Background: Flavopiridol (FLAP) is a promising chemotherapeutic agent undergoing clinical phase I and phase II trials, and a number of studies have elucidated its hepatic metabolism and biliary disposition. Methods: In present study, the intestinal disposition of orally administered FLAP was characterized through pharmacokinetic studies in rats as well as ...

PURPOSE: Although sutures evolved in last decade and the product spectrum broadened largely, they can be still classified into two: monofilament and multifilament. Sutures are the mainstay of orthopedic procedures like fascial closures, tendon repairs or tenodesis. In every repair, a suture loop is created. This suture loop is prone ...

Objective:The aim of the study was to determine whether heart failure is associated with an increased risk of major osteoporotic fractures that is independent of bone mineral density (BMD).Methods:We conducted a population-based cohort study in Manitoba, Canada, by linking a clinical registry of all adults 50 yr of age and ...

PURPOSE: The purpose of this study was to compare the tendon graft holding power of the newly devised modified finger-trap (MFT) suture technique with other currently used sutures. METHODS: We used 40 fresh-frozen porcine flexor profundus tendons randomly divided into 4 groups of 10 specimens. The experimental procedure was designed ...

PURPOSE: The use of inappropriate cementation techniques has been suggested as an adverse factor for the long-term survival of hip-resurfacing arthroplasty. Inadequate initial fixation, thermal osteonecrosis and interface biological reactions are possible causes of failure. We analysed morphological changes associated with the cementation technique in a large collection of retrieved ...

: The initial goals of the treatment of slipped capital femoral epiphysis (SCFE) are to stabilize the epiphysis, prevent slip progression, and avoid complications. In situ fixation with a single screw is the most accepted procedure to provide an optimal fixation, but fixation failure and slip progression suggest that the ...

INTRODUCTION: There is a large variety of ruptures of tendons and ligaments in trauma surgery. Reliable data about the most appropriate suture technique and suture material for ruptured tendons are sparse. This human cadaveric study compares the biomechanical properties of three suture materials and three suture techniques for semitendinosus tendon ...

Late failure of microsurgical flaps is a rare event and it has been reported as a consequence of compression of the vascular pedicle or late infection. We report a case of late partial failure occurring 3 weeks post-operatively which was shown by vascular imaging to be caused by a previously ...

BACKGROUND:: No study to date has evaluated cortical thickness as it relates to locking plate failure or screw pullout in the proximal humerus. The purpose of this study is to determine the relationship between proximal humerus cortical thickness and locked plate hardware failure in a cadaveric proximal humerus fracture model. ...

OBJECTIVES: The aim of this study was to compare the fracture load of veneered anterior zirconia crowns using normal and Weibull distribution of complete and censored data. METHODS: Standardized zirconia frameworks for maxillary canines were milled using a CAD/CAM system and randomly divided into 3 groups (N=90, n=30 per group). ...

BACKGROUND: Failure rates of constrained cups for treating recurrent dislocation in revision THA range from 40% to 100%. Although constrained liners are intended to stabilize the hip by mechanically preventing dislocation, the resulting loss of range of motion may lead to impingement and, ultimately, implant failure. QUESTIONS/PURPOSES: We therefore documented ...

PURPOSE: The purpose of our study was to determine whether secondary fixation is needed when lateral femoral wall breach occurs and whether the diameter of the femoral tunnel affects the cyclical and ultimate load to failure of 3 different suspensory fixation devices. METHODS: Sixty fresh-frozen porcine femora were dissected to ...

BACKGROUND: The main theoretic advantage of proximal olecranon fracture intramedullary fixation is decreased soft-tissue irritation and, potentially, less subsequent hardware removal. Despite this possible benefit, questions remain as to whether intramedullary devices are capable of controlling olecranon fractures to the same extent as locking plates. This study evaluates the ability ...

Acquired bone marrow failure can result after infections caused by viruses, exposure to toxins, or chemicals. Majority of acquired cases of marrow failure labeled as "idiopathic" are probably immune mediated through activated T-cells and cytokines. We observed pancytopenia in the second week, after pharyngeal diphtheria in a 14-year-old child. Bone ...

Background:  This study aimed to review the survival of bone grafting procedures, performed by surgical trainees and assess factors affecting survival of these bone grafts as an adjunct to implant rehabilitation. Methods:  Data were collected from patients between 2003 and 2009 receiving bone grafting. Graft failure was defined as any ...

BACKGROUND: Successful treatment of intertrochanteric femoral fractures was reportedly influenced by the position of the fixation devices, by reduction quality and by fracture type. METHODS: The records of 227 patients with intertrochanteric fractures treated by intramedullary hip screws were analysed retrospectively. The angle and distance from the femur head apex ...

