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Vitturi Nicola N Division of Metabolic Diseases, Department of Medicine, University Hospital of Padova-Italy, Via Giustiniani 2, 35128, Padova, Italy, - - 2014
The aim of our study was the evaluation of anthropometric measurements [waist circumference and sagittal abdominal diameter (SAD)] and abdominal bioelectrical impedance analysis (BIA) (ViScan, TANITA) in comparison to several abdominal ultrasonographic (US) measurements to estimate visceral fat deposition and liver steatosis in a population of 105 subjects. All 105 ...
Gonçalves Inês O IO Research Center in Physical Activity, Health and Leisure, Faculty of Sport, University of Porto, Portugal. Electronic address: - - 2014
Mitochondrial membrane lipid composition is a critical factor in non-alcoholic steatohepatitis (NASH). Exercise is the most prescribed therapeutic strategy against NASH and a potential modulator of lipid membrane. Thus, we aimed to analyze whether physical exercise exerted preventive (voluntary physical activity-VPA) and therapeutic (endurance training-ET) effect on NASH-induced mitochondrial membrane ...
Nesic Jelena J School of Psychology, University of Sussex, Falmer, Brighton, - - 2014
Stress is known to play an important role in alcohol abuse, whereas binge drinking may increase individuals' susceptibility to the development of alcohol dependence. We set out to investigate whether binge drinkers (BDs) or non-BDs (NBDs) are at a greater risk of an increase in their desire for alcohol following ...
Dou Xiaobing X College of Life Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China; Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, - - 2014
Overactive lipolysis in adipose tissue contributes to the pathogenesis of alcoholic liver disease (ALD); however, the mechanisms involved have not been elucidated. We previously reported that chronic alcohol consumption produces a hypomethylation state in adipose tissue. In this study we investigated the role of hypomethylation in adipose tissue in alcohol-induced ...
Sofi Francesco F Francesco Sofi, Alessandro Casini, Department of Experimental and Clinical Medicine, University of Florence, 50134 Florence, - - 2014
Non-alcoholic fatty liver disease (NAFLD) represents the most common chronic liver disease in Western countries, being considered as the hepatic manifestation of metabolic syndrome. NAFLD has a common pathogenic background to that of metabolic syndrome, and shares many risk factors such as obesity, hypertension, insulin resistance and dyslipidemia. Although there ...
Pyun Chang-Won CW Department of Food Science and Biotechnology of Animal Resources, Konkuk University, Seoul, 143-701, Republic of - - 2014
BALB/c mice were exposed to chronic alcohol-induced oxidative stress by intragastric administration of excessive ethanol (5 g/kg body weight) during the 24-week period. Curcumin (0.016%) or capsaicin (0.014%) containing diets were fed with or without ethanol treatment in four groups. There was no statistically significant difference in the behavioral test ...
Li Qiong Q Center for Translational Biomedical Research, University of North Carolina at Greensboro, Kannapolis, North - - 2014
Alcohol abuse frequently causes niacin deficiency in association with the development of alcoholic liver disease. The objective of the present study was to determine whether dietary nicotinic acid (NA) deficiency exaggerates and whether dietary NA supplementation alleviates alcohol-induced fatty liver. Male Sprague-Dawley rats were pair-fed with 4 isocaloric liquid diets: ...
Yoshihiko Terashima T Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chu-o-ku, Kobe, Hyogo 650-0017, - - 2014
Non-alcoholic fatty liver disease (NAFLD) is the commonest form of chronic liver disease in developed countries. Non-alcoholic steatohepatitis (NASH), which represents advanced stage NAFLD, is increasingly being recognized as a major cause of liver-related morbidity and mortality. However, no effective drugs against NASH have yet been developed. Therefore, we searched ...
Deng Jie J Department of Medical Imaging, Ann & Robert H. Lurie Children's Hospital of Chicago, 225 E. Chicago Ave., Box 9, Chicago, IL, 60611-2605, USA, - - 2014
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in children. The gold standard for diagnosis is liver biopsy. MRI is a non-invasive imaging method to provide quantitative measurement of hepatic fat content. The methodology is particularly appealing for the pediatric population because of its ...
