Search Results
Results 451 - 500 of 647
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Reed D M - - 1989
A prospective study of autopsy-determined measures of atherosclerosis in aortas and coronary and cerebral arteries was completed for a group of 83 men who were free of clinical cardiovascular disease and cancer when they entered the Cooperative Lipoprotein Phenotyping Study in 1970. Total cholesterol minus high density lipoprotein cholesterol (HDL-C) ...
Mohindroo A - - 1989
Studies on the preventive role of trifluoperazine on cholesterol and adrenaline-induced experimental atherosclerosis in rabbits, revealed that trifluoperazine completely prevented the development of atherosclerotic lesions in both the aorta and coronary arteries of animals administered atherogenic diet and adrenaline (im) despite the fact that this drug had no significant effect ...
Sharda N - - 1989
In this study the long term effects of vasectomy on serum lipid profile, in vitro platelet aggregability and the risk of developing acute myocardial infarction have been elucidated in a monkey model. Four groups were made viz. (I) atherogenic diet fed vasectomised, (II) atherogenic diet fed control, (III) stock diet ...
Bush M J - - 1989
Twelve male M. fascicularis monkeys were divided into two groups of 6 animals each. One group (BASAL) was fed a diet containing 24% protein, 38% carbohydrate and 20% fat, while the other group (ATHER) received an identical diet with the addition of 4.08 g/kg diet cholesterol. The animals were studied ...
Jacobsson L - - 1989
The susceptibilities of male and female mini-pigs of the Göttingen strain to experimental hyperlipoproteinemia and atherosclerosis were studied and compared. Hyperlipoproteinemia was induced in groups of pigs of each sex by adding 11.2% egg yolk and 0.5% cholesterol to the diet. The initial increase in the plasma cholesterol concentration was ...
Oki M - - 1989
Whole-body vibration suppresses the development of atherosclerosis in the rabbit (Oki and Matoba, 1987). The present study was designed to clarify whether the effect of vibration on atherosclerosis depends on the frequency of vibration. Longitudinal vibrations at a frequency of 30 or 60 Hz was applied to 12 New Zealand ...
Toda T - - 1989
In order to test the anti-atherosclerotic function of elastase, 44 Japanese quails, 40 d of age, were used in this study. An atherogenic diet contained 15% corn oil and 2% cholesterol. Elaszym was orally administered at a dose of 6,000 EL units per kg body weight 3 times a week ...
Nestel P J - - 1989
Atherosclerosis is a multifactorial disorder in which nutritional factors are closely related to a number of the manifestations of the disease. Sounder nutritional principles might therefore prevent atherosclerosis itself or its major complications. Optimising nutrients would diminish monocyte adhesion to endothelium, suppress platelet aggregation, prevent oxidative modification of lipoproteins, minimise ...
Gaton E - - 1988
The effects of activation of the phagocytic system by BCG on the development of diet-induced atherosclerosis was studied in chicken. Injections of BCG had a marked effect on atherogenesis, which was either inhibitory or stimulatory, depending on the route of BCG administration and on the timing. A slight, but significant ...
Muscari A - - 1988
To assess the possible involvement of humoral immunity in diffuse atherosclerosis, IgG, IgA, IgM, C3 and C4 were measured in the sera of 23 atherosclerotic subjects (at least 3 stenoses greater than 75% in the arteries of the limbs and neck, as assessed by panangiography) and of 20 controls (possible ...
Baekey P A - - 1988
We studied the effect of dietary grapefruit pectin on plasma cholesterol and the development of atherosclerosis in 18 miniature swine. Pigs were randomized to one of three diets: no added fat (I), added fat/cellulose (II), and added fat/pectin (III). Plasma cholesterol was measured monthly. Arteries were examined for atherosclerosis at ...
Gordon G B - - 1988
Dehydroepiandrosterone (DHEA) is an endogenous steroid that blocks carcinogenesis, retards aging, and exerts antiproliferative properties. In vitro, it is a potent inhibitor of glucose-6-phosphate dehydrogenase, the first committed step of the pentose phosphate pathway. In man, serum levels of DHEA and its sulfate peak in early adulthood and drop markedly ...
Manuck S B - - 1988
Epidemiologic evidence increasingly implicates psychosocial variables in the development of coronary heart disease in human beings, an association that appears to be independent of the effects of other coronary disease risk factors. It has been hypothesized that behavioral influences on coronary heart disease are mediated by activation of the sympathetic ...
Watanabe Y - - 1988
In this paper, we examined whether the development of atherosclerosis in the Watanabe heritable hyperlipidemic (WHHL) rabbit, an animal model of familial hypercholesterolemia in man, could be prevented by the reduction of serum cholesterol levels. Pravastatin sodium (the generic name of CS-514), a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) ...
Murray C D - - 1988
The clonal nature of atherosclerotic plaques has been examined in diet-induced atherosclerosis of interspecies hybrid hare females (Lepus timidus (female) X Lepus europaeus (male], which exhibit genetic mosaicism with respect to glucose-6-phosphate dehydrogenase (G6P-D). Four diet groups have been used: control pellet diet, hyperlipemic (HL) diet, and HL diet supplemented ...
Kim D N - - 1988
We studied progression of atherosclerotic lesions in the coronaries and abdominal aortas of swine fed hyperlipidemic (HL) diets producing serum cholesterol levels of about 700 mg/dl for up to 18 months with killings at 9, 13.5 and 18 months on diet. We studied changes in lesions in subsets given after ...
Kaul P L - - 1988
Varying degrees of aortic sudanophilia (5 to 75 per cent) comparable to human atherosclerotic lesions (fatty streaks/spots) developed in all nine experimental goats receiving 2 g of protected cholesterol daily for two, four and nine months. From the fifth month onward, the serum cholesterol level stabilised at 450 to 525 ...
Rogers W R - - 1988
In separate experiments, we fed 30 male and 25 female baboons a diet enriched in cholesterol and saturated fat for periods of 3.3 and 2.6 years. Using operant conditioning with water rewards, we trained the animals to puff on smoking machines in a human-like manner. Half of the animals smoked ...
Wissler R W - - 1988
The major life-threatening events in advanced atherosclerosis are precipitated by the plaque. Thrombosis in the muscular arteries and rupture of the large elastic arteries usually follows rupture of the plaque's fibrous cap. The smooth muscle cell (SMC) participates in many aspects of the atherosclerotic process: lipid uptake, synthesis of plaque ...
Arntzenius A C - - 1988
The reverse of progression of atherosclerotic disease is regression of atherosclerosis: established lesions get smaller. Animal experiments and post mortem findings have provided investigators with considerable evidence of the reversibility of atherosclerosis. It was, however, with arteriography in living man, as used in prospective intervention trials, that proof was given ...
Shively C A - - 1988
The relationships between regional obesity, atherosclerosis and atherosclerosis risk factors were studied in female cynomolgus monkeys (Macaca fascicularis). In a retrospective necropsy study it was found that females with relatively high central: peripheral fat deposition had three times more extensive coronary artery atherosclerosis. In a second experiment it was found ...
Fujitani R M - - 1988
The development of arteriosclerotic peripheral vascular lesions following balloon catheter and mechanical fragmentation of the arterial myointima combined with an atherogenic diet was studied in a canine model. The ileofemoral arteries of five mongrel dogs (mean wt 22 +/- 2 kg) were selectively cannulated and subjected to balloon catheter and ...
Kottke B A - - 1988
Atherosclerosis-induced coronary heart disease remains the major cause of death and disability in industrialized countries. Hypercholesterolemia is recognized as a causative factor in the development of atherosclerosis. While the lowering of cholesterol levels as a treatment goal has met with general agreement and acceptance, the preferred methods for doing so ...
Bansal N - - 1987
The development of humoral and cell-mediated immune responses and circulating immune complexes following vasectomy were studied in rhesus monkeys fed a high cholesterol (atherogenic) diet. Four groups of monkeys were studied: (i) sham-vasectomized males fed a normal stock diet, (ii) sham-vasectomized males fed an atherogenic diet, (iii) vasectomized males fed ...
Kaplan J R - - 1987
We studied the effect of propranolol on the diet-induced coronary artery atherosclerosis (CAA) in 30 adult male cynomolgus monkeys living in social groupings of five animals each. Animals in the "treated" segment (n = 15) consumed propranolol, which was mixed into an atherogenic diet. Animals in the "untreated" group (n ...
Jacobson M S - - 1987
Two populations of immigrants to London and to the West Indies from the Indian subcontinent have higher than expected morbidity and mortality from atherosclerosis but do not show the commonly accepted major risk factors. This study investigated the hypothesis that ghee, a clarified butter product prized in Indian cooking, contains ...
Daoud A S - - 1987
Administration of ethane-1-hydroxy-1,1-diphosphonate (EHDP) to swine with pre-established atherosclerosis resulted in lower lesion calcium concentration, smaller lesions and a decrease in the area of lesions involved in necrosis. Atherosclerosis was developed in Yorkshire swine by balloon catheter-injury to the abdominal aorta, followed by a high cholesterol-high lipid (HL) diet for ...
Heistad D D - - 1987
Diet-induced atherosclerosis in primates impairs vasodilator responses and greatly potentiates vasoconstrictor responses to serotonin. Serotonin may play an important role in the pathogenesis of vasospasm. In diet-induced regression of atherosclerosis, intimal lesions are reduced, but maximal vasodilator responses do not improve, perhaps because of vascular fibrosis. Our goal was to ...
Fincham J E - - 1987
We have described and measured aortic and arterial atherosclerosis in adult female Vervet monkeys (n = 61) after application of dietary treatments for 47 months. The diets were compounded entirely of normal food items for westernized people, with no extra cholesterol added. A 'Western' diet (WD), known to induce hypercholesterolaemia, ...
Rawlins R G - - 1987
The relationship between serum total cholesterol (STC) and social dominance rank was investigated in adult (greater than or equal to 5 year old) males of a single, naturally-formed free-ranging troop of rhesus monkeys (Macaca mulatta) on Cayo Santiago, Puerto Rico. Dominance rank, age and body weight were not correlated with ...
Clarkson T B - - 1987
Recently the nature of the cellular and molecular events in atherogenesis have been elucidated better. Some of these findings may be important in explaining individual differences in susceptibility to atherosclerosis that are independent of known risk factors. Nonhuman primates are valuable models for the study of mechanisms of diet-induced atherosclerosis. ...
Massmann J - - 1987
Experiments were conducted with domestic swine in an attempt to accelerate and/or modify spontaneous or cholesterol-induced atherosclerosis through immune complex-produced changes in the arterial wall. For the purpose of comparison, another experiment was carried out with rabbits. Swine differed completely from rabbits in that various experimental designs failed to produce ...
Ito M - - 1987
The effects of magnesium (Mg) supplement on coronary arteries of 61 swine, fed various levels of vitamin D3 (VD3), were studied by light and electron microscopy. High frequencies of smooth muscle cell degeneration were observed in groups of swine fed various levels of excess VD3. Swine fed moderately excessive level ...
Eggen D A - - 1987
Atherosclerotic lesions were induced in rhesus monkeys by feeding them a high-fat, high-cholesterol diet for 2 years. Arteries were examined after autopsy of a subgroup of animals (group P) and cholesterol was removed from the diet of the remaining animals. Lesions were examined in other subgroups after 30 weeks (group ...
Denholm E M - - 1987
Atherosclerosis occurs in the aorta of White Carneau pigeons proximal to the celiac bifurcation, where monocyte adhesion and migration into lesions have been demonstrated. This study documents chemoattractants that might be responsible for monocyte adherence and migration. Ten-week-old pigeons were fed either a cholesterol-free (normal) diet or a 0.4% cholesterol ...
Jacobsson L - - 1987
The influence of clofibrate on the plasma lipoprotein pattern in hyperlipidemic mini-pigs was studied and an attempt was made to characterize the type of atherosclerosis produced in this animal model. Thirty-two female mini-pigs of the Göttingen strain were used. Experimental hypercholesterolemia and atherosclerosis were produced in 16 of the animals ...
Kuske T T - - 1987
There is new impetus for dietary intervention in response to the recent data relating levels of circulating lipids and lipoproteins to atherosclerosis risk. Certain levels of cholesterol, stratified for age and sex, are associated with "moderate" and "high" risk of atherosclerosis. Knowing the relationship of diet to lipid levels and ...
Bansal N - - 1986
Five groups of male rhesus monkeys, Gp. I--sham-vasectomized stock diet-fed (SVS), Gp. II--vasectomized stock diet-fed (VS), Gp. III--sham-vasectomized atherogenic diet-fed (SVA), Gp. IV--vasectomized atherogenic diet-fed (VA) and Gp. V--atherogenic diet-fed vasectomized monkeys (AV) were observed for a period of 1 1/2 years. Vasectomy per se had no effect on the ...
Wones R G - - 1986
Atherosclerosis with its complications is the most important health problem affecting American adults. The levels of serum cholesterol, of high and low density lipoproteins, and of apolipoproteins A1, A2, and B are major risk factors for the development of atherosclerotic lesions. Animal studies suggest that chlorinated drinking water may elevate ...
Weingand K W - - 1986
In this retrospective study of diet-induced atherosclerosis in male cynomolgus macaques, juvenile (2.5-3.5 years) and adult (6-12 years) monkeys that had consumed comparable atherogenic diets resulting in similar plasma lipid concentrations showed marked differences in coronary artery atherosclerotic lesion characteristics and extent. Adult animals (n = 16) developed more extensive ...
Klumpp S A - - 1986
Pathologic evaluations of pigeons dying between September 1984 and August 1985 are reported for a production colony of 1200-1800 White Carneau and Show Racer pigeons ranging in age from hatchlings to 12 years. Infectious diseases were the common causes of death in pigeons younger than 1 year; salmonellosis and nephritis ...
Iverson F - - 1986
Butylated hydroxyanisole (BHA) given by gavage to female cynomolgus monkeys on 5 days/wk for 84 days produced transient changes in selected serum chemistry and haematology parameters. Terminal observations revealed increased liver size, decreased hepatic monooxygenase activity and an increase in the mitotic index of the oesophageal epithelium. Several of these ...
Kunitomo M - - 1986
This study offers findings which should aid in the development of a convenient animal model of atherosclerosis. Inbred Fisher strain rats were fed an atherogenic diet containing 1.5% cholesterol and 0.5% cholic acid and given a single subcutaneous injection of adjuvant (Mycobacterium butyricum) into the base of the tail. The ...
Hoff H F - - 1986
Arterial wall sulfated glycosaminoglycans (GAG) of matrix proteoglycans have been implicated in the retention of plasma low density lipoproteins in the early stages of atherosclerosis. We have studied modifications in porcine aortic GAG composition after 4 and 11 weeks of diet-induced hypercholesterolemia. After these time intervals no grossly visible atherosclerotic ...
Alderson L M - - 1986
The atherogenicity of dietary peanut oil (PO) was examined in cynomolgus monkeys fed semipurified diets for 15 months. Four groups of six monkeys were fed diets containing 0.22 mg/kcal (0.1%) cholesterol and 0%, 5%, 10%, or 20% PO. An additional group was fed 2.0% cholesterol and 20% PO to serve ...
Svindland A D - - 1986
Computerised morphometry was used to define the distribution of aortic atheroma in 10 normal White Carneau pigeons (age 42 months) and in groups of 10 weanling or mature birds given a cholesterol coated diet for 24 weeks. Mean serum total and HDL-cholesterol was substantially higher in cholesterol fed animals (15 ...
Freiman P C - - 1986
To test the hypothesis that atherosclerosis impairs endothelium-dependent vascular relaxation, we examined the effect of the endothelium-dependent vasodilators acetylcholine and thrombin and the endothelium-independent vasodilator nitroglycerin on iliac arteries from normal cynomolgus monkeys and cynomolgus monkeys with diet-induced atherosclerosis. Rings of iliac artery were suspended in organ chambers at their ...
Kritchevsky D - - 1986
A semipurified, cholesterol-free diet containing 40% carbohydrate can produce aortic sudanophilia or aortic atherosclerosis in vervet monkeys (Cercopithecus aethiops pygerethrus) depending on the particular carbohydrate fed. Four groups of vervet monkeys (three males and three females per group) were fed semipurified diets containing lactose. Two of the groups were also ...
Kerttula Y - - 1986
The effect of repeated intravenous administration of bacterial lipopolysaccharide (LPS) on serum lipids and on aortic atherosclerosis was studied in rabbits on basal diet and on hypercholesterolemic diets containing 0.15-1.0% cholesterol. LPS (10 or 100 ng/kg body weight) was administered 3 times per week for 3 or 6 weeks. No ...
Clarkson T B - - 1986
We report here the effect of a moderately atherogenic diet on the progression of atherosclerosis among cynomolgus macaques that were either vasectomized or sham vasectomized. Both groups were compared to sham vasectomized monkeys fed a control Monkey Chow diet. As expected, slight hyperlipoproteinemia induced by the moderately atherogenic diet increased ...
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