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Kareinen Ilona I Wihuri Research institute, - - 2014
Reverse cholesterol transport (RCT) pathway from macrophage foam cells initiates when HDL particles cross the endothelium, enter the interstitial fluid, and induce cholesterol efflux from these cells. We injected [3H]cholesterol-loaded J774 macrophages into the dorsal skin of mice and measured the transfer of macrophage-derived [3H]cholesterol to feces (m-RCT). Injection of ...
Tuso Phillip P Physician Leader for Total Health in Southern California. - - 2014
A plant-based diet is increasingly becoming recognized as a healthier alternative to a diet laden with meat. Atherosclerosis associated with high dietary intake of meat, fat, and carbohydrates remains the leading cause of mortality in the US. This condition results from progressive damage to the endothelial cells lining the vascular ...
Ogalla Elena E Department of Pharmacology, School of Pharmacy, University of Seville, C/ Profesor Garcia-Gonzalez 2, 41012 Seville, - - 2014
Objective: We analyzed the structural, mechanical, myogenic and functional properties of resistance arteries of ApoE KO compared to wild type (WT) mice. We also determined the influence of saturated fat in comparison to virgin olive oil-enriched diets in vascular wall abnormalities. Methods: Male ApoE KO (ApoE) and WT mice (8-weeks-old) ...
Martinez Laurent O LO INSERM, UMR 1048, Institut des Maladies Métaboliques et Cardiovasculaires de Toulouse, Toulouse, France; Université de Toulouse III, UMR 1048, Toulouse, France; CHU Toulouse, Department of Biochemistry, Toulouse, France. Electronic address: - - 2014
The atheroprotective property of High Density Lipoprotein (HDL) is supported by many epidemiological studies and cellular and in vivo approaches on animal models. While the anti-atherogenic effects of HDL are thought to derive primarily from its role in reverse cholesterol transport, together with anti-inflammatory, anti-oxidant, anti-thrombotic and cytoprotective properties, the mechanisms ...
El-Seweidy Mohamed Mahmoud MM Department of Biochemistry, Faculty of Pharmacy, Zagazig University, Sharkia Gov, Zagazig, 44519, Egypt, - - 2014
Micro and macrovascular complications occurring during hyperlipidemia are mostly attributed to haemostatic impairment and vascular endothelial dysfunction. Cholesteryl ester transfer protein (CETP) inhibitors have been emerged recently as promising hypocholesterolemic agents to confer protection against lipid-mediated atherosclerosis. Therefore, 10-dehydrogingerdione (DHGD), a novel CETP inhibitor isolated from ginger rhizomes, was selected ...
Gong Yong-Zhen YZ Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha, PR - - 2014
Background: Ezetimibe is a potent inhibitor of Niemann-Pick type C1-Like 1 and has been approved for the treatment of hypercholesterolemia. Our preliminary study showed that ezetimibe promotes cholesterol efflux from vascular smooth muscle cells (VSMCs). Our aim was to investigate the cellular mechanisms underlying the ezetimibe actions. Methods and Results: ...
Kusku-Kiraz Zeynep Z Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Capa, 34093, Istanbul, - - 2014
The aim of this study was to determine the levels of regulatory peptides apelin, glucagon-like peptide (GLP-1) and visfatin in hypercholesterolemic and hyperhomocysteinemic state and to examine their relation with nitric oxide (NO) metabolism. 32 Male guinea pigs were divided into four groups and each group was fed as follows: ...
Hohsfield Lindsay A LA Laboratory of Psychiatry and Experimental Alzheimer's Research, Department of Psychiatry and Psychotherapy, Medical University of Innsbruck, A-6020 Innsbruck, - - 2014
Several studies have shown that elevated plasma cholesterol levels (i.e. hypercholesterolemia) serve as a risk factor for late-onset Alzheimer's disease (AD). However, it remains unclear how hypercholesterolemia may contribute to the onset and progression of AD pathology. In order to determine the role of hypercholesterolemia at various stages of AD, ...
