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Harnod Dorji D Surgical Intensive Care Unit, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, - - 2014
Impaired cardiovascular autonomic regulation is a non-motor symptom of Parkinson's disease (PD) and may increase long-term morbidity. This study applied frequency-domain analysis of heart rate variability (HRV) to understand the progression of sympathetic and parasympathetic cardiac regulation in patients with PD. In this cross-sectional study, 21 male and 11 female ...
Reddy Sashank K SK 1] Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA [2] Department of Plastic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, - - 2014
Changes in the hair cycle underlie age-related alopecia, but the causative mechanisms have remained unclear. Chen et al. point to an imbalance between stem cell-activating and -inhibitory signals as the key determinant of age-related regenerative decline. Further, they identify a secreted protein, follistatin, that may be able to shift the ...
Lim Ai Ing AI Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Room 301, Professorial Block, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, - - 2014
Kidney injury molecule-1 (KIM-1) serves as a useful marker for monitoring tubular injury, and sustained KIM-1 expression may be implicated in chronic kidney fibrosis. In this study, we examine the kinetics and mechanisms of KIM-1 release in human proximal tubular epithelial cells (PTEC) under the activation by major pathologic players ...
Bao Qi Q Department of Plastic and Reconstructive Surgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China; Institute of Gastroenterology, Zhejiang University - - 2014
Aging represents an important health issue not only for the individual, but also for society in general. Burdens associated with aging are expanding as longevity increases. This has led to an enhanced focus on issues related to aging and age-related diseases. Until recently, anti-aging endocrine-therapy has been largely limited to ...
Sopher Aviva B - - 2014
Abstract Objectives: This study aimed to [1] confirm that nonobese adolescents with polycystic ovary syndrome (PCOS) have higher anti-Mullerian hormone (AMH) than controls; [2] examine the relationship of AMH with PCOS features and hormonal profile; and [3] approximate an AMH value that discriminates between adolescents with PCOS and controls. Design: ...
Shenoy Kausalya K Department of Biology, University of Kentucky, 101 Morgan Building, Lexington, KY 40506, USA. Electronic address: - - 2014
Performing appropriate mating behaviors is crucial to male reproductive success, especially in species where mating is predominantly via female mate choice. Mating behaviors are hormonally regulated and may be sexually selected traits: courtship displays are selected via mate choice, while forced copulations and aggressive behaviors are selected for via intrasexual ...
Liu Julia J Center for Molecular Medicine, National Heart, Lung and Blood Institute, NIH Bethesda, MD - - 2014
Although historically reactive oxygen species have been implicated as a potential cause of ageing, recent evidence suggests that a modest increase in oxidants can actually extend lifespan. A new study suggests that, in Caenorhabditis elegans, reactive oxygen species regulate longevity through a pathway classically linked to apoptosis.
Quéré Ronan R Institut National de la Santé et de la Recherche Médicale UMR866, 21000 Dijon, France;Labex LipSTIC and laurent.delva@u-bourgogne.fr - - 2014
The hematopoietic system declines with age. Myeloid-biased differentiation and increased incidence of myeloid malignancies feature aging of hematopoietic stem cells (HSCs), but the mechanisms involved remain uncertain. Here, we report that 4-mo-old mice deleted for transcription intermediary factor 1γ (Tif1γ) in HSCs developed an accelerated aging phenotype. To reinforce this ...
Goe Nirupa N Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, - - 2014
The hypothalamic-pituitary-adrenal (HPA) axis is a major component of the systems that respond to stress, by coordinating the neuroendocrine and autonomic responses. Tightly controlled regulation of HPA responses is critical for maintaining mental and physical health, as hyper- and hypo-activity have been linked to disease states. A long history of ...
Downs Charles A CA Emory University, Physiology and Pediatrics , 2015 Uppergate Drive , Suite 310K , Atlanta, Georgia, United States, 30322 , 4047274702 ; - - 2014
The receptor for advanced glycation end-products (RAGE), a multi-ligand member of the immunoglobulin family, may play a crucial role in the regulation of lung fluid balance. We quantified soluble RAGE (sRAGE), a decoy isoform, and advanced glycation end-products (AGEs) from the BAL fluid of smokers and non-smokers, and tested the ...
