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Lim Whasun W Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 136-713, Republic of - - 2014
Cholesterol homeostasis is strictly maintained to prevent abnormal biological processes that arise from excessive accumulation of cholesterol in tissues. Although dyslipidemia causes reproductive dysfunction and endocrine disruption in male rats, regulatory factors and mechanisms have not been clearly demonstrated. Therefore, the present study investigated the histology of male reproductive organs ...
Hobbs Thomas - - 2014
Context • Recent changes in usage guidelines have created the potential for millions more Americans to be prescribed statin medications. Caution should be advised because the risk of adverse effects of statins may outweigh their benefits and preclude their preventive use for patients without confirmed cardiovascular disease (CVD) who present ...
Fulton Sharon L SL a Nutrition and Metabolism Group, Centre for Public Health , Queen's University Belfast , - - 2014
ABSTRACT Increasing fruit and vegetable (FV) consumption is associated with reduced risk of major diseases. However, it is unclear if health benefits are related to increased micronutrient intake or to improvements in overall diet profile. This review aimed to assess if increasing FV consumption had an impact on diet profile. ...
Lentjes Marleen Ah MA 1University of Cambridge,Department of Public Health and Primary Care, EPIC-Norfolk Study,2 Worts Causeway,Strangeways Research Laboratories,Cambridge CB1 - - 2014
Dietary supplements are commonly consumed but may not be beneficial for everyone. It is known that supplement users have healthy behaviour characteristics but until now concordance between spouses living in the same household has not been investigated and concordance may be an important behavioural determinant. Prospective cohort study, cross-sectional data ...
Gratz Silvia W SW a Rowett Institute of Nutrition and Health , University of Aberdeen , Aberdeen , - - 2014
Dietary exposure to deoxynivalenol (DON) has been reported previously in the UK, but levels were low and most individuals are well protected by the maximum permitted levels in food set by the European Commission. However, no information is available on annual fluctuation in dietary DON exposure. We hypothesised that dietary ...
Gilmore L Anne LA From the Pennington Biomedical Research Center, Baton Rouge, - - 2014
Estimates of energy intake (EI) in humans have limited validity.OBJECTIVE: The objective was to test the accuracy and precision of the intake-balance method to estimate EI during weight gain induced by overfeeding.DESIGN: In 2 studies of controlled overfeeding (1 inpatient study and 1 outpatient study), baseline energy requirements were determined ...
Davies Js J Consultant Endocrinologist, Department of Endocrinology, University Hospital of Wales, Cardiff CF14 - - 2014
Vitamin D is a particularly important sterol hormone and its effects beyond bone are increasingly recognised. Over the last decade clinical interest has grown in vitamin D, with increased recognition of deficiency and hence increased prescribing of vitamin D products. However, the increased prescription of vitamin D has generally been ...
- - 2014
Patients with evidence of vascular disease are at increased risk for subsequent vascular events despite effective use of statins to lower the low-density lipoprotein (LDL) cholesterol level. Niacin lowers the LDL cholesterol level and raises the high-density lipoprotein (HDL) cholesterol level, but its clinical efficacy and safety are uncertain. After ...
Guo Yuan-Lin YL Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, BeiLiShi Road 167, Beijing 100037, China; Department of pathology, Beijing Hospital, Beijing 100730, - - 2014
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a novel circulating protein, which plays an important role in the regulation of cholesterol metabolism. Over the past decade, experimental and clinical studies have established that over- or poor expression of PCSK9 had a key impact on not only circulating PCSK9 and low ...
Wu Felicia F Department of Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan, 48824 Department of Agricultural, Food, and Resource Economics, Michigan State University, East Lansing, Michigan, 48824 - - 2014
Naturally occurring foodborne toxins are common in subsistence diets of low-income human populations worldwide. Often, these populations rely on one or two staple foods for the bulk of their calories, making them more susceptible to chronic intake of certain toxins. Exposure to common foodborne toxins is associated with diverse conditions ...
Valayannopoulos Vassili V Ref Centre IEM, Necker-Enf Malades Hosp, IMAGINE Institute and Paris Descartes University, Paris, - - 2014
Lysosomal Acid Lipase Deficiency is an autosomal recessive enzyme deficiency resulting in lysosomal accumulation of cholesteryl esters and triglycerides. LAL-CL04, an ongoing extension study, investigates the long-term effects of sebelipase alfa, a recombinant human lysosomal acid lipase. Sebelipase alfa (1 mg/kg or 3 mg/kg) was infused every-other-week to eligible subjects. ...