León-Muñoz L M LM CIBERESP, Madrid, Spain; Department of Preventive Medicine and Public Health, Universidad Autónoma de Madrid/IdiPaz, 28049 Madrid, - - 2014
Over the last 50 years, people in Spain have increasingly been eating their main meal away from home and are shifting from the typical Mediterranean diet (MD). In addition, wine consumption has decreased whereas beer intake has risen. Consequently, it is uncertain if the Mediterranean drinking pattern (MDP; moderate alcohol ...
Yu Yao Ting YT The Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University , Tianjin , P. R. - - 2014
Spacer can effectively reduce the steric hindrance and synergistic effect of the hydrophilic and hydrophobic ligands immobilized in adsorbents can improve the specific adsorption for low-density lipoprotein (LDL). In this paper, in order to improve the adsorption capacity for the Low-density lipoprotein-cholesterol (LDL-C), specifically, amphiphilic adsorbent based on polyvinyl alcohol ...
Gołębiowski Marek M Laboratory of Natural Product Analysis, Department of Environmental Analysis, Institute for Environmental and Human Health Protection, Faculty of Chemistry, University of Gdańsk, ul. Wita Stwosza 63, PL-80-308 Gdańsk. - - 2014
The composition of the cuticular and internal lipids of larvae and pupae of Lucilia sericata was studied using chromatographic techniques. The lipids from both stages of L. sericata had similar free fatty acid (FFA) profiles and also contained alcohols and cholesterol. The range of the number of C-atoms detected for ...
Schwingel Paulo Adriano PA 1Programa de Pós-graduação em Medicina e Saúde (PPgMS), Faculdade de Medicina da Bahia (FMB), Universidade Federal da Bahia (UFBA), Rua Augusto Viana S/N, Salvador, - - 2014
Anabolic-androgenic steroids (AAS) are used to enhance physical performance and/or appearance. The aim of this study was to evaluate the influence of the concomitant use of alcohol, tobacco, cocaine, and AAS on blood lipid profiles of 145 asymptomatic male bodybuilders from the Northeast region of Brazil. Interviews, clinical exams, and ...
Liu Jing J Second Clinical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, - - 2014
The aim of the present study was to investigate toll-like receptor-4 (TLR4) signalling at different stages of non-alcoholic fatty liver disease (NAFLD) induced by high fat high fructose (HFHFr) diet in mice. TLR4 wild type (WT) and mutant (TLR4mut) mice were fed with either standard chow (SC) or HFHFr diet ...
Parlesak Alexandr A Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark (DTU), Kamitorvet, Building 208, DK-2800 Lyngby, - - 2014
So far, little is known about the effect of nutrition and lifestyle on the composition of circulating lipoprotein subfractions. In the current study, we measured the correlations among physical activity, nutrient intake, smoking, body-mass index (BMI), and age with the concentration of triglycerides, cholesterol, phospholipids, and apolipoproteins (ApoA1, ApoA2 and ...
Goldsmith Jason R JR School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, USA, - - 2014
Dietary impacts on health may be one of the oldest concepts in medicine; however, only in recent years have technical advances in mass spectroscopy, gnotobiology, and bacterial sequencing enabled our understanding of human physiology to progress to the point where we can begin to understand how individual dietary components can ...
Hendrikx T T Department of Molecular Genetics, Maastricht University, Maastricht, The - - 2014
Many studies show an association between the accumulation of cholesterol inside lysosomes and the progression towards inflammatory disease states that are closely related to obesity. While in the past, the knowledge regarding lysosomal cholesterol accumulation was limited to its association with plaque severity during atherosclerosis, recently, a growing body of ...
Wakabayashi I I Department of Environmental and Preventive Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, - - 2014
Lipid-related indices, including the ratio of LDL cholesterol to HDL cholesterol, the ratio of triglycerides to HDL cholesterol and lipid accumulation product, are known to be good discriminators for cardiovascular disease. The aim of this study was to clarify the relationships between smoking and the lipid indices in patients with ...