El-Farahaty Reham M RM Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, - - 2014
This work aimed to evaluate the metabolic and atherogenic effects of long-term antiepileptic drugs in a group of Egyptian epileptic patients. Sixty-nine epileptic patients on antiepileptic drug monotherapy for at least 2 years and 34 control subjects were recruited in this study. Patients were divided into 5 subgroups according to ...
Levinson Stanley S SS Department of Veteran Affairs Medical Center, 800 Zorn Avenue, Louisville, KY, United States. Electronic address: - - 2015
There is a strong epidemiological relationship between high density lipoproteins and atherosclerotic coronary vascular disease (ASCVD). The process of reverse cholesterol transport (RCT) has been hypothesized to help explain this relationship. The corollary that raising HDL should reduce ASCVD is also drawn from this relationship. In recent years, the metabolism ...
Uitz Elisabeth E Elisabeth Uitz, Babak Bahadori, Department of Internal Medicine 2, University Hospital of St. Poelten, Karl Landsteiner Private University of Health and Life Sciences, Probst-Fuehrer-Str. 4, - - 2014
Although high density lipoprotein (HDL)-mediated reverse cholesterol transport is crucial to the prevention and reversal of atheroma, a recent meta-analysis makes evident that current pharmaceutical strategies for modulating HDL cholesterol levels lower cardiovascular risk only to the extent that they concurrently decrease low density lipoprotein (LDL) cholesterol. This corresponds well ...
Lanham S A SA Bone and Joint Research Group, Human Development and Health, Institute of Developmental Sciences, Faculty of Medicine, University of Southampton, Southampton, SO16 6YD, - - 2014
Studies suggest bone growth & development and susceptibility to vascular disease in later life are influenced by maternal nutrition, during intrauterine and early postnatal life. There is evidence for a role of vitamin K-dependent proteins (VKDPs) including Osteocalcin, Matrix-gla protein, Periostin, and Gas6, in both bone and vascular development. We ...
Prüfer Nicole - - 2014
Abstract The high-density lipoprotein (HDL) is one of the most important endogenous cardiovascular protective markers. HDL is an attractive target in the search for new pharmaceutical therapies and in the prevention of cardiovascular events. Some of HDL's anti-atherogenic properties are related to the signaling molecule sphingosine-1-phosphate (S1P), which plays an ...
Jamshed Humaira H Natural Product Research Unit, Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan; - - 2014
Almonds are reported to be protective against cardiovascular diseases (CVDs); however, the possible mode of action has only infrequently been explored. This study aimed at investigating the mechanistic basis for the benefits of almonds in atherosclerotic CVDs. Three studies in 3 groups of rats were designed with the use of ...
Abraham Nader G NG From the Departments of Medicine and Pharmacology, New York Medical College, Valhalla (N.G.A., M.L.S.); Departments of Medicine and Obstetrics and Gynecology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV (K.S., A.M.S.); Biochemistry Section and Medicinal Chemistry Section, Department of Drug Sciences, University of Catania, Catania, Italy (L.V.); Department of Clinical and Experimental Sciences, Division of Anatomy and Physiopathology, University of Brescia, Brescia, Italy (G.F., R.R.); Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC (C.L., D.C.Z.). - - 2014
Obesity is a global epidemic and a common risk factor for endothelial dysfunction and the subsequent development of diabetes mellitus and vascular diseases such as hypertension. Epoxyeicosatrienoic acids (EETs) are cytochrome P450 (CYP)-derived metabolites of arachidonic acid that contribute to vascular protection by stimulating vasodilation and inhibiting inflammation. Heme oxygenase-1 ...
Park Jong-Ho JH From the Department of Stroke Neurology, Myongji Hospital, Goyang, Korea (J.-H.P.); Department of Biostatistics, College of Medicine, Korea University, Seoul, Korea (J.L.); and Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina (J.-H.P., - - 2014
Expert consensus guidelines recommend low-density lipoprotein cholesterol as the primary serum lipid target for recurrent stroke risk reduction. However, mounting evidence suggests that other lipid parameters might be additional therapeutic targets or at least also predict cardiovascular risk. Little is known about the effects of nontraditional lipid variables on recurrent ...