Kaiser Kathryn A KA From the Office of Energetics, School of Public Health (KAK, AWB, and DBA), the Nutrition Obesity Research Center (KAK, AWB, MMBB, JMS, and DBA), the Department of Nutrition, School of Health Professions (MMBB), and the Division of Preventive Medicine, School of Medicine (JMS), University of Alabama at Birmingham, Birmingham, AL, and the Department of Nutrition Science, Purdue University, West Lafayette, IN - - 2014
A common dietary recommendation for weight loss, especially in lay public outlets, is to eat more fruit and vegetables (F/Vs). Without a compensatory reduction in total energy intake, significant weight loss would be unlikely.OBJECTIVE: We aimed to synthesize the best available evidence on the effectiveness of the general recommendation to ...
Malhotra Anita A Department of Physiology, Government Medical College, Chandigarh, - - 2014
A cholesterol-lowering diet and several other dietary interventions have been suggested as a management approach either independently or as an adjuvant to drug therapy in children and adults with familial hypercholesterolaemia (FH). However, a consensus has yet to be reached on the most appropriate dietary treatment. Plant sterols are commonly ...
Walker Thomas B TB a Applied Nutrition, Canisius College , Buffalo , New - - 2014
Conventional dietary guidelines put forth by health care institutions and providers for the past 40 years have stressed the importance of reducing the amount of dietary fat consumed. Such a diet is purported to mitigate metabolic risk factors and optimize the ability to achieve or maintain a healthy body weight. However, ...
Khajeh Aboozar A Department of Chemical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Hafez Avenue, 15914 Tehran, - - 2014
In this work, molecular dynamics (MD) simulations with atomistic details were performed to examine the influence of the cholesterol on the interactions and the partitioning of the hydrophobic drug ibuprofen in a fully hydrated 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) bilayer. Analysis of MD simulations indicated that ibuprofen molecules prefer to be located in ...
Soret Samuel S From the Department of Environmental Health and Geoinformatics Sciences (SS), the Office of Public Health Practice (SS, KJ-S, and JS), the Department of Nutrition (AM, KJ-S, HH, and JS), and the Center for Health Research (MB), School of Public Health, Loma Linda University, Loma Linda, - - 2014
Greenhouse gas emissions (GHGEs) are a major consequence of our dietary choices. Assessments of plant-based compared with meat-based diets are emerging at the intersection of public health, environment, and nutrition.OBJECTIVES: : The objective was to compare the GHGEs associated with dietary patterns consumed in a large population across North America ...
Wong Julia Mw JM From the Clinical Nutrition and Risk Factor Modification Center, St Michael's Hospital, Toronto, Canada; the New Balance Obesity Foundation Obesity Prevention Center, Boston Children's Hospital, Boston, MA; and the Department of Pediatrics, Harvard Medical School, Boston, - - 2014
Many dietary patterns have been associated with cardiometabolic risk reduction. A commonality between these dietary patterns is the emphasis on plant-based foods. Studies in individuals who consume vegetarian and vegan diets have shown a reduced risk of cardiovascular events and incidence of diabetes. Plant-based dietary patterns may promote a more ...
Bonekamp Susanne S Clinical MRI, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins School of Medicine, Baltimore, Maryland, - - 2014
To describe the spatial distribution of liver fat,using MRI-estimated proton density fat fraction (PDFF), in adults with nonalcoholic fatty liver disease (NAFLD). This Investigational Review Board-approved, Health Insurance Portability and Accountability Act-compliant study prospectively enrolled 50 adults (30 women, 20 men) with biopsy-proven NAFLD. Hepatic PDFF was measured by low-flip-angle ...
Marti-Soler Helena H Institute of Social and Preventive Medicine, University of Lausanne, Lausanne, - - 2014
To assess the seasonality of cardiovascular risk factors (CVRF) in a large set of population-based studies. Cross-sectional data from 24 population-based studies from 15 countries, with a total sample size of 237 979 subjects. CVRFs included Body Mass Index (BMI) and waist circumference; systolic (SBP) and diastolic (DBP) blood pressure; total, ...