Thompson Anne Marie AM Dartmouth Medical - - 2014
Loss of vascular smooth muscle cell (VSMC) function is a hallmark of vascular disease. VSMCs become increasingly dysregulated, apoptotic and senescent as we age. Sirtuin 1 (SirT1) is a deactylase that regulates substrates associated with stress mitigation, metabolism and aging. Our aim was to examine the role of SirT1 in ...
Portelius Erik E Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, - - 2014
Background: Individuals with Down's syndrome (DS) develop early Alzheimer's disease (AD) with β-amyloid (Aβ) plaque pathology. The extra amyloid precursor protein (APP) gene copy in DS is believed to result in a 50% increase in Aβ production, but it is unclear how this relates to the development of other AD ...
Bugeja Lyndal L Coroners Prevention Unit, Coroners Court of Victoria, Victoria, Australia Monash Injury Research Institute, Monash University, Victoria, - - 2014
To investigate whether the Victorian mandatory personal flotation device wearing regulations that came into effect on 1 December 2005 reduced drowning deaths among recreational boaters in Victoria, Australia. A retrospective population-based 'before and after' study using Victorian coronial data on drowning deaths of occupants of recreational vessels operating in Victorian ...
Wang Jia-Wei JW National Key Laboratory of Plant Molecular Genetics (NKLPMG), Institute of Plant Physiology and Ecology (SIPPE), Shanghai Institutes for Biological Sciences (SIBS), Shanghai 200032, P. R. China - - 2014
Precise flowering time is critical to reproductive success. In response to diverse exogenous and endogenous cues including age, hormones, photoperiod, and temperature, the floral transition is controlled by a complex regulatory network, which involves extensive crosstalks, feedback, or feedforward loops between the components within flowering time pathways. The newly identified ...
Pinkney Jonathan J Plymouth University Peninsula Schools of Medicine and Dentistry, Centre for Clinical Trials and Population Studies, Obesity and Metabolism research group, University Medicine, Derriford Hospital level 7, Plymouth PL6 8DH., United - - 2014
Background: The regulation and role of Sex Hormone Binding Globulin (SHBG) in children are poorly defined. Here we investigated whether adiposity-related mechanisms regulate SHBG and whether SHBG levels are associated with the age of puberty. Methods: Longitudinal modelling of annual physiological and endocrine measurements from age 5-15 years in a ...
Luedi Rudolf R Department of Neurology, Inselspital, University Hospital Bern and University of Bern, Freiburgstrasse 10, 3010, Bern, - - 2014
Elderly patients generally experience less favorable outcomes and higher mortality after acute stroke than younger patients. The aim of this study was to analyze the influence of age on outcome and safety after endovascular therapy in a large cohort of patients aged between 20 and 90 years. We prospectively acquired data ...
Kermath Bailey A BA Institute for - - 2014
The role of the hypothalamus in female reproductive senescence is unclear. Here, we identified novel molecular neuroendocrine changes during the natural progression from regular reproductive cycles to acyclicity in middle-aged female rats, comparable to the perimenopausal progression in women. Expression of 48 neuroendocrine genes was quantified within 3 hypothalamic regions: ...
Kaarniranta Kai K Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland , Kuopio , Finland - - 2014
Abstract Age-related macular degeneration (AMD) is a multifactorial eye disease that is associated with aging, family history, smoking, obesity, cataract surgery, arteriosclerosis, hypertension, hypercholesterolemia and unhealthy diet. Gender has commonly been classified as a weak or inconsistent risk factor for AMD. This disease is characterized by degeneration of retinal pigment ...
Zhu Yunhua - - 2014
The number of newly formed neurons declines rapidly during aging, and this decrease in neurogenesis is associated with decreased function of neural stem/progenitor cells (NPCs). Here, we determined that a WIP1-dependent pathway regulates NPC differentiation and contributes to the age-associated decline of neurogenesis. Specifically, we found that WIP1 is expressed ...
Perry Nicole B NB Department of Human Development and Family Studies, University of North Carolina at Greensboro, Greensboro, NC. - - 2014
Early assessments of children's physiological functioning are shown to predict subsequent developmental outcomes. However, individual changes that occur in the development of physiological systems may be associated with the pattern of change in behavior across time. Thus, we examined change in respiratory sinus arrhythmia (RSA), an index of physiological regulation, ...