Heimlich J Brett JB Department of Physiology, Georgia Regents University, 30912, Augusta, - - 2014
The current study was designed to determine whether ET-1 derived from endothelial cells contributes to oxidative stress in the glomerulus of mice subjected to a high salt diet and/or hypoxia. C57BL6/J control mice or vascular endothelial cell ET-1 knockout (VEET KO) mice were subjected to three-hour exposure to hypoxia (8% ...
Fuller Mark M From the Departments of Biochemistry and Biomedical Sciences (M.F., O.D., V.S., D.A., M.M., N.D., B.L.T.), Pathology and Molecular Medicine (J.M., S.A.I.), and Biology (S.A.I.), McMaster University, Hamilton, Ontario, Canada; and Thrombosis and Atherosclerosis Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada (M.F., O.D., V.S., M.M., N.D., - - 2014
Deficiency of the high-density lipoprotein receptor, scavenger receptor class B, type I (SR-BI), in apolipoprotein E knockout or hypomorphic mice, respectively, results in spontaneous or diet-inducible occlusive coronary artery (CA) atherosclerosis, myocardial infarction, and early death. Here, we examine effects of SR-BI deficiency on cardiovascular phenotypes in low-density lipoprotein receptor ...
Yu Qi Q Institute of Basic and Translational Medicine, Xi'an Medical University, Xi'an, Shaanxi, P. R. - - 2014
Low-density lipoprotein (LDL) is the major atherogenic lipoprotein and the primary target of lipid-lowering therapy for treating ischemic cardiovascular disease. Apolipoprotein B (apoB), an important structural component of LDL, plays a key role in cholesterol transport and removal in vascular wall. On the other hand, under pathological process, apoB interacts ...
O'Hare Elizabeth A EA University of Maryland School of Medicine, United - - 2014
Hyperlipidemia and arterial cholesterol accumulation are primary causes of cardiovascular events. Monogenic forms of hyperlipidemia and recent GWAS indicate that genetics plays an important role. Zebrafish are a useful model for studying the genetic susceptibility to hyperlipidemia owing to conservation of many components of lipoprotein metabolism - including those related ...
Uemura Hirokazu H Department of Preventive Medicine,Institute of Health Biosciences, The University of Tokushima Graduate School,3-18-15 - - 2014
Studies on the associations of dietary Ca and vitamin D intakes with arterial stiffness are scarce. In the present study, these associations were evaluated in Japanese men. Data from a total of 535 eligible men, aged 35-69 years, who participated in the baseline survey of a cohort study in Tokushima ...
Khouri Roger K RK Jr Division of Plastic Surgery, Brigham and Women's Hospital, Boston, Mass.; University of Michigan Medical School, Ann Arbor, Mich.; Gulliver Preparatory School, Pinecrest, Fla.; College of Engineering, Boston University, Boston, Mass.; Institute of Plastic Reconstructive and Aesthetic Surgery, University of Padova, Padova, Italy; and Harvard Medical School, Boston, - - 2014
Fat grafting is now widely used in plastic surgery. Long-term graft retention can be unpredictable. Fat grafts must obtain oxygen via diffusion until neovascularization occurs, so oxygen delivery may be the overarching variable in graft retention. We studied the peer-reviewed literature to determine which aspects of a fat graft and ...
Lopez-Jimenez Francisco F Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN. Electronic address: - - 2014
The American College of Cardiology/American Heart Association (ACC/AHA) Task Force on Practice Guidelines has recently released the new cholesterol treatment guideline. This update was based on a systematic review of the evidence and replaces the previous guidelines from 2002 that were widely accepted and implemented in clinical practice. The new ...
