Search Results
Results 1 - 50 of 3925
1 2 3 4 5 6 7 8 9 10 >
Chaplin Robert R Centre for Quality Improvement, Royal College of Psychiatrists, London, UK; Oxford Health Foundation NHS Trust, Oxford, - - 2014
This study aimed to evaluate the access, experiences and outcomes of older adults receiving psychological therapies in comparison with adults of working age METHODS: Primary and secondary care providers of psychological therapy services participated in the National Audit of Psychological Therapies. The main standards of access, experience and outcomes were ...
Perluigi Marzia M Department of Biochemical Sciences, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185, Rome, - - 2014
Down syndrome (DS) is the most frequent genetic cause of intellectual disability characterized by the presence of three copies of chromosome 21 (Chr21). Individuals with DS have sufficient neuropathology for a diagnosis of Alzheimer's disease (AD) after the age of 40years. The aim of our study is to gain new ...
Lewinska Anna A Department of Biochemistry and Cell Biology, University of Rzeszow, Rzeszow, - - 2014
The nucleolus is speculated to be a regulator of cellular senescence in numerous biological systems (Guarente, Genes Dev 11(19):2449-2455, 1997; Johnson et al., Curr Opin Cell Biol 10(3):332-338, 1998). In the budding yeast Saccharomyces cerevisiae, alterations in nucleolar architecture, the redistribution of nucleolar protein and the accumulation of extrachromosomal ribosomal ...
Shimoda Yoshiaki Y Department of Cardiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii, Kawaramachi-Hirokoji, Kamigyo, Kyoto602-8566, - - 2014
Organ functions are altered and impaired during aging, thereby resulting in increased morbidity of age-related diseases such as Alzheimer's disease, diabetes, and heart failure in the elderly. Angiogenesis plays a crucial role in the maintenance of tissue homeostasis, and aging is known to reduce the angiogenic capacity in many tissues. ...
Chondrogianni Niki N National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, 48 Vas. Constantinou Ave. 116 35 Athens, - - 2014
Aging is a natural biological process that is characterized by a progressive accumulation of macromolecular damage. In the proteome, aging is accompanied by decreased protein homeostasis and function of the major cellular proteolytic systems, leading to the accumulation of unfolded, misfolded or aggregated proteins. In particular, the proteasome is responsible ...
Kawai-Toyooka Hiroko H Department of Biological Sciences, Graduate School of Science, University of Tokyo, Tokyo, - - 2014
Male and female, generally defined based on differences in gamete size and motility, likely have multiple independent origins, appearing to have evolved from isogamous organisms in various eukaryotic lineages. Recent studies of the gamete fusogen GCS1/HAP2 indicate that this protein is deeply conserved across eukaryotes, and its exclusive and/or functional ...
Liu Jie J University of - - 2014
A reduced sinoatrial node (SAN) functional reserve underlies the age-associated decline in heart rate acceleration in response to stress. SAN cells function involves an oscillatory coupled-clock system: the sarcoplasmic reticulum (SR), a Ca(2+) clock and the electrogenic-sarcolemmal membrane clock. Ca(2+)-activated-calmodulin-AC/CaMKII-cAMP/PKA-Ca(2+) signaling regulated by phosphodiesterase (PDE) activity drives SAN cells automaticity. ...
Chen Chih-Chiang CC 1] Department of Pathology, University of Southern California, Los Angeles, California, USA [2] Institute of Clinical Medicine and Department of Dermatology, National Yang-Ming University, Taipei, Taiwan [3] Department of Dermatology, Taipei Veterans General Hospital, Taipei, - - 2014
Hair cycling is modulated by factors both intrinsic and extrinsic to hair follicles. Cycling defects lead to conditions such as aging associated alopecia. Recently we demonstrated that mouse skin exhibits regenerative hair waves, reflecting a coordinated regenerative behavior in follicle populations. Here, we use this model to explore the regenerative ...
Tang Youcai Y Department of Pathology, School of Medicine, Saint Louis University, St Louis, MO, - - 2014
Non-alcoholic steatohepatitis (NASH) is a major risk factor for hepatic fibrogenesis. NASH is often found in diabetic patients with hyperglycemia. Hyperglycemia induces non-enzymatic glycation of proteins, yielding advanced glycation end-products (AGEs). Effects of AGEs are mainly mediated by two categories of cytoplasmic membrane receptors. Receptor for AGEs (RAGE) is associated ...
