Search Results
Results 1 - 50 of 3998
1 2 3 4 5 6 7 8 9 10 >
Harnod Dorji D Surgical Intensive Care Unit, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, - - 2014
Impaired cardiovascular autonomic regulation is a non-motor symptom of Parkinson's disease (PD) and may increase long-term morbidity. This study applied frequency-domain analysis of heart rate variability (HRV) to understand the progression of sympathetic and parasympathetic cardiac regulation in patients with PD. In this cross-sectional study, 21 male and 11 female ...
Nair M K C MK Child Development Centre, Thiruvananthapuram Medical College, Thiruvananthapuram, 695011, Kerala, India, - - 2014
To document the experiences of the intervention given to children who attended the developmental therapy clinic of Child Development Centre (CDC) Kerala, a specialized clinic for providing developmental intervention/therapy for babies less than two years with developmental delay/disability. All the babies referred to this speciality clinic from developmental screening/evaluation clinics ...
Robinette Jennifer W JW Department of Psychology and Social Behavior, University of California, Irvine. - - 2014
Exposure to psychosocial stressors often elicits increases in negative affect and blood pressure (BP). Rumination, or thinking about a stressor after it passes, is associated with delayed recovery. Given that older age is associated with greater BP reactivity to psychosocial stressors, rumination may be more detrimental to the recovery of ...
Lay Elizabeth E Department of Veterinary Medicine, University of Cambridge, Cambridge, - - 2014
Sera from a large panel of normal subjects were typed for three common polymorphisms, one in C3 (R102G) and two in Factor H (V62I and Y402H) that influence predisposition to age related macular degeneration and to some forms of kidney disease. Three groups of sera were tested; those that were ...
Kumaran Nagalingam N School of Earth, Environmental and Biological Sciences, Queensland University of Technology, Brisbane, - - 2014
In male tephritid fruit flies of the genus Bactrocera, feeding on secondary plant compounds (sensu lato male lures = methyl eugenol, raspberry ketone and zingerone) increases male mating success. Ingested male lures alter the male pheromonal blend, normally making it more attractive to females and this is considered the primary ...
Reddy Sashank K SK 1] Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA [2] Department of Plastic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, - - 2014
Changes in the hair cycle underlie age-related alopecia, but the causative mechanisms have remained unclear. Chen et al. point to an imbalance between stem cell-activating and -inhibitory signals as the key determinant of age-related regenerative decline. Further, they identify a secreted protein, follistatin, that may be able to shift the ...
Dunlop Cheryl E CE MRC Centre for Reproductive Health, University of Edinburgh , - - 2014
Abstract Folliculogenesis is the process by which waves of small primordial follicles possessing immature oocytes are recruited to undergo development into large antral follicles, with one then being selected for ovulation of a fully competent oocyte. Folliculogenesis can be divided into three stages: follicle recruitment, selection and ovulation, and has ...
Oshima Motohiko M Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, - - 2014
The decline in the regenerative potential of tissues is one of the most evident characteristics of aging. Stem cell aging determines the aging phenotypes of tissues, and has thus been recognized as one of the hallmarks of mammalian aging. An emerging body of evidence supports an essential role for epigenetic ...
Zhang WeiLi W State Key Laboratory of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China, - - 2014
A consistent association has been observed between leukocyte telomere length (LTL) and atherosclerosis, but the mechanisms underlying these associations are still not well understood. Premature biology aging was evident in atherosclerotic plaques, characterized by reduced cell proliferation, irreversible growth arrest and apoptosis, and telomere attrition. As atherosclerosis is a state ...
Griffiths Helen R HR *School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, - - 2014
The oxidoreductase Trx-1 (thioredoxin 1) is highly conserved and found intra- and extra-cellularly in mammalian systems. There is increasing interest in its capacity to regulate immune function based on observations of altered distribution and expression during ageing and disease. We have investigated previously whether extracellular T-cell or peripheral blood mononuclear ...
Yuan Rong R The Jackson Laboratory, Bar Harbor, Maine. Geriatric Research Division, Internal Medicine, School of Medicine, Southern Illinois University, Springfield. - - 2014
We previously reported that insulin-like growth factor 1 (IGF1) was involved in coregulating female sexual maturation and longevity. To understand the underlying genetic mechanisms, based on the strain survey assays of development and aging traits, we crossed two mouse strains, KK/HIJ and PL/J, and produced 307 female F2 mice. We ...
