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Vande Loock Kim K Laboratory of Cell Genetics, Faculty of Science and Bio-engineering, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium, National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, Vassileos Constantinou Avenue 48, 11635 Athens, Greece, Division of Medical Science, School of Life Science, University of Bradford, Bradford, West Yorkshire, BD7 1DP, UK, Department of Histology and Department of Social Medicine, School of Medicine, University of Crete, PO Box 2208, 71003 Heraklion, Greece, Centre for Research in Environmental Epidemiology (CREAL), Dr. Aiguader 88, 08003 Barcelona, Spain, Grup de Mutagenesi, Departament de Genetica i de Microbiologia, Universitat Autonoma de Barcelona, Placa Civica, 08193 Cerdanyola del Vallès, Ellaterra, Spain, Hospital del Mar Medical Research Institute, Dr. Aiguader 88, 08003 Barcelona, Spain, Division of Environmental Medicine, Norwegian Institute of Public Health, PO Box 4404 Nydalen, 0403 Oslo, Norway, Department of Public Health, University of Copenhagen, Norregade 10, 1165 Copenhagen, Denmark, Laboratory of Antropogenetics, Faculty of Science and Bio-engineering, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium, Epidemiology, Biostatistics, and Clinical Trials, IRCCS AOU San Martino-IST-National Cancer Research Institute, R. Benzi 10, 16132 Genoa, Italy, Department of Toxicogenomics, University of Maastricht, Minderbroedersberg 4-6, 6211 LK Maastricht, the Netherlands, Municipal Institute of Medical Research, Dr. Aiguader 88, 08003 Barcelona, Spain, CIBER Epidemiologia y Salud Pública (CIBERESP), Casanova 143, 08036 Barcelona, Spain and National School of Public Health, Alexandras Avenue 196, 11521 Athens, Greece - - 2014
The use of biomarkers of early genetic effects, predictive for cancer, such as micronuclei (MN) in lymphocytes, may help to investigate the association between diet and cancer. We hypothesised that the presence of mutagens in the diet may increase MN formation. A 'pooled' standardised analysis was performed by applying the ...
Dirandeh E E Department of Animal Science, Sari Agricultural Sciences and Natural Resources University, Sari, Iran. Electronic address: - - 2014
Feeding n-6 polyunsaturated fatty acids (PUFA) increases the endometrial percentages of linoleic and arachidonic acids (AA), enhances the synthesis of prostaglandin F2α (PGF2α), and improves uterine health. In contrary, the n-3 PUFA, eicosapentaenoic acid, and docosahexaenoic acid may play pivotal roles by suppressing the synthesis of uterine PGF2α, a component ...
Kopec Anna K AK Michigan State - - 2014
Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of obesity and metabolic syndrome. Robust coagulation cascade activation is common in obese patients with NAFLD. We identified a critical temporal relationship between thrombin generation and the manifestation of hepatic steatosis, inflammation and injury in C57BL/6J mice fed a high fat ...
Li Xiao-Lin XL Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, - - 2014
High-density lipoprotein (HDL) has cardioprotective properties. Each HDL particle has a few molecules of apolipoprotein A-I (apoA-I) and carries various amounts of cholesterol. The ratio of high-density lipoprotein cholesterol (HDL-C) to apoA-I may reflect mean HDL particle size. HDL-C/apoA-I ratio may provide more information than HDL-C and apoA-I in predicting ...
Kim Ji Hyun JH Division of Meridian and Structural Medicine, School of Korean Medicine, Pusan National University, Yangsan, Gyeongnam 626-870, Republic of - - 2014
Probucol, a lipid-lowering agent with anti-oxidant properties, is involved in protection against atherosclerosis, while cilostazol, an antiplatelet agent, has diverse neuroprotective properties. In this study, we investigated the anti-inflammatory effects of probucol and cilostazol on focal cerebral ischemia with hypercholesterolemia. Apolipoprotein E (ApoE) knockout (KO) mice were fed a high-fat diet (HFD) with or ...
Wu Chia-Lung CL Department of Orthopaedic Surgery, Duke University Medical Center, Durham, North Carolina, USA Department of Biomedical Engineering, Duke University Medical Center, Durham, North Carolina, - - 2014
The mechanisms linking obesity and osteoarthritis (OA) are not fully understood and have been generally attributed to increased weight, rather than metabolic or inflammatory factors. Here, we examined the influence of fatty acids, adipokines, and body weight on OA following joint injury in an obese mouse model. Mice were fed ...