Lamichhane A P AP Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, - - 2014
Youth with type 1 diabetes (T1DM) are at substantially increased risk for adverse vascular outcomes, but little is known about the influence of dietary behavior on cardiovascular disease (CVD) risk profile. We aimed to identify dietary intake patterns associated with CVD risk factors and evaluate their impact on arterial stiffness ...
Koldamova Radosveta R Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219. Electronic address: - - 2014
ATP-binding cassette transporter A1 (ABCA1) mediates cholesterol efflux to lipid-free apolipoprotein A-I (apoA-I) and apolipoprotein E (apoE). ABCA1 is an essential regulator of High Density Lipoproteins (HDL) and reverse cholesterol transport - a role that determines its importance for atherosclerosis. Over the last 10years studies have provided convincing evidence that ...
Wang Huifen H Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA and Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, - - 2014
Cardiovascular disease remains the leading cause of morbidity and mortality in the United States and other developed countries, and is fast growing in developing countries, particularly as life expectancy in all parts of the world increases. Current recommendations for the prevention of cardiovascular diseaseissued jointly from the American Academy of ...
Hosoi Toru T Department of Pharmacotherapy, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan. Electronic address: - - 2014
Obesity is associated with several diseases including diabetes, nonalcoholic steatohepatitis (NASH), hypertension, cardiovascular disease, and cancer. Therefore, anti-obesity drugs have the potential to prevent these diseases. In the present study, we demonstrated that flurbiprofen, a nonsteroidal anti-inflammatory drug (NSAID), exhibited therapeutic potency against obesity. Mice were fed a high-fat diet ...
Dai Xiaoyu X Department of Nephrology, West China Hospital of Sichuan University, - - 2014
Abstract Objective: As ever widening array of anti-hyperglycaemic agents are now available, the effect of these drugs on lipids is increasingly complex and controversial. The present meta-analysis was designed to clarify the effect of dual combination of noninsulin anti-hyperglycaemic agents on lipids in type 2 diabetes. Methods: Randomized control trials ...
Garoufi Anastasia - - 2014
Small dense low density lipoprotein-cholesterol (sdLDL-C) molecules are more atherogenic compared with large buoyant ones. Phytosterols-enriched diets are effective in decreasing total cholesterol (TC) and low density lipoprotein-cholesterol (LDL-C) concentrations in hyperlipidemic children without significant adverse effects. Limited data on the impact of such a diet on sdLDL-C levels is ...
Zhan Yiqiang Y Key Laboratory of Public Health Safety, Ministry of Education, School of Public Health, Fudan University, Shanghai, - - 2014
Background: The associations of triglyceride (TG) to high-density lipoprotein cholesterol ratio (HDL‑C) and total cholesterol (TC) to HDL‑C ratio and low ankle brachial index (ABI) were seldom investigated. Patients and methods: A population based cross-sectional survey was conducted and 2982 participants 60 years and over were recruited. TG, TC, HDL‑C, ...
Katsanos Christos S CS Center for Metabolic and Vascular Biology, Arizona State University/Mayo Clinic Arizona, Scottsdale, AZ; and School of Life Sciences, Arizona State University,Tempe, AZ - - 2014
The typical diet of individuals in Western societies results in metabolic responses associated with fed-state fat metabolism for most of the daily life of the individual. This fat metabolism is characterized specifically by an increase in the concentration of plasma lipids, primarily triglycerides. Increased postprandial lipemia, which is typically observed ...
Sardinha Aline Nascimento AN Programa de Formação em Pesquisa, Departamento de Medicina Preventiva, Faculdade de Medicina, Universidade de São Paulo; Graduação em Nutrição, Faculdade de Saúde Pública, Universidade de São - - 2014
The objective of this study was to estimate the household availability of fibers in Brazil and to identify the dietary sources of this nutrient. Data from the 2008-09 Household Budget Survey were used to estimate national household availability and density of fibers and also according to stratifications defined by income ...
Salonen Anne A Immunobiology Research Program, Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Helsinki, - - 2014
There is growing interest in understanding how diet affects the intestinal microbiota, including its possible associations with systemic diseases such as metabolic syndrome. Here we report a comprehensive and deep microbiota analysis of 14 obese males consuming fully controlled diets supplemented with resistant starch (RS) or non-starch polysaccharides (NSPs) and ...