Falandry Claire C Claire Falandry, Marc Bonnefoy, and Gilles Freyer, Hospices Civils de Lyon and Lyon University, Lyon; and Eric Gilson, Centre Hospitalier Universitaire of Nice and Nice University Sophia Antipolis, Nice, France. - - 2014
Over the last 50 years, major improvements have been made in our understanding of the driving forces, both parallel and opposing, that lead to aging and cancer. Many theories on aging first proposed in the 1950s, including those associated with telomere biology, senescence, and adult stem-cell regulation, have since gained ...
Lim Ai Ing AI Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Room 301, Professorial Block, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, - - 2014
Kidney injury molecule-1 (KIM-1) serves as a useful marker for monitoring tubular injury, and sustained KIM-1 expression may be implicated in chronic kidney fibrosis. In this study, we examine the kinetics and mechanisms of KIM-1 release in human proximal tubular epithelial cells (PTEC) under the activation by major pathologic players ...
Bao Qi Q Department of Plastic and Reconstructive Surgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China; Institute of Gastroenterology, Zhejiang University - - 2014
Aging represents an important health issue not only for the individual, but also for society in general. Burdens associated with aging are expanding as longevity increases. This has led to an enhanced focus on issues related to aging and age-related diseases. Until recently, anti-aging endocrine-therapy has been largely limited to ...
Sopher Aviva B - - 2014
Abstract Objectives: This study aimed to [1] confirm that nonobese adolescents with polycystic ovary syndrome (PCOS) have higher anti-Mullerian hormone (AMH) than controls; [2] examine the relationship of AMH with PCOS features and hormonal profile; and [3] approximate an AMH value that discriminates between adolescents with PCOS and controls. Design: ...
Shenoy Kausalya K Department of Biology, University of Kentucky, 101 Morgan Building, Lexington, KY 40506, USA. Electronic address: - - 2014
Performing appropriate mating behaviors is crucial to male reproductive success, especially in species where mating is predominantly via female mate choice. Mating behaviors are hormonally regulated and may be sexually selected traits: courtship displays are selected via mate choice, while forced copulations and aggressive behaviors are selected for via intrasexual ...
Liu Julia J Center for Molecular Medicine, National Heart, Lung and Blood Institute, NIH Bethesda, MD - - 2014
Although historically reactive oxygen species have been implicated as a potential cause of ageing, recent evidence suggests that a modest increase in oxidants can actually extend lifespan. A new study suggests that, in Caenorhabditis elegans, reactive oxygen species regulate longevity through a pathway classically linked to apoptosis.
Quéré Ronan R Institut National de la Santé et de la Recherche Médicale UMR866, 21000 Dijon, France;Labex LipSTIC and laurent.delva@u-bourgogne.fr - - 2014
The hematopoietic system declines with age. Myeloid-biased differentiation and increased incidence of myeloid malignancies feature aging of hematopoietic stem cells (HSCs), but the mechanisms involved remain uncertain. Here, we report that 4-mo-old mice deleted for transcription intermediary factor 1γ (Tif1γ) in HSCs developed an accelerated aging phenotype. To reinforce this ...
Goe Nirupa N Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, - - 2014
The hypothalamic-pituitary-adrenal (HPA) axis is a major component of the systems that respond to stress, by coordinating the neuroendocrine and autonomic responses. Tightly controlled regulation of HPA responses is critical for maintaining mental and physical health, as hyper- and hypo-activity have been linked to disease states. A long history of ...
Kraiwong Ratchanok - - 2014
According to demographic changes, the size of the aging population has rapidly increased. Thailand has been facing the "aging society" since 2005 and the "aged society" has been projected to appear by the year 2025. Increased life expectancy is associated with health problems and risks, specifically chronic diseases and disability. ...
Downs Charles A CA Emory University, Physiology and Pediatrics , 2015 Uppergate Drive , Suite 310K , Atlanta, Georgia, United States, 30322 , 4047274702 ; - - 2014
The receptor for advanced glycation end-products (RAGE), a multi-ligand member of the immunoglobulin family, may play a crucial role in the regulation of lung fluid balance. We quantified soluble RAGE (sRAGE), a decoy isoform, and advanced glycation end-products (AGEs) from the BAL fluid of smokers and non-smokers, and tested the ...