An eight-year-old, neutered female Rottweiler was presented with lameness of seven days duration. Radiographs were consistent with a distal radial bone tumour. Limb-sparing surgery was performed using a commercially available endoprosthesis with a locking bone plate. Histopathological examination of the resected bone revealed an intraosseous fibrosarcoma, and postoperative adjuvant chemotherapy ...

Migration of orthopedic wires to a solid organ or body cavity is a rare complication that can cause various symptoms and may lead to death. We report a patient with Kirschner wire (K-wire) migration from the right pelvic cavity, a previous fracture site, into the right ventricle of the heart. ...

We investigated the hypothesis that exogenous collagen cross-linking can augment intact regions of tendon to mitigate mechanical propagation of partial tears. We first screened the low toxicity collagen cross-linkers genipin, methylglyoxal and ultra-violet (UV) light for their ability to augment tendon stiffness and failure load in rat tail tendon fascicles ...

We examined the mechanical response of the distal radius pre-fracture and at fracture under dynamic impact loads. The distal third of eight human cadaveric radii were potted and placed in a custom designed pneumatic impact system. The distal intra-articular surface of the radius rested against a model scaphoid and lunate, ...

BACKGROUND: Augmentation of rotator cuff tears aims to strengthen the repair and reduce rerupture, yet studies still report high failure rates. This study determines key mechanical properties of rotator cuff repair patches, including establishing values for toughness and measuring the shear properties of repair patches and human rotator cuff tendons. ...

ABSTRACT: Tissue expansion is an effective method in head and neck reconstruction for large defects. Tissue expansion allows enlarged local tissue for advancement or rotation flaps and could result in satisfactory aesthetic and functional outcomes.A 14-year-old boy presented with a 7 × 9-cm traumatic defect on his forehead. We planned ...

The integrity of bone-cement interface is essential for the long-term stability of cemented total joint arthroplasty. Although several studies have been carried out on bone-cement interface at continuum level, micromechanics of the interface has been studied only recently for tensile and shear loading cases. Fundamental studies of bone-cement interface at ...

HYPOTHESIS: Failure rates of rotator cuff repairs are reported to be as high as 90%, in part because of gap formation at the repair site that occurs before healing. The purpose of this study was to evaluate whether the application of an extracellular matrix (ECM) graft (Conexa; Tornier, Edina, MN, ...

Hip fracture and heart failure are becoming more prevalent conditions in hospitalized patients. Despite differences in postoperative outcomes from other intermediate risk procedures, guidelines classify hip fracture repair as an intermediate risk operation. This population-based study sought to examine the prevalence and incidence of heart failure in hip fracture patients. ...

The in vitro biomechanical properties of three methods for internal fixation of femoral neck fractures were evaluated. Fifty cadaveric femura from Beagle dogs were used. Ten intact femora served as controls. In 40 femura, an osteotomy of the femoral neck was performed to simulate a transverse fracture. With the remaining ...

BACKGROUND: Options for repair of distal biceps tendon ruptures are well-described. However, scant data exist in the literature regarding failure strength of the native tendon. We hypothesize that a) the distal biceps tendon failure strength is sensitive to loading angle, and b) the failure strength is greater than what has ...

The use of bicortical screws to fix metacarpal fractures has been suggested to provide no added biomechanical advantage over unicortical screw fixation. However, this was only demonstrated in static loading regimes, which may not be representative of biological conditions. The present study was done to determine whether similar outcomes are ...

PURPOSE: To determine whether the number of distal locking screws significantly affects stability of a cadaveric simulated distal radius fracture fixed with a volar locking plate. METHODS: We created AO/ASIF type C2 fractures in 10 matched pairs of human fresh-frozen cadaveric wrists and then fixed them using volar locking plates. ...

PURPOSE: The purpose of this study was to determine the maximum load and point of failure of the construct during tensioning of the lateral row of a transosseous-equivalent (TOE) rotator cuff repair. METHODS: In 6 fresh-frozen human shoulders, a TOE rotator cuff repair was performed, with 1 suture from each ...

Several techniques are described for fixation of Vancouver B1 femoral shaft fractures after total hip arthroplasty. Twenty-four femurs were scanned by dual x-ray absorptiometry scanned and matched for bone mineral density. Femurs were implanted with a cemented simulated total hip prosthesis with a simulated periprosthetic femur fracture distal to the ...

As rotator cuff repair techniques have improved, failure of the tendon to heal to the proximal humerus is less likely to occur from weak tendon-to-bone fixation. More likely causes of failure include biologic factors such as intrinsic tendon degeneration, fatty atrophy, fatty infiltration of muscle, and lack of vascularity of ...

The relationship between microarchitecture to the failure mechanism and mechanical properties can be assessed through experimental and computational methods. In this study, both methods were utilised using bovine cadavers. Twenty four samples of cancellous bone were extracted from fresh bovine and the samples were cleaned from excessive marrow. Uniaxial compression ...