Brinksma Aeltsje A Department of Pediatric Oncology and Hematology, Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; School of Nursing and Health, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address: - - 2014
Despite a widespread belief that adequate dietary intake is needed to maintain weight during childhood cancer treatment, conclusive data about adequacy of intake are lacking. Therefore, we aimed to assess the adequacy of energy and protein intake in a heterogeneous childhood cancer population against 3 different norms. We conducted a ...
Bigornia Sherman J SJ Department of - - 2014
Evidence of the association between milk and childhood adiposity remains inconsistent, with few data available regarding the effects by dairy fat intake amount. This study examined the relation between dairy consumption (total and full and reduced fat) at age 10 y on risk of excess adiposity at age 13 y ...
Shen Yongchun - - 2014
Many studies have investigated whether pleural cholesterol levels can aid in diagnosis of pleural exudates, and the results have varied considerably. To gain a more reliable answer to this question, we meta-analyzed the literature on using pleural cholesterol or the ratio of cholesterol in pleural fluid to cholesterol in serum ...
Karliner Joel S JS VA Medical Center & University of California, San Francisco, - - 2014
A major pharmaceutical success story of the late 20(th) century was the introduction of statins into clinical medicine. This class of drugs (the firefighters) has contributed to reduced morbidity and mortality from atherosclerotic cardiovascular disease by lowering total cholesterol levels, particularly LDL cholesterol (the arsonists), and also by raising HDL ...
Dickinson Annette A a Dickinson Consulting, LLC , St. Paul , - - 2014
Objective: Consumer usage of dietary supplements is prevalent in the United States, and total usage is higher than reported in recent National Health and Nutrition Examination Surveys (NHANES), because these surveys capture usage only in the 30 days prior to the respondent's interview and do not capture occasional and seasonal use ...
Petrescu Cristina - - 2014
In the study we conducted we aimed at investigating the relation between personality profiles and risk diet behaviors in teenagers. This study was a case-control one and we applied 2 questionnaires (Freiburg Personality Inventory--FPI with 212 items) and CORT 2004 (items Q94-Q116 of diet behavior) on a sample of 2908 ...
Maughan Ron R School of Sport & Exercise Sciences, Loughborough University, Loughborough, Leicestershire, United - - 2014
Many athletes use dietary supplements, with use more prevalent among those competing at the highest level. Supplements are often self-prescribed and their use is likely to be based on an inadequate understanding of the issues at stake. Supplementation with essential micronutrients may be useful when a diagnosed deficiency cannot be ...
Loria-Kohen Viviana V IMDEA-Food Institute. CEI UAM+CSIC, Madrid, - - 2014
The association of dairy food consumption with the risk for developing cardiovascular disease (CVD) has been investigated in many studies, but results often have been contradictory. The aim of the present study was to determine whether genetic polymorphisms are associated with interindividual variation in the response of CVD risk biomarker ...
Mariani Laura H LH University of Michigan Medical School and Arbor Research Collaborative for Health, Ann Arbor, Michigan. Electronic address: - - 2014
This study examined rates and determinants of vitamin D supplementation among Chronic Renal Insufficiency Cohort (CRIC) participants and determined the association between dose and 25-hydroxyvitamin D (25(OH)D) level. The 2010 Institute of Medicine Report noted a significant increase in vitamin D supplementation in the general population, but use in chronic ...
Wu Alan H B AH Clinical Chemistry Laboratory, Department of Laboratory Medicine, San Francisco General Hospital, University of California, San Francisco, 1001 Potrero Avenue, San Francisco, CA 94110, USA. Electronic address: - - 2014
Increased total serum cholesterol and low-density lipoprotein cholesterol concentrations are associated with atherosclerosis and risk for myocardial infarction and stroke. Those who have high cholesterol with other factors that predispose them to cardiovascular disease should be treated with cholesterol-lowering medications. The pathophysiology of hyperlipidemia is important in the proper selection ...
Khazan Marjan M Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IR - - 2014
Adulterated herbal weight loss products with containing undeclared synthetic drugs are common and responsible for many serious health damages. The purpose of the study was to determine five synthetic adulterants in eight common herbal weight loss supplements, which are currently sold in Iran markets, to verify their presence in supplements, ...