Neal-Perry Genevieve G Department of Obstetrics & - - 2014
This study investigated potential mechanisms by which age and insulin-like growth factor 1 receptor (IGF1r) signaling in the neuroendocrine hypothalamus affect estradiol positive feedback effects on gonadotropin releasing hormone (GnRH) neuronal activation and on kisspeptin and N-methyl-D-aspartate (NMDA)-induced luteinizing hormone (LH) release, and on the abundance of NMDA receptor subunits ...
Belin Stephane S F.M. Kirby Neurobiology Center, Children's Hospital, and Department of Neurology, Harvard Medical School, Boston, MA 02115, - - 2014
Axon regeneration capacity often declines with age. One might assume that loss of regeneration is an obvious consequence of organismal aging. However, in the latest issue of Neuron, Byrne et al. (2014) demonstrate that regeneration ability and aging are regulated cell-autonomously within neurons, and can be decoupled.
Maschan Michael M Federal Research Center for Pediatric Hematology, Oncology and Immunology, Moscow, - - 2014
We describe an infant who developed juvenile myelomonocytic leukemia (JMML) at the age of 6 months. Myeloproliferation was effectively controlled by low-dose cytosine arabinoside and 13-cis retinoic acid therapy. Two years after therapy for JMML was stopped, at the age of 5 years, the patient developed autoimmune thrombotic thrombocytopenic purpura ...
Macarthur Jacqueline A L JA Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United - - 2014
Nonallelic homologous recombination (NAHR) between highly similar duplicated sequences generates chromosomal deletions, duplications and inversions, which can cause diverse genetic disorders. Little is known about interindividual variation in NAHR rates and the factors that influence this. We estimated the rate of deletion at the CMT1A-REP NAHR hotspot in sperm DNA ...
Aldwin Carolyn M CM Program in Human Development & Family - - 2014
To examine emotion regulation in later life, we contrasted the modified hedonic treadmill theory with developmental theories, using hassles and uplifts to assess emotion regulation in context. The sample was 1,315 men from the VA Normative Aging Study aged 53 to 85 years, who completed 3,894 observations between 1989 and ...
Dai Dao-Fu DF Department of Pathology, University of Washington, 1959 NE Pacific Ave, Seattle, WA, 98195, - - 2014
Chronic caloric restriction (CR) and rapamycin inhibit the mechanistic target of rapamycin (mTOR) signaling, thereby regulating metabolism and suppressing protein synthesis. Caloric restriction or rapamycin extends murine lifespan and ameliorates many aging-associated disorders; however, the beneficial effects of shorter treatment on cardiac aging are not as well understood. Using a ...
Jones Robin M RM Department of Hearing and Speech Sciences, Vanderbilt University, 1215 21st Avenue South, Room 10221 MCE South Tower, Nashville, TN 37232, United States. Electronic address: - - 2014
The purpose of this study was to assess the relation between emotional reactivity and regulation associated with fluent and stuttered utterances of preschool-age children who stutter (CWS) and those who do not (CWNS). Participants were eight 3 to 6-year old CWS and eight CWNS of comparable age and gender. Participants ...
Aro Tuija - - 2014
PURPOSE The study aimed at gaining understanding on the associations of different types of early language and communication profiles with later self-regulation skills utilizing longitudinal data from toddler-age to kindergarten-age. METHOD Children with early language profiles representing expressive delay, broad delay (i.e., expressive, social, and/or symbolic), and typical language development ...
Hu Zheng Z Department of Biochemistry and Molecular Biology, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, - - 2014
All eukaryotic cells divide a finite number of times, although the mechanistic basis of this replicative aging remains unclear. Replicative aging is accompanied by a reduction in histone protein levels, and this is a cause of aging in budding yeast. Here we show that nucleosome occupancy decreased by 50% across ...
Gheorghe Marius - - 2014
Genome-wide expression profiles are altered during biological aging and can describe molecular regulation of tissue degeneration. Age-regulated mRNA expression trends from cross-sectional studies could describe how aging progresses. We developed a novel statistical methodology to identify age-regulated expression trends in cross-sectional datasets. We studied six cross-sectional RNA expression profiles from ...