Thompson Anne Marie AM Dartmouth Medical - - 2014
Loss of vascular smooth muscle cell (VSMC) function is a hallmark of vascular disease. VSMCs become increasingly dysregulated, apoptotic and senescent as we age. Sirtuin 1 (SirT1) is a deactylase that regulates substrates associated with stress mitigation, metabolism and aging. Our aim was to examine the role of SirT1 in ...
Portelius Erik E Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, - - 2014
Background: Individuals with Down's syndrome (DS) develop early Alzheimer's disease (AD) with β-amyloid (Aβ) plaque pathology. The extra amyloid precursor protein (APP) gene copy in DS is believed to result in a 50% increase in Aβ production, but it is unclear how this relates to the development of other AD ...
Bugeja Lyndal L Coroners Prevention Unit, Coroners Court of Victoria, Victoria, Australia Monash Injury Research Institute, Monash University, Victoria, - - 2014
To investigate whether the Victorian mandatory personal flotation device wearing regulations that came into effect on 1 December 2005 reduced drowning deaths among recreational boaters in Victoria, Australia. A retrospective population-based 'before and after' study using Victorian coronial data on drowning deaths of occupants of recreational vessels operating in Victorian ...
Wang Jia-Wei JW National Key Laboratory of Plant Molecular Genetics (NKLPMG), Institute of Plant Physiology and Ecology (SIPPE), Shanghai Institutes for Biological Sciences (SIBS), Shanghai 200032, P. R. China - - 2014
Precise flowering time is critical to reproductive success. In response to diverse exogenous and endogenous cues including age, hormones, photoperiod, and temperature, the floral transition is controlled by a complex regulatory network, which involves extensive crosstalks, feedback, or feedforward loops between the components within flowering time pathways. The newly identified ...
Pinkney Jonathan J Plymouth University Peninsula Schools of Medicine and Dentistry, Centre for Clinical Trials and Population Studies, Obesity and Metabolism research group, University Medicine, Derriford Hospital level 7, Plymouth PL6 8DH., United - - 2014
Background: The regulation and role of Sex Hormone Binding Globulin (SHBG) in children are poorly defined. Here we investigated whether adiposity-related mechanisms regulate SHBG and whether SHBG levels are associated with the age of puberty. Methods: Longitudinal modelling of annual physiological and endocrine measurements from age 5-15 years in a ...
Luedi Rudolf R Department of Neurology, Inselspital, University Hospital Bern and University of Bern, Freiburgstrasse 10, 3010, Bern, - - 2014
Elderly patients generally experience less favorable outcomes and higher mortality after acute stroke than younger patients. The aim of this study was to analyze the influence of age on outcome and safety after endovascular therapy in a large cohort of patients aged between 20 and 90 years. We prospectively acquired data ...
Kermath Bailey A BA Institute for - - 2014
The role of the hypothalamus in female reproductive senescence is unclear. Here, we identified novel molecular neuroendocrine changes during the natural progression from regular reproductive cycles to acyclicity in middle-aged female rats, comparable to the perimenopausal progression in women. Expression of 48 neuroendocrine genes was quantified within 3 hypothalamic regions: ...
Kaarniranta Kai K Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland , Kuopio , Finland - - 2014
Abstract Age-related macular degeneration (AMD) is a multifactorial eye disease that is associated with aging, family history, smoking, obesity, cataract surgery, arteriosclerosis, hypertension, hypercholesterolemia and unhealthy diet. Gender has commonly been classified as a weak or inconsistent risk factor for AMD. This disease is characterized by degeneration of retinal pigment ...
Zhu Yunhua - - 2014
The number of newly formed neurons declines rapidly during aging, and this decrease in neurogenesis is associated with decreased function of neural stem/progenitor cells (NPCs). Here, we determined that a WIP1-dependent pathway regulates NPC differentiation and contributes to the age-associated decline of neurogenesis. Specifically, we found that WIP1 is expressed ...