Shaneshin Mahboubeh - - 2014
The role of under- and overreporting of energy intake in determining the dietary patterns is yet unclear, especially in the Middle Eastern countries. This study identifies the prevalence of misreporting among Tehranian women aged 18-45 years and to compare the dietary intake patterns of plausible and all energy reporters. Dietary ...
Anwar Muhammad M Department of Chemical Pathology and Endocrinology, Armed Forces Institute of Pathology (AFIP), - - 2014
Objective: To compare the Friedewald and modified Friedewald formulae with direct homogeneous assay for serum lowdensity lipoprotein cholesterol (LDL-C) levels estimation. Study Design: Cross-sectional study. Place and Duration of Study: Armed Forces Institute of Pathology, Rawalpindi, from June to December 2011. Methodology: Healthy subjects of either gender, from Rawalpindi, aged ...
Gubbels Jessica S JS Department of Health Promotion, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, PO Box 616, Maastricht 6200 MD, The Netherlands. - - 2014
The goal of the current study was to assess dietary intake in a large sample (N = 1016) of Dutch toddlers (1-3 years old), both at childcare and at home. Dietary intake during two weekdays was recorded using an observation format applied by childcare staff for intake at childcare, and ...
Lanzi Stefano S Institute of Sport Sciences University of Lausanne (ISSUL), University of Lausanne, Lausanne, Switzerland ; Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, - - 2014
This study aimed to compare fat oxidation, hormonal and plasma metabolite kinetics during exercise in lean (L) and obese (O) men. Sixteen L and 16 O men [Body Mass Index (BMI): 22.9±0.3 and 39.0±1.4 kg(.)m(-2)] performed a submaximal incremental test (Incr) on a cycle-ergometer. Fat oxidation rates (FORs) were determined ...
Eftekhari Mohammad Hassan MH Nutrition Department, School of Health and Nutrition, Shiraz University of Medical Sciences, Shiraz, - - 2014
Cardiovascular diseases (CVD) are the most serious cause of mortality in developed and developing countries. Epidemiological studies indicated that dyslipidemia is the major risk factor of CVD. Dyslipidemia can be modified either by proper lifestyle or medical intervention or by the combination of both. Conjugated linoleic acids (CLA) and ω3 ...
Ruiz Ruiz Jorge Carlos JC Departamento de Ingeniería Química-Bioquímica. Instituto Tecnológico de Mérida. Mérida. Yucatán. México.. - - 2014
As the last century saw a decline in the burden of nutritional deficiency and infectious disease, the global burden of chronic disease, cardiovascular disease (CVD) in particular, is increasing. CVD is the leading cause of death in the developed countries. Significant research efforts on the prevention and treatment of this ...
Sun Jing J Griffith Health Institute, Griffith University, Gold Coast Campus, Parkland Q4222, Australia. - - 2014
Aim: This article examined the association between dietary patterns and cardiovascular risk factors in Chinese older adults. Methods: For this study, older adults with one or more cardiovascular risk factors or a history of cardiovascular disease were randomly selected using health check medical records from the Changshu and Beijing Fangshan ...
Fayet-Moore Flavia F Nutrition Research Australia, Level 13, 167 Macquarie St, Sydney, NSW 2000, Australia. - - 2014
Nutrient composition data, representative of the retail supply, is required to support labelling and dietetic practice. Because beef mince represents approximately 30% of all beef dishes prepared in Australian households, a national survey of the different types of mince available for purchase in representative retail outlets was conducted. Sixty-one samples ...
Lowndes Joshua J Rippe Lifestyle Institute, 215 Celebration Place, Suite 300, Celebration, FL 34747, USA. - - 2014
The American Heart Association (AHA) and World Health Organization (WHO) have recommended restricting calories from added sugars at lower levels than the Institute of Medicine (IOM) recommendations, which are incorporated in the Dietary Guidelines for Americans 2010 (DGAs 2010). Sucrose (SUC) and high fructose corn syrup (HFCS) have been singled ...
Medeiros Júnior Jorge Luiz JL State University of Rio de Janeiro, Rio de Janeiro, RJ, - - 2014
To investigate the effect of dietary lipid quantity and/or quality on penis morphology in adult rats. Thirty-eight male Wistar rats were divided into 4 groups: normal lipid diet (NL), high-fat diet rich in saturated fatty acids (HF-S), high-fat diet rich in polyunsaturated fatty acids (HF-P), and high-fat diet rich in ...
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