Alic Nazif N Department of Genetics, Evolution and Environment, Institute of Healthy Ageing, University College London, Darwin Building, Gower Street, London WC1E 6BT, - - 2014
Drosophila melanogaster and Caenorhabditis elegans each carry a single representative of the Forkhead box O (FoxO) family of transcription factors, dFOXO and DAF-16, respectively. Both are required for lifespan extension by reduced insulin/Igf signaling, and their activation in key tissues can extend lifespan. Aging of these tissues may limit lifespan. ...
Ramkumar Charusheila C Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, MA, 01655, - - 2014
The age-dependent decline in the self-renewal capacity of stem cells plays a critical role in aging, but the precise mechanisms underlying this decline are not well understood. By limiting proliferative capacity, senescence is thought to play an important role in age-dependent decline of stem cell self-renewal, although direct evidence supporting ...
Saez Isabel I Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Co-logne, Joseph Stelzmann Strasse 26, 50931 Cologne, - - 2014
Damaged and misfolded proteins accumulate during the aging process, impairing cell function and tissue homeostasis. These perturbations to protein homeostasis (proteostasis) are hallmarks of age-related neurodegenerative disorders such as Alzheimer's, Parkinson's or Huntington's disease. Damaged proteins are degraded by cellular clearance mechanisms such as the proteasome, a key component of ...
Watson Sara - - 2014
The treatment of adolescent males with hypogonadism using testosterone is dependent on the underlying diagnosis as well as the patient's and family's preferences. Those with testicular failure, always a pathologic condition, begin lifelong therapy, while short-term therapy is often begun for those who have a delayed puberty. There is a ...
Khapre Rohini V RV Center for Gene Regulation in Health and Diseases, BGES, Cleveland State University, Cleveland, - - 2014
The circadian clock, an internal time-keeping system, has been linked with control of aging, but molecular mechanisms of regulation are not known. BMAL1 is a transcriptional factor and core component of the circadian clock; BMAL1 deficiency is associated with premature aging and reduced lifespan. Here we report that activity of ...
Fujii Takashi T Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1, Ogawahigashi, Kodaira, Tokyo 187-8502, - - 2014
Regulation of hypothalamic-pituitary-adrenal (HPA) axis reactivity plays an important role in the development of stress-related psychiatric disorders. FK506 binding protein 5 (FKBP5) modulates HPA axis reactivity via glucocorticoid receptor (GR; NR3C1) sensitivity and signaling. The T allele of the single nucleotide polymorphism, FKBP5 rs1360780 (C/T), is associated with higher FKBP5 ...
Van Borsel John J Department of Speech Language and Hearing Research, Ghent University , Ghent , Belgium - - 2014
Abstract In general, speech language therapy for transsexual persons focuses on pitch and pitch variation and more recently also on resonance. Other communicative aspects are dealt with far less often, especially language. This study investigated to what extent conversational topics might need attention in therapy for transsexual persons. A total ...
Yeap Bu B BB School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia; Department of Endocrinology and Diabetes, Fremantle Hospital, Fremantle, Western - - 2014
Lower testosterone (T) levels are associated with poorer health outcomes in older men, but associations in younger or middle-aged men are uncertain and data for dihydrotestosterone (DHT) and estradiol (E2) are limited. We assessed associations of circulating T, DHT and E2 with physical and health-related factors in a cohort comprising ...
Savage Shane W SW Departments of Psychiatry, Vanderbilt University School of Medicine, Nashville, - - 2014
Objective: To investigate the relationship of novelty seeking traits(NS) with midbrain dopamine(DA) receptors and acyl ghrelin levels(AG) in normal weight(NW) and obese females. NS predict addictive behaviors and are hypothesized to contribute to eating behaviors. In healthy, NS are negatively associated with DA receptors in the substantia nigra(SN). We hypothesized ...
Shelton Annie L AL School of Psychiatry and Psychology, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria 3800, - - 2014
There is evidence which demonstrates that a subset of males with a premutation CGG repeat expansion (between 55 and 200 repeats) of the fragile X mental retardation 1 gene exhibit subtle deficits of executive function that progressively deteriorate with increasing age and CGG repeat length. However, it remains unclear whether ...