Perry Nicole B NB Department of Human Development and Family Studies, University of North Carolina at Greensboro, Greensboro, NC. - - 2014
Early assessments of children's physiological functioning are shown to predict subsequent developmental outcomes. However, individual changes that occur in the development of physiological systems may be associated with the pattern of change in behavior across time. Thus, we examined change in respiratory sinus arrhythmia (RSA), an index of physiological regulation, ...
Scridon Alina A Physiology Department, University of Medicine and Pharmacy of Tîrgu Mureş, Tîrgu Mureş 540139, Romania Unité de Neurocardiologie, EA 4612, Université Lyon 1, Lyon F-69008, - - 2014
The timecourse of left atrial Pitx2 down-regulation in the setting of atrial tachyarrhythmias remains unknown. Accordingly, we aimed to assess the age dependency of left atrial Pitx2 expression in an experimental model of spontaneous atrial tachyarrhythmias in rats. Atrial sampling was performed in three groups (n = 4 each) of ...
Liu Xianbao X Department of Cardiology, Key Division of Ministry of Health; Provincial Key Laboratory of Cardiovascular Research, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, - - 2014
Previous studies have demonstrated that biological aging has a negative influence on the therapeutic effects of mesenchymal stem cells (MSCs)-based therapy. Using a rat myocardial infarction (MI) model, we tested the hypothesis that silent mating type information regulation 2 homolog 1 (SIRT1) may ameliorate the phenotype and improve the function ...
Rimmelé Pauline P Department of Developmental & Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, - - 2014
Aging hematopoietic stem cells (HSCs) exhibit defective lineage specification that is thought to be central to increased incidence of myeloid malignancies and compromised immune competence in the elderly. Mechanisms underlying these age-related defects remain largely unknown. We show that the deacetylase Sirtuin (SIRT)1 is required for homeostatic HSC maintenance. Differentiation ...
Cassell Erin E Monash Injury Research Institute, Monash University (Clayton Campus), Clayton, Victoria, - - 2014
To estimate the effect of the 2005 Victorian mandatory personal flotation device (PFD) wearing regulations on PFD use by occupants of small (hull length ≤4.8 m) power recreational vessels. Before-after observational study investigating the probability of PFD use among occupants of small vessels before and after the regulations were introduced compared ...
Singh Amardeep A Department of Ophthalmology, Copenhagen University Hospital Roskilde, Køgevej 7-13, 4000 Roskilde, Denmark. - - 2014
Age-related macular degeneration (AMD) is a leading cause of visual impairment in the aged population worldwide. The mechanisms underlying this multifactorial and heterogenic disease are complex and incompletely understood. There is increasing evidence to suggest that regulatory differences in the immune system are involved in the development of the various ...
Ostojic Dragana D University of Windsor, Ontario, - - 2014
This exploratory study investigated how the timing of female pubertal maturation was associated with the symptoms of ADHD in a non-clinical female undergraduate sample (N = 253). Participants (M age = 20.2 ± 1.7 years) completed a set of self-report rating scales examining pubertal onset and ADHD symptoms and related ...
McCauley Brenna S BS Huffington Center on Aging, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA. Electronic address: - - 2014
Aging induces myriad cellular and, ultimately, physiological changes that cause a decline in an organism's functional capabilities. Although the aging process and the pathways that regulate it have been extensively studied, only in the last decade have we begun to appreciate that dynamic histone methylation may contribute to this process. ...
Hassanien Intisar T E IT Animal Ecology I, University of Bayreuth, 95448 Bayreuth, - - 2014
In the polyandric moth, S. frugiperda, juvenile hormone (JH) is transferred from the male accessory reproductive glands (AG) to the female bursa copulatrix (BC) during copulation (see Hassanien et al., 2014). Here we used the RNA interference technique to study the role of allatoregulating neuropeptides in controlling the synthesis and ...
Gramapurohit N P NP Department of Zoology, University of Pune, Ganeshkhind, Pune 411 007 India. Electronic address: - - 2014
In amphibians, although genetic factors are involved in sex determination, gonadal sex differentiation can be modified by exogenous steroid hormones suggesting a possible role of sex steroids in regulating the process. We studied the effect of testosterone propionate (TP) and estradiol-17β (E2) on gonadal differentiation and sex ratio at metamorphosis ...
