementation and P-excretion. Phytase supplementation effect on P-retention in poultry has been investigated, but the effect sizes were highly variable. The present study's objective was to conduct several meta-analyses to quantitatively summarize the phytase ...
Solak Kamila A KA Institute for Risk Assessment Sciences, Faculty of Veterinary Medicine Utrecht University, Yalelaan 104, 3584 CM, Utrecht, The Netherlands. Electronic address: - - 2014
Flavanones such as naringenin (NAR) and 8-prenylnaringenin (8-PN) are increasingly used as dietary supplements despite scientific concern regarding adverse effects on female reproduction upon excessive intake. In the present study, NAR and 8-PN (0.3-1μM) significantly affected porcine oocyte maturation in vitro by decreasing cumulus expansion. In addition, NAR and 8-PN ...
Takechi Ryusuke - - 2014
Probucol has been shown to prevent cerebral capillary disturbances characterized by blood-to-brain extravasation of plasma derived proteins and neurovascular inflammation in mice maintained on western-styled diets for 12 weeks. However the effect of probucol on capillary integrity in aging models with capillary dysfunction is not known. Wild-type C57BL6 mice were ...
Mantis John G JG Biology Department, Boston College, Chestnut Hill, MA, - - 2014
The ketogenic diet (KD) is known to be anticonvulsant and anti-epileptogenic. While the mechanism behind this therapeutic benefit is unclear, a reduction of circulating glucose levels through calorie restriction (CR) has been implicated. Foods or drinks that elevate blood glucose are known to compromise the therapeutic benefit of the KD ...
Kricka Tajana - - 2014
Development of new technologies for the efficient use of proteins of animal origin, apart from heat treatment in rendering facilities that was used to date, has become the primary goal of the integral waste management system. The emergence of bovine spongiform encephalopathy in Europe and in the World in the ...
Selter Jessica H JH Johns Hopkins University School of Medicine, Baltimore, MD, - - 2014
Unlike anticonvulsant drugs and vagus nerve stimulation, there are no guidelines regarding adjustments to ketogenic diet regimens to improve seizure efficacy once the diet has been started. A retrospective chart review was performed of 200 consecutive patients treated with the ketogenic diet at Johns Hopkins Hospital from 2007 to 2013. ...
Herman-Lara Erasmo E Instituto Tecnológico de Tuxtepec , Tuxtepec, Oaxaca , Mexico - - 2014
Abstract The objective of this study was to evaluate the effect of micronized insoluble fiber from starfruit bagasse as an ingredient of a functional food (FF) or as micronized insoluble fiber-rich fraction (IFRF) and its effects in vivo on lipids metabolism in a murine model. Experimental animals were divided in ...
Snell Terry W TW School of Biology, Georgia Institute of Technology, Atlanta, GA, 30332-0230, USA. Electronic address: - - 2014
Diet has profound effects on animal longevity and manipulation of nutrient sensing pathways is one of the primary interventions capable of lifespan extension. This often is done through caloric restriction (CR) and a variety of CR mimics have been identified that produce life extending effects without adhering to the rigorous ...
Veggiotti Pierangelo P Department of Child Neurology and Psychiatry C. Mondino National Neurological Institute, Via Mondino, 2, 27100, Pavia, Italy, - - 2014
GLUT1 deficiency syndrome (GLUT1DS) results from impaired glucose transport into the brain: awareness of its wide phenotypic spectrum is a prerequisite in order to ensure an early diagnosis, treating the patients is the subsequent challenge to allow prompt compensation for the brain's lack of fuel. The ketogenic diet (KD) plays ...
Roddy Thomas P TP Merck Research Laboratories, Merck & Co., Inc. Kenilworth, NJ USA - - 2014
Inhibition of cholesteryl ester transfer protein (CETP) has been vigorously pursued as a potential therapy to treat patients who are at elevated risk for coronary artery disease. Anacetrapib, a novel CETP inhibitor, has been shown clinically to raise HDL cholesterol and reduce LDL cholesterol when provided as monotherapy or when ...
van Karnebeek Clara D M CD Centre for Molecular Medicine and Therapeutics, 3091-950 West 28th Avenue, Vancouver, Canada, V5Z 4H4, - - 2014
Background: Seventy-five percent of patients with pyridoxine-dependent epilepsy (PDE) due to Antiquitin (ATQ) deficiency suffer from developmental delay and/or intellectual disability (IQ < 70) despite seizure control. An observational study showed that adjunct treatment with a lysine-restricted diet is safe, results in partial normalization of lysine intermediates in body fluids, ...
Roberts Susan B SB Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA. Electronic address: - - 2014
While short-term studies demonstrate consistent effects of dietary protein, fiber, glycemic index and energy density on energy intake, long-term effectiveness trials typically indicate small or non-significant effects of these dietary factors on long-term weight change. In consequence, most lifestyle interventions for weight control typically focus on a single dietary factor, ...
Matsuzono Kosuke - - 2014
Objective and importance: Although ketogenic diet therapy is effective in refractory seizures in childhood, its effect on adult encephalitis with similar refractory seizures and prolonged encephalopathy has not been well reported. Clinical presentation: We report here a case of a 22-year-old man with acute encephalitis with refractory repetitive partial seizures ...
Schmidt Julie Berg JB 1University of - - 2014
Aim: To examine the effects of GLP-1 and PYY3-36, separately and in combination, on energy intake, energy expenditure, appetite sensations, glucose and fat metabolism, ghrelin and vital signs in healthy overweight men. Methods: 25 healthy, male subjects participated in this randomized, double-blinded, placebo-controlled 4-arm crossover study (BMI:29±3 kg/m2, age:33±9 years). ...
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