Paz H A HA Department of Animal Science, University of Nebraska-Lincoln, Lincoln - - 2014
The objective of this study was to evaluate the effects of feeding different amounts of low-fat distillers dried grains with solubles (DDGS) in diets with or without supplementation of rumen-protected Lys (RPL) on lactation responses and AA utilization. Eight multiparous Holstein cows averaging 188 ± 13 DIM were assigned to ...
Schroeder A R AR University of Illinois at Urbana-Champaign, Department of Animal Sciences, Urbana, IL - - 2014
The objectives of this study were to determine the interaction of feeding dried corn distillers grains ( DDGS: ) or modified wet corn distillers grains ( MDGS: ) with or without CaO treatment to feedlot steers on: (1) growth performance and carcass characteristics; and (2) diet digestibility, pattern of intake, ...
Bertz Fredrik - - 2014
The aim of this study was to evaluate dietary changes during and after a dietary treatment shown to result in significant and sustained weight loss among lactating overweight and obese women. This is crucial before clinical implementation. Data were collected from the LEVA (in Swedish: Livsstil för Effektiv Viktminskning under ...
Anhê Fernando F FF Department of Medicine, Faculty of Medicine, Cardiology Axis of the Quebec Heart and Lung Institute, Quebec, Quebec, Canada Institute of Nutrition and Functional Foods, Laval University, Quebec, Quebec, - - 2014
The increasing prevalence of obesity and type 2 diabetes (T2D) demonstrates the failure of conventional treatments to curb these diseases. The gut microbiota has been put forward as a key player in the pathophysiology of diet-induced T2D. Importantly, cranberry (Vaccinium macrocarpon Aiton) is associated with a number of beneficial health ...
Norén Erik - - 2014
Very low calorie diet (VLCD) is routinely used in programs for treatment of obesity and before bariatric surgery in order to reduce risk of postoperative complications. Aspartame, an artificial sweetener, is commonly used in VLCD and is well approved as a food additive without any adverse effects. The development of ...
Romero L F LF Danisco Animal Nutrition, DuPont Industrial Biosciences, Marlborough, Wiltshire, UK - - 2014
The ileal energy contribution of protein, starch, and fat in response to 2 exogenous enzyme combinations was studied in 2 digestibility assays with 21- (experiment 1; 432 birds) and 42-d-old (experiment 2; 288 birds) Ross 308 broiler chickens. A 2 × 2 × 3 factorial arrangement of treatments with 2 ...
Meléndez Giselle C GC From the 1Department of Pathology/Comparative Medicine, Wake Forest School of Medicine, Winston-Salem, NC; and 2University of Hawaii Cancer Center, Honolulu, - - 2014
The objective of this study was to use a well-established monkey model of atherosclerosis to determine how life stage and preexisting atherosclerosis influence the effectiveness of high-isoflavone soy diet in inhibiting progression of atherosclerosis. For 34 months, premenopausal monkeys were fed an atherogenic diet, with protein derived primarily from either ...
Sumithran Priya P Department of Medicine (Austin Health), University of Melbourne, Heidelberg Repatriation Hospital, Heidelberg, VIC, 3081, Australia, - - 2014
Orlistat, an inhibitor of intestinal lipase, has been available for the treatment of obesity for nearly two decades. In conjunction with a hypocaloric diet, orlistat treatment results in a placebo-subtracted reduction in body weight of around 3 kg at 1 year, and increases the likelihood of achieving clinically significant (≥5 %) weight loss ...
Arriola Apelo S I SI Department of Dairy Science, Virginia Tech, Blacksburg - - 2014
When fed to meet the metabolizable protein requirements of the National Research Council, dairy cows consume an excess of N, resulting in approximately 75% of dietary N being lost to the environment as urine and feces. Reductions in environmental N release could be attained through an improvement in N efficiency. ...
Holligan Simone D SD Department of Nutritional Sciences,The Pennsylvania State University,110 Chandlee Laboratory,University - - 2014
A randomised, cross-over, controlled-feeding study was conducted to evaluate the cholesterol-lowering effects of diets containing pistachios as a strategy for increasing total fat (TF) levels v. a control (step I) lower-fat diet. Ex vivo techniques were used to evaluate the effects of pistachio consumption on lipoprotein subclasses and functionality in ...