Scridon Alina A Physiology Department, University of Medicine and Pharmacy of Tîrgu Mureş, Tîrgu Mureş 540139, Romania Unité de Neurocardiologie, EA 4612, Université Lyon 1, Lyon F-69008, - - 2014
The timecourse of left atrial Pitx2 down-regulation in the setting of atrial tachyarrhythmias remains unknown. Accordingly, we aimed to assess the age dependency of left atrial Pitx2 expression in an experimental model of spontaneous atrial tachyarrhythmias in rats. Atrial sampling was performed in three groups (n = 4 each) of ...
Liu Xianbao X Department of Cardiology, Key Division of Ministry of Health; Provincial Key Laboratory of Cardiovascular Research, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, - - 2014
Previous studies have demonstrated that biological aging has a negative influence on the therapeutic effects of mesenchymal stem cells (MSCs)-based therapy. Using a rat myocardial infarction (MI) model, we tested the hypothesis that silent mating type information regulation 2 homolog 1 (SIRT1) may ameliorate the phenotype and improve the function ...
Cassell Erin E Monash Injury Research Institute, Monash University (Clayton Campus), Clayton, Victoria, - - 2014
To estimate the effect of the 2005 Victorian mandatory personal flotation device (PFD) wearing regulations on PFD use by occupants of small (hull length ≤4.8 m) power recreational vessels. Before-after observational study investigating the probability of PFD use among occupants of small vessels before and after the regulations were introduced compared ...
Singh Amardeep A Department of Ophthalmology, Copenhagen University Hospital Roskilde, Køgevej 7-13, 4000 Roskilde, Denmark. - - 2014
Age-related macular degeneration (AMD) is a leading cause of visual impairment in the aged population worldwide. The mechanisms underlying this multifactorial and heterogenic disease are complex and incompletely understood. There is increasing evidence to suggest that regulatory differences in the immune system are involved in the development of the various ...
Ostojic Dragana D University of Windsor, Ontario, - - 2014
This exploratory study investigated how the timing of female pubertal maturation was associated with the symptoms of ADHD in a non-clinical female undergraduate sample (N = 253). Participants (M age = 20.2 ± 1.7 years) completed a set of self-report rating scales examining pubertal onset and ADHD symptoms and related ...
McCauley Brenna S BS Huffington Center on Aging, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA. Electronic address: - - 2014
Aging induces myriad cellular and, ultimately, physiological changes that cause a decline in an organism's functional capabilities. Although the aging process and the pathways that regulate it have been extensively studied, only in the last decade have we begun to appreciate that dynamic histone methylation may contribute to this process. ...
Hassanien Intisar T E IT Animal Ecology I, University of Bayreuth, 95448 Bayreuth, - - 2014
In the polyandric moth, S. frugiperda, juvenile hormone (JH) is transferred from the male accessory reproductive glands (AG) to the female bursa copulatrix (BC) during copulation (see Hassanien et al., 2014). Here we used the RNA interference technique to study the role of allatoregulating neuropeptides in controlling the synthesis and ...
Gramapurohit N P NP Department of Zoology, University of Pune, Ganeshkhind, Pune 411 007 India. Electronic address: - - 2014
In amphibians, although genetic factors are involved in sex determination, gonadal sex differentiation can be modified by exogenous steroid hormones suggesting a possible role of sex steroids in regulating the process. We studied the effect of testosterone propionate (TP) and estradiol-17β (E2) on gonadal differentiation and sex ratio at metamorphosis ...
Tobin W O WO Department of Neurology, The Adelaide and Meath Hospital, Dublin, Incorporating the National Children's Hospital, Trinity College Dublin, Dublin, - - 2014
The impact of commencing or changing antiplatelet therapy on von Willebrand factor antigen (VWF:Ag) and von Willebrand factor propeptide (VWF:Ag II) levels has not been comprehensively assessed following TIA or ischaemic stroke. In this pilot, longitudinal, observational analytical study, VWF:Ag and VWF:Ag II levels were simultaneously quantified in platelet poor ...
Kodama Keita K Center for Environmental Risk Research, National Institute for Environmental Studies, Tsukuba, Ibaraki 305-8506, Japan. Electronic address: - - 2014
We investigated effects of severe hypoxia (dissolved oxygen <1mll(-1)) on recruitment of mantis shrimp Oratosquilla oratoria in Tokyo Bay. Ten-year field surveys were conducted to examine quantitative relationships in annual mean densities of larvae and juveniles, and spatial distribution of juveniles and severe hypoxia. There was no significant correlation between ...