Bukiya Anna A Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, Memphis, - - 2014
Binge drinking represents the major form of excessive alcohol (ethanol [EtOH]) consumption in the United States. Episodic (such as binge) drinking results in blood alcohol levels (BAL) of 18 to 80 mM and leads to alcohol-induced cerebral artery constriction (AICAC). AICAC was shown to arise from EtOH-induced inhibition of large-conductance, calcium/voltage-gated ...
Chang Hong-Chou HC Institute of Medicine, Chung-Shan Medical University, - - 2014
Obesity is associated with a great diversity of diseases including non-alcoholic fatty liver disease. Our previous report suggested that Hibiscus sabdariffa extracts (HSE) had a metabolic-regulating and liver-protecting potential. In this study, we performed a clinical trial to further confirm the effect of HSE. Subjects with a BMI ≧ 27 ...
Marchini Adriana Mathias Pereira da Silva AM Department of Biosciences and Diagnostics, Institute of Science and Technology, UNESP - State University of Sao Paulo, São José dos Campos, São Paulo, - - 2014
Studies suggest that chronic alcoholism as well as oestrogen deficiencies may affect bones in general, including alveolar bone and, by doing so, increase individuals' susceptibility to develop progressive periodontal disease. This paper aims to verify the influence of chronic alcoholism and/or oestrogen deficiencies in the apoptosis of bone cells of ...
O'Gorman A A UCD Institute of Food and Health, University College Dublin, Belfield, Dublin 4, Ireland; UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, - - 2014
Reliable dietary assessments are essential when attempting to understand the complex links between diet and health. Traditional methods for collecting dietary exposure can be unreliable, therefore there is an increasing interest in identifying biomarkers to provide a more accurate measurement. Metabolomics is a technology that offers great promise in this ...
Lee Hae-In HI Department of Food and Nutrition, Sunchon National University, Suncheon, 540-950, South - - 2014
This study investigated the effects of scopoletin on alcohol-induced hepatic lipid accumulation in diet-induced obese mice and its mechanism. Alcohol (25% v/v, 5g/kg body weight) was orally administered once a day for 6 weeks to mice fed with a high-fat diet (35%kcal) with or without scopoletin (0.05%, wt/wt). Scopoletin reduced ...
- - 2014
[This corrects the article DOI: 10.1371/journal.pone.0086724.].
Spolding Briana B Metabolic Research Unit, School of Medicine, Deakin University, Geelong, Victoria, - - 2014
A major impediment to establishing new treatments for non-alcoholic steatohepatitis is the lack of suitable animal models that accurately mimic the biochemical and metabolic characteristics of the disease. The aim of this study was to explore a unique polygenic animal model of metabolic disease as a model of non-alcoholic steatohepatitis ...
Adeyemi O S OS Department of Biological Sciences, Landmark University, Omu-Aran 370102, Kwara State, - - 2014
Background. The Moringa oleifera plant has been implicated for several therapeutic potentials. Objective. To evaluate whether addition of M. oleifera to diet has protective effect against nickel-induced nephrotoxicity in rats. Methodology. Male Wistar rats were assigned into six groups of five. The rats were given oral exposure to 20 mg/kg nickel ...
Kondoh Tomoko T Division of Preventive Medicine and Diabetes Education, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, 1-1 Mukaihata-cho, Fushimi-ku, Kyoto 612-8555, Japan. Electronic - - 2014
Summary: Objective: The aim of this study was to assess the relationship between dietary factors and abdominal subcutaneous and visceral adipose tissue in overweight and obese men.Methods: A pooled cross-sectional analysis was conducted to evaluate the associations between dietary factors (nutrition, dietary pattern and alcohol consumption) and subcutaneous fat area ...
Carr Rotonya M RM University of Pennsylvania, Perelman School of Medicine, Department of Medicine, Gastroenterology Division, Philadelphia, Pennsylvania, United States of - - 2014
Perilipin 2 (Plin2) is a lipid droplet protein that has roles in both lipid and glucose homeostasis. An increase in Plin2 in liver is associated with the development of steatosis, glucose intolerance, and ceramide accumulation in alcoholic liver disease. We investigated the role of Plin2 on energy balance and glucose ...