Ahn Younghee Y Department of Pediatrics, Alberta Children's Hospital Research Institute for Child and Maternal Health, Faculty of Medicine, University of Calgary, Calgary, Alta., - - 2014
Autism spectrum disorder (ASD) is a highly prevalent neurodevelopmental disorder characterized by abnormal social interactions, communication deficits and stereotyped or repetitive behaviors. Although the etiology of ASD remains elusive, converging lines of research indicate that mitochondrial dysfunction may play a substantive role in disease pathophysiology. Without an established causal link, ...
Matthews James C JC Department of Animal and Food Sciences, University of Kentucky, Lexington, KY, 40546, USA, - - 2014
Selenium (Se) is an important trace mineral that, due to deficiencies in the soil in many parts of the USA, must be supplemented directly to the diet of foraging cattle. Both organic and inorganic forms of dietary Se supplements are available and commonly used, and it is known that Se ...
Paranandi Anu A Tufts Medical Center, Division of Geographic Medicine and Infectious Diseases, Boston, Massachusetts, United States ; - - 2014
Abstract Objective: Hypertriglyceridemia and low HDL-cholesterol (HDL-C) have been identified as independent risk factors for accelerated cardiovascular disease in the general population, and may contribute to a presumed accelerated risk for cardiovascular disease in HIV-infected individuals. We evaluated the effect of omega-3 fatty acid treatment on triglycerides, LDL-C, HDL-C and ...
Mannarino Massimo R MR Unit of Internal Medicine, Angiology and Arteriosclerosis Diseases, Department of Medicine, University of Perugia, Perugia, Italy. Electronic address: - - 2014
Hypercholesterolemia is a well-established modifiable cardiovascular risk factor and its treatment is an essential aim in preventing cardiovascular disease. Current guidelines highlight lifestyle intervention as a primary issue in the treatment of the patient with hypercholesterolemia. Therapeutic lifestyle changes are often insufficient to achieve desirable cholesterol levels. This is particularly ...
Mäki Markku M Tampere Center for Child Health Research, University of Tampere and Tampere, University Hospital, Tampere, - - 2014
The basis for celiac disease (CD) treatment is a strict lifelong gluten-free diet. On the diet, the small intestinal mucosal injury heals and gluten-induced symptoms and signs disappear. The mucosal healing is a prerequisite for sustaining health and is also obtained with a diet containing oats and trace amounts of ...
Xie Baogang - - 2014
D-glucaro 1,4-lacton (1,4-GL) has been shown to have a hypocholesterolemic effect in rats and human subjects. However, little information is known concerning the alteration of metabolome associated with the effect. Here, we show that 1,4-GL delays the development of hypercholesterolemia with the coadministration of high fat high cholesterol diet (HFHC) ...
Shi Shu-Tian ST 1Department of Cardiology, Anzhen Hospital, Capital Medical University; 2Beijing Institute of Heart Lung and Blood Vessel - - 2014
The beta-3-adrenoceptor (β3-AR) protects against the progression of atherosclerosis. However, the specific mechanism of this antiatherosclerotic effect is still not clear. Thus, the aim of this study was to understand the antiatherosclerotic effects of β3-AR. Thirty-six male homozygous apolipoprotein E-deficient mice and wild-type C57BL/6J mice were randomized into 6 treatment ...
Altemus Jessica B JB Genomic Medicine Institute, The Cleveland Clinic Foundation, Cleveland, OH, USA. Electronic address: - - 2014
Previous studies have shown ezetimibe treatment results in a 2-6-fold increase in reverse cholesterol transport (RCT). However, recent sterol balance studies question the role of biliary sterol secretion in RCT, and challenge the hypothesis that ezetimibe increases RCT through decreased absorption of biliary cholesterol in the intestine. We set out ...