Gooren Louis L Emeritus VU Medical Center, Amsterdam, The Netherlands; Androconsult, Chiang Mai, - - 2014
Guidelines for cross-sex hormone treatment of transsexual people are now in place. However, little attention has been paid to the issue of treatment suitability for older people. Does existing treatment need to be adapted as subjects age, and does it make a difference if treatment is only started when the ...
Ickowicz Diana E - - 2014
Amphotericin B (AMB) arabinogalactan (AG) conjugate was synthesized by the conjugation of AMB to oxidized AG by reductive amination. The conjugate was evaluated for in vitro antifungal activity and in vivo toxicity. Optimization of the conjugation process was investigated using large batches of 100 grams, which are 20 times larger ...
Mancini Mara M University of "Tor Vergata", Department of Experimental Medicine and Surgery, Via Montpellier 1, Rome 00133, - - 2014
The skin protects humans from the surrounding environment. Tissues undergo continuous renewal throughout an individual's lifetime; however, there is a decline in the regenerative potential of tissue with age. The accumulation of senescent cells over time probably reduces tissue regenerative capacity and contributes to the physiological ageing of the tissue ...
Novak Alison C AC Toronto Rehabilitation Institute, Toronto, ON, - - 2014
The ability to safely negotiate obstacles is an important component of independent mobility, requiring adaptive locomotor responses to maintain dynamic balance. This study examined the effects of aging and visual-vestibular interactions on whole-body and segmental control during obstacle crossing. Twelve young and 15 older adults walked along a straight pathway ...
Shams Kim - - 2014
Abstract Background: Aromatase inhibitors (AIs) have been used off-label to increase adult height in short adolescent males. Studies have shown that AIs increase the predicted adult height (PAH) while delaying bone age (BA) maturation. We sought to determine whether AI therapy increases PAH in boys with short stature or rapid ...
Chaplin Robert R Centre for Quality Improvement, Royal College of Psychiatrists, London, UK; Oxford Health Foundation NHS Trust, Oxford, - - 2014
This study aimed to evaluate the access, experiences and outcomes of older adults receiving psychological therapies in comparison with adults of working age METHODS: Primary and secondary care providers of psychological therapy services participated in the National Audit of Psychological Therapies. The main standards of access, experience and outcomes were ...
Perluigi Marzia M Department of Biochemical Sciences, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185, Rome, - - 2014
Down syndrome (DS) is the most frequent genetic cause of intellectual disability characterized by the presence of three copies of chromosome 21 (Chr21). Individuals with DS have sufficient neuropathology for a diagnosis of Alzheimer's disease (AD) after the age of 40years. The aim of our study is to gain new ...
Lewinska Anna A Department of Biochemistry and Cell Biology, University of Rzeszow, Rzeszow, - - 2014
The nucleolus is speculated to be a regulator of cellular senescence in numerous biological systems (Guarente, Genes Dev 11(19):2449-2455, 1997; Johnson et al., Curr Opin Cell Biol 10(3):332-338, 1998). In the budding yeast Saccharomyces cerevisiae, alterations in nucleolar architecture, the redistribution of nucleolar protein and the accumulation of extrachromosomal ribosomal ...
He Kan K Center for Stem Cell and Translational Medicine, School of Life Sciences, Anhui University, Hefei City, Anhui, P. R. China, - - 2014
Numerous genetic targets and some individual pathways associated with aging have been identified using the worm model. However, less is known about the genetic mechanisms of aging in genome wide, particularly at the level of multiple pathways as well as the regulatory networks during aging. Here, we employed the gene ...
Camchong Jazmin J University of Minnesota, Psychiatry Department, United States. Electronic address: - - 2014
Previously identified resting functional connectivity (FC) differences in individuals with stimulant use disorder (SUD) suggest an imbalance in neural regions that mediate behavioral aspects relevant to addiction such as emotion regulation and reward processing. There is a need to further investigate these differences across time between those that relapse and ...
Shimoda Yoshiaki Y Department of Cardiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii, Kawaramachi-Hirokoji, Kamigyo, Kyoto602-8566, - - 2014
Organ functions are altered and impaired during aging, thereby resulting in increased morbidity of age-related diseases such as Alzheimer's disease, diabetes, and heart failure in the elderly. Angiogenesis plays a crucial role in the maintenance of tissue homeostasis, and aging is known to reduce the angiogenic capacity in many tissues. ...