Oguchi Hideyo H From the Departments of Internal Medicine and Urology, School of Medicine, Keio University, Tokyo, - - 2014
The role of salt intake in the development of hypertension is prominent, but its mechanism has not been fully elucidated. Our aim was to examine the effect of transient salt intake during the prehypertensive period in hypertensive model animals. Dahl salt-sensitive rats and spontaneously hypertensive rats were fed from 6 ...
Emmons Racine R - - 2014
Objective To determine the influence of lipid concentration, lipid particle size, and total abdominal fat (TAF) on postprandial lipemic response (PPLr) in persons with spinal cord injury (SCI). Methods Thirty-five persons with SCI (17 paraplegia, 18 tetraplegia) and 18 able-bodied (AB) individuals participated. Following a 10-hour fast, blood was drawn ...
Sato Akiko A *Department of Health and Sports, Niigata University of Health and Welfare, Niigata, Japan; Departments of †Sports Sciences; and ‡Sports Medicine, Japan Institute of Sports Sciences, Tokyo, Japan; and §Faculty of Sport Sciences, Waseda University, Saitama, - - 2014
To investigate supplement use among Japanese elite athletes. We conducted a cross-sectional survey study using individual interviews during athletes' medical evaluations. One to 5 months before the Olympic Games in 2012, London, United Kingdom. Five hundred fifty-two Japanese athletes for the London Games, including candidates. Sex, sports, supplement category, and ...
- - 2014
According to the United States Centers for Disease Control and Prevention, osteoarthritis (OA) affects nearly 27 million Americans aged 25 and older. While there is evidence that obesity, joint injury and some sports are risk factors for incident knee OA, the factors associated with its progression remain unclear.
Zarepoor Leila L Guelph Food Research Centre, Agriculture and Agri-Food - - 2014
Flaxseed (FS) is a dietary oilseed containing a variety of anti-inflammatory bioactives including fermentable fiber, phenolic compounds (lignans), and the n3-polyunsaturated fatty acid (n3-PUFA) α-linolenic acid. The objective of this study was to determine the effects of FS, and its n3-PUFA-rich kernel or lignan- and soluble fibre-rich hull, on colitis ...
Deminice Rafael R Laboratory of Nutrition and Metabolism, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Av. Bandeirantes 3900, Ribeirao Preto, Sao Paulo, Brazil; Department of Physical Education, Faculty of Physical Education and Sport, State University of Londrina, Rodovia Celso Garcia Cid | Pr 445 Km 380 | Campus Universitário, Londrina, Paraná, Brazil. Electronic address: - - 2014
To study the effects of taurine supplementation on homocysteine (Hcy) metabolism and liver injury in rats fed a choline-deficient diet. Thirty rats were divided into three groups (n=10), to receive one of the following diets for 4weeks: control diet (C), choline-deficient diet (CDD), or choline-deficient diet supplemented with taurine (CDDT). ...
Nistala Ravi R Divisions of Nephrology and - - 2014
Therapies to prevent renal injury in obese hypertensive individuals are being actively sought due to the obesity epidemic arising from the western diet (WD) which is high in fructose and fat. Recently, activation of the immune system and hyperuricemia, observed with high fructose intake, have been linked to the pathophysiology ...
Golshanraz A A Sports Medicine Federation, Tehran, - - 2014
Dietary supplement use is common in athletes. Besides their cost, they may have side effects on health and performance. They may also cause inadvertent doping violation. The study aimed to explore the frequency, type, believes, attitudes and knowledge of participants regarding dietary supplements. KAP analysis, cross sectional, cluster sampling, year ...
Habibi Javad J Diabetes and Cardiovascular Center, University of Missouri-Columbia School of Medicine, Columbia, Mo., USA ; Department of Medicine, University of Missouri-Columbia School of Medicine, Columbia, Mo., USA ; Division of Endocrinology and Metabolism, University of Missouri-Columbia School of Medicine, Columbia, Mo., USA ; Division of Research Service, Harry S. Truman Memorial Veterans' Hospital, Columbia, Mo., - - 2014
It is increasingly recognized that there is sexual dimorphism in kidney disease progression; however, this disparity is lost in the presence of diabetes where women progress at a similar rate to men. The renin-angiotensin-aldosterone system (RAAS) is known to regulate diabetes-induced kidney injury, and recent literature would suggest that gender ...