Winickoff Jonathan P JP From the Department of Pediatrics, Harvard Medical School and Mass General Hospital for Children (J.P.W.), the Public Health Advocacy Institute at Northeastern University School of Law (M.G.), and the Department of Health Policy and Management, Harvard School of Public Health (M.M.M.) - all in Boston; and the Edmond J. Safra Center for Ethics, Harvard University, Cambridge, MA - - 2014
On November 19, 2013, New York City Mayor Michael Bloomberg signed into law the "Tobacco 21" bill, imposing the strictest age restriction on tobacco sales of any major U.S. city.(1) Beginning in May 2014, it will be illegal to sell tobacco products and electronic cigarettes to persons younger than 21 ...
Angel Sánchez-Garrido Miguel M Department of Cell Biology, Physiology and Immunology, University of - - 2014
Reproduction is sensitive to insufficient body energy reserves, especially in females. Metabolic regulation of male reproductive axis is less obvious, and the impact of conditions of persistent energy excess has received moderate attention. Yet, the escalating prevalence of obesity and the clinical evidence of its deleterious effects on male fertility ...
Gonçalves David D Eco-Ethology Research Unit, ISPA-Instituto Universitário, , Rua Jardim do Tabaco 34, Lisboa 1149-041, Portugal, Centro de Ciências do Mar, Universidade do Algarve, , Campus de Gambelas, Faro 8005-139, Portugal, Department of Science and Environment, University of St Joseph, , Rua de Londres 16, Macau, People's Republic of China (SAR), Champalimaud Neuroscience Programme, Instituto Gulbenkian de Ciência, , Oeiras, - - 2014
The mechanisms regulating sexual behaviours in female vertebrates are still poorly understood, mainly because in most species sexual displays in females are more subtle and less frequent than displays in males. In a sex-role reversed population of a teleost fish, the peacock blenny Salaria pavo, an external fertilizer, females are ...
Li Xiao-Wei XW Key Laboratory of Plant Protection Resources and Pest Management, Ministry of Education, Northwest A&F University, Yangling, Shaanxi, China ; Department of Entomology, Cornell University, New York State Agricultural Experiment Station, Geneva, New York, United States of - - 2014
Post-mating, sexual interactions of opposite sexes differ considerably in different organisms. Post-mating interactions such as re-mating behavior and male harassment can affect the fitness of both sexes. Echinothrips americanus is a new insect pest in Mainland China, and little is known about its post-mating interactions. In this study, we observed ...
Zhang Qingqing Q Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, - - 2014
Background. A recent study has reported that high circulating 25-hydroxyvitamin D [25(OH)D] is associated with low circulating thyroid-stimulating hormone (TSH) levels, but only in younger individuals. The goal of the present study was to explore the relationship between vitamin D status and circulating TSH levels with thyroid autoimmunity and thyroid ...
Maggio Marcello M Section of Geriatrics, Department of Clinical and Experimental Medicine, University of Parma, Via Gramsci 14, 43100 Parma, Italy ; Geriatric Rehabilitation Department, University-Hospital of Parma, Via Gramsci 14, 43100 Parma, - - 2014
The role of nutritional status as key factor of successful aging is very well recognized. Among the different mechanisms by which nutrients may exert their beneficial effects is the modulation of the hormonal anabolic milieu, which is significantly reduced with aging. Undernutrition and anabolic hormonal deficiency frequently coexist in older ...
Chang Shiow-Huey SH Public Health Department, Santa Clara County, San Jose, CA, United States. Electronic address: - - 2013
Completion of the recommended 9-month course of isoniazid to treat latent tuberculosis infection in children remains poor and is often affected by adverse effects, including hepatitis, to medication. We evaluated the frequency of isoniazid therapy completion and factors associated with failure to complete therapy in patients aged 0-18 years. We ...
Harm Jonathan - - 2013
It has been suggested that intrinsic abilities for regulating emotions remain stable or improve with Ageing, but to date, no studies have examined age-related differences in extrinsic emotion regulation. Since humour has been found to be an effective form of emotion regulation, we used a paradigm similar to that of ...
Brent Colin S CS USDA Arid Land Agricultural Research Center, 21881 N. Cardon Lane, Maricopa, AZ 85238, USA. Electronic address: - - 2013
Newly mated females of the plant bug, Lygus hesperus Knight, enter a refractory period during which their sexual receptivity to courting males is greatly reduced for several days. This behavioral change appears to be induced by male-derived factors delivered in the spermatophore during copulation. To better understand the source of ...