Yao Ruiqing R Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, - - 2014
To elucidate the effect of the polyphenols contained in alcoholic beverages on the metabolic stress induced by ethanol consumption, four groups of mice were fed for five weeks on Lieber's diet with or without ethanol, with ethanol plus ellagic acid, and with ethanol plus trans-resveratrol. Alcoholic fatty liver was observed ...
Ganji Shobha H SH - - 2013
Non-alcoholic fatty liver disease (NAFLD), a leading cause of liver damage, comprises of a spectrum of liver abnormalities including the early fat deposition in the liver (hepatic steatosis) and advanced nonalcoholic steatohepatitis (NASH). Niacin decreases plasma triglycerides, but its effect on hepatic steatosis is elusive. To examine the effect of ...
Chang Chia Ju CJ Department of Pharmacy & Graduate Institute of Pharmaceutical Technology, Tajen University, Yanpu Shiang, Ping Tung Shien, Taiwan, - - 2013
The beneficial effects of the ethanol extract of Zingiber zerumbet rhizome (EEZZR) for use in the treatment of non-alcoholic fatty liver disease (NAFLD) were investigated. Syrian golden hamsters were fed a high-fat diet to induce NAFLD. EEZZR (100, 200, or 300 mg/kg) were orally administered by gavage once daily for ...
Pan Min-Hsiung - - 2013
Nonalcoholic fatty liver disease (NAFLD) refers to a wide spectrum of liver disease that is not from excess alcohol consumption, but is often associated with obesity, type 2 diabetes, and metabolic syndrome. NAFLD pathogenesis is complicated and involves oxidative stress, lipotoxicity, mitochondrial damage, insulin resistance, inflammation, and excessive dietary fat ...
Fan Jian-Gao - - 2013
Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum ranging from simple steatosis to non-alcoholic steatohepatitis, which causes an increased risk of cirrhosis, type 2 diabetes, and cardiovascular complications. With the worldwide growing incidence of obesity, sedentary lifestyle, and unhealthy dietary pattern, NAFLD has currently been recognized as a major health ...
Clugston Robin D - - 2013
CD36 is a scavenger receptor with multiple ligands and cellular functions, including facilitating cellular uptake of free fatty acids (FFA). Chronic alcohol consumption increases hepatic CD36 expression, leading to the hypothesis that this promotes uptake of circulating FFA, which then serve as a substrate for triglyceride (TG) synthesis and the ...
Pruis Maurien G M - - 2013
Metabolic programming via components of the maternal diet during gestation may play a role in the development of different aspects of the metabolic syndrome. Using a mouse model we aimed to characterize the role of maternal western type diet in the development of non-alcoholic fatty liver disease (NAFLD) in the ...
Wang Linlong - - 2013
An increase in susceptibility to metabolic syndromes (MetS) in rat offspring that experienced prenatal caffeine exposure (PCE) has been previously demonstrated. The present study aimed to clarify this increased susceptibility and elucidate the mechanism of foetal origin that causes or contributes to adult non-alcoholic fatty liver disease (NAFLD) as a ...
Clarke John D - - 2013
Non-alcoholic steatohepatitis (NASH) is a progressive form of non-alcoholic fatty liver disease (NAFLD) and is a major cause of liver cirrhosis and hepatic failure. The methionine choline-deficient diet (MCD) is a frequently used hepatotoxicity animal model of NASH that induces hepatic transaminase (ALT, AST) elevations and hepatobiliary histological changes similar ...
Katsiki Niki - - 2013
Abstract In this issue of the journal Pintó et al.(1) report the achievement of fasting triglyceride (TG) target values (≤ 2.2 mmol/L; 200 mg/dL) in patients (n = 929) attending lipid clinics of the Spanish Arteriosclerosis Society. Those who did not reach the TG goal (56% of the study population) ...
Chang Yuan-Yen - - 2013
Chronic alcohol consumption leads to steatohepatitis and cirrhosis. Naturally fermented noni juice (NJ) contains polyphenols, polysaccharides, and some trace minerals. This study was to explore protective effects of NJ against chronic alcohol consumption. Mice were assigned randomly to one of the following groups: (1) Control: control liquid diet and distilled ...