Tobin W O WO Department of Neurology, The Adelaide and Meath Hospital, Dublin, Incorporating the National Children's Hospital, Trinity College Dublin, Dublin, - - 2014
The impact of commencing or changing antiplatelet therapy on von Willebrand factor antigen (VWF:Ag) and von Willebrand factor propeptide (VWF:Ag II) levels has not been comprehensively assessed following TIA or ischaemic stroke. In this pilot, longitudinal, observational analytical study, VWF:Ag and VWF:Ag II levels were simultaneously quantified in platelet poor ...
Kodama Keita K Center for Environmental Risk Research, National Institute for Environmental Studies, Tsukuba, Ibaraki 305-8506, Japan. Electronic address: - - 2014
We investigated effects of severe hypoxia (dissolved oxygen <1mll(-1)) on recruitment of mantis shrimp Oratosquilla oratoria in Tokyo Bay. Ten-year field surveys were conducted to examine quantitative relationships in annual mean densities of larvae and juveniles, and spatial distribution of juveniles and severe hypoxia. There was no significant correlation between ...
Gooren Louis L Emeritus VU Medical Center, Amsterdam, The Netherlands; Androconsult, Chiang Mai, - - 2014
Guidelines for cross-sex hormone treatment of transsexual people are now in place. However, little attention has been paid to the issue of treatment suitability for older people. Does existing treatment need to be adapted as subjects age, and does it make a difference if treatment is only started when the ...
Ickowicz Diana E - - 2014
Amphotericin B (AMB) arabinogalactan (AG) conjugate was synthesized by the conjugation of AMB to oxidized AG by reductive amination. The conjugate was evaluated for in vitro antifungal activity and in vivo toxicity. Optimization of the conjugation process was investigated using large batches of 100 grams, which are 20 times larger ...
Mancini Mara M University of "Tor Vergata", Department of Experimental Medicine and Surgery, Via Montpellier 1, Rome 00133, - - 2014
The skin protects humans from the surrounding environment. Tissues undergo continuous renewal throughout an individual's lifetime; however, there is a decline in the regenerative potential of tissue with age. The accumulation of senescent cells over time probably reduces tissue regenerative capacity and contributes to the physiological ageing of the tissue ...
Novak Alison C AC Toronto Rehabilitation Institute, Toronto, ON, - - 2014
The ability to safely negotiate obstacles is an important component of independent mobility, requiring adaptive locomotor responses to maintain dynamic balance. This study examined the effects of aging and visual-vestibular interactions on whole-body and segmental control during obstacle crossing. Twelve young and 15 older adults walked along a straight pathway ...
Shams Kim - - 2014
Abstract Background: Aromatase inhibitors (AIs) have been used off-label to increase adult height in short adolescent males. Studies have shown that AIs increase the predicted adult height (PAH) while delaying bone age (BA) maturation. We sought to determine whether AI therapy increases PAH in boys with short stature or rapid ...
Chaplin Robert R Centre for Quality Improvement, Royal College of Psychiatrists, London, UK; Oxford Health Foundation NHS Trust, Oxford, - - 2014
This study aimed to evaluate the access, experiences and outcomes of older adults receiving psychological therapies in comparison with adults of working age METHODS: Primary and secondary care providers of psychological therapy services participated in the National Audit of Psychological Therapies. The main standards of access, experience and outcomes were ...
Perluigi Marzia M Department of Biochemical Sciences, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185, Rome, - - 2014
Down syndrome (DS) is the most frequent genetic cause of intellectual disability characterized by the presence of three copies of chromosome 21 (Chr21). Individuals with DS have sufficient neuropathology for a diagnosis of Alzheimer's disease (AD) after the age of 40years. The aim of our study is to gain new ...
Lewinska Anna A Department of Biochemistry and Cell Biology, University of Rzeszow, Rzeszow, - - 2014
The nucleolus is speculated to be a regulator of cellular senescence in numerous biological systems (Guarente, Genes Dev 11(19):2449-2455, 1997; Johnson et al., Curr Opin Cell Biol 10(3):332-338, 1998). In the budding yeast Saccharomyces cerevisiae, alterations in nucleolar architecture, the redistribution of nucleolar protein and the accumulation of extrachromosomal ribosomal ...
1 2 3 4 5 6 7 8 9 10 >