Silva P R B PR Department of Veterinary Population Medicine, University of Minnesota, St. Paul 55108; Department of Animal Science, University of Minnesota, St. Paul - - 2014
The objectives of the current experiment were to determine the effects of 2 prepartum stocking densities on milk yield, concentration of metabolites during the peripartum period, and health and reproductive parameters of dairy cows. Jersey cows enrolled in the experiment at 254 ± 3 d of gestation were balanced for ...
Schroeder J W JW Department of Animal Sciences, North Dakota State University, Fargo 58108. Electronic address: - - 2014
Four multicannulated (rumen, duodenum, and ileum) Holstein steers (459.7 ± 46.4 kg of initial body weight) were used in a 4 × 4 Latin square design to determine the effect of flaxseed processing method on ruminal fermentation and digestibility. Treatments were based on inclusion of (1) 7.5% linseed meal (control), ...
Xin Hai-Guang HG Department of Infectious Disease, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai, 200003, - - 2014
Baicalein, a naturally occurring flavone, has been proved as a promising chemopreventive compound for many chronic human diseases. The aim of this work was to investigate whether treatment with baicalein prevented nonalcoholic steatohepatitis (NASH) induced by methionine-choline-deficient (MCD) diet. Rats were divided into four experimental groups and fed for 8 ...
Rawal Sumit S Graduate Toxicology Program, and Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT 84322, - - 2014
Turkeys are extremely sensitive to aflatoxin B1 (AFB1) which causes decreased growth, immunosuppression and liver necrosis. The purpose of this study was to determine whether probiotic Lactobacillus, shown to be protective in animal and clinical studies, would likewise confer protection in turkeys, which were treated for 11 days with either AFB1 ...
Dallmeier Dhayana D University of Ulm Medical Center, Department of Internal Medicine II - Cardiology, Albert-Einstein-Allee 23, D-89081 Ulm, Germany. Electronic address: - - 2014
Considerable progress has been achieved in the treatment of dyslipidemias. However, half of cardiovascular events occur in individuals with average or low cholesterol levels and there is still a considerable residual risk with 70% of patients having an event despite statin treatment. In the era of personalized medicine there is ...
Gonsalves Nirmala N Division of Gastroenterology & Hepatology, Northwestern University-Feinberg School of Medicine, 676 North Saint Claire, Suite 1400, Chicago, IL 60611, - - 2014
Emerging evidence supports impaired epithelial barrier function as the key initial event in the development of eosinophilic esophagitis (EoE) and other allergic diseases. Symptom resolution, histologic remission, and prevention of both disease and treatment-related complications are the goals of treatment. Successful dietary treatments include elemental, empirical elimination and allergy test ...
Conneely M M Animal & Grassland Research and Innovation Centre, Teagasc, Moorepark, Fermoy, Co. Cork, Ireland; School of Veterinary Medicine, University College Dublin, Dublin 4, - - 2014
Absorption of adequate IgG from colostrum is critical to provide the newborn calf with adequate immunological protection and resistance to disease. Excessive iodine supplementation of the prepartum ewe reduces IgG absorption of her offspring; it is possible that excessive iodine supplementation of the prepartum dairy cow may similarly impair the ...
Goldgof Margalit M NIH, United - - 2014
The chemical uncoupler 2,4-dinitrophenol (DNP) was an effective and widely used weight loss drug in the early 1930s. However, DNP's physiology has not been studied in detail as toxicity, including hyperthermia and death, reduced interest in the clinical use of chemical uncouplers. To investigate DNP action, mice fed a high ...
Lu T T Department of Animal and Poultry Sciences, Virginia Tech, Blacksburg - - 2014
The aim of the study was to determine the effects of a dietary antioxidant blend (AB) and vitamin E on performance, oxidative status, and meat quality. Cobb 500 male broilers (n = 1,200, d 0) were randomly distributed into 6 treatments with 10 replicate pens. Treatments included 1) HO: high ...
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