Cao Heng H Department of Cardiology, Shanghai First People's Hospital, College of Medicine, Shanghai Jiaotong University, Shanghai 200080, P.R. - - 2014
Atherosclerosis is an inflammatory disease involving the immune response. In addition to lowering the cholesterol level, the peroxisome proliferator-activated receptor α (PPAR-α) can prevent atherosclerosis via its pleiotropic anti-inflammatory effects. However, the role of PPAR-α in modulating inflammatory progression of atherosclerosis has rarely been studied. Thus, we aimed to investigate ...
Shin Jung Hyu JH Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon, Chungbuk, - - 2014
In this study, we investigated the hepatoprotective effects of aged black garlic (ABG) in rodent models of liver injury. ABG inhibited carbon tetrachloride-induced elevation of aspartate transaminase (AST) and alanine transaminase (ALT), which are markers of hepatocellular damage, in SD rats. D-galactosamineinduced hepatocellular damage was also suppressed by ABG treatment. ...
Kucukoglu Ozlem O Department of Internal Medicine I, Center for Internal Medicine, University Medical Center Ulm, Albert-Einstein-Allee 23, D-89081, Ulm, - - 2014
Mallory-Denk bodies (MDBs) are protein aggregates consisting of ubiquitinated keratins 8/18 (K8/K18). MDBs are characteristic of alcoholic and non-alcoholic steatohepatitis (NASH) and discriminate between the relatively benign simple steatosis and the more aggressive NASH. Given the emerging evidence for a genetic predisposition to MDB formation and NASH development in general, ...
Yang Zecheng Z Department of Surgery, Second Hospital, Jilin University, Changchun, Jilin 130041, P.R. - - 2014
Obesity is associated with increased infarct volumes and adverse outcomes following ischemic stroke. However, its effect on anesthetic postconditioning‑induced neuroprotection has not been investigated. The present study examined the effect of sevoflurane postconditioning on focal ischemic brain injury in diet‑induced obesity. Sprague‑Dawley rats were fed a high‑fat diet (HF; 45% kcal ...
Velten Markus M Center for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Columbus, - - 2014
The preterm infant is often exposed to maternal and neonatal inflammatory stimuli and is born with immature lungs, resulting in a need for oxygen therapy. Nutritional intervention with docosahexaenoic acid (DHA; 6.3 g/kg of diet) has been shown to attenuate inflammation in various human diseases. Previous studies demonstrated that maternal ...
Korkmaz H - - 2014
Objective: We aimed to investigate the effect of fish oil on the hepatic injury and cell cycle phases as well as cellular proliferation- regeneration in a rat model of acute hepatic injury induced by carbon tetrachloride.Background: Compensatory cell proliferation and tissue regeneration occurs as an endogenous response following chemical damage ...
David Michael A MA Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, United States of America; Department of Biomedical Engineering, University of Rochester, Rochester, New York, United States of - - 2014
The obesity epidemic has resulted in a large increase in type 2 diabetes (T2D). While some secondary complications of T2D are well recognized and their cellular and molecular mechanisms are defined, the impact of T2D on the musculoskeletal system is less understood. Clinical evidence suggests that tendon strength and repair ...
Littlejohns Ben B Bristol Heart Institute, School of Clinical Sciences, Faculty of Medicine and Dentistry, University of Bristol, Bristol, United - - 2014
High-fat diet with obesity-associated co-morbidities triggers cardiac remodeling and renders the heart more vulnerable to ischemia/reperfusion injury. However, the effect of high-fat diet without obesity and associated co-morbidities is presently unknown. To characterize a non-obese mouse model of high-fat diet, assess the vulnerability of hearts to reperfusion injury and to ...
Li Xiaofeng X RWTH Aachen University, Aachen, - - 2013
The aim of this study was to determine the role of the chemokine receptor CXCR7 in atherosclerosis and vascular remodeling. CXCR7 is the alternative receptor of CXCL12, which regulates stem cell-mediated vascular repair and limits atherosclerosis via its receptor CXCR4. Wire-induced injury of the carotid artery was performed in mice ...
Tyagi Ethika E Department of Integrative Biology & Physiology, UCLA, Los Angeles, CA 90095, - - 2014
We assessed whether the protective action of progesterone on traumatic brain injury (TBI) could be influenced by the consumption of omega-3 fatty acids during early life. Pregnant Sprague-Dawley rats were fed on omega-3 adequate or deficient diet from 3rd day of pregnancy and their female offspring were kept on the ...
Desai Moreshwar S MS Section of Pediatric Critical Care, Baylor College of Medicine, Houston, - - 2013
Triggers and exacerbants of cirrhotic cardiomyopathy (CC) are poorly understood, limiting treatment options in patients with chronic liver diseases. Liver transplantation alone reverses some features of CC, but the physiology behind this effect has never been studied. We aimed to determine whether reversal of liver injury and fibrosis in mouse ...