Chrostek Lech - - 2013
The effect of severity of liver cirrhosis, an alcoholic and non-alcoholic genesis, on the results of serum lipids and lipoproteins was evaluated. Serum cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-Ch), and low-density lipoprotein cholesterol (LDL-Ch) were measured in the sera of 59 patients suffering from alcoholic cirrhosis and 34 patients with ...
Wakabayashi Ichiro - - 2013
The ratio of triglycerides to HDL cholesterol (TG/HDL-C ratio) and lipid accumulation product (LAP: a continuous marker of lipid over-accumulation determined by waist circumference and triglycerides) have been proposed to be good predictors of cardiovascular disease. The aim of this study was to clarify the relationships between heavy alcohol drinking ...
Simet Samantha M - - 2013
Previously we have shown that chronic alcohol intake causes alcohol-induced ciliary dysfunction (AICD), leading to non-responsive airway cilia. AICD likely occurs through the downregulation of nitric oxide (NO) and cyclic nucleotide-dependent kinases, protein kinase G (PKG) and protein kinase A (PKA). Studies by others have shown that dietary supplementation with ...
Okubo Hirofumi - - 2013
Gut microbiota alternations are associated with various disorders. In this study, gut microbiota changes were investigated in a methionine-choline deficient (MCD) diet-induced non-alcoholic steatohepatitis (NASH) rodent model, and the effects of administering Lactobacillus casei strain Shirota (LcS) on the development of NASH were also investigated. Mice were divided into three ...
Chung Hye-Kyung - - 2013
The aim of the present study was to evaluate the associations between dietary patterns and blood levels of lead and mercury in Korean adults. A total of 858 Korean adults (⩾20 years) who participated in the Korea National Health and Nutrition Examination Survey (KNHANES) V-1 2010 were included in this ...
Nascimento André F AF Nutrition and Cancer Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA; ; Department of Internal Medicine, Botucatu School of Medicine, São Paulo State University (UNESP), Botucatu, São Paulo, - - 2013
Chronic alcohol intake decreases adiponectin and sirtuin 1 (SIRT1) expressions, both of which have been implicated in various biological processes including inflammation, apoptosis and metabolism. We have previously shown that moderate consumption of alcohol aggravates liver inflammation and apoptosis in rats with pre-existing nonalcoholic steatohepatitis (NASH). This study investigated whether ...
Okazaki Shunichiro - - 2013
Alcohol-induced osteonecrosis of the femoral head (ONFH) is observed in alcohol abusers and patients with alcoholic fatty liver disease. It has been reported that Toll-like receptor 4 (TLR4) signalling plays a crucial role in the pathogenesis of alcoholic fatty liver disease. We previously reported a corticosteroid-induced ONFH rat model, and ...
Reichold Astrid A Department of Nutritional Medicine, University of Hohenheim (180 a), Fruwirthstrasse 12, 70599 Stuttgart, - - 2013
In the last three decades the prevalence of non-alcoholic fatty liver disease has markedly increased. Results from epidemiologic studies indicate that not only a general overnutrition but rather a diet rich in sugar, fat and cholesterol (= Western style diet) maybe a risk factor for the development of non-alcoholic fatty ...
González-Reimers Emilio - - 2013
Alcohol induces cytokine secretion by Kupffer cells, which may exert also deleterious effects on distant organs, mediated in part by cytokine-derived increased production of reactive oxygen species (ROS). It is therefore important to assess antioxidant levels. The objective of this study is to analyse the relation of antioxidant vitamins with ...
Lee Hae-In - - 2013
This study investigated the hepatoprotective effects of low doses of curcumin against liver damage induced by chronic alcohol intake and a high-fat diet. We also examined several potential underlying mechanisms including action on alcohol metabolism, antioxidant activity, AMPK level and lipid metabolism. Alcohol (25% v/v, 5 g/kg body weight) was ...
Su Yi-Ming - - 2013
Exposure to an adverse intrauterine environment increases the risk for adult metabolic syndrome. However, the influence of prenatal hypoxia on the risk of fatty liver disease in offspring is unclear. The purpose of the present study was to evaluate the role of reduced fetal oxygen on the development and severity ...
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