Schmitz Anja A Genetic Epidemiology Research Branch, National Institute of Mental Health (NIMH), Bethesda, MD, - - 2013
The goal of this study was to examine the association between affective development, puberty, and gender using the startle reflex as a marker of defensive mechanisms. Thirty-one male and thirty-five female adolescents aged ten to thirteen participated in a prospective study with up to five assessments. Longitudinal analyses revealed a ...
Fries Christopher J CJ Department of Sociology, 317 Isbister Building, University of Manitoba, Winnipeg, Manitoba R3T 2N2, - - 2014
Taking its cue from Estes and Binney's (1989) assertion that individual and subjective views of aging often reflect a hegemony characteristic of biomedicalization, this study assesses the subjective views that a group of older adult users of CAM therapies have of aging, health, healing, and self care. Reflexive sociological interviews ...
Vrooman Lisa A - - 2013
Increasing age of the woman is a well-documented risk factor for meiotic errors, but the effect of paternal age is less clear. Although it is generally agreed that spermatogenesis declines with age, the mechanisms that account for this remain unclear. Because meiosis involves a complex and tightly regulated series of ...
Palmer Alexis K - - 2013
Initiating highly active antiretroviral therapy (HAART) with low CD4 counts or AIDS-defining illnesses (ADIs) increases risk of treatment failure and death. We examined factors associated with late initiation among 18- to 29-year-olds within the Canadian Observational Cohort (CANOC) collaboration, a multi-site study of HIV-positive persons who initiated HAART after 2000. ...
Wen Hui - - 2013
C. elegans is widely used as a model organism in the study of aging and evaluation of anti-aging drugs due to its unique characteristics. In this work, we set out to investigate polydatin, a natural resveratrol glycoside, and its role in extending lifespan, improving oxidative stress resistance, and the possible ...
Stone Amy L - - 2013
Queer spaces are significant for understanding transgender inclusion as "queer spaces were places where individuals were expected to be attentive to or aware of alternative possibilities for being, including non-normative formulations of bodies, genders, desires and practices" ( Nash, 2011 , p. 203). Indeed, in this interview study of members ...
Tumkiratiwong Panas - - 2013
We monitored annual fecal sex hormones and reproductive displays of five individuals of males and females Thai sarus crane (Grus antigone sharpii), a flock of five males and females black-headed Ibis (Threskiornis melanocephalus), and five pair bonded lesser adjutant stork (Leptoptilos javanicus), all maintained in captivity at Bangprha Waterbird Breeding ...
Maures Travis J - - 2013
How the longevity of individuals of one sex is affected by those of the opposite sex is still largely unclear. In the nematode Caenorhabditis elegans, the presence of males accelerated aging and shortened the life span of individuals of the opposite sex (hermaphrodites), including long-lived or sterile hermaphrodites. The male-induced ...
Keyes Brice E - - 2013
Hair production is fueled by stem cells (SCs), which transition between cyclical bouts of rest and activity. Here, we explore why hair growth wanes with age. We show that aged hair follicle SCs (HFSCs) in mice exhibit enhanced resting and abbreviated growth phases and are delayed in response to tissue-regenerating ...
Behringer Verena - - 2013
We present information on age related changes of thyroid hormone levels in bonobos (N = 96) and chimpanzees (N = 100) ranging between one and 56 years of age. Fresh urine samples were used for hormone measurements with a commercial competitive total triiodothyronine (T3) ELISA. In both species, immature individuals had higher TT3 levels ...
Yao Chen - - 2013
Many complex human diseases exhibit sex or age differences in gene expression. However, the presence and extent of genotype-specific variations in gene regulation are largely unknown. Here we report results of a comprehensive analysis of expression regulation of genetic variation related to 11,672 complex disease associated SNPs as a function ...
Andersson Veronica - - 2013
The activity of the ubiquitin-proteasome system, UPS, declines during aging in several multicellular organisms. The reason behind this decline remains elusive. Here, using yeast as a model system, we show that while the level and potential capacity of the 26S proteasome is maintained in replicatively aged cells, the UPS is ...
1 2 3 4 5 6 7 8 9 10 >