Cheung Hoi-Hung HH Laboratory of Clinical and Developmental Genomics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA ; School of Biomedical Sciences, Faculty of Medicine, the Chinese University of Hong Kong, Shatin, N.T., 852 Hong Kong - - 2014
Werner syndrome (WS) patients exhibit premature aging predominantly in mesenchyme-derived tissues, but not in neural lineages, a consequence of telomere dysfunction and accelerated senescence. The cause of this lineage-specific aging remains unknown. Here, we document that reprogramming of WS fibroblasts to pluripotency elongated telomere length and prevented telomere dysfunction. To ...
Chondrogianni Niki N National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, 48 Vas. Constantinou Ave. 116 35 Athens, - - 2014
Aging is a natural biological process that is characterized by a progressive accumulation of macromolecular damage. In the proteome, aging is accompanied by decreased protein homeostasis and function of the major cellular proteolytic systems, leading to the accumulation of unfolded, misfolded or aggregated proteins. In particular, the proteasome is responsible ...
Kawai-Toyooka Hiroko H Department of Biological Sciences, Graduate School of Science, University of Tokyo, Tokyo, - - 2014
Male and female, generally defined based on differences in gamete size and motility, likely have multiple independent origins, appearing to have evolved from isogamous organisms in various eukaryotic lineages. Recent studies of the gamete fusogen GCS1/HAP2 indicate that this protein is deeply conserved across eukaryotes, and its exclusive and/or functional ...
Liu Jie J University of - - 2014
A reduced sinoatrial node (SAN) functional reserve underlies the age-associated decline in heart rate acceleration in response to stress. SAN cells function involves an oscillatory coupled-clock system: the sarcoplasmic reticulum (SR), a Ca(2+) clock and the electrogenic-sarcolemmal membrane clock. Ca(2+)-activated-calmodulin-AC/CaMKII-cAMP/PKA-Ca(2+) signaling regulated by phosphodiesterase (PDE) activity drives SAN cells automaticity. ...
Rajasekharreddy Pala P Biology and Biotechnology Division, Academy of Scientific and Innovative Research, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500607, Andhra Pradesh, - - 2014
A one-step and eco-friendly process for the synthesis of silver-(protein-lipid) nanoparticles (Ag-PL NPs) (core-shell) has been developed using the seed extract from wild Indian Almond tree, Sterculia foetida (L.) (Sterculiaceae). The reaction temperature played a major role in controlling the size and shell formation of NPs. The amount of NPs ...
Chen Chih-Chiang CC 1] Department of Pathology, University of Southern California, Los Angeles, California, USA [2] Institute of Clinical Medicine and Department of Dermatology, National Yang-Ming University, Taipei, Taiwan [3] Department of Dermatology, Taipei Veterans General Hospital, Taipei, - - 2014
Hair cycling is modulated by factors both intrinsic and extrinsic to hair follicles. Cycling defects lead to conditions such as aging associated alopecia. Recently we demonstrated that mouse skin exhibits regenerative hair waves, reflecting a coordinated regenerative behavior in follicle populations. Here, we use this model to explore the regenerative ...
Tang Youcai Y Department of Pathology, School of Medicine, Saint Louis University, St Louis, MO, - - 2014
Non-alcoholic steatohepatitis (NASH) is a major risk factor for hepatic fibrogenesis. NASH is often found in diabetic patients with hyperglycemia. Hyperglycemia induces non-enzymatic glycation of proteins, yielding advanced glycation end-products (AGEs). Effects of AGEs are mainly mediated by two categories of cytoplasmic membrane receptors. Receptor for AGEs (RAGE) is associated ...
Neal-Perry Genevieve G Department of Obstetrics & - - 2014
This study investigated potential mechanisms by which age and insulin-like growth factor 1 receptor (IGF1r) signaling in the neuroendocrine hypothalamus affect estradiol positive feedback effects on gonadotropin releasing hormone (GnRH) neuronal activation and on kisspeptin and N-methyl-D-aspartate (NMDA)-induced luteinizing hormone (LH) release, and on the abundance of NMDA receptor subunits ...
Belin Stephane S F.M. Kirby Neurobiology Center, Children's Hospital, and Department of Neurology, Harvard Medical School, Boston, MA 02115, - - 2014
Axon regeneration capacity often declines with age. One might assume that loss of regeneration is an obvious consequence of organismal aging. However, in the latest issue of Neuron, Byrne et al. (2014) demonstrate that regeneration ability and aging are regulated cell-autonomously within neurons, and can be decoupled.
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