Leung Christopher - - 2013
Advanced glycation end-products (AGEs) levels are high in western diets and contribute to tissue injury via activation of RAGE (receptor for AGEs) and generation of reactive oxygen species (ROS). Here, we determined if high dietary AGE intake worsens progression of non-alcoholic fatty liver disease (NAFLD). Male Sprague Dawley rats were ...
Beason David P - - 2013
Rotator cuff tendon tears represent a major component of reported orthopaedic injuries. In addition, more than one quarter of U.S. adults either currently have high cholesterol levels or have reduced their previously high cholesterol levels through the use of pharmaceuticals. Our clinical data have already linked hypercholesterolemia to full-thickness rotator ...
Gilbert Olivia O Department of Medicine, MedStar Georgetown University Hospital, 3800 Reservoir Road, Washington DC 2007, USA. Electronic address: - - 2014
Lipid optimization comprises a therapeutic cornerstone of primary and secondary cardiovascular disease prevention. This systematic review and meta-analysis sought to clarify patterns of lipid profiles in spinal cord injury (SCI) patients compared to able-bodied individuals as well as among subgroups of SCI patients stratified by sex, activity level, race, and ...
Spradley Frank T FT Section of Experimental Medicine, Department of Medicine, Medical College of Georgia, Georgia Regents University Augusta, 30912, - - 2013
We designed experiments to test the hypothesis that Dahl salt-sensitive (SS) rats are sensitive to high-fat diet (HFD)-induced hypertension and renal injury via an inflammatory mechanism. Twelve-week-old Dahl SS rats were maintained on a normal diet (ND; 14% fat), HFD (59% fat), or HFD supplemented with the lymphocyte immunosuppressive agent, ...
Navarro Victor J - - 2013
Herbal and dietary supplement use is common. Most marketed products consist of complex mixtures. Although they are perceived as safe, instances of hepatotoxicity attributable to these products underscore their potential for injury, but the exact component that is responsible for injury is difficult to discern. The lenient regulatory environment in ...
Sleeman Philippa - - 2013
Obesity confers a survival advantage in the critically ill and in patients undergoing cardiac surgery. We explored whether an obesogenic high fat diet could confer protection against post cardiopulmonary bypass (CPB) acute kidney injury (AKI) in a swine model. In this study, 28 anaesthetised adult female Landrace White swine (55 ...
Zhong Wei W Center for Translational Biomedical Research and Dept. of Nutrition, Univ. of North Carolina at Greensboro, North Carolina Research Campus, 500 Laureate Way, Suite 4226, Kannapolis, NC 28081. - - 2013
Endotoxemia is a causal factor in the development of alcoholic liver injury. The present study aimed at determining the interactions of ethanol with different fat sources at the gut-liver axis. Male Sprague-Dawley rats were pair fed control or ethanol liquid diet for 8 wk. The liquid diets were based on ...
Pan Si-Yuan - - 2013
Hyperlipidemia is referred to as hypercholesterolemia, hypertriglyceridemia, or both in combined hyperlipidemia. Here, a novel mouse model of combined hyperlipidemia is described. Mice were orally given a single dose of a modeling agent (MA) made of a mixture of schisandrin B/cholesterol/bile salts (1/2/0.5 g/kg) suspended in olive oil. MA treatment ...
Figueroa Johnny D - - 2013
Chronic neuropathic pain is a frequent comorbidity following spinal cord injury (SCI) and often fails to respond to conventional pain management strategies. Preventive administration of docosahexaenoic acid (DHA) or consumption of a diet rich in omega-3 polyunsaturated fatty acids (O3PUFAs) confers potent prophylaxis against SCI and improves functional recovery. The ...
Bhushan Bharat B Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, - - 2013
Bile acids play a critical role in liver injury and regeneration, but their role in acetaminophen (APAP)-induced liver injury is not known. We tested the effect of bile acid modulation on APAP hepatotoxicity using C57BL/6 mice, which were fed a normal diet, a 2% cholestyramine (CSA)-containing diet for bile acid ...
Wong S - - 2013
A 28-year-old man with a T12 incomplete paraplegia after a spinal cord injury (SCI) was referred for weight management in October 2011. He reported a weight gain from about 120 to 180.3 kg since his SCI. He put on a further 11.4 kg in January 2012 despite intensive dietetic treatment, including very ...
Wang Tao - - 2013
Purpose: Repetitive mild traumatic brain injury (TBI) is a major military and sports health concern. The purpose of this study was to determine if a diet rich in omega-3 fatty acids would reduce cognitive deficits and neuronal cell death in a novel fluid percussion rat model of repetitive mild TBIs. ...
Tan Terrence C H - - 2013
BACKGROUND: Combined iron overload and alcohol may promote synergistic chronic liver injury and toxicity. The role of specific dietary fats in influencing the development of co-toxic alcoholic liver disease needs further evaluation and is investigated in this study. METHODS: Wild-type (WT) and the iron-loaded Hfe-null (Hfe(-/-) ) mice were fed ...
Owens D R - - 2013
The nonnative brown marmorated stink bug, Halyomorpha halys Stål (Hemiptera: Pentatomidae), has become an abundant pest of mid-Atlantic soybean since its introduction in the mid-1990s. Currently, there is little information indicating how this new pest should be managed in soybean or if economic thresholds developed for native stink bugs should ...
Greco Tiffany - - 2013
Increasing attention is being paid to nutritional and metabolic management of traumatic brain injury patients. The gross metabolic changes that occur after injury have been found to be influenced by both macronutrients, that is, dietary ratios of fat, carbohydrates, and protein, and micronutrients, for example, vitamins and minerals. Alterations in ...
Shi Jin Dong JD Department of Respiratory Medicine, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai 200240, - - 2013
Bleomycin causes acute lung injury through production of reactive species and initiation of inflammation. Previous work has shown alteration to the production of reactive oxygen species results in attenuation of injury. Vitamin E, in particular, γ-tocopherol, isoform, has the potential to scavenge reactive oxygen and nitrogen species. This study examines ...
Guseva M V - - 2013
Choline diet promotes improvement of the brain cognitive functions in rats with moderate-to-severe traumatic brain injury. In previous studies, the rats received choline being standart (0.2%) or choline-supplemented (2%) diet for 2 weeks prior to and 2 weeks after experimental brain injury. To the end of the experiments (in 4 ...
Navarro Victor J VJ Division of Hepatology, Einstein Medical Center, 5401 Old York Road, Suite 505, Philadelphia, PA 19141, USA. - - 2013
Many herbal dietary supplements (HDS) contain green tea extract (GTE) and its component catechins, although their presence may not always be indicated on the product label. Because GTE and catechins have been implicated in human hepatotoxicity in several case reports, our objective was to determine whether catechins were present in ...
Brennan S A - - 2013
Blackberry (Rubus spp.) production in Florida has increased > 100% within the past two decades. and several insect pests, including stink bugs (Heteroptera: Pentatomidae), have been observed feeding on this crop. The objectives for this study were to determine the stink bug species present in blackberry; to develop monitoring tools ...
Liu Jian J Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL 35294-0012, - - 2013
Obesity is associated with elevated risk of heart disease. A solid understanding of the safety and potential adverse effects of high-fat, low-carbohydrate diet (HFLCD) similar to that used by humans for weight loss on the heart is crucial. High fat intake is known to promote increases in reactive oxygen species ...
Jia Rui - - 2013
Silymarin, a mixture of bioactive flavonolignans from the milk thistle (Silybum marianum), is traditionally used in herbal medicine to defend against various hepatotoxic agents. The aim of the present study was to evaluate the protective effect of silymarin against carbon tetrachloride (CCl(4))-induced liver injury in fish. Common carp, with an ...
Ranganathan Kavitha - - 2013
The use of fat grafting as a treatment for radiation and thermal injury is a recent application of a historically well-described operation. The autologous transplantation of fat has been used to treat reconstructive and cosmetic concerns for the past century. In those suffering from tissue fibrosis, contractures, and deformity, the ...
Kim Kwangsoon - - 2013
BACKGROUND & AIMS: Hepatic ischemia/reperfusion (I/R) injury may activate innate immunity through the interaction of toll-like receptor 4 (TLR4) with endogenous ligands. Omega-3 polyunsaturated fatty acids (ω-3 PUFAs) exert suppressive effects on innate immunity through various mechanisms. In this study, we investigated the effect of dietary supplementation with ω-3 PUFAs ...
Rossi H L HL Department of Neurology, University of Iowa, Iowa City, IA, - - 2013
Obesity has been associated with multiple chronic pain disorders, including migraine. We hypothesized that diet-induced obesity would be associated with a reduced threshold for thermal nociception in the trigeminal system. In this study, we sought to examine the effect of diet-induced obesity on facial pain behavior. Mice of two different ...
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