A 66-year-old woman with congestive heart failure suspected to have multiple myeloma underwent bone scintigraphy. The bone scintigraphy using technetium-99m hydroxymethylene-diphosphonate showed the following interesting findings: absent skeletal uptake; increased gastrointestinal, myocardial, and soft tissue uptake; migration of radionuclide to bilateral pleural effusions. Histopathological examination revealed that the patient suffered ...

Minimally-invasive fixation using a locking plate and early motion is normal practice. However, technical errors and pitfalls are common. This surgery has a set of rules that encompass both the mechanics of the internal fixation system and the implantation itself. If these rules are not strictly followed, alignment defects and/or ...

The Achillon" Achilles tendon repair system combines the benefits of open repair and percutaneous repair and has excellent clinical results with minimal complications. The Krackow locking loop has been the standard suture technique for many surgeons in open Achilles repair. We determined to see how the Achillon repair compared with ...

BACKGROUND: Pathologic proximal femur fractures result in substantial morbidity for patients with skeletal metastases. Surgical treatment is widely regarded as effective; however, failure rates associated with the most commonly used operative treatments are not well defined. QUESTIONS/PURPOSES: We therefore compared surgical treatment failure rates among intramedullary nailing, endoprosthetic reconstruction, and ...

INTRODUCTION: A tibial nail with fixed-angle locking screws intends to combine the advantages of angular stability and intramedullary stabilization in extraarticular proximal tibial fractures. The goal of this study is to analyze if the angle stable tibial nail (ASN) is biomechanically more stable than an established conventional standard nail (CN). ...

OBJECTIVE:: To evaluate the outcomes of displaced intracapsular femoral neck fractures treated with a cephalomedullary device. DESIGN:: Retrospective study. SETTING:: Level I trauma center. PATIENTS:: Between 2002 and 2008, 18 patients with displaced intracapsular femoral neck fractures were treated at our Level I trauma center with a cephalomedullary nail. There ...

Suture anchors and screws are commonly used for fixation of humeral greater tuberosity (GT) fractures in either arthroscopic or open surgeries, but no biomechanical studies have been performed to compare the strength of fixation constructs using these two implants. This cadaveric study aimed to compare the biomechanical strength of three ...

OBJECTIVE:: To determine whether a new femoral neck plate has a higher risk for secondary fracture after implant removal than the current standard treatment for intracapsular hip fractures. METHODS:: Six pairs of human cadaver femora (age, 56 ± 5.6 years; range, 48-64 years; two female and four male donors) were ...

The surgical treatment of medial clavicle nonunion is associated with high complication and failure rates, particularly with regard to metal work migration. Therefore, we describe a simple surgical procedure for displaced medial clavicle fractures using a small T-shaped plate and multiple tension band sutures. After stabilizing the medial clavicle fracture ...

OBJECTIVE: Fixation of ankle fractures in elderly patients is associated with reduced stability conditioned by osteoporotic bone. Therefore, fixation with implants providing improved biomechanical features could allow a more functional treatment, diminish implant failure and avoid consequences of immobilisation. MATERIALS AND METHODS: In the actual study, we evaluated a lateral ...

The Ludloff oblique metatarsal osteotomy is an effective method to correct hallux valgus deformity, although a number of problems have been associated with it, including inherent instability, delayed union, dorsal malunion, and fixation failure. The purpose of the present study was to compare the mechanical characteristics of fixation of the ...

Monitoring of free flap perfusion and early identification of flap failure is an indispensable prerequisite for flap salvage. Although many methods of free flap monitoring are available, there is still no single reliable continuous non-invasive perfusion monitoring technique which will also assist in the early recognition of flap failure. In ...

Assessment of bone fracture risk is the first step in the prevention of traumatic events. In several previous study the use of bone mineral density and bone volume fraction was suggested for the identification of the failure zone, nonetheless the limits of this approach were also investigated, underling the need ...

We propose that the simple method of passing an extra suture through the Mitek anchor eyelet before bony insertion provides a safety net against failure of the preloaded suture and gives extra strength to the core repair.

Background: When reviewing anterior cruciate ligament instability, age, gender, activity level, associated injury, and type of graft should all be considered. Hypothesis: The authors hypothesized that patients under 25 years of age will have higher failure rates with anterior cruciate ligament reconstruction than those older than 25 years, and that ...

Piedmont is a region in northwestern Italy counting 4.2 million inhabitants. The purpose of our study was to update data on incidence and outcomes of hip fractures (HF) in our region to present days. The data of all patients affected by HF in 2003 in Piedmont (total: 5,386 patients) were ...

BACKGROUND.: Bone disease is one of the major complications of solid organ transplantation, causes considerable morbidity, and most patients are treated with immunosuppressant drugs after graft. The majority of studies reported rapid bone loss and an increased incidence of fractures after transplantation. The aim of our study